DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and DSCAML1

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:XP_011541219.1 Gene:DSCAML1 / 57453 HGNCID:14656 Length:2065 Species:Homo sapiens


Alignment Length:1950 Identity:617/1950 - (31%)
Similarity:932/1950 - (47%) Gaps:218/1950 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 FLHEPPHRVEFSNNSGGLIECSGHGSPPPEVEWTPIPPQQDMVFQL-------SNGSMMFYPFTA 91
            |:::...:|.||::.|.::.|...|||...:.|  .....|.::.:       :||::..|||:.
Human    27 FVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRW--YLATGDDIYDVPHIRHVHANGTLQLYPFSP 89

  Fly    92 EKYRHEVHATVYRCKLRNLVGTVLSREVHVRGVVNQKYAVQVHDEYVMTGNTAVLKCQVPSYMSE 156
            ..:...:|...|.|...|..|.:.|..:.|:.|..:.|.|:|.|:..|.||.||.||.:||.:.|
Human    90 SAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQE 154

  Fly   157 FVLVTAWVQDTGMHLYPNTDIGGKYTVLSNGELYINNAGPNDAYKSYTCRTVNRLTGEVQISTYP 221
            :|.|.:|.:|| :.:.|.    .::.:..:|.|||::....||..:|.|.|.::.:||.:.|. .
Human   155 YVSVVSWEKDT-VSIIPE----HRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSN-G 213

  Fly   222 GRIIVT------EPKGMVQPRINVEK-----HSMRHVVLNGQTT-LPCIAQGHPVPTYRWFKEEN 274
            .|:.||      :|..:..|..::..     ||..  |..|.|. |||.|.|:|:|..||.|:..
Human   214 ARLSVTGLARAADPLCLPDPAESIPTILDGFHSQE--VWAGHTVELPCTASGYPIPAIRWLKDGR 276

  Fly   275 EQLLPLQLSERITIVSAGLLKITKARLEDSGKYLCWVNNTAGEETIQVSLTVTAPLTAHLQPQVQ 339
                ||....|.|....| |.|:..|.||||.|:|.|.||.|.......|.|..||...|.|:..
Human   277 ----PLPADSRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKL 336

  Fly   340 TVDVDKDAQFQCIVSGHPVHDVNWLHDGKPILRDNRVEI--LTDPPRLIIKKVQKEDPGMYQCFV 402
            ...:.......|.::|.|...:.|..:.:.:|.|..:.|  |:: ..|:|...||...|.||||.
Human   337 KTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSN-ETLLITSAQKSHSGAYQCFA 400

  Fly   403 SNEWEQIQSTAELQLGDASPELLYWFSEQTLQPGPTVSLKCVATGNPLPQFTWSLDGFPIPDSSR 467
            :.:.:..|..|.:.|.|.:|.::..|||:.:.||...||.|.|.|.|.|..||:||..||.....
Human   401 TRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGS 465

  Fly   468 FLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLPYIREMPKITGIS 532
            ....||.......|||:|::..:..|||.|.|||:|.:|...:.|::|:.|.|.||.|..||.::
Human   466 HRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVA 530

  Fly   533 GSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQRAYNNGTLIIEQLQRLEDAGTYTCMAQNKQKQ 597
            |.|.::.|.|.|||...|.|.:|...||.|.||..:.||||.:..:|:..|.|.|.|....:.:.
Human   531 GRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL 595

  Fly   598 TSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQILEGDLPVSFRWERNGKPLIGTGNEVFR 662
            :..::|.:.|.|||.|.|.:.....:  |....|.|.:..||:|:...|.::|:.:| :|:.|..
Human   596 SISQSVHVAVKVPPLIQPFEFPPASI--GQLLYIPCVVSSGDMPIRITWRKDGQVII-SGSGVTI 657

  Fly   663 RLDEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTVNVPPKWILEPKDSSAQAGADVLLH 727
            ...|:.:||.|..:|..|:|||||||||.|.|......|.|.|||:::::|.:.....|...:|:
Human   658 ESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLN 722

  Fly   728 CQSSGYPTPTITWKKAIGP-TPGEYKDFLYEPTVQLFPNGTIFFKKISKESQGHFLCEAKNNIGS 791
            |...|||.|.:.||.|.|. .|.:|........:|:.||.::..:.:.:|..|::||:|.|.:|:
Human   723 CSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGT 787

  Fly   792 GVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDNPIDFKWKIQATQQYLDESLDSRYT 856
            .:||.:||.|.:||...:........||....:.|..:|:.||..:|:...|  .:|.....||.
Human   788 DISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDT--VIDPDRVMRYA 850

  Fly   857 IRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQEVPEQPKNLRINSQQSRS 921
            |..:...|.:||.|.:....|.|:..:.|.|.|::|:|...|||.|||.|:.|: |.|...::||
Human   851 IATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPE-LEIREVKARS 914

  Fly   922 LQLTWSQPFAGNSPIEEYHIYYKQISDIW---QNAEHL--TIAGAQTVINIQQLRPAKAYHIRMS 981
            :.|.|:|.|.|||.|..:.|.||..||.|   |:..::  ||..|    ||..|.||..|.|||.
Human   915 MNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQA----NIVDLHPASVYSIRMY 975

  Fly   982 AENKLGASEFSEVVQVTTLEEVPSGPPLAVRAEPKSSTEIFVTWDAPERDHWNGILLGYYVGYQM 1046
            :.||:|.||.|:.:.::|.|..|.|||:.|..:|.:|..|.|||.||:::..||::.||.:||  
Human   976 SFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGY-- 1038

  Fly  1047 SLTPEDKEVNPTQGFSFKTVEVRSHFGGET-VLANLNKFTQYHVIVQAYTSQGSGPPSKEIAVQT 1110
                  :|.:|.....:..||:::....|. .|.||.||.||.|:|||:...|:||.|.||...|
Human  1039 ------RENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATT 1097

  Fly  1111 MEDVPSSPPESPQCDVLGSTSIYITWSPPDIDGQNGKIKGYKVFYISVDELYET----DPEVVKS 1171
            :|||||.|||:.:...:.|....|:||.|.....||.:|||:|.:.|   ||..    :.:.:.:
Human  1098 LEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWS---LYVDGEWGEMQNITT 1159

  Fly  1172 TNQYVTIENLRKYTNYTVWVLAYTKVGDGMKTKPFYCRTHEDVPSAPQAIKAIPASSSKIIISWL 1236
            |.:.|.:..:.|:|||:|.|||||:.|||:::...|.:|.||||..|..|||:|:|:|.:::|||
Human  1160 TRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWL 1224

  Fly  1237 PPDLPNGDITGYTFYMSMLEGGR----EEGTHKRLLGPFVEMHETVRTQESATYQFWLTASTKMG 1297
            ||..|||.|..||.:.|....|:    |..|....|  |..:....|.|:   |..|:.|.|..|
Human  1225 PPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQL--FYRIAHLNRGQQ---YLLWVAAVTSAG 1284

  Fly  1298 EGEKTQVVTVPPNNKVPARIVSFSQRIVTPWKEHLELPCRKVGAPAPVTIWRQDGHN----METS 1358
            .|..::.||:.|..|.||:|:||...:.|||.:.:.|||..||.|||...|.:|..:    :...
Human  1285 RGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMD 1349

  Fly  1359 ARKTIAKNGTLYMKECQASDAGNYTCSVENTWGKDEIVYNIVVKVPPEAPNLTVINAYTDSLLLE 1423
            ..:.|..||||.::..:|.|:|.|||:..||.|.|.|:.|::|:|||:.|.|||......|:.|.
Human  1350 GHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLT 1414

  Fly  1424 WMDNSHGGSPILGYVINYKRDNG-DWEELQVDSKTTSHLLTNLWCGTRYQLYITAYNKIGTGLPC 1487
            |:...:|||.|.|:|:.|..||. :|:::.:.|...|..|.:|.|||.|::.:.|.|.:|:|...
Human  1415 WIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRIS 1479

  Fly  1488 DIVNSYTKGNPPVQPKHSQMITN-NSTSVTCWLDSWGDGGCGILYFMIESRVYGRSSWAVVSNHI 1551
            :|:.:.|.|..|...|...:.|: |||.....|..|.:|||.|...::|.|..|  :||......
Human  1480 EIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKG--TWAWQGLRA 1542

  Fly  1552 PPTERIYTVSDLVPGTKYQLKVTAHNNAGSTTAIYNFTTLSTQGVIYNNDHSTPVSHLSDLPFYA 1616
            ..:..:: :::|...|.|:|::.|.|:||.......|.||...|              |.:|...
Human  1543 NSSGEVF-LTELREATWYELRMRACNSAGCGNETAQFATLDYDG--------------STIPPIK 1592

  Fly  1617 N-----------FKLLLPICFSLLMLLALIGAALFLRKRKLASQARLASSSMSESPSLAN-LQNK 1669
            :           |.:..|:      :||.:|.||....||...:.||  ..:.::.|||. |.:|
Human  1593 SAQGEGDDVKKLFTIGCPV------ILATLGVALLFIVRKKRKEKRL--KRLRDAKSLAEMLISK 1649

  Fly  1670 QNRDQQYLAVRCNPGTSAPRGSNSN-----------DSGSFGKAEGNEYIEDICPYATFQLNKQT 1723
            .||...      .|....|:|...:           |.      ||.:.:.|  ..||..:....
Human  1650 NNRSFD------TPVKGPPQGPRLHIDIPRVQLLIEDK------EGIKQLGD--DKATIPVTDAE 1700

  Fly  1724 YSESSYSGNVYSGPYHSVRGSFVYH--------------DVKP----------ESYHSKEPEY-- 1762
            :|::       ..|.....|..::|              |::|          :|.||....|  
Human  1701 FSQA-------VNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSRKNVKSAHSTRNRYSS 1758

  Fly  1763 ----TKVR------------RKVGRLR-------DPHSESQESDNPGSTDSEVRKILTLHIPITE 1804
                ||.:            |.||...       |.:|.|...|    ||.....:::.....:.
Human  1759 QWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQD----TDKGRNSMVSTESASST 1819

  Fly  1805 YDTLGSESDNDVSARALNSAKYRAQRDTQDETSSSSETTPT-----SMTRKSKPPFAARKGGKPG 1864
            |:.|....::......|..||:........::||...||.|     |||..|.|       .:||
Human  1820 YEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMSTP-------SEPG 1877

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386 23/96 (24%)