DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and NCAM2

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:XP_011527877.1 Gene:NCAM2 / 4685 HGNCID:7657 Length:874 Species:Homo sapiens


Alignment Length:746 Identity:186/746 - (24%)
Similarity:305/746 - (40%) Gaps:87/746 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   405 EWEQIQSTAELQLGDASPELLY---------WFSEQTLQPGPTVSLKCVATGNPLPQFTWSLDGF 460
            :|:..::   |.|.:..||..|         ..|:..|..|.:....|.|.|.|     .|:|.:
Human    23 DWKYNEA---LYLEEGQPETYYRTALLQVTISLSKVELSVGESKFFTCTAIGEP-----ESIDWY 79

  Fly   461 PIPDSSRFLVGQYVTIH-DDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKV-NIYGLPYIR 523
            . |...:.:..|.|.:. :.|.|.:.|.|...||.|.|.|.|.:|.|:...:..| .||.....|
Human    80 N-PQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFR 143

  Fly   524 EMPKITGIS------GSDLIVKCPVAGYPIDKIHW---ERDGQTLPINRRQRAYNNGTLIIEQLQ 579
            |:     :|      |.|..|.|.|:..|...:.|   ..:..|:..||.....||...|:.  .
Human   144 EV-----VSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILN--I 201

  Fly   580 RLEDAGTYTCMAQNKQK-QTSRRNVEIQVLVPPKI-MPIQAMTNMLREGMRAAISCQILEGDLPV 642
            ...|.|.|.|..:.:.: :...|::.:.|.|||.| ||.::.......|.....||: ..|....
Human   202 NKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCR-ASGSPEP 265

  Fly   643 SFRWERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTVNVPP 707
            :..|.||||.:  ..||.: .|...:..|.:.:|.:...|.|.|.|:|.||.:.....|.|.|.|
Human   266 AISWFRNGKLI--EENEKY-ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP 327

  Fly   708 KWILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQL---FPNGTIF 769
            . |::.|:.:......|.|.|.:.|.|.|.||||:|:........|...:..:::   ..:.::.
Human   328 H-IIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLH 391

  Fly   770 FKKISKESQGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDNPI 834
            .|.:.....|.:.|||.:.|| |..|.::|.:.....|.:........:|..:::.|:|:.:.|.
Human   392 IKDVKLSDSGRYDCEAASRIG-GHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPA 455

  Fly   835 DFKWKIQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQ 899
            ...|:....      .|.::.|...:....|....|.|:.|...|.|.|.|.|:|..|.......
Human   456 SIHWRRDKL------VLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYI 514

  Fly   900 LIVQEVPEQPKNLRINSQQSRSLQLTWSQPFA-GNSPIEEYHIYYKQI-SDIWQNA-EHLTIAGA 961
            |.:.:||..|..::|......:.::::::|.: |..||..|.:..|:: |:||:.. .|    |.
Human   515 LALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSH----GV 575

  Fly   962 QTVINIQQLRPAKAYHIRMSAENKLGASEFSEVVQVTTLEEVPSGPPLAVRAEPKS--STEIFVT 1024
            ||::.:..|.|...|.||::|.|..|..::|::....||......|| ::..:|.|  |.::.:|
Human   576 QTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPP-SIHGQPSSGKSFKLSIT 639

  Fly  1025 WDAPERDHWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGETVLANLNKFTQYHV 1089
                ::|.....:|.|.|.|:    .:|||   .|....|....:.|.    :|.:|.....|.|
Human   640 ----KQDDGGAPILEYIVKYR----SKDKE---DQWLEKKVQGNKDHI----ILEHLQWTMGYEV 689

  Fly  1090 IVQAYTSQG---------SGPPSKEIAVQTM 1111
            .:.|....|         |.||...|...|:
Human   690 QITAANRLGYSEPTVYEFSMPPKPNIIKDTL 720

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353
Ig strand C' 276..279 CDD:409353
Ig strand D 285..289 CDD:409353
Ig strand E 292..298 CDD:409353
Ig strand F 305..313 CDD:409353
Ig strand G 316..326 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549 2/11 (18%)
Ig strand B 347..351 CDD:409549
Ig strand C 360..364 CDD:409549
Ig strand E 383..387 CDD:409549
Ig strand F 397..402 CDD:409549
Ig strand G 410..413 CDD:409549 0/2 (0%)
IgI_4_Dscam 422..516 CDD:409548 28/104 (27%)
Ig strand B 439..443 CDD:409548 0/3 (0%)
Ig strand C 452..456 CDD:409548 0/3 (0%)
Ig strand E 482..486 CDD:409548 1/3 (33%)
Ig strand F 496..501 CDD:409548 2/4 (50%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 21/96 (22%)
Ig strand B 536..540 CDD:409550 1/3 (33%)
Ig strand C 549..553 CDD:409550 1/6 (17%)
Ig strand E 571..575 CDD:409550 0/3 (0%)
Ig strand F 586..591 CDD:409550 2/4 (50%)
Ig strand G 600..603 CDD:409550 1/2 (50%)
Ig 610..703 CDD:416386 27/93 (29%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 2/8 (25%)
Ig strand C 641..648 CDD:409353 1/6 (17%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 1/4 (25%)
Ig strand E 668..675 CDD:409353 1/6 (17%)
Ig strand F 682..690 CDD:409353 4/7 (57%)
Ig strand G 693..702 CDD:409353 1/8 (13%)
IgI_7_Dscam 706..801 CDD:409546 25/97 (26%)
Ig strand B 724..728 CDD:409546 2/3 (67%)
Ig strand C 737..741 CDD:409546 2/3 (67%)
Ig strand E 766..770 CDD:409546 0/3 (0%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 1/2 (50%)
Ig 818..904 CDD:416386 19/85 (22%)
putative Ig strand B 820..827 CDD:409353 0/6 (0%)
putative Ig strand C 835..841 CDD:409353 1/5 (20%)
putative Ig strand C' 853..856 CDD:409353 0/2 (0%)
putative Ig strand D 862..866 CDD:409353 0/3 (0%)
putative Ig strand E 868..874 CDD:409353 2/5 (40%)
putative Ig strand F 881..889 CDD:409353 4/7 (57%)
putative Ig strand G 892..902 CDD:409353 2/9 (22%)
FN3 906..999 CDD:238020 25/95 (26%)
FN3 1006..1110 CDD:238020 27/114 (24%)
fn3 1117..1203 CDD:394996
FN3 1215..1307 CDD:238020
Ig <1334..1401 CDD:416386
Ig strand C 1345..1349 CDD:409353
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
NCAM2XP_011527877.1 Ig1_NCAM-2 46..137 CDD:143274 25/96 (26%)
I-set 47..136 CDD:254352 25/94 (27%)
I-set 142..218 CDD:254352 20/82 (24%)
IGc2 153..214 CDD:197706 17/62 (27%)
Ig 233..326 CDD:299845 28/96 (29%)
I-set 240..323 CDD:254352 22/86 (26%)
Ig5_NCAM-2 325..422 CDD:143278 26/98 (27%)
IG_like 333..420 CDD:214653 22/87 (25%)
IG_like 438..515 CDD:214653 18/82 (22%)
IGc2 439..507 CDD:197706 17/73 (23%)
FN3 521..613 CDD:238020 25/95 (26%)
fn3 619..703 CDD:278470 23/99 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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