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Protein Alignment Dscam4 and CDON

DIOPT Version :10

Sequence 1:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster
Sequence 2:	NP_001230526.1	Gene:	CDON / 50937	HGNCID:	17104	Length:	1287	Species:	Homo sapiens

Alignment Length:	1018	Identity:	208/1018 - (20%)
Similarity:	373/1018 - (36%)	Gaps:	239/1018 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 SGHPVHD-VNWLHDGKPILRDNRVE-ILTDPPRLIIKKVQKEDPGMYQCFVSNEWEQIQS----T 412
            |..||.. ::|||:||.:  |..:| :......|.|..:.....|.|||..:|....|.|    .
Human    51 SAQPVTTRISWLHNGKTL--DGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATV 113

  Fly   413 AELQLGDASPELLYWFSEQTLQPGPTVSLKC-VATGNPLPQFTWSLDGFPIPDSSRFLVGQYVTI 476
            :...|||......:..:.:....|   .:.| |...||..:..:.:.|..:..|:.    .|:.:
Human   114 SVAVLGDFGSSTKHVITAEEKSAG---FIGCRVPESNPKAEVRYKIRGKWLEHSTE----NYLIL 171

  Fly   477 HDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLPYIREMPK-------------- 527
            ..   .::.|.||..||.|.|.|.|.|   .|:|..||...|...:...|.
Human   172 PS---GNLQILNVSLEDKGSYKCAAYN---PVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQA 230

  Fly   528 ITGISGSDLIVKCPVAGYPIDKIHWERDGQTL-PINRRQRAYNNGTLIIEQLQRLEDAGTYTCMA 591
            :..:|.|.:.::|.|:|.|..:::|.:|||.: |.:..:|.|::  |..:.:.. .|:|.|:|||
Human   231 LAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSH--LATDSVDP-ADSGNYSCMA 292

  Fly   592 QNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQILEGDLPVSFRWERNGKPL--- 653
            .||..........:.||....|.. .....::..|.....:|.: .|:...:..|..|.:|:
Human   293 GNKSGDVKYVTYMVNVLEHASISK-GLQDQIVSLGATVHFTCDV-HGNPAPNCTWFHNAQPIHPS 355

  Fly   654 ---IGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIASNVAG----TERFTVPLTVNVPPKWIL 711
               :..||           .|.|..::.:..|.|.|:|.|..|    |.|..:.......|..|.
Human   356 ARHLTAGN-----------GLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIIT 409

  Fly   712 EPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIG---PTPGEY------KDFLYEPT-VQLFP-- 764
            .|..:....|..|.|.|.:||.|.|.|.|..:.|   ..|.:.      |..|..|. :.|.|
Human   410 APVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVY 474

  Fly   765 -------NGTIFFKKISKESQGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQV 822
                   ..::..:.:::|..|.::|||.|..|:..::...:.|    .|:|.|      |.:.|
Human   475 FVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVV----PFETNT------KAETV 529

  Fly   823 HVQCNVQGDNPIDFKWKIQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYR---QDTGIYI 884
            .:....|.|                           |:...||  ||.|:..::.   ..:.:..
Human   530 TLPDAAQND---------------------------DRSKRDG--SETGLLSSFPVKVHPSAVES 565

  Fly   885 CQASNAFGQDEMSIQLIVQEVPEQPKNLRINSQQSR---SLQLTWSQPFAGNSPIEEYHIYYKQI 946
            ....||.|          ..||:.|  :.::..|:.   :..|.|.....|..||..|.:.|:::
Human   566 APEKNASG----------ISVPDAP--IILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKL 618

  Fly   947 SD------IWQNAEHLTIAGAQTVINIQQLRPAKAYHIRMSAENKLGASEFSEVVQVTTLEEV-- 1003
            .|      .|..   :.:.|::..:::.:|.|:..|.:.|.|.:..|..:.:.:...|:.|:.
Human   619 DDGVGMLGSWHT---VRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTAS 680

  Fly  1004 -----PSGPPLAVRAEP----------------------------------KSSTEIFVTWDAPE 1029
                 .|.||:.:...|                                  .|.|.::||| .|
Human   681 SKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTW-IP- 743

  Fly  1030 RDHWNGILLGYYVGYQ----------------MSLTPEDKEVNPTQGFSFKTVEVRSHFGGETVL 1078
            |.:....:..:.|.|:                ..|:.|.:.:.|...:.|:.:.: :|: ||:..
Human   744 RANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAI-NHY-GESFR 806

  Fly  1079 ANLNKFTQYHVIVQAYTSQGSGPPSKEIAVQTMEDVPSSPPESPQCDVLGSTSIYITWSPPDIDG 1143
            ::.::  .|.|:         |.|::      ....|.:.|.....:.:..|.|.:.|:......
Human   807 SSASR--PYQVV---------GFPNR------FSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSN 854

  Fly  1144 QNGKIKGYKVFYISVDELYETD--PEVVKSTNQYVTIENLRKYTNYTVWVLAYTKVGDGMKTKPF 1206
            .|..|:|:.::|...|...::|  .:||:.:.|:..|.:|:..|:|.:.:..:.:.|:...:...
Human   855 NNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVM 919

  Fly  1207 YCRTHEDVPSAPQAIKAIPASSSKII--ISWLPPDLPNGDITG 1247
            .|.|         .:|.:|.:|...:  :|..|..|.:|...|
Human   920 ICET---------KVKRVPGASEYPVKDLSTPPNSLGSGGNVG 953

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.