DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and lrit1a

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_001018174.2 Gene:lrit1a / 553943 ZFINID:ZDB-GENE-040924-5 Length:643 Species:Danio rerio


Alignment Length:656 Identity:121/656 - (18%)
Similarity:205/656 - (31%) Gaps:187/656 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1194 YTKVGDGMKTKPFYCRTHED--VPSA-----------PQAIKAIPASS----SKIIISWLP---- 1237
            |..:.||.:.:...|...|.  ||::           ..|||.||:.:    |.:...|:.    
Zfish    31 YHNLSDGSRARSVICNDPEISLVPASFPGDTSKLRIEKTAIKRIPSEAFSYLSNLEFLWMSFNVL 95

  Fly  1238 PDLPNGDITGYTFYMSMLEGGREEGTHKRLLGPF-------------VEMH---------ETVRT 1280
            ..|.:....|    :..||..|.:|..   |..|             :::|         |....
Zfish    96 SSLNSDSFRG----LYSLEELRLDGNS---LSSFPWESLMDMPSLRLLDIHNNQLSSLPSEAALY 153

  Fly  1281 QESATY----------------QFWLTASTKMGEGEKTQVVTVPPN--------------NKVPA 1315
            .::.||                ..|||....:|......::.:..|              .|.|:
Zfish   154 MKNITYLDLSSNNLLTVPAEVLNTWLTIKPTLGAESSKLILGLHDNPWLCDCRLYDLVQFQKSPS 218

  Fly  1316 RIVSFSQ----------------------------------RIVTPWKEHLELPCRKVGAPAPVT 1346
            ..|:|..                                  |:.:....::.|.|..||.|.|..
Zfish   219 LSVAFIDTRLRCADPESLSGVLFSDAELRRCQGPRVHTAVARVRSAVGNNVLLRCGTVGVPIPEL 283

  Fly  1347 IWRQ-DGHNMETSARKTIAKNGTLY----MKECQASDAGNYTCSVENTWGKDEIVYNIVV----- 1401
            .||: ||..:..:.....:|.|.::    :......|.|.|.|...|..|..|.|.::::     
Zfish   284 AWRRADGKPLNGTVLLENSKEGIVWSILSVPAVSYRDTGKYICKATNYAGSAEAVISLIINDAPK 348

  Fly  1402 ----------KVPPEAPNLTVINAYTDSLLLEWMD-NSHGGSPILGYVINYKRDNGDWEELQVDS 1455
                      |:..:.||..|..||.:..:..::. ....|.|:.| .::|   .|.:..::.|:
Zfish   349 MENPTLDPKPKLKSKKPNTMVKAAYQEKHIATYVSPTPKNGLPLSG-TVSY---TGPYPGMESDN 409

  Fly  1456 KTTSHLLTNLWCGTRYQLYITAYNKIGTGLPCDIVNSYTKGNPPVQPKHSQMITNNSTSVTCWLD 1520
            ...|.:.|.......:         :.|.|.....|:.:....|.:...|..:..::....|.  
Zfish   410 AANSRMNTQTASPDGF---------LETNLSNLAANTSSLQQDPDRVVRSVKVIGDTDYTVCL-- 463

  Fly  1521 SW------GDGGCGILYFMIESRVYGRSSWAVVSNHIPPTERIYTVSDLVPGTKYQLKVTAHNNA 1579
            :|      ......:||     .|:|......: |..|...|| .:..|||.|||.         
Zfish   464 NWRAPTAKNTTAFSVLY-----AVFGERDMRRI-NVSPGNNRI-VIEGLVPKTKYI--------- 512

  Fly  1580 GSTTAIYNFTTLSTQGVIYNNDHSTPVSHLSDLPFYANFKLLLPICFSLLMLLALIGAALFLRKR 1644
             :...:........|.||::.|.:...:....|   .|..::...|...:.|..::......||.
Zfish   513 -ACVCVKGLIPKKEQCVIFSTDAAASANGTQKL---INVVVITVACVIAVPLTVIVCCGALKRKI 573

  Fly  1645 K--LASQARLASSSMSESPSLANLQNKQNRDQQYL----AVRCNPGTSAPRGSNSNDSGSFGKAE 1703
            |  |...::....|.....:|:.....:..:.:||    |...|...||   .:|.||.|..|.|
Zfish   574 KKFLGKNSKDIQDSYVTFETLSPSTKAKGLEGEYLTRLNAEESNRLLSA---RSSLDSESTAKIE 635

  Fly  1704 G--NEY 1707
            |  |||
Zfish   636 GQPNEY 641

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353
Ig strand C' 276..279 CDD:409353
Ig strand D 285..289 CDD:409353
Ig strand E 292..298 CDD:409353
Ig strand F 305..313 CDD:409353
Ig strand G 316..326 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549
Ig strand B 347..351 CDD:409549
Ig strand C 360..364 CDD:409549
Ig strand E 383..387 CDD:409549
Ig strand F 397..402 CDD:409549
Ig strand G 410..413 CDD:409549
IgI_4_Dscam 422..516 CDD:409548
Ig strand B 439..443 CDD:409548
Ig strand C 452..456 CDD:409548
Ig strand E 482..486 CDD:409548
Ig strand F 496..501 CDD:409548
Ig strand G 509..512 CDD:409548
IgI_5_Dscam 520..607 CDD:409550
Ig strand B 536..540 CDD:409550
Ig strand C 549..553 CDD:409550
Ig strand E 571..575 CDD:409550
Ig strand F 586..591 CDD:409550
Ig strand G 600..603 CDD:409550
Ig 610..703 CDD:416386
Ig strand A 611..613 CDD:409353
Ig strand A' 620..624 CDD:409353
Ig strand B 627..636 CDD:409353
Ig strand C 641..648 CDD:409353
Ig strand C' 650..652 CDD:409353
Ig strand D 659..664 CDD:409353
Ig strand E 668..675 CDD:409353
Ig strand F 682..690 CDD:409353
Ig strand G 693..702 CDD:409353
IgI_7_Dscam 706..801 CDD:409546
Ig strand B 724..728 CDD:409546
Ig strand C 737..741 CDD:409546
Ig strand E 766..770 CDD:409546
Ig strand F 780..785 CDD:409546
Ig strand G 794..797 CDD:409546
Ig 818..904 CDD:416386
putative Ig strand B 820..827 CDD:409353
putative Ig strand C 835..841 CDD:409353
putative Ig strand C' 853..856 CDD:409353
putative Ig strand D 862..866 CDD:409353
putative Ig strand E 868..874 CDD:409353
putative Ig strand F 881..889 CDD:409353
putative Ig strand G 892..902 CDD:409353
FN3 906..999 CDD:238020
FN3 1006..1110 CDD:238020
fn3 1117..1203 CDD:394996 3/8 (38%)
FN3 1215..1307 CDD:238020 24/148 (16%)
Ig <1334..1401 CDD:416386 20/71 (28%)
Ig strand C 1345..1349 CDD:409353 0/3 (0%)
Ig strand D 1363..1366 CDD:409353 0/2 (0%)
Ig strand E 1367..1372 CDD:409353 1/8 (13%)
Ig strand F 1380..1388 CDD:409353 3/7 (43%)
Ig strand G 1394..1401 CDD:409353 2/6 (33%)
FN3 1405..1494 CDD:238020 16/89 (18%)
FN3 1499..1580 CDD:238020 18/86 (21%)
lrit1aNP_001018174.2 leucine-rich repeat 61..84 CDD:275378 5/22 (23%)
LRR_8 63..119 CDD:290566 13/62 (21%)
LRR_RI <77..175 CDD:238064 14/104 (13%)
leucine-rich repeat 85..108 CDD:275378 3/26 (12%)
LRR_8 108..167 CDD:290566 10/61 (16%)
leucine-rich repeat 109..132 CDD:275378 6/25 (24%)
leucine-rich repeat 133..156 CDD:275378 2/22 (9%)
leucine-rich repeat 157..170 CDD:275378 2/12 (17%)
LRRCT 199..243 CDD:214507 5/43 (12%)
I-set 252..343 CDD:254352 21/90 (23%)
Ig 259..333 CDD:299845 18/73 (25%)
fn3 448..515 CDD:278470 17/85 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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