DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and cntn3a.1

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:XP_697914.4 Gene:cntn3a.1 / 569437 ZFINID:ZDB-GENE-081030-10 Length:1028 Species:Danio rerio


Alignment Length:1179 Identity:265/1179 - (22%)
Similarity:461/1179 - (39%) Gaps:242/1179 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   221 PGRIIVTEPKGMVQPRINVEKHSMRHVVLNGQTTLPCIAQGHPVPTYRWFKEENEQLLPLQLSER 285
            |.|.:.|:..|.:...:::.:.|.       :.|..|.|||.|.|:|||  :.|:..:..|...|
Zfish    23 PLRPVFTKQPGSIVFPLHLNEPSR-------EVTFSCEAQGRPPPSYRW--KMNDSFISPQPGSR 78

  Fly   286 ITIVSAGLLKITKA-RLEDSGKYLCWVNNTAGEETI---QVSLTVTAPLTAHLQ---PQVQTVDV 343
            .:| |.|.|:|::. :.||:|.|.|..:|:.|  ||   :.||.:     |:|:   .|:::...
Zfish    79 YSI-SGGNLRISQLNKEEDAGIYQCLASNSFG--TILSREASLHI-----AYLEEFKTQMRSPVR 135

  Fly   344 DKDAQFQCIVSGHPVH----DVNWLHDGKP--ILRDNRVEILTDPPRLIIKKVQKEDPGMYQCFV 402
            .::.|...::.|.|.:    ..:|:.:..|  :.:|.|..:......|.|.||:..|.|.|.|.|
Zfish   136 VREGQGVVLLCGPPAYMGELTFSWIFNEYPSFVEQDTRRFVSQKTGNLYIAKVEPSDVGNYTCVV 200

  Fly   403 SNEWEQ--IQS-------TAELQLGDASPELLYWFSE-QTLQPGPTVSLKCVATGNPLPQFTWSL 457
            :|...|  :|.       .::..:|:..|::...|.| ..:..|.||.|:|.|.|||:|..:|..
Zfish   201 TNTVTQNRVQGPPTPLILRSDGIMGEYEPKIEVQFPEVLAVAKGLTVKLECFALGNPVPAISWRR 265

  Fly   458 -DGFPIP------DSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVN 515
             ||.|.|      .||..|               .|...::||.|.|.|.|:|:.||.:...:::
Zfish   266 PDGVPFPRKVDVSKSSGVL---------------EIPYFQQEDAGPYECVAENSRGKNTGKGRLS 315

  Fly   516 IYGLPYIREMPKITGISGSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQRAYNNGTLIIEQLQR 580
            .|..|::.|.|:       |:                            |||.:...|       
Zfish   316 FYAPPHLVEKPQ-------DV----------------------------QRAIDESLL------- 338

  Fly   581 LEDAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQILEGDLPVSFR 645
                  :.|.|..|.|.                                             |:|
Zfish   339 ------WECKASAKPKP---------------------------------------------SYR 352

  Fly   646 WERNGKPLIGTGNEVFR-RLDEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPL-TVNVPPK 708
            |.:||:||     |.|. |:...:.:|.|..::...:|.|.|||.|..|.......| .:.|.|.
Zfish   353 WLKNGEPL-----ESFEDRIQVINGALSISSLTLSDTGMYQCIAENRHGRVFANAELRVIAVAPD 412

  Fly   709 W---ILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEP-TVQLFPNGTIF 769
            :   :|:.: :.|:.|.|||:.|:....|...|:|:|.        |:.|.|. .|.:..||::.
Zfish   413 FSNSVLKAQ-TLARQGGDVLIECRPRMSPRGMISWRKG--------KEALRESHRVSVLDNGSLR 468

  Fly   770 FKKISKESQGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDNPI 834
            ...|:|...|.:.|.|:|..|. .|....|.|..|....:|..|:.|..|:.|.:.|.|..|..:
Zfish   469 ISNITKLDAGLYTCVARNQFGV-ASSAGTLVVKEPTIITSKATQLDVTVGESVVIPCQVSRDPSL 532

  Fly   835 DFKWKIQATQQYLDESLDSRY--TIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMS 897
            |.::.....:|.::......|  .:......|.|:..:.:.|     .|.|.|..........::
Zfish   533 DVRFTWFFNEQLINFGSHGGYFEKVGGASAGDIMIRNIQLRH-----AGRYTCAVQTKVDSASIA 592

  Fly   898 IQLIVQEVPEQPKNLRINSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQISDI-WQNAEHL--TIA 959
            ..::|:..|:.|.::|::.....:..::||.....:||:..|:|..:....: ||.|:.:  ::.
Zfish   593 TDVVVRGPPDPPLDIRVDEVTETTSFVSWSPGPDNHSPVFAYNIQIRSPFSLGWQAAKTVPESLG 657

  Fly   960 GAQTVINIQQLRPAKAYHIRMSAENKLGASEFSEVVQ-VTTLEEVPSGPPLAVRAEPKSSTEIFV 1023
            |.|:...:.:|.|...|..|:.|.|.:|..|.::..| :.|.:.:|...|..|.....|.:|:.:
Zfish   658 GQQSSARVVELSPWVEYEFRVLATNSIGTGEPTKPSQKIRTKDTMPRITPARVSGGGGSRSELVI 722

  Fly  1024 TWDAPERDHWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGETVLAN--LNKFTQ 1086
            ||:....:...|...||.|.::           |..|.::....|.|......:..|  :..|:.
Zfish   723 TWEPVPEEQQAGPGFGYVVAFR-----------PLGGQNWMQAAVTSPDASRYIFKNDSIPPFSP 776

  Fly  1087 YHVIVQAYTSQGSGPPSKEIAVQTMEDVPSSPPESPQCDVLGSTSIYITWSPPDIDGQNGKIKGY 1151
            :||.|..|.::|.||......:.:.|:.||..|...:...|.::.:.::|.|........:|.||
Zfish   777 FHVKVGVYNNKGEGPFGPVTTIYSAEEEPSRAPSRIRAKSLSASEVEVSWKPLPWSTSRTRIMGY 841

  Fly  1152 KVFYISVDELYETDPEVVKSTNQYVT--IENLRKYTNYTVWVLAYTKVGDGMKTKPFYCRTHEDV 1214
            ::.|.|..:..:| ..|:::.....:  |..|...:.|.:.:.||...|.|..:......|....
Zfish   842 ELRYWSTKDRPDT-ASVMRTVGNRTSAVIRGLDPSSTYNIKLKAYNSAGVGPDSAVVNVTTKRPP 905

  Fly  1215 PSAPQAIKAIPASSSKIIISWLPPDLPNGDITGYTFYMSMLEGGREEGTHKRLLGPFVEMHETVR 1279
            ||..........:.||:|:.|              .::..||...|      ::|..|...::.:
Zfish   906 PSQSPVKVMWNTTDSKLILKW--------------DHVKALENESE------VMGYKVMYKQSRQ 950

  Fly  1280 TQESAT----------------YQFWLTASTKMGEGEKTQVVTVPPNNKVPARIVSFS-QRIVTP 1327
            |:.|..                |...:...::.|||..::.:|:|  ....|..:.|: :|...|
Zfish   951 TRPSVVETNSTSLELSLPVDEDYIIQIKPVSEGGEGSSSKQITIP--RIAVAHAIGFAPERKALP 1013

  Fly  1328 WKEHLELPC 1336
            ....|.|.|
Zfish  1014 VFVTLVLHC 1022

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386 30/94 (32%)
Ig strand A 235..238 CDD:409353 0/2 (0%)
Ig strand A' 244..248 CDD:409353 0/3 (0%)
Ig strand B 251..258 CDD:409353 1/6 (17%)
Ig strand C 266..271 CDD:409353 3/4 (75%)
Ig strand C' 276..279 CDD:409353 0/2 (0%)
Ig strand D 285..289 CDD:409353 1/3 (33%)
Ig strand E 292..298 CDD:409353 3/5 (60%)
Ig strand F 305..313 CDD:409353 3/7 (43%)
Ig strand G 316..326 CDD:409353 5/12 (42%)
IgC2_3_Dscam 329..417 CDD:409549 22/105 (21%)
Ig strand B 347..351 CDD:409549 1/3 (33%)
Ig strand C 360..364 CDD:409549 0/3 (0%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 2/4 (50%)
Ig strand G 410..413 CDD:409549 1/9 (11%)
IgI_4_Dscam 422..516 CDD:409548 31/101 (31%)
Ig strand B 439..443 CDD:409548 2/3 (67%)
Ig strand C 452..456 CDD:409548 0/3 (0%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 2/4 (50%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 12/86 (14%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 0/3 (0%)
Ig strand E 571..575 CDD:409550 1/3 (33%)
Ig strand F 586..591 CDD:409550 1/4 (25%)
Ig strand G 600..603 CDD:409550 0/2 (0%)
Ig 610..703 CDD:416386 20/94 (21%)
Ig strand A 611..613 CDD:409353 0/1 (0%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 0/8 (0%)
Ig strand C 641..648 CDD:409353 3/6 (50%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 2/5 (40%)
Ig strand E 668..675 CDD:409353 2/6 (33%)
Ig strand F 682..690 CDD:409353 5/7 (71%)
Ig strand G 693..702 CDD:409353 2/9 (22%)
IgI_7_Dscam 706..801 CDD:409546 27/98 (28%)
Ig strand B 724..728 CDD:409546 2/3 (67%)
Ig strand C 737..741 CDD:409546 1/3 (33%)
Ig strand E 766..770 CDD:409546 1/3 (33%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 1/2 (50%)
Ig 818..904 CDD:416386 15/87 (17%)
putative Ig strand B 820..827 CDD:409353 1/6 (17%)
putative Ig strand C 835..841 CDD:409353 1/5 (20%)
putative Ig strand C' 853..856 CDD:409353 1/4 (25%)
putative Ig strand D 862..866 CDD:409353 1/3 (33%)
putative Ig strand E 868..874 CDD:409353 0/5 (0%)
putative Ig strand F 881..889 CDD:409353 3/7 (43%)
putative Ig strand G 892..902 CDD:409353 0/9 (0%)
FN3 906..999 CDD:238020 23/96 (24%)
FN3 1006..1110 CDD:238020 23/105 (22%)
fn3 1117..1203 CDD:394996 18/87 (21%)
FN3 1215..1307 CDD:238020 17/107 (16%)
Ig <1334..1401 CDD:416386 2/3 (67%)
Ig strand C 1345..1349 CDD:409353
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
cntn3a.1XP_697914.4 I-set 26..120 CDD:254352 32/105 (30%)
Ig 26..117 CDD:299845 30/102 (29%)
Ig 122..217 CDD:299845 21/94 (22%)
IG_like 132..206 CDD:214653 17/73 (23%)
Ig 229..317 CDD:299845 31/102 (30%)
I-set 229..309 CDD:254352 31/94 (33%)
I-set 320..406 CDD:254352 32/183 (17%)
Ig 323..406 CDD:299845 31/180 (17%)
IG_like 421..499 CDD:214653 25/87 (29%)
Ig 427..499 CDD:299845 24/80 (30%)
IG_like 514..597 CDD:214653 15/87 (17%)
Ig 518..601 CDD:299845 14/87 (16%)
FN3 601..698 CDD:238020 23/96 (24%)
FN3 707..799 CDD:238020 23/102 (23%)
FN3 808..901 CDD:238020 18/93 (19%)
FN3 916..994 CDD:238020 15/97 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.010

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