DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and CNTN2

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:XP_024305154.1 Gene:CNTN2 / 6900 HGNCID:2172 Length:1200 Species:Homo sapiens


Alignment Length:1409 Identity:322/1409 - (22%)
Similarity:498/1409 - (35%) Gaps:381/1409 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 GPIFLHEP-----PHRVEFSNNSGGLIECSGHGSPPPEVEW----TPIPPQQDMVFQLSNGSMMF 86
            ||:|..:|     |   |.|.....|:.|....|||....|    |.:..:.....||..|:::.
Human    49 GPVFEDQPLSVLFP---EESTEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVI 110

  Fly    87 Y-PFTAEKYRHEVHATVYRCKLRNLVGTVLSREVHVRGVVNQKYA------VQVHDEYVMTGNTA 144
            . |..|:      .|.||:|...|.||||:|||..:|....|:::      |:.|:     |...
Human   111 MNPTKAQ------DAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHE-----GWGV 164

  Fly   145 VLKCQVPSYMSEFVLVTAWVQDTGMHLYPN---TDIGGKYTVLSNGELYINNAGPNDAYKSYTCR 206
            :|.|..|::...  |...|:    ::.:||   || |..:...:.|.|||.....:| ..:|:|.
Human   165 MLPCNPPAHYPG--LSYRWL----LNEFPNFIPTD-GRHFVSQTTGNLYIARTNASD-LGNYSCL 221

  Fly   207 TVNRLTGEVQ--ISTYPGRIIVTEPKGMVQPRINVEKHSMRHVVLNGQTTLPCIAQGHPVPTYRW 269
            ..:.:....:  .|.:....:..|...:..|.|.....:..:.::..|.||.|.|.|:|||..:|
Human   222 ATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKW 286

  Fly   270 FKEENEQLLPLQLSERITIVSAGLLKITKARLEDSGKYLCWVNNTAGEETIQVSLTVTAPLTAHL 334
            .|.:.      .||.:.| .:...|:|.....||.|.|.|...|:.|.:|:|..:.|.|      
Human   287 RKVDG------SLSPQWT-TAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQA------ 338

  Fly   335 QPQVQTV------DVDKDAQFQCIVSGHPVHDVNWLHDGKPILRDNRVEILTDPPRLIIKKVQKE 393
            ||:...|      |:..:.::.|..:|.|...|.||.:|:|:...||||:|....|  ..|:..|
Human   339 QPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLR--FSKLSLE 401

  Fly   394 DPGMYQCFVSNEWEQIQSTAELQLGDASPELLYWFSEQTLQP---------GPTVSLKCVATGNP 449
            |.|||||...|:...|.::|||.:...:|:.       .|.|         |..:.:.|.....|
Human   402 DSGMYQCVAENKHGTIYASAELAVQALAPDF-------RLNPVRRLIPAARGGEILIPCQPRAAP 459

  Fly   450 LPQFTWSLDGFPIPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKV 514
            .....||.....:.:|||      ||:..|  ..:.|.|:...|.|:|||.|:|.:|      |.
Human   460 KAVVLWSKGTEILVNSSR------VTVTPD--GTLIIRNISRSDEGKYTCFAENFMG------KA 510

  Fly   515 NIYGLPYIREMPKIT-GISGSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQRAYNNGTLIIEQL 578
            |..|:..:|:..||| ..|.:|:                                          
Human   511 NSTGILSVRDATKITLAPSSADI------------------------------------------ 533

  Fly   579 QRLEDAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQILEGDLPVS 643
             .|.|..|..|.|.:                                           :..:.::
Human   534 -NLGDNLTLQCHASH-------------------------------------------DPTMDLT 554

  Fly   644 FRWERNGKPL-IGTGNEVFRR--LDEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTVNV 705
            |.|..:..|: .......:||  :.|....|.|.:....|.|.|||:|..|.             
Human   555 FTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVV------------- 606

  Fly   706 PPKWILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQLFPNGTIFF 770
                      .||...|.||:.    |.|          ||..|.....:.:.|:||        
Human   607 ----------DSASKEATVLVR----GPP----------GPPGGVVVRDIGDTTIQL-------- 639

  Fly   771 KKISKESQGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQ-CNVQGD--- 831
             ..|:....|          |.::|........||           .|.|||... .|::|:   
Human   640 -SWSRGFDNH----------SPIAKYTLQARTPPA-----------GKWKQVRTNPANIEGNAET 682

  Fly   832 ------NP-IDFKWKIQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASN 889
                  .| :|:::::                |...:|..|..|  |.|...|..........|.
Human   683 AQVLGLTPWMDYEFRV----------------IASNILGTGEPS--GPSSKIRTREAAPSVAPSG 729

  Fly   890 AFGQDEMSIQLIVQEVPEQPKNLRINSQQSRSLQLTWSQPFAGNSPIEEYHI-YYKQISDIWQNA 953
            ..|......:|||...|           .||..|         |.....|.: :.:|.|..||.|
Human   730 LSGGGGAPGELIVNWTP-----------MSREYQ---------NGDGFGYLLSFRRQGSTHWQTA 774

  Fly   954 EHLTIAGAQT---VINIQQLRPAKAYHIRMSAENKLGASEFSEVVQVTTLEEVPSGPPLAVRAEP 1015
            .   :.||..   |.:.:.:||...:.:::.:.|:.|....|....|.:.||.|...|..|.|:.
Human   775 R---VPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKG 836

  Fly  1016 KSSTEIFVTWDAPERDHWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGETV--L 1078
            .||:|:.|||:..::| .|||||||.:.|..:   .|||....:        ||: .|.:|.  :
Human   837 VSSSEMNVTWEPVQQD-MNGILLGYEIRYWKA---GDKEAAADR--------VRT-AGLDTSARV 888

  Fly  1079 ANLNKFTQYHVIVQAYTSQGSGPPSKEIAVQTMEDVPSSPPESPQCDVLGSTSIYITWSPPDIDG 1143
            :.|:..|:|||.|:||...|:||.|......||:..|..||.:... ...|:|:.|.|.|.....
Human   889 SGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISW-TFSSSSLSIKWDPVVPFR 952

  Fly  1144 QNGKIKGYKVFYISVDELYETDPEVVKSTNQYVTIENLRKYTNYTVWVLAYTKVGDGMKTKPFYC 1208
            ....:.|||:.|  .::|:.| |.:..:...::.|.......:..|.:......|||:..:....
Human   953 NESAVTGYKMLY--QNDLHLT-PTLHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIV 1014

  Fly  1209 RTHEDVPSAPQAIKAIPASSSKIIISWLPPDLPNGDITGYTFYMSMLEGGREEGTHKRLLGPFVE 1273
            |.....|..|.:.:.|..          ||....|........:|..:|..:.|.:        :
Human  1015 RNGGAAPPLPLSPREIQD----------PPRYLRGSFPPRPTPISTRKGKWKAGRN--------Q 1061

  Fly  1274 MHETVRTQESATYQFWLTASTKMGEGEKTQ---------------VVTV----PPNNKVPARIVS 1319
            :..::||.....:......|.:..||.:.|               .|.|    ||:..:|...::
Human  1062 VQSSLRTASPPPFYPAPRTSPRAREGRRVQGEAEDQPAIANGLQSTVGVGLRRPPSRPLPGLQLA 1126

  Fly  1320 F---------SQRIVTPWKEHLEL-----PCRKVGA----PAPV 1345
            .         |....|||..|..|     |.|..||    |.|:
Human  1127 LHKHDGGEHGSPPSTTPWHRHFPLRGDADPHRLPGALILEPLPL 1170

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386 32/102 (31%)
Ig strand A 32..35 CDD:409353 1/2 (50%)
Ig strand A' 41..45 CDD:409353 1/3 (33%)
Ig strand B 48..57 CDD:409353 2/8 (25%)
Ig strand D 75..78 CDD:409353 0/2 (0%)
Ig strand E 83..88 CDD:409353 0/5 (0%)
Ig strand F 101..109 CDD:409353 3/7 (43%)
Ig strand G 112..124 CDD:409353 7/11 (64%)
Ig 235..326 CDD:416386 27/90 (30%)
Ig strand A 235..238 CDD:409353 1/2 (50%)
Ig strand A' 244..248 CDD:409353 0/3 (0%)
Ig strand B 251..258 CDD:409353 3/6 (50%)
Ig strand C 266..271 CDD:409353 1/4 (25%)
Ig strand C' 276..279 CDD:409353 0/2 (0%)
Ig strand D 285..289 CDD:409353 1/3 (33%)
Ig strand E 292..298 CDD:409353 2/5 (40%)
Ig strand F 305..313 CDD:409353 3/7 (43%)
Ig strand G 316..326 CDD:409353 3/9 (33%)
IgC2_3_Dscam 329..417 CDD:409549 31/93 (33%)
Ig strand B 347..351 CDD:409549 0/3 (0%)
Ig strand C 360..364 CDD:409549 1/3 (33%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 4/4 (100%)
Ig strand G 410..413 CDD:409549 0/2 (0%)
IgI_4_Dscam 422..516 CDD:409548 25/102 (25%)
Ig strand B 439..443 CDD:409548 0/3 (0%)
Ig strand C 452..456 CDD:409548 0/3 (0%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 3/4 (75%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 11/87 (13%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 0/3 (0%)
Ig strand E 571..575 CDD:409550 0/3 (0%)
Ig strand F 586..591 CDD:409550 2/4 (50%)
Ig strand G 600..603 CDD:409550 0/2 (0%)
Ig 610..703 CDD:416386 15/95 (16%)
Ig strand A 611..613 CDD:409353 0/1 (0%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 0/8 (0%)
Ig strand C 641..648 CDD:409353 2/6 (33%)
Ig strand C' 650..652 CDD:409353 0/1 (0%)
Ig strand D 659..664 CDD:409353 2/6 (33%)
Ig strand E 668..675 CDD:409353 2/6 (33%)
Ig strand F 682..690 CDD:409353 5/7 (71%)
Ig strand G 693..702 CDD:409353 0/8 (0%)
IgI_7_Dscam 706..801 CDD:409546 17/94 (18%)
Ig strand B 724..728 CDD:409546 2/3 (67%)
Ig strand C 737..741 CDD:409546 0/3 (0%)
Ig strand E 766..770 CDD:409546 0/3 (0%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 1/2 (50%)
Ig 818..904 CDD:416386 20/96 (21%)
putative Ig strand B 820..827 CDD:409353 3/7 (43%)
putative Ig strand C 835..841 CDD:409353 1/5 (20%)
putative Ig strand C' 853..856 CDD:409353 0/2 (0%)
putative Ig strand D 862..866 CDD:409353 1/3 (33%)
putative Ig strand E 868..874 CDD:409353 2/5 (40%)
putative Ig strand F 881..889 CDD:409353 0/7 (0%)
putative Ig strand G 892..902 CDD:409353 2/9 (22%)
FN3 906..999 CDD:238020 20/96 (21%)
FN3 1006..1110 CDD:238020 37/105 (35%)
fn3 1117..1203 CDD:394996 19/85 (22%)
FN3 1215..1307 CDD:238020 16/106 (15%)
Ig <1334..1401 CDD:416386 7/21 (33%)
Ig strand C 1345..1349 CDD:409353 0/1 (0%)
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
CNTN2XP_024305154.1 Ig 49..142 CDD:325142 31/101 (31%)
Ig2_Contactin-2-like 144..241 CDD:143204 22/109 (20%)
Ig 252..337 CDD:325142 27/91 (30%)
Ig4_Contactin-2-like 341..425 CDD:143205 29/85 (34%)
Ig5_Contactin 446..518 CDD:319278 24/85 (28%)
Ig6_Contactin-2 537..616 CDD:143262 22/144 (15%)
FN3 631..718 CDD:238020 23/134 (17%)
FN3 739..813 CDD:238020 21/96 (22%)
FN3 828..920 CDD:238020 37/104 (36%)
Atrophin-1 <1002..1197 CDD:331285 36/187 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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