DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam4 and iglon5

DIOPT Version :9

Sequence 1:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster
Sequence 2:	NP_001017775.2	Gene:	iglon5 / 550472	ZFINID:	ZDB-GENE-050417-297	Length:	332	Species:	Danio rerio

Alignment Length:	295	Identity:	75/295 - (25%)
Similarity:	110/295 - (37%)	Gaps:	55/295 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   625 EGMRAAISCQILEGDLPVSFRWERNGKPLIGTGNEVFRRLDEYSA--------------SLVIEH 675
            ||....:.|:|.|         |...|..:...|.:|...|::|.              |:.||.
Zfish    40 EGESVVLRCKIDE---------EVTHKAWLNRSNILFTGTDKWSLDSRVSLENNNNSDFSIRIER 95

  Fly   676 ISSDHSGNYTCI--ASNVAGTERFTVPLTVNVPPKWILEPKDSSAQAGADVLLHCQSSGYPTPTI 738
            :.....|.|||.  |.|...|..  |.|.|.||.:.:...:|.|...|.||.|.|.:.|.|.|||
Zfish    96 VMVADEGPYTCSFQARNKPRTAH--VYLIVQVPARIVNISQDKSVNEGEDVNLFCLAVGRPEPTI 158

  Fly   739 TWKKAIGPTPGEYKDFLYEPTVQLFPNGTIF-FKKISKESQGHFLCEAKNNIGSGVSKVIFLKVN 802
            ||           |||.|    .|...|... ..:|.:.....|.|...|.:....::.:.:.||
Zfish   159 TW-----------KDFKY----GLLNEGEFLEITEIKRHQAEDFECITNNGVAPPDTRKVKVTVN 208

  Fly   803 VPAHFQTKTKQISVAKGKQVHVQCNVQGDNPIDFKWKIQATQQYLDE--SLDSRYTIRDQVLDDG 865
            .|. ..|..|.:....||...::|.........|:|       |.|:  .::|..|::  :.::.
Zfish   209 YPP-IITDVKNMPAQVGKTAILRCEAMAVPTASFEW-------YRDDRRPVESDNTLK--IKNEK 263

  Fly   866 MVSELGISHTYRQDTGIYICQASNAFGQDEMSIQL 900
            ..|.|..::...:..|.|.|.|||..|....|:.|
Zfish   264 TRSLLLFTNVTEKHFGNYTCFASNRLGASNASMLL 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386
		Ig strand A	235..238	CDD:409353
		Ig strand A'	244..248	CDD:409353
		Ig strand B	251..258	CDD:409353
		Ig strand C	266..271	CDD:409353
		Ig strand C'	276..279	CDD:409353
		Ig strand D	285..289	CDD:409353
		Ig strand E	292..298	CDD:409353
		Ig strand F	305..313	CDD:409353
		Ig strand G	316..326	CDD:409353
		IgC2_3_Dscam	329..417	CDD:409549
		Ig strand B	347..351	CDD:409549
		Ig strand C	360..364	CDD:409549
		Ig strand E	383..387	CDD:409549
		Ig strand F	397..402	CDD:409549
		Ig strand G	410..413	CDD:409549
		IgI_4_Dscam	422..516	CDD:409548
		Ig strand B	439..443	CDD:409548
		Ig strand C	452..456	CDD:409548
		Ig strand E	482..486	CDD:409548
		Ig strand F	496..501	CDD:409548
		Ig strand G	509..512	CDD:409548
		IgI_5_Dscam	520..607	CDD:409550
		Ig strand B	536..540	CDD:409550
		Ig strand C	549..553	CDD:409550
		Ig strand E	571..575	CDD:409550
		Ig strand F	586..591	CDD:409550
		Ig strand G	600..603	CDD:409550
		Ig	610..703	CDD:416386	23/93 (25%)
		Ig strand A	611..613	CDD:409353
		Ig strand A'	620..624	CDD:409353
		Ig strand B	627..636	CDD:409353	1/8 (13%)
		Ig strand C	641..648	CDD:409353	0/6 (0%)
		Ig strand C'	650..652	CDD:409353	0/1 (0%)
		Ig strand D	659..664	CDD:409353	1/4 (25%)
		Ig strand E	668..675	CDD:409353	3/20 (15%)
		Ig strand F	682..690	CDD:409353	5/9 (56%)
		Ig strand G	693..702	CDD:409353	2/8 (25%)
		IgI_7_Dscam	706..801	CDD:409546	25/95 (26%)
		Ig strand B	724..728	CDD:409546	2/3 (67%)
		Ig strand C	737..741	CDD:409546	3/3 (100%)
		Ig strand E	766..770	CDD:409546	1/4 (25%)
		Ig strand F	780..785	CDD:409546	2/4 (50%)
		Ig strand G	794..797	CDD:409546	0/2 (0%)
		Ig	818..904	CDD:416386	20/85 (24%)
		putative Ig strand B	820..827	CDD:409353	1/6 (17%)
		putative Ig strand C	835..841	CDD:409353	2/5 (40%)
		putative Ig strand C'	853..856	CDD:409353	1/2 (50%)
		putative Ig strand D	862..866	CDD:409353	0/3 (0%)
		putative Ig strand E	868..874	CDD:409353	2/5 (40%)
		putative Ig strand F	881..889	CDD:409353	4/7 (57%)
		putative Ig strand G	892..902	CDD:409353	3/9 (33%)
		FN3	906..999	CDD:238020
		FN3	1006..1110	CDD:238020
		fn3	1117..1203	CDD:394996
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
iglon5	NP_001017775.2	IG_like	33..123	CDD:214653	23/93 (25%)
		Ig	35..123	CDD:299845	23/93 (25%)
		Ig	125..>183	CDD:299845	23/72 (32%)
		I-set	128..207	CDD:254352	24/93 (26%)
		IG_like	217..298	CDD:214653	20/89 (22%)
		ig	223..296	CDD:278476	18/81 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910