DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam4 and dpr16

DIOPT Version :9

Sequence 1:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster
Sequence 2:	NP_001287169.1	Gene:	dpr16 / 40619	FlyBaseID:	FBgn0037295	Length:	488	Species:	Drosophila melanogaster

Alignment Length:	437	Identity:	96/437 - (21%)
Similarity:	145/437 - (33%)	Gaps:	128/437 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 GKPILRDNRVEILTDPPRLIIKKVQKEDPGMYQCFVSNEWEQIQSTAELQLGDASPELLYWFSEQ 431
            |.|:|      :|.|..:      |:|    |...|.:.|.....||.|..|.:.|..|..|.|
  Fly    84 GSPVL------MLGDDQQ------QQE----YDTTVVDSWSDRPDTATLTKGFSIPSYLPPFPE- 131

  Fly   432 TLQPGPTVSLKCVATGNPLPQFTWSLDGFPIP----DSSRFLVGQYVTIHDDVISHVNISNVKE- 491
             ..|.....:...|:....|.......|.|:|    :.||      :..:|.......:...||
  Fly   132 -FIPADLPHMLRNASSGAAPPADIGPSGSPMPSKPNEQSR------LHAYDSEQKAQQLRREKEL 189

  Fly   492 --------------------EDGGEYT---CTAQNAIGK--------------VSHSAKVNIYGL 519
                                ...|::.   |......||              |.|:..:|....
  Fly   190 AKERELLPRRQLSLPPLNATVQAGQHAYLPCKLNQHSGKPLSWVRLRDEHIIAVDHTTFINDARF 254

  Fly   520 PYIREMPKITG-ISGSDL-IVKCPVAGYPIDKIHWERDGQTLPINRRQRAYNNGTLIIEQLQRLE 582
            ..:.:...:|. :||..| ....|||.......|....||    .|...:..:.||.|:.: .||
  Fly   255 ASLLQSTTLTTLVSGGALSTTATPVAALGNSFAHAVPGGQ----ERGNSSSLSWTLQIKYV-NLE 314

  Fly   583 DAGTYTCMAQNKQKQTSRRNVEIQV-LVPPKIMPIQAMTNMLREGMRAAISCQILEGDL--PVSF 644
            |||.|.|....:.|.:::    :|: ::.|:...|......::.|.|..:.| |:.|.|  |...
  Fly   315 DAGWYECQLATEPKMSAK----VQLFVITPRTELIGDRQRFVKAGSRVELHC-IVRGTLEAPKYI 374

  Fly   645 RWERNGKPLIGTGNEV-------FRRLD-------EYS----ASLVIEHISSDHSGNYTCIASNV 691
            .|.| |...:...||.       :.::|       |::    .||||..:...|||||||
  Fly   375 FWYR-GDQQVTAENEASGAQSGWYTQIDRNIFGSTEHNRNTIGSLVIPLVRKIHSGNYTC----- 433

  Fly   692 AGTERFTVPLTVNVPPKWILEPKDSSAQAGADVLLHCQSSGYPTPTI 738
                                ||::|:|   |.:.||..|..|....|
  Fly   434 --------------------EPENSAA---ASMQLHVLSGEYSASAI 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386
		Ig strand A	235..238	CDD:409353
		Ig strand A'	244..248	CDD:409353
		Ig strand B	251..258	CDD:409353
		Ig strand C	266..271	CDD:409353
		Ig strand C'	276..279	CDD:409353
		Ig strand D	285..289	CDD:409353
		Ig strand E	292..298	CDD:409353
		Ig strand F	305..313	CDD:409353
		Ig strand G	316..326	CDD:409353
		IgC2_3_Dscam	329..417	CDD:409549	13/49 (27%)
		Ig strand B	347..351	CDD:409549
		Ig strand C	360..364	CDD:409549
		Ig strand E	383..387	CDD:409549	0/3 (0%)
		Ig strand F	397..402	CDD:409549	1/4 (25%)
		Ig strand G	410..413	CDD:409549	0/2 (0%)
		IgI_4_Dscam	422..516	CDD:409548	21/135 (16%)
		Ig strand B	439..443	CDD:409548	0/3 (0%)
		Ig strand C	452..456	CDD:409548	0/3 (0%)
		Ig strand E	482..486	CDD:409548	0/3 (0%)
		Ig strand F	496..501	CDD:409548	1/7 (14%)
		Ig strand G	509..512	CDD:409548	1/2 (50%)
		IgI_5_Dscam	520..607	CDD:409550	22/88 (25%)
		Ig strand B	536..540	CDD:409550	1/4 (25%)
		Ig strand C	549..553	CDD:409550	1/3 (33%)
		Ig strand E	571..575	CDD:409550	2/3 (67%)
		Ig strand F	586..591	CDD:409550	2/4 (50%)
		Ig strand G	600..603	CDD:409550	0/2 (0%)
		Ig	610..703	CDD:416386	27/112 (24%)
		Ig strand A	611..613	CDD:409353	1/1 (100%)
		Ig strand A'	620..624	CDD:409353	0/3 (0%)
		Ig strand B	627..636	CDD:409353	2/8 (25%)
		Ig strand C	641..648	CDD:409353	2/6 (33%)
		Ig strand C'	650..652	CDD:409353	1/1 (100%)
		Ig strand D	659..664	CDD:409353	1/11 (9%)
		Ig strand E	668..675	CDD:409353	4/10 (40%)
		Ig strand F	682..690	CDD:409353	5/7 (71%)
		Ig strand G	693..702	CDD:409353	0/8 (0%)
		IgI_7_Dscam	706..801	CDD:409546	10/33 (30%)
		Ig strand B	724..728	CDD:409546	1/3 (33%)
		Ig strand C	737..741	CDD:409546	1/2 (50%)
		Ig strand E	766..770	CDD:409546
		Ig strand F	780..785	CDD:409546
		Ig strand G	794..797	CDD:409546
		Ig	818..904	CDD:416386
		putative Ig strand B	820..827	CDD:409353
		putative Ig strand C	835..841	CDD:409353
		putative Ig strand C'	853..856	CDD:409353
		putative Ig strand D	862..866	CDD:409353
		putative Ig strand E	868..874	CDD:409353
		putative Ig strand F	881..889	CDD:409353
		putative Ig strand G	892..902	CDD:409353
		FN3	906..999	CDD:238020
		FN3	1006..1110	CDD:238020
		fn3	1117..1203	CDD:394996
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
dpr16	NP_001287169.1	IG_like	205..337	CDD:214653	30/140 (21%)
		Ig	<298..338	CDD:299845	12/44 (27%)
		IG_like	352..447	CDD:214653	31/124 (25%)
		Ig	358..439	CDD:143165	25/107 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900