DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam4 and tutl

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_001303307.1 Gene:tutl / 46015 FlyBaseID:FBgn0010473 Length:1536 Species:Drosophila melanogaster


Alignment Length:1796 Identity:373/1796 - (20%)
Similarity:608/1796 - (33%) Gaps:538/1796 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   266 TYRW------------FKEENEQLLPLQLSER--------------ITI------------VSAG 292
            ::||            .||:.:|..||::.|:              .||            .:|.
  Fly     9 SHRWCRALSTQHNTEKSKEQQQQSQPLEIPEQRASKCRGDIDRTTTTTIPASKTLTASPAKTAAF 73

  Fly   293 LLKIT---KARLEDSGKYLCWVNNTAGE-----ETIQVSLTVTAPLTAHLQPQVQTVDVDKDAQF 349
            .:|.|   ::|....|..:| |....|:     .||||...|...|.|.|....|..::.:||  
  Fly    74 TVKTTRRRRSRRRAEGSSIC-VPIRRGQGSTPTPTIQVLQFVLVSLLALLAKNAQAHNIPEDA-- 135

  Fly   350 QCIVSGHPVHDVNWLHDGKPILRDNRVEILTDPPRLIIKKVQKEDPGMYQCFVSNEWEQIQSTAE 414
                    ||....|.:|  ::.:..||...|.|                               
  Fly   136 --------VHITAILGEG--VIFNCHVEFPNDHP------------------------------- 159

  Fly   415 LQLGDASPELLYWFSEQTLQPGPTVSLKCVATGNPLPQFTWSLDGFP--IPDSSRFLVGQYVTIH 477
                  .|.:|.|            ..|...||:.||.:.| .:.:|  |.:..:   |:...:.
  Fly   160 ------VPYVLQW------------DKKVSETGSDLPIYIW-YESYPEHIEEGYK---GRVSRVS 202

  Fly   478 DDV---ISHVNISNVKEEDGGEYTCTA--------QNAIGKVSHSAKVNIYGLPYIREMPK-ITG 530
            .|.   .:.:|::|::|.|.|.|.|..        |:..|...|   ::::..|.....|: |..
  Fly   203 QDSPFGSASLNLTNIRESDQGWYECKVVFLNRDPKQHKNGTWFH---LDVHAPPRFSVTPEDIIY 264

  Fly   531 IS-GSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQRAYNNGTLIIEQLQRLEDAGTYTCMAQNK 594
            :: |..:|:.|...|.|..:|.|.:|...:..:.....:|:||.:.....|.||.|.|||:|:|.
  Fly   265 VNLGDSIILNCQADGTPTPEILWYKDANPVDPSPTVGIFNDGTELRISTIRHEDIGEYTCIARNG 329

  Fly   595 QKQTSRRNVEI-----QVLVPPKIMPIQAMTNMLR-EGMRAAISCQILEGDLPVSFRWERNGKPL 653
            :.|.|.....|     .::|||        ||..: ||.:...||:.......|:.||.|.|.|:
  Fly   330 EGQVSHTARVIIAGGAVIMVPP--------TNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPV 386

  Fly   654 IGTGNEVFRRLDEYSASLVIEHISSDHSGNYTC-IASNVAGTERFTVPLTVNVPPKWILEPKDSS 717
            ........|.......||:|..|..|.||.|.| :.:.:...:..:..|:|..|.|....|....
  Fly   387 REVAALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQY 451

  Fly   718 AQAGADVLLHCQSSGYP-TPTITW---KKAIGPTPGEYKDFLYEPTVQLFPNGTIFFKKISKESQ 778
            .......::.|.....| ...:||   |:.:  .|.:.||      :.:..||::.|.::::|.|
  Fly   452 LPFRLAGVVQCYIKSSPQLQYVTWTKDKRLL--EPYQMKD------IVVMANGSLLFTRVNEEHQ 508

  Fly   779 GHFLCEAKNNIG-SGVSKVIFLKVNVPAHFQTKTKQISVAK-GKQVHVQCN---VQGDNPIDFKW 838
            |.:.|...|..| :|.|.|:.:.|..|..|..:.:.:...| |..|.:.|:   .:|......||
  Fly   509 GQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKW 573

  Fly   839 KIQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQ 903
            :.|..:| |.||..:|..|..        ..:.|.:..|:|.|.|.|..||.........||:::
  Fly   574 QRQEGEQ-LTESQRNRIKISG--------GNITIENLRREDFGYYQCVVSNEVATLMAVTQLVIE 629

  Fly   904 EV-PEQPKNLRINSQQSRSLQLTWSQPFAGNSPI-EEYHIYYKQ--ISDIWQNAEHLTIAGAQTV 964
            .. |..|.|:...:.:| |:.|.|...::|.|.. ::|.|::::  ::| ||... :|.:|: |.
  Fly   630 GTQPHAPYNITGKATES-SITLQWLPGYSGGSEYKQDYTIWFREAGVND-WQTIS-VTPSGS-TQ 690

  Fly   965 INIQQLRPAKAYHIRMSAENKLGASEFSEVVQVTTLEEVPSGP---------------------- 1007
            :.|..|.....|..::...|.||....|:|:.|.|||:.|:.|                      
  Fly   691 VTINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAAPRNVKAATQPPDSFFQLMPDEAD 755

  Fly  1008 --------------------PLAVRAE-PK-------SSTEI----FVTWDAP-ERDHWNGILLG 1039
                                |..:|.: ||       |.||:    .:||.:| ||.|   |:..
  Fly   756 LLAYFDIYFHTDSRGTLVYSPPKLRVKGPKPGPPRNVSVTEVSNGFLITWQSPLERAH---IVKF 817

  Fly  1040 YYVGYQM----------SLTPEDKEVNPTQGFSFKTVEVRSHFGGET----VLANLNKFTQYHVI 1090
            |.:.|:.          .:.||:     ||..      |::..||.|    ||||..|       
  Fly   818 YTIKYRTDAQWKTLNRGQIRPEE-----TQYL------VKNLVGGRTYYFRVLANSEK------- 864

  Fly  1091 VQAYTSQGSGPPSKEIAVQTMEDVPSS-PPESPQCDVLGS-----TSIYITWSPPDIDGQNGKIK 1149
                        |.|.:.:....||:. ..::....|:|.     .:|.::.....|..:..:.|
  Fly   865 ------------SYESSDEVKFPVPARVKHKAITAGVVGGILFFIVAIILSVCAVKICNKRKRRK 917

  Fly  1150 GYKVFYISVDELYETDPEVVKSTNQYV------TIEN----LRKYTNYTVWVLAYTKVGDGMKTK 1204
            ..|.|.:....:  ||...:.:.|.::      :|.:    |:||..        |::       
  Fly   918 QEKEFNMVACRI--TDARNIAANNHHLHNRSTGSISSGQVPLKKYKQ--------TRI------- 965

  Fly  1205 PFYCRTHEDVPSAPQAIKAIPASSSKIIISWLPPDLPNGDITGYTFYMS-MLEGGREE---GTHK 1265
                          .::.||..:    |:.|:.|  |:.....::.|.| .||.|.|:   |..:
  Fly   966 --------------SSLTAILIA----ILHWIWP--PDRCTNCHSIYSSPNLEDGDEDDGGGGRR 1010

  Fly  1266 RLLGPFVEMHETVRTQESATYQFWLTAS--TKMGEGEKTQV---VTVPPNNKVPARIVSFSQRIV 1325
            |.:.         |.|.|...:|.|...  :|:|..::|..   |.|........|..:.||:..
  Fly  1011 RSVS---------RIQRSLDGRFVLDVEGVSKLGYSQQTLESGNVDVVDGGLFERRNSNVSQKSS 1066

  Fly  1326 TPWKEHLELPCRKVGAPAPVTIWRQDGHNMETSARKTIAKNGTLYMKECQASDAGNYTCSVENTW 1390
            :.....|.   |:....|..: ||          |..:|.:..|.::.. |..|..:...:....
  Fly  1067 SDDGGFLS---RRNFITARAS-WR----------RPLVASSSQLSLQSA-ADSARGFLQGLLKIG 1116

  Fly  1391 GKDEIVYNIVVKVPPEAPNL-----------TVINAYTDSLLLEWMDNSHGGSPILGYVINYKRD 1444
            .|..       .|||.:.:.           .|:..||.|      :|.:|.:            
  Fly  1117 AKQS-------AVPPNSQSYFDEAVSGARYQNVLRPYTSS------NNLYGNA------------ 1156

  Fly  1445 NGDWEELQVDSKTTSHLLTNLWCGT---RYQLYITAYNKIGTGLPCDIVNSYTKGNPPVQPKHSQ 1506
                     |.....|:  |...|:   :.|||          .|..|...::.....:||.|.|
  Fly  1157 ---------DRSRPLHI--NTISGSLSQQQQLY----------TPSRISRIFSSSPQQLQPHHQQ 1200

  Fly  1507 MITNNSTSVTCWLDSWGDGGCGILYFMIESRVYGRSSWAVVSNHIPPTERIYTVSDLVPGTKYQL 1571
            ::.::           |..|....:|...|.||..:|....|:::....|.|  |..:|..:...
  Fly  1201 LLLSS-----------GGSGAYPTHFSDLSTVYPPNSAERSSHNLSSRYRYY--SQELPSLRTIQ 1252

  Fly  1572 KVTAHNNAGSTTAIYNFTTLSTQGVIYNNDHSTPVSHLSDLP-------FYANFKLLLPICFSLL 1629
            :.|..........:              .||..|:    .||       :|.:.....|      
  Fly  1253 EETRRQQQQKQHPL--------------EDHFVPL----QLPSPPSWRSYYQSQASYRP------ 1293

  Fly  1630 MLLALIGAALFLRKR-------KLASQARLASSSMSESPSL-ANLQNKQNRDQQYLAVRCNPGTS 1686
                        |.|       :|.|..:.....:|..|.| .||:|..|..          |..
  Fly  1294 ------------RTRWYPRHHSRLFSNRQQQHEMLSPLPQLNLNLRNSMNPG----------GLE 1336

  Fly  1687 APRGSNSNDSGSFGKAEGNEYIEDICPYATFQLNKQTYSESSYSGNVYSGPY----HSVRGSFVY 1747
            |...|.|:.|| ||....:.:......:......:...|...:||  |.|..    .:..||:.|
  Fly  1337 ASPESRSSSSG-FGSKNTSNHPGSTSEWRLLPPYRAPPSPPKHSG--YFGGQQAQGQTPHGSYSY 1398

  Fly  1748 HDVKPESYHSKEPEYTKVR--RKVGRLR-------------------DPHSESQESDNPGSTDSE 1791
            .       .:..|.||...  ..:.||.                   |.|.|...:....|..|.
  Fly  1399 P-------RATTPPYTMAHWLEMISRLNAATDSNLPKAPCPVDVGSVDGHYEFDPATPTPSASSM 1456

  Fly  1792 VRKILTLHIPITEY--DTLGSESDNDVSARALNSAKYRAQR 1830
            :|:.|.|||....|  .|||..|.:.:.:.|......|.||
  Fly  1457 LREDLNLHIDTHPYHHHTLGPLSGSLLHSHAPYGGGARKQR 1497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386 22/105 (21%)
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353 2/16 (13%)
Ig strand C' 276..279 CDD:409353 1/2 (50%)
Ig strand D 285..289 CDD:409353 2/29 (7%)
Ig strand E 292..298 CDD:409353 2/8 (25%)
Ig strand F 305..313 CDD:409353 3/7 (43%)
Ig strand G 316..326 CDD:409353 5/14 (36%)
IgC2_3_Dscam 329..417 CDD:409549 14/87 (16%)
Ig strand B 347..351 CDD:409549 1/3 (33%)
Ig strand C 360..364 CDD:409549 0/3 (0%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 0/4 (0%)
Ig strand G 410..413 CDD:409549 0/2 (0%)
IgI_4_Dscam 422..516 CDD:409548 23/106 (22%)
Ig strand B 439..443 CDD:409548 0/3 (0%)
Ig strand C 452..456 CDD:409548 0/3 (0%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 2/4 (50%)
Ig strand G 509..512 CDD:409548 1/2 (50%)
IgI_5_Dscam 520..607 CDD:409550 26/93 (28%)
Ig strand B 536..540 CDD:409550 1/3 (33%)
Ig strand C 549..553 CDD:409550 1/3 (33%)
Ig strand E 571..575 CDD:409550 2/3 (67%)
Ig strand F 586..591 CDD:409550 3/4 (75%)
Ig strand G 600..603 CDD:409550 0/2 (0%)
Ig 610..703 CDD:416386 25/94 (27%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 2/3 (67%)
Ig strand B 627..636 CDD:409353 2/8 (25%)
Ig strand C 641..648 CDD:409353 3/6 (50%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 1/4 (25%)
Ig strand E 668..675 CDD:409353 3/6 (50%)
Ig strand F 682..690 CDD:409353 3/8 (38%)
Ig strand G 693..702 CDD:409353 0/8 (0%)
IgI_7_Dscam 706..801 CDD:409546 23/99 (23%)
Ig strand B 724..728 CDD:409546 0/3 (0%)
Ig strand C 737..741 CDD:409546 2/6 (33%)
Ig strand E 766..770 CDD:409546 1/3 (33%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 1/2 (50%)
Ig 818..904 CDD:416386 24/89 (27%)
putative Ig strand B 820..827 CDD:409353 1/6 (17%)
putative Ig strand C 835..841 CDD:409353 2/5 (40%)
putative Ig strand C' 853..856 CDD:409353 1/2 (50%)
putative Ig strand D 862..866 CDD:409353 0/3 (0%)
putative Ig strand E 868..874 CDD:409353 1/5 (20%)
putative Ig strand F 881..889 CDD:409353 3/7 (43%)
putative Ig strand G 892..902 CDD:409353 2/9 (22%)
FN3 906..999 CDD:238020 26/95 (27%)
FN3 1006..1110 CDD:238020 32/172 (19%)
fn3 1117..1203 CDD:394996 15/101 (15%)
FN3 1215..1307 CDD:238020 23/100 (23%)
Ig <1334..1401 CDD:416386 10/66 (15%)
Ig strand C 1345..1349 CDD:409353 0/3 (0%)
Ig strand D 1363..1366 CDD:409353 1/2 (50%)
Ig strand E 1367..1372 CDD:409353 1/4 (25%)
Ig strand F 1380..1388 CDD:409353 0/7 (0%)
Ig strand G 1394..1401 CDD:409353 0/6 (0%)
FN3 1405..1494 CDD:238020 16/102 (16%)
FN3 1499..1580 CDD:238020 17/80 (21%)
tutlNP_001303307.1 V-set 137..250 CDD:284989 30/170 (18%)
IG_like 137..229 CDD:214653 27/146 (18%)
I-set 253..341 CDD:254352 25/87 (29%)
IGc2 268..331 CDD:197706 20/62 (32%)
I-set 346..437 CDD:254352 26/98 (27%)
Ig 349..437 CDD:299845 26/95 (27%)
Ig 459..530 CDD:299845 20/78 (26%)
IG_like 549..628 CDD:214653 24/87 (28%)
IGc2 551..617 CDD:197706 21/74 (28%)
FN3 633..725 CDD:238020 26/95 (27%)
FN3 786..874 CDD:238020 27/120 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.910

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