DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and robo4

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:XP_689255.3 Gene:robo4 / 560765 ZFINID:ZDB-GENE-020809-1 Length:1134 Species:Danio rerio


Alignment Length:990 Identity:197/990 - (19%)
Similarity:321/990 - (32%) Gaps:323/990 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   501 AQNAIGK-----------VSH---------SAKVNIYGLPYIREMPKITGIS-GSDLIVKCPVAG 544
            ||.:.||           .||         |..|:...||.|...|....:. ||...:.|...|
Zfish    32 AQRSEGKGHLRHRLMHQRASHRDRAHRRKGSRLVSEINLPRIVHHPSDVVVRVGSPATLSCRAEG 96

  Fly   545 YPIDKIHWERDGQTLPINRRQR-----AYNNGTL----IIEQLQRLEDAGTYTCMAQNKQKQTSR 600
            .|...|.|.|:||.|..::...     ...:|:|    ::...:.......|.|:|.|.....:.
Zfish    97 NPEPTIQWLRNGQPLDTDKMDAQSQPIVLPDGSLFFFSVVPGRKGQSHEAVYACIAHNSIGNATS 161

  Fly   601 RNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQILEGDLPVSFRWERNGKPLIGTGNEVFRRLD 665
            ||..:.:....:...:|.....:..|..|.|:|....|....:..|.::| .||.:.||.:   .
Zfish   162 RNASLHIAALREDFRVQPSDVEVAIGEMATINCSPPVGHPEPNVTWRKDG-ILINSSNEHY---T 222

  Fly   666 EYSASLVIEHISSDHSGNYTCIASNVAGT-ERFTVPLTVNVPPKWILEPKDSSAQAGADVLLHCQ 729
            |....|:|.....:.||.|:|||||:.|. |.....|:|...|..:.:|:|.|.|.|......|:
Zfish   223 ELKGKLIIAPAQKNDSGVYSCIASNMIGVRESRAARLSVLAKPVLLRKPEDVSVQLGESAQFFCE 287

  Fly   730 SSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQLFPNGTIFFKKISKESQGHFLCEAKNNIGSGVS 794
            :.|.|.|:|.|.:..||.|                             .|.:|.           
Zfish   288 ADGDPMPSIEWSREQGPLP-----------------------------NGRYLI----------- 312

  Fly   795 KVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDNPIDFKWKIQATQQYLDESLDSRYTIRD 859
                                                 ||              |.||...|..  
Zfish   313 -------------------------------------NP--------------DHSLQIHYVT-- 324

  Fly   860 QVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQEVPEQPKNLRINSQQSRSLQL 924
                             .||.|.|.|...|..|....|.||:|::                    
Zfish   325 -----------------AQDMGRYSCTVENKLGVSVASAQLLVED-------------------- 352

  Fly   925 TWSQPFAGNSPIEEYHIYYKQISDIWQNAEHLTIAGAQTVINIQQLRPAKAYHIRMSAENKLGAS 989
                  ||.:.:.:.|   |::|.:..:.|::|:                     ||.     ||
Zfish   353 ------AGGTRLRDLH---KELSALRVSLENVTV---------------------MST-----AS 382

  Fly   990 EFSEVVQVTTLEEVPSGPPLAVRAEPKSSTEIFVTWDAPERDHWNGILLGYYVGYQMSLTPEDKE 1054
            ..|:|  :..|:...|.|                        |:   |.|:.|.|: ||.|...:
Zfish   383 NMSQV--MWKLQSFGSQP------------------------HY---LEGFEVLYR-SLLPASSD 417

  Fly  1055 VNPTQGFSFKTV---EVRSHFGGETVLANLNKFTQYHVIVQAYTSQGSGPPSKEIAVQTMEDVPS 1116
                  ::.:.|   .:.:|.|      .|.:..:|...|:.|.|...|..|....::..|.|||
Zfish   418 ------WTAQRVPQPSLHTHVG------PLKRGYKYEFKVRPYGSSLYGRESNTRHLRVPEIVPS 470

  Fly  1117 SPPESPQCDVLG--STSIYITWSPPDIDGQNGKIKGYKVFYISVDELYETDPEVVKSTNQYVTIE 1179
            :.|:.....:..  :.:::::|.||..|..||.|:||:|:.:..:|....:..|...|:. :.|.
Zfish   471 AAPQDVSITMPAERNDTVHLSWEPPPHDAHNGIIQGYQVWCVESEEQTSFNWTVDSGTHS-IEIF 534

  Fly  1180 NLRKYTNYTVWVLAYTKVGDGMKTKPFYCRTHEDVPSAPQAIKAIPASSSKIIISWLPPDLPNGD 1244
            .|.....|.|.|.|....|.|:::.|:.......:.:.|.....:..|.   .:|.:...:..|.
Zfish   535 TLLPSRLYWVTVAAVNGAGVGVQSDPYKLLIESRLEATPYQTGILSMSH---FVSVIKEPVFIGS 596

  Fly  1245 ----------ITGYTFYMSMLE----GGREEGTHKRLLGPFVEMHE-TVRTQESATYQFWLTAST 1294
                      ||....|...:.    .|:..|.::      :|..: .::.:.:|....|::...
Zfish   597 VGTLLWCVLMITAVFLYRRHIRPANPSGKSSGLYR------LESEDLIIKHRMAAPDSPWISGGW 655

  Fly  1295 KMGEGEKTQVVTVPPNNKVPARIVSFSQRIVTPWKEHLELPCRKVGAPAPVTIWRQDGHNMETSA 1359
            :            |.:|..|      .|.:.||.:|:..|  |:  ...|:|: ::|.:.:. ||
Zfish   656 R------------PGSNSEP------KQGLWTPSQENSGL--RR--TTLPITV-KKDPNPLR-SA 696

  Fly  1360 RKTIAKN----GTLYMK-------------ECQASDAGNYTCSVENTWGKDE-IVYNIVVK---- 1402
            ...:..|    ||.|:.             .|.....||.......|....| ||...||:    
Zfish   697 VPIVPDNCGVYGTFYVDLTGNGLKTFNSPGRCPRMPHGNSQLQNSETIRITEPIVKTAVVRELQA 761

  Fly  1403 VP-----PEAPNLTV 1412
            :|     |..||:.|
Zfish   762 LPWKRTLPAQPNMGV 776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353
Ig strand C' 276..279 CDD:409353
Ig strand D 285..289 CDD:409353
Ig strand E 292..298 CDD:409353
Ig strand F 305..313 CDD:409353
Ig strand G 316..326 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549
Ig strand B 347..351 CDD:409549
Ig strand C 360..364 CDD:409549
Ig strand E 383..387 CDD:409549
Ig strand F 397..402 CDD:409549
Ig strand G 410..413 CDD:409549
IgI_4_Dscam 422..516 CDD:409548 8/34 (24%)
Ig strand B 439..443 CDD:409548
Ig strand C 452..456 CDD:409548
Ig strand E 482..486 CDD:409548
Ig strand F 496..501 CDD:409548 197/990 (20%)
Ig strand G 509..512 CDD:409548 2/11 (18%)
IgI_5_Dscam 520..607 CDD:409550 22/96 (23%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 1/3 (33%)
Ig strand E 571..575 CDD:409550 2/7 (29%)
Ig strand F 586..591 CDD:409550 2/4 (50%)
Ig strand G 600..603 CDD:409550 1/2 (50%)
Ig 610..703 CDD:416386 26/93 (28%)
Ig strand A 611..613 CDD:409353 0/1 (0%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 3/8 (38%)
Ig strand C 641..648 CDD:409353 1/6 (17%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 1/4 (25%)
Ig strand E 668..675 CDD:409353 2/6 (33%)
Ig strand F 682..690 CDD:409353 5/7 (71%)
Ig strand G 693..702 CDD:409353 2/9 (22%)
IgI_7_Dscam 706..801 CDD:409546 17/94 (18%)
Ig strand B 724..728 CDD:409546 0/3 (0%)
Ig strand C 737..741 CDD:409546 1/3 (33%)
Ig strand E 766..770 CDD:409546 0/3 (0%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 0/2 (0%)
Ig 818..904 CDD:416386 17/85 (20%)
putative Ig strand B 820..827 CDD:409353 0/6 (0%)
putative Ig strand C 835..841 CDD:409353 0/5 (0%)
putative Ig strand C' 853..856 CDD:409353 0/2 (0%)
putative Ig strand D 862..866 CDD:409353 0/3 (0%)
putative Ig strand E 868..874 CDD:409353 0/5 (0%)
putative Ig strand F 881..889 CDD:409353 3/7 (43%)
putative Ig strand G 892..902 CDD:409353 4/9 (44%)
FN3 906..999 CDD:238020 13/92 (14%)
FN3 1006..1110 CDD:238020 19/106 (18%)
fn3 1117..1203 CDD:394996 22/87 (25%)
FN3 1215..1307 CDD:238020 12/106 (11%)
Ig <1334..1401 CDD:416386 18/84 (21%)
Ig strand C 1345..1349 CDD:409353 1/3 (33%)
Ig strand D 1363..1366 CDD:409353 0/2 (0%)
Ig strand E 1367..1372 CDD:409353 3/4 (75%)
Ig strand F 1380..1388 CDD:409353 2/7 (29%)
Ig strand G 1394..1401 CDD:409353 3/7 (43%)
FN3 1405..1494 CDD:238020 4/8 (50%)
FN3 1499..1580 CDD:238020
robo4XP_689255.3 Ig1_Robo 70..169 CDD:143317 23/98 (23%)
I-set 71..168 CDD:254352 22/96 (23%)
I-set 175..261 CDD:254352 26/89 (29%)
Ig2_Robo 177..261 CDD:143201 26/87 (30%)
I-set 265..350 CDD:254352 33/194 (17%)
Ig 282..350 CDD:299845 27/177 (15%)
FN3 373..448 CDD:214495 25/142 (18%)
FN3 472..560 CDD:238020 22/88 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.910

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