DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam4 and DIP-epsilon

DIOPT Version :9

Sequence 1:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	385	Identity:	91/385 - (23%)
Similarity:	156/385 - (40%)	Gaps:	79/385 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 TVDVDKDAQFQCIVSGHPVHDVNWLHDGKPILRDNRVEILTDPPR---------------LIIKK 389
            ||...::.:..|.|.....:.|.|:|..:..:......::|..||               |.|..
  Fly    62 TVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWFLHINN 126

  Fly   390 VQKEDPGMYQCFVSNEWEQIQS-TAELQLG-----------DASPELLYWFSEQTLQPGPTVSLK 442
            ||:||.|.|.|       ||.: ||:.|.|           ||...     |:..::.|..|:|:
  Fly   127 VQEEDRGRYMC-------QINTVTAKTQYGFVKVVVPPNIDDALTS-----SDIIVREGDNVTLR 179

  Fly   443 CVATGNPLPQFTWSLDGFPIPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAI-G 506
            |.|.|:|.|...|..|     |.::.::.:.:.:||.....:.:..:.....|.|.|.|.|.: .
  Fly   180 CKAKGSPEPTIKWKRD-----DGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPP 239

  Fly   507 KVSHSAKVNIYGLPYIREMPKITGIS-GSDLIVKCPVAGYPIDKIHWERDG------------QT 558
            .||...||::...|.:....::.||. |.::.::|.:...|....:|.|:.            :|
  Fly   240 SVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTET 304

  Fly   559 LPINRRQRAYNNGTLIIEQLQRLEDAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNML 623
            :|.:...:|  ...|.|..:|. .|.|.|.|:|:|.:.... .|:::.:..||...|....|.:.
  Fly   305 IPGHPSYKA--TMRLTITNVQS-SDYGNYKCVAKNPRGDMD-GNIKLYMSSPPTTQPPPTTTTLR 365

  Fly   624 REGMRAAISCQI-LEG--DLPVSFRWERNGKPLIGTG--NEVFRRLDEYSASLVIEHISS 678
            |....||   :| |:|  :.|::    .||..::|.|  |.|..     |....|:::|:
  Fly   366 RTTTTAA---EIALDGYINTPLN----GNGIGIVGEGPTNSVIA-----SGKSSIKYLSN 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386
		Ig strand A	235..238	CDD:409353
		Ig strand A'	244..248	CDD:409353
		Ig strand B	251..258	CDD:409353
		Ig strand C	266..271	CDD:409353
		Ig strand C'	276..279	CDD:409353
		Ig strand D	285..289	CDD:409353
		Ig strand E	292..298	CDD:409353
		Ig strand F	305..313	CDD:409353
		Ig strand G	316..326	CDD:409353
		IgC2_3_Dscam	329..417	CDD:409549	23/92 (25%)
		Ig strand B	347..351	CDD:409549	0/3 (0%)
		Ig strand C	360..364	CDD:409549	1/3 (33%)
		Ig strand E	383..387	CDD:409549	3/18 (17%)
		Ig strand F	397..402	CDD:409549	2/4 (50%)
		Ig strand G	410..413	CDD:409549	0/3 (0%)
		IgI_4_Dscam	422..516	CDD:409548	23/94 (24%)
		Ig strand B	439..443	CDD:409548	2/3 (67%)
		Ig strand C	452..456	CDD:409548	0/3 (0%)
		Ig strand E	482..486	CDD:409548	0/3 (0%)
		Ig strand F	496..501	CDD:409548	2/4 (50%)
		Ig strand G	509..512	CDD:409548	1/2 (50%)
		IgI_5_Dscam	520..607	CDD:409550	21/99 (21%)
		Ig strand B	536..540	CDD:409550	0/3 (0%)
		Ig strand C	549..553	CDD:409550	0/3 (0%)
		Ig strand E	571..575	CDD:409550	1/3 (33%)
		Ig strand F	586..591	CDD:409550	2/4 (50%)
		Ig strand G	600..603	CDD:409550	0/2 (0%)
		Ig	610..703	CDD:416386	20/74 (27%)
		Ig strand A	611..613	CDD:409353	1/1 (100%)
		Ig strand A'	620..624	CDD:409353	1/3 (33%)
		Ig strand B	627..636	CDD:409353	3/9 (33%)
		Ig strand C	641..648	CDD:409353	1/6 (17%)
		Ig strand C'	650..652	CDD:409353	1/1 (100%)
		Ig strand D	659..664	CDD:409353	1/4 (25%)
		Ig strand E	668..675	CDD:409353	2/6 (33%)
		Ig strand F	682..690	CDD:409353
		Ig strand G	693..702	CDD:409353
		IgI_7_Dscam	706..801	CDD:409546
		Ig strand B	724..728	CDD:409546
		Ig strand C	737..741	CDD:409546
		Ig strand E	766..770	CDD:409546
		Ig strand F	780..785	CDD:409546
		Ig strand G	794..797	CDD:409546
		Ig	818..904	CDD:416386
		putative Ig strand B	820..827	CDD:409353
		putative Ig strand C	835..841	CDD:409353
		putative Ig strand C'	853..856	CDD:409353
		putative Ig strand D	862..866	CDD:409353
		putative Ig strand E	868..874	CDD:409353
		putative Ig strand F	881..889	CDD:409353
		putative Ig strand G	892..902	CDD:409353
		FN3	906..999	CDD:238020
		FN3	1006..1110	CDD:238020
		fn3	1117..1203	CDD:394996
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	25/99 (25%)
		Ig	69..139	CDD:143165	17/76 (22%)
		IG_like	165..249	CDD:214653	23/93 (25%)
		IGc2	172..237	CDD:197706	18/69 (26%)
		IG_like	267..348	CDD:214653	18/84 (21%)
		Ig	270..339	CDD:299845	16/71 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810