DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and Sdk2

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:XP_006247755.1 Gene:Sdk2 / 360652 RGDID:1310397 Length:2175 Species:Rattus norvegicus


Alignment Length:1854 Identity:437/1854 - (23%)
Similarity:698/1854 - (37%) Gaps:460/1854 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   351 CIVSGHPVHDVNWLHDGKPILRDNRVEILTDPPRLIIKKVQKEDPGMYQCFVSNEW-EQIQSTAE 414
            |:..|....:..|||:.:.:.|.: :|.     |.:|..:.:...|.|:|.|.|.. ..:|...|
  Rat    51 CMAEGSWPLEFKWLHNNRELTRFS-LEY-----RYMITSLDRTHAGFYRCIVRNRMGALLQRQTE 109

  Fly   415 LQLGDASPELLYWFSE----QTLQPGPTVSLKCVATGN-PLPQFTWSLDGFPIPDSSRFLVGQYV 474
            :|:.     .:..|.|    |::..|....:|.....: |.||.||..||..||.|||..    :
  Rat   110 VQVA-----YMGSFEEGEKHQSVSHGEAAVIKAPRISSFPRPQVTWFRDGRKIPPSSRIA----I 165

  Fly   475 TIHDDVISHVNISNVKEEDGGEYTCTA---QNAIGKVSHS---AKVNIYG-----LPYIREMPKI 528
            |:.:.::    |.:....|.|.|...|   :|...|.|..   |..|:.|     .|.|...||.
  Rat   166 TLENTLV----ILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLAVENVGGPADPIAPTIIIPPKN 226

  Fly   529 TGI--SGSDLIVKCPVAGYPIDKIH--WERDGQTL-----PINRRQRAYNNGTLIIEQLQRLEDA 584
            |.:  ..|::.::|.....|:.|:|  |::||..|     ..|||....|         ..:.||
  Rat   227 TSVVAGTSEVTMECVANARPLIKLHIVWKKDGALLSNGISDYNRRLTITN---------PMVSDA 282

  Fly   585 GTYTCMAQNKQKQTS--RRNVEIQVLVPPKIM--PIQAMTNMLREGMRAAISCQILEGDLPVSFR 645
            |.|.|.|..:....:  .|...:.||.||:.:  |.:.:|..:.:.:  .|.|: .:|..|.|..
  Rat   283 GYYECEAMLRSSSVAPVTRGAYLSVLEPPQFVREPERHITAEMEKVV--DIPCR-AKGVPPPSIT 344

  Fly   646 WERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTV-NVPPKW 709
            |.::. .|:..| ::.|........|.|..:..|.:|...|.|.|.||..:.:..|.| ::.|..
  Rat   345 WYKDA-ALVEVG-KLTRFKQRSDGGLQISGLLPDDTGMVQCFAHNAAGEAQTSTYLAVTSIAPNI 407

  Fly   710 ILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQ-----LFPNGTIF 769
            ...|.||:...|..|:|.|::||.|.|.|||:|      ||  ..|...:||     |..:|::.
  Rat   408 TRGPLDSTVIDGMSVVLACETSGAPRPAITWQK------GE--RILASGSVQLPRFTLLESGSLL 464

  Fly   770 FKKISKESQGHFLCEAKNNIG---SGVSKVIFLKVNVPAHFQTKTKQ-ISVAKGKQVHVQCNVQG 830
            .........|.:.|.|.|:.|   :....|::.:..:     ||..| .||.||.|..:.|.|..
  Rat   465 ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRI-----TKPPQDQSVIKGTQASMVCGVTH 524

  Fly   831 DNPIDFKWKIQATQQYLDE------SLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASN 889
            |.        :.|.:|:.|      ::::...||   ||..  ..|.||.|:..|.|.|.|:..:
  Rat   525 DP--------RVTVRYVWEKDGATLAVETNPRIR---LDRN--GSLHISQTWSGDIGTYTCRVLS 576

  Fly   890 AFGQDEMSIQLIVQEVPEQPKN--LRINSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQISDIWQN 952
            |.|.|..:..|.|:::|..|::  ..:::.:.|::.|||::||.||||:..|      |.::.:|
  Rat   577 AGGNDSRNAHLRVRQLPHAPEHPVATLSTMERRAINLTWAKPFDGNSPLMRY------ILEMSEN 635

  Fly   953 AEHLTIAGAQ-----TVINIQQLRPAKAYHIRMSAENKLGASEFS-EVVQVTTLEEVPSGPPLAV 1011
            ....||..|.     |.:.::.|.||::|..|:.|.|.:|..:|| :..:|:..||.|:.||..|
  Rat   636 NAPWTILLASVDPEATSVMVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNV 700

  Fly  1012 RAEPKSSTEIFVTWDAPERDHWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTV---EVRSHFG 1073
            .|..:::..|.:.|..|...|.||||.||.:.|.::..|        .|:.||.:   :|.:   
  Rat   701 IASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLP--------VGYQFKNITDADVNN--- 754

  Fly  1074 GETVLANLNKFTQYHVIVQAYTSQGSGPPSKEIAVQTMEDVPSSPPESPQCDVLGSTSIYITWSP 1138
              .:|.:|..:|.|.:.|.||.|.|.|..|.::...|::.||:.||.:...:...||:|..||:.
  Rat   755 --LLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTAIRFTWNA 817

  Fly  1139 PDIDGQNGKIKGYKVFYISVDELYETDPEVVKSTNQYVT------IENLRKYTNYTVWVLAYTKV 1197
            |.....||..:|||:  |:.:...|.:..:|.:...:..      :..|:|:|.|...||.:|..
  Rat   818 PSPQFINGINQGYKL--IAWEPTQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTP 880

  Fly  1198 GDGMKTKPFYCRTHEDVPSAPQAIKAIPASSSKIIISWLPPDLPNGDITGY-------------- 1248
            |||.::.|...|||||||.....:.......:.:.:||..|...||.:|||              
  Rat   881 GDGPRSSPQLVRTHEDVPGPVGHLSFNDILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRV 945

  Fly  1249 TFYM-----------------------SMLEGGR--------EEGTHKRLLGPFVEMHETVRTQE 1282
            |.|:                       :|...|:        ..|....|.|....:..:.....
  Rat   946 THYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGAPTNLGISNIGPR 1010

  Fly  1283 SATYQF------------WLTAST--KMGEGEK------------TQVVTVPPNNKVPARIVSFS 1321
            |.|.||            |:..:.  .:||||:            .:.:.||..|  |....||.
  Rat  1011 SVTLQFRPGYDGKTSISRWVVEAQVGMIGEGEEWLLIYQLSNEPDARSMEVPDLN--PFTYYSFR 1073

  Fly  1322 QRIV-----TPWKEHLELPCRKVG--------APAPVTI-----------W-------------- 1348
            .|.|     :|..:    |.||:.        |||.||:           |              
  Rat  1074 MRQVNIVGTSPPSQ----PSRKIQTLQAPPDMAPANVTLRTASETSLWLRWMPLPEMEYNGNPES 1134

  Fly  1349 --------RQDGHNMETSARKTIA----------------KNGTLYMKECQASDA-GNYTCSVEN 1388
                    |.|||.      ||::                :..|.|..:.||.:| |:      .
  Rat  1135 VGYKIKYSRSDGHG------KTLSHTVQDRVEREYTIEDLEEWTEYRVQVQAFNAIGS------G 1187

  Fly  1389 TWGKDEIVYNIVVKVPPEAP-NLTVINAYTDSLLLEWMD--NSHGGSPILGYVINYKRDNGD--- 1447
            .|.: .:|......||...| |::.:...:.|:|:.|.:  .:.....:|||.:.||..:.|   
  Rat  1188 PWSQ-AVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEIPEADRNGLVLGYKVRYKEKDSDSQA 1251

  Fly  1448 --WEELQVDSKTTSHLLTNLWCGTRYQLYITAYNKIGTGLPCDIVNSYTKGNPPVQPKHSQMITN 1510
              |  |...:.:.|..||.|.....|::.:.|:.:||.|.|         .:||:..:....:..
  Rat  1252 RFW--LVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP---------SHPPILERTLDDVPG 1305

  Fly  1511 ----------NSTSV-TCWLDSWGDGGCGILYFMIESRVYGRSSWAVVSNHIPPTERIYTVSDLV 1564
                      .:||| ..|.......|. ||.:.|..|:...::.......:.|:.|.|..:.|.
  Rat  1306 PPMGILFPEVRTTSVRLIWQPPATPNGI-ILAYQITHRLNATTANTATVEVLAPSARQYMATGLK 1369

  Fly  1565 PGTKYQLKVTAHNNAGSTTAIYNFTTLSTQGVIYNNDHSTPVSHLSD-------LPFYANFKLLL 1622
            |.:.|..::||....|...|. ....::|:........|.||....|       |.:......|.
  Rat  1370 PESVYLFRITAQTRKGWGEAA-EALVVTTEKRDRPQPPSKPVVQQEDVKARSVLLSWEPGSDGLS 1433

  Fly  1623 PICFSLLMLLALIGAALFLRKRKLAS-QARLASSSMSESPSLANLQNKQNRDQQYLAVRCNPGTS 1686
            |:.:            ..::.|:|.| :..|.|:|:|.:.|            .:...|..|.||
  Rat  1434 PVRY------------YTIQTRELPSGRWALHSASVSHNAS------------AFTVDRLKPFTS 1474

  Fly  1687 AP-RGSNSNDSGSFGKAEGNE-------------YIEDICPYATFQ--LNKQTYSESSYSGNVYS 1735
            .. |...:||.|....:|.:|             .|..:.|:.|..  :..|..||...:| :..
  Rat  1475 YKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPSEDKING-ILL 1538

  Fly  1736 G--------PYHSVRGSFVYHDVKPESYHSKEPEYTKVRRKVGRLRDPHSESQESDNPGSTDSEV 1792
            |        .|..:|| |....:....  :|..|.|.: ..:..|..|.....|.||        
  Rat  1539 GFRIRYRELLYEGLRG-FTLRGINNPG--AKWAELTSL-YSMRNLTRPSLTQYELDN-------- 1591

  Fly  1793 RKILTLH----IPITEYDTLGS---ESDNDV-------SARALNSAKYRAQRDTQDETSSSS--- 1840
               ||.|    |.::.|:.:|.   ....:|       :|...|.|.:.|.....|.|....   
  Rat  1592 ---LTKHRRYEIRMSVYNAVGEGPLSPPQEVFVGEAVPTAAPQNVAIHSATATQLDVTWEPPPLD 1653

  Fly  1841 --------------ETTPTSMTRKSKPPFAARKGGKPGTSGKRHVRSSSGYSSHNEETTFSISNY 1891
                          |....::|.:.|..|.|....|        :::.:||      |.:.:|  
  Rat  1654 NQNGDIQGYKIYFWEVQRRNLTERVKTLFLAENSVK--------LKNLTGY------TAYMVS-- 1702

  Fly  1892 PPNYQDHINPPARFSDAND---KTKTQTSPRMRA 1922
                      .|.|:.|.|   .|.||...:..|
  Rat  1703 ----------VAAFNAAGDGPRSTPTQGQTQQAA 1726

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353
Ig strand C' 276..279 CDD:409353
Ig strand D 285..289 CDD:409353
Ig strand E 292..298 CDD:409353
Ig strand F 305..313 CDD:409353
Ig strand G 316..326 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549 16/66 (24%)
Ig strand B 347..351 CDD:409549 437/1854 (24%)
Ig strand C 360..364 CDD:409549 0/3 (0%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 2/4 (50%)
Ig strand G 410..413 CDD:409549 1/2 (50%)
IgI_4_Dscam 422..516 CDD:409548 27/104 (26%)
Ig strand B 439..443 CDD:409548 0/3 (0%)
Ig strand C 452..456 CDD:409548 2/3 (67%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 1/4 (25%)
Ig strand G 509..512 CDD:409548 1/5 (20%)
IgI_5_Dscam 520..607 CDD:409550 25/97 (26%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 2/5 (40%)
Ig strand E 571..575 CDD:409550 0/3 (0%)
Ig strand F 586..591 CDD:409550 2/4 (50%)
Ig strand G 600..603 CDD:409550 1/2 (50%)
Ig 610..703 CDD:416386 23/94 (24%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 1/3 (33%)
Ig strand B 627..636 CDD:409353 2/8 (25%)
Ig strand C 641..648 CDD:409353 3/6 (50%)
Ig strand C' 650..652 CDD:409353 0/1 (0%)
Ig strand D 659..664 CDD:409353 1/4 (25%)
Ig strand E 668..675 CDD:409353 2/6 (33%)
Ig strand F 682..690 CDD:409353 3/7 (43%)
Ig strand G 693..702 CDD:409353 1/8 (13%)
IgI_7_Dscam 706..801 CDD:409546 29/102 (28%)
Ig strand B 724..728 CDD:409546 2/3 (67%)
Ig strand C 737..741 CDD:409546 2/3 (67%)
Ig strand E 766..770 CDD:409546 1/3 (33%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 0/2 (0%)
Ig 818..904 CDD:416386 26/91 (29%)
putative Ig strand B 820..827 CDD:409353 1/6 (17%)
putative Ig strand C 835..841 CDD:409353 0/5 (0%)
putative Ig strand C' 853..856 CDD:409353 0/2 (0%)
putative Ig strand D 862..866 CDD:409353 2/3 (67%)
putative Ig strand E 868..874 CDD:409353 2/5 (40%)
putative Ig strand F 881..889 CDD:409353 3/7 (43%)
putative Ig strand G 892..902 CDD:409353 3/9 (33%)
FN3 906..999 CDD:238020 30/100 (30%)
FN3 1006..1110 CDD:238020 31/106 (29%)
fn3 1117..1203 CDD:394996 26/91 (29%)
FN3 1215..1307 CDD:238020 25/162 (15%)
Ig <1334..1401 CDD:416386 23/124 (19%)
Ig strand C 1345..1349 CDD:409353 3/36 (8%)
Ig strand D 1363..1366 CDD:409353 0/18 (0%)
Ig strand E 1367..1372 CDD:409353 2/4 (50%)
Ig strand F 1380..1388 CDD:409353 1/7 (14%)
Ig strand G 1394..1401 CDD:409353 1/6 (17%)
FN3 1405..1494 CDD:238020 23/96 (24%)
FN3 1499..1580 CDD:238020 18/91 (20%)
Sdk2XP_006247755.1 IG_like 43..112 CDD:214653 16/66 (24%)
IGc2 43..101 CDD:197706 14/55 (25%)
IG_like 123..206 CDD:214653 24/90 (27%)
Ig 135..191 CDD:299845 19/63 (30%)
IG_like 225..307 CDD:214653 22/90 (24%)
IGc2 236..289 CDD:197706 17/61 (28%)
I-set 311..400 CDD:254352 22/93 (24%)
Ig 329..397 CDD:143165 18/72 (25%)
I-set 405..495 CDD:254352 28/97 (29%)
Ig 419..495 CDD:299845 24/83 (29%)
Ig 505..589 CDD:299845 28/96 (29%)
IG_like 505..589 CDD:214653 28/96 (29%)
FN3 593..684 CDD:238020 29/96 (30%)
FN3 696..789 CDD:238020 31/105 (30%)
FN3 797..893 CDD:238020 27/97 (28%)
FN3 898..986 CDD:238020 13/87 (15%)
FN3 996..1090 CDD:238020 20/99 (20%)
FN3 1102..1197 CDD:238020 20/107 (19%)
FN3 1204..1293 CDD:238020 23/99 (23%)
FN3 1304..1397 CDD:238020 19/94 (20%)
FN3 1403..1487 CDD:238020 22/107 (21%)
FN3 1506..1619 CDD:238020 26/128 (20%)
FN3 1629..1722 CDD:238020 22/118 (19%)
FN3 1727..1808 CDD:238020 437/1854 (24%)
FN3 1840..1919 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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