DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam4 and SDK2

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens


Alignment Length:1872 Identity:429/1872 - (22%)
Similarity:700/1872 - (37%) Gaps:496/1872 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   351 CIVSGHPVHDVNWLHDGKPILRDNRVEILTDPPRLIIKKVQKEDPGMYQCFVSNEW-EQIQSTAE 414
            |:..|....:..|||:.:.:.:.: :|.     |.:|..:.:...|.|:|.|.|.. ..:|...|
Human    48 CMAEGSWPLEFKWLHNNRELTKFS-LEY-----RYMITSLDRTHAGFYRCIVRNRMGALLQRQTE 106

  Fly   415 LQLGDASPELLYWFSE----QTLQPGPTVSLKCVATGN-PLPQFTWSLDGFPIPDSSRFLVGQYV 474
            :|:.     .:..|.|    |::..|....::.....: |.||.||..||..||.|||..    :
Human   107 VQVA-----YMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIA----I 162

  Fly   475 TIHDDVISHVNISNVKEEDGGEYTCTA---QNAIGKVSHSAKVNIYGL--------PYIREMPKI 528
            |:.:.::    |.:....|.|.|...|   :|...|.|....:.:..:        |.|...||.
Human   163 TLENTLV----ILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKN 223

  Fly   529 TGI--SGSDLIVKCPVAGYPIDKIH--WERDGQTL-----PINRRQRAYN-NGTLIIEQLQRLED 583
            |.:  ..|::.::|.....|:.|:|  |::||..|     ..|||....| .|:          |
Human   224 TSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGS----------D 278

  Fly   584 AGTYTCMA--QNKQKQTSRRNVEIQVLVPPKIM--PIQAMTNMLREGMRAAISCQILEGDLPVSF 644
            ||.|.|.|  ::....:..|...:.||.||:.:  |.:.:|..:.:.:  .|.|| .:|..|.|.
Human   279 AGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVV--DIPCQ-AKGVPPPSI 340

  Fly   645 RWERNGKPLIGTGNEV-----FRRLDEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTV- 703
            .|.::...:     ||     ||:.::  ..|.|..:..|.:|.:.|.|.|.||..:.:..|.| 
Human   341 TWYKDAAVV-----EVEKLTRFRQRND--GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVT 398

  Fly   704 NVPPKWILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQL-----F 763
            ::.|.....|.||:...|..|:|.|::||.|.|.|||:|      ||  ..|...:|||     .
Human   399 SIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQK------GE--RILASGSVQLPRFTPL 455

  Fly   764 PNGTIFFKKISKESQGHFLCEAKNNIG---SGVSKVIFLKVNVPAHFQTKTKQ-ISVAKGKQVHV 824
            .:|::..........|.:.|.|.|:.|   :....|::.:..:     ||..| .||.||.|..:
Human   456 ESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRI-----TKPPQDQSVIKGTQASM 515

  Fly   825 QCNVQGDNPIDFKW---KIQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQ 886
            .|.|..|..:..::   |..||.     ..:|...||   ||..  ..|.||.|:..|.|.|.|:
Human   516 VCGVTHDPRVTIRYIWEKDGATL-----GTESHPRIR---LDRN--GSLHISQTWSGDIGTYTCR 570

  Fly   887 ASNAFGQDEMSIQLIVQEVPEQPKN--LRINSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQISDI 949
            ..:|.|.|..|..|.|:::|..|::  ..:::.:.|::.|||::||.||||:..|      |.::
Human   571 VISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRY------ILEM 629

  Fly   950 WQNAEHLTIAGAQ-----TVINIQQLRPAKAYHIRMSAENKLGASEFS-EVVQVTTLEEVPSGPP 1008
            .:|....|:..|.     |.:.::.|.||::|..|:.|.|.:|..:|| :..:|:..||.|:.||
Human   630 SENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPP 694

  Fly  1009 LAVRAEPKSSTEIFVTWDAPERDHWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTV---EVRS 1070
            ..|.|..:::..|.:.|..|...|.||||.||.:.|.::..|        .|:.||.:   :|.:
Human   695 QNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLP--------VGYQFKNITDADVNN 751

  Fly  1071 HFGGETVLANLNKFTQYHVIVQAYTSQGSGPPSKEIAVQTMEDVPSSPPESPQCDVLGSTSIYIT 1135
                 .:|.:|..:|.|.:.|.||.|.|.|..|.::...|::.||:.||.:...:...||:|..|
Human   752 -----LLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFT 811

  Fly  1136 WSPPDIDGQNGKIKGYKVFYISVDELYETDPEVVKSTNQYVT------IENLRKYTNYTVWVLAY 1194
            |:.|.....||..:|||:  |:.:...|.:..:|.:...:..      :..|:|:|.|...||.:
Human   812 WNAPSPQFINGINQGYKL--IAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCF 874

  Fly  1195 TKVGDGMKTKPFYCRTHEDVPSAPQAIKAIPASSSKIIISWLPPDLPNGDITGY----------- 1248
            |..|||.::.|...|||||||.....:.......:.:.:||..|...||.:|||           
Human   875 TTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTN 939

  Fly  1249 ---TFYM-----------------------SMLEGGR--------EEGTHKRLLGPFVEMHETVR 1279
               |.|:                       :|...|:        ..|....|.||...:..:..
Human   940 TRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNI 1004

  Fly  1280 TQESATYQF------------WLTAST--KMGEGEK------------TQVVTVPPNNKVPARIV 1318
            ...|.|.||            ||..:.  .:||||:            .:.:.||..|  |....
Human  1005 GPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLN--PFTCY 1067

  Fly  1319 SFSQRIV-----TPWKEHLELPCRKVG--------APAPVTI-----------W----------- 1348
            ||..|.|     :|..:    |.||:.        |||.|::           |           
Human  1068 SFRMRQVNIVGTSPPSQ----PSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGN 1128

  Fly  1349 -----------RQDGHNMETS--ARKTIAKNGTL--------YMKECQASDA-GNYTCSVENTWG 1391
                       |.|||....|  .:..:.::.|:        |..:.||.:| |:      ..|.
Human  1129 PESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGS------GPWS 1187

  Fly  1392 KDEIVYNIVVKVPPEAP-NLTVINAYTDSLLLEWMD--NSHGGSPILGYVINYKRDNGD-----W 1448
            : .:|......||...| |::.:...:.|:|:.|.:  .:.....:|||.:.||..:.|     |
Human  1188 Q-TVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFW 1251

  Fly  1449 EELQVDSKTTSHLLTNLWCGTRYQLYITAYNKIGTGLPCDIVNSYTKGNPPVQPKHSQMITN--- 1510
              |...:.:.|..||.|.....|::.:.|:.:||.|.|         .:||:..:....:..   
Human  1252 --LVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP---------SHPPILERTLDDVPGPPM 1305

  Fly  1511 -------NSTSV-TCWLDSWGDGGCGILYFMIESRVYGRSSWAVVSNHIPPTERIYTVSDLVPGT 1567
                   .:||| ..|.......|. ||.:.|..|:...::.......:.|:.|.||.:.|.|.:
Human  1306 GILFPEVRTTSVRLIWQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPES 1369

  Fly  1568 KYQLKVTAHNNAGSTTAIYNFTTLSTQGVIYNNDHSTPVSH-----------------------L 1609
            .|..::||....|...|. ....::|:    ..|...|.|.                       |
Human  1370 VYLFRITAQTRKGWGEAA-EALVVTTE----KRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGL 1429

  Fly  1610 SDLPFYANFKLLLPICFSLLMLLALIGAALFLRKRKLAS-QARLASSSMSESPSLANLQNKQNRD 1673
            |.:.:|.                        ::.|:|.| :..|.|:|:|.:.|           
Human  1430 SPVRYYT------------------------IQTRELPSGRWALHSASVSHNAS----------- 1459

  Fly  1674 QQYLAVRCNPGTSAP-RGSNSNDSGSFGKAEGNE-------------YIEDICPYATFQ--LNKQ 1722
             .::..|..|.||.. |...:||.|....:|.:|             .|..:.|:.|..  :..|
Human  1460 -SFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQ 1523

  Fly  1723 TYSESSYSGNVYSG--------PYHSVRGSFVYHDVKPESYHSKEPEYTKVRRKVGRLRDPHSES 1779
            ..:|...:| :..|        .|..:|| |....:                             
Human  1524 PPAEDKING-ILLGFRIRYRELLYEGLRG-FTLRGI----------------------------- 1557

  Fly  1780 QESDNPGSTDSEVRKILTL----HIPITEY--DTLGSESDNDVSARALNSAKYRAQRDTQDETSS 1838
               :|||:|.:|:..:.::    ...:|:|  |.|......::.....|:.         .|..|
Human  1558 ---NNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAV---------GEGPS 1610

  Fly  1839 S-------SETTPTSMTRK---------------SKPPFAARKGGKPG--------TSGKRHVRS 1873
            |       .|..||:..|.               ..||..::.|...|        ..|....|.
Human  1611 SPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERV 1675

  Fly  1874 SSGYSSHNEETTFSISNYPPNYQDHINPPARFSDAND---KTKTQTSPRMRA 1922
            .:.:.:.|.....:::.|..    ::...|.|:.|.|   .|.||...:..|
Human  1676 KTLFLAENSVKLKNLTGYTA----YMVSVAAFNAAGDGPRSTPTQGQTQQAA 1723

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353
Ig strand C' 276..279 CDD:409353
Ig strand D 285..289 CDD:409353
Ig strand E 292..298 CDD:409353
Ig strand F 305..313 CDD:409353
Ig strand G 316..326 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549 15/66 (23%)
Ig strand B 347..351 CDD:409549 429/1872 (23%)
Ig strand C 360..364 CDD:409549 0/3 (0%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 2/4 (50%)
Ig strand G 410..413 CDD:409549 1/2 (50%)
IgI_4_Dscam 422..516 CDD:409548 25/101 (25%)
Ig strand B 439..443 CDD:409548 0/3 (0%)
Ig strand C 452..456 CDD:409548 2/3 (67%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 1/4 (25%)
Ig strand G 509..512 CDD:409548 1/2 (50%)
IgI_5_Dscam 520..607 CDD:409550 26/98 (27%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 2/5 (40%)
Ig strand E 571..575 CDD:409550 1/3 (33%)
Ig strand F 586..591 CDD:409550 2/4 (50%)
Ig strand G 600..603 CDD:409550 1/2 (50%)
Ig 610..703 CDD:416386 25/99 (25%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 1/3 (33%)
Ig strand B 627..636 CDD:409353 3/8 (38%)
Ig strand C 641..648 CDD:409353 3/6 (50%)
Ig strand C' 650..652 CDD:409353 0/1 (0%)
Ig strand D 659..664 CDD:409353 4/9 (44%)
Ig strand E 668..675 CDD:409353 2/6 (33%)
Ig strand F 682..690 CDD:409353 3/7 (43%)
Ig strand G 693..702 CDD:409353 1/8 (13%)
IgI_7_Dscam 706..801 CDD:409546 29/102 (28%)
Ig strand B 724..728 CDD:409546 2/3 (67%)
Ig strand C 737..741 CDD:409546 2/3 (67%)
Ig strand E 766..770 CDD:409546 1/3 (33%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 0/2 (0%)
Ig 818..904 CDD:416386 28/88 (32%)
putative Ig strand B 820..827 CDD:409353 1/6 (17%)
putative Ig strand C 835..841 CDD:409353 1/8 (13%)
putative Ig strand C' 853..856 CDD:409353 1/2 (50%)
putative Ig strand D 862..866 CDD:409353 2/3 (67%)
putative Ig strand E 868..874 CDD:409353 2/5 (40%)
putative Ig strand F 881..889 CDD:409353 3/7 (43%)
putative Ig strand G 892..902 CDD:409353 4/9 (44%)
FN3 906..999 CDD:238020 29/100 (29%)
FN3 1006..1110 CDD:238020 31/106 (29%)
fn3 1117..1203 CDD:394996 26/91 (29%)
FN3 1215..1307 CDD:238020 27/162 (17%)
Ig <1334..1401 CDD:416386 21/118 (18%)
Ig strand C 1345..1349 CDD:409353 2/36 (6%)
Ig strand D 1363..1366 CDD:409353 0/2 (0%)
Ig strand E 1367..1372 CDD:409353 2/12 (17%)
Ig strand F 1380..1388 CDD:409353 1/7 (14%)
Ig strand G 1394..1401 CDD:409353 1/6 (17%)
FN3 1405..1494 CDD:238020 23/96 (24%)
FN3 1499..1580 CDD:238020 19/91 (21%)
SDK2NP_001138424.1 Ig 27..109 CDD:299845 15/66 (23%)
IG_like 40..109 CDD:214653 15/66 (23%)
I-set 120..203 CDD:254352 23/90 (26%)
Ig 132..210 CDD:299845 21/85 (25%)
IG_like 222..304 CDD:214653 23/91 (25%)
IGc2 233..286 CDD:197706 18/62 (29%)
I-set 308..397 CDD:254352 24/98 (24%)
Ig 326..394 CDD:143165 20/77 (26%)
I-set 402..492 CDD:254352 28/97 (29%)
Ig 416..492 CDD:299845 24/83 (29%)
Ig 502..586 CDD:299845 30/93 (32%)
IG_like 502..586 CDD:214653 30/93 (32%)
FN3 590..681 CDD:238020 28/96 (29%)
FN3 693..786 CDD:238020 31/105 (30%)
FN3 794..890 CDD:238020 27/97 (28%)
FN3 895..983 CDD:238020 13/87 (15%)
FN3 993..1087 CDD:238020 22/99 (22%)
FN3 1099..1194 CDD:238020 18/101 (18%)
FN3 1201..1290 CDD:238020 23/99 (23%)
FN3 1301..1394 CDD:238020 20/94 (21%)
FN3 1400..1484 CDD:238020 20/119 (17%)
FN3 1503..1616 CDD:238020 24/155 (15%)
FN3 1626..1719 CDD:238020 16/96 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729 5/17 (29%)
FN3 1724..1805 CDD:238020 429/1872 (23%)
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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