DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and itgb4

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:XP_005166847.1 Gene:itgb4 / 335269 ZFINID:ZDB-GENE-030131-7209 Length:1931 Species:Danio rerio


Alignment Length:1372 Identity:266/1372 - (19%)
Similarity:437/1372 - (31%) Gaps:425/1372 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   633 CQILEGDLPVSFRWERNGKPLIG---------------TGNEVFRRLDEYSASLV-IEHISSDHS 681
            |:.....||:|...|.|.:..:|               ||....|:.||....:| ::.:..|.:
Zfish   601 CECEHSGLPLSPTCEANFQQQVGMCEAKRSCVQCQAWSTGERKGRKCDECPFKIVRVDELEEDKN 665

  Fly   682 GNYTC----------------IASNVAGTE-RFTVPLTVNVPPK---WILEPKDSSAQAGADVLL 726
            ...||                ..||:...| |..|....:.||.   |:: |..........:||
Zfish   666 VIETCSFRDEDDDCTYHYNVNYPSNITDKEHRVLVKKKKDCPPAGFLWLI-PLIMFLMLLLGLLL 729

  Fly   727 --------HCQSSGYPTPTITWKKAIGPTPGEY--------KDFLYEPTVQLFP---NGTIFFKK 772
                    .|||.....|.....:.:|....:|        .|:|..|.|:..|   ...:.:|.
Zfish   730 LCCWKYCACCQSCLALLPCCARGRMVGFKENQYLLRQSFLQNDYLDTPMVRSGPLKSTDVVRWKV 794

  Fly   773 ISKESQG--HFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKG-----------KQVHV 824
            .....:|  |...:.:.|....:...:.|::|         :|.|....           ::|..
Zfish   795 ADNVHRGTNHPQNQIRPNPKETIQYPVSLRLN---------RQFSEVLSNPDARDTDMLRREVED 850

  Fly   825 QCN-----VQGDNPID---FKWKIQATQQYLDESLD-------SRY----TIRDQVLDDGMVSEL 870
            ..|     :.|..|:.   |:.:..:.::..:..:|       |.|    .:.|:.:..|...:|
Zfish   851 NLNDVFLQIPGAQPVQKTLFRTQRNSGKRQNNTIVDTVLSAPRSSYPDIVKLTDKQVQSGNFRDL 915

  Fly   871 GI---SHTYRQDTGIYICQASNAF------------------GQDEMSIQLIVQ--EVP------ 906
            .:   .:|...|.     :|:.|.                  .:|:...:|:||  :||      
Zfish   916 KVIPGYYTVASDK-----EAAGAVEFPENVESVDVRVPLFIKDEDDEKKELLVQAVDVPVGIAKI 975

  Fly   907 -EQPKNLRINSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQ--ISDIWQNAEHLTIAGAQTVINIQ 968
             :...|:.:..:|:.|: .|:.:|         .:.|.:|  :::|....:.:....||...:..
Zfish   976 GKDHVNITVLKEQASSV-FTFLEP---------SYTYSRQDGVANIPIKRQIIEDGRAQVTYSTA 1030

  Fly   969 QLRPA-KAYHIRMSAENKLGASEFSEVVQVTTLE------------------------------- 1001
            .|... |..:|.:..:...||.|..::|.|..||                               
Zfish  1031 DLTAKDKKDYISVDGDLSYGAGETEKIVPVKLLELGEQDGLLEDKQVKQFVMDLTNPRQSAKLGR 1095

  Fly  1002 ------EVPSGPPLAVRAEPKSSTEIFVTWDA--------------PERDHWNGILLGYY-VGYQ 1045
                  .:...|..:|.|. |.||:.|.|.|:              |...||.......: :...
Zfish  1096 YPRTVITIADKPESSVMAF-KKSTQTFSTTDSLYTIPVERTGNRETPATVHWRTNKASRFDISSP 1159

  Fly  1046 MSLTPEDKE----VNPTQGFSFKTVEVRSH--------FGGETVLANLNKFTQYHVIVQAYTSQG 1098
            :...|.:.|    :||           |:|        |..|.:..:.|.........:...:.|
Zfish  1160 LKFAPGEAEKNILINP-----------RTHPSPIIPEKFNLELLDPSNNAIIGKRKTTEVIVTDG 1213

  Fly  1099 SGPPSKEIAVQTMEDV---PSSP------PESPQCDVLGSTSIYITWSPPDIDGQNGKIKGYKVF 1154
            .| ..|....|.||.|   .:||      |.:.:....|..:|.:.|.|    .||.  .||||.
Zfish  1214 RG-DGKNQDFQKMEYVTQTATSPGGRLYSPANIKAVATGPKNIRLNWKP----SQNA--NGYKVK 1271

  Fly  1155 YISVDELYETDPE------VVKSTNQYVTIENLRKYTNYTVWVLAYTKVGDGMKTKPFYCRTHED 1213
            |    .:| .|||      .||:....:|  ||..|.:|.:.|..|..:|||..:....|:|.||
Zfish  1272 Y----WIY-GDPEDKAKFMDVKTPQAELT--NLDPYCDYEMRVCGYNALGDGNYSDIIQCQTLED 1329

  Fly  1214 VPSAPQAIKAIPASSSKIIISWLPPDLPNGDITGY-TFYMSMLEGGREEGTHKRLL--GPFVEMH 1275
            :|..|..:.....|.:...:||..|...||.|||| ..||.:.|..:..|..|:::  .|...|.
Zfish  1330 IPGEPGRLAFNVISPTVTQVSWAEPAEANGIITGYEVIYMPINEDKKPTGPPKKVMIDNPKKRML 1394

  Fly  1276 ETVRTQESATYQFWLTASTKMGEG-----------EKTQVVTVP--------------------- 1308
            .....|.|.||.:.:.||.|:|.|           :.|:.:::|                     
Zfish  1395 LIENLQPSQTYCYKVRASNKVGWGPYREATINLASQPTRPMSIPIIPDIPIVDAEAGEEYDSYLM 1459

  Fly  1309 --------PNNKVPARIVSFS--QRIVTPWKEHLELPCRKVGAPAPVTIWRQDGHNMETSARKTI 1363
                    |.:.:...:...|  |.:...|:::...|....|                 |..:.|
Zfish  1460 YSNEVLRSPTSSLRPSVTDLSDDQFVNGKWEQNFLFPGGGGG-----------------SLSRNI 1507

  Fly  1364 AKNGTLYMKECQASDAGNYTCSVENTWGKDE-------------IVYNIVVKVPPEAPNLTVINA 1415
            :.:.|.|......::..|.:.:.....||..             :..:::::...|..:.|..:.
Zfish  1508 SSSSTTYSHSTPRTNVTNNSSTTTYISGKGGSTTHRYDVRDGGLLKEDVILRKRSENRHYTEGDG 1572

  Fly  1416 YTDSLLLEWMDNSHGGSPILGYVINYKRDNGDWEELQVDSKTTSHLLTNLWCGTRYQLYITAYNK 1480
            ..||::   |.|..||                             ||.||...:..|...|:|:.
Zfish  1573 VRDSIV---MGNLSGG-----------------------------LLDNLGVSSFSQTTSTSYSL 1605

  Fly  1481 IGTG-----------LPCDIVNSYTKGNPPVQPKHSQMITNNSTSVTCWLDSWGDGGCG------ 1528
            ....           |..|.|...::..|.|....|:::. ::...|....||.:..|.      
Zfish  1606 SSRARTQSEDINDALLNLDSVLQESRFTPGVPATPSRLVF-SALGHTALKVSWQEPHCESDVLGY 1669

  Fly  1529 -ILYFMIESRVYGRSSWAVVSNHIPPTERIYTVSDLVPGTKYQLKVTAHNNAGSTTAIYNFTTLS 1592
             :||.:|..   |......|:|   |.:....|.||:|...|..||.|.:..|...        .
Zfish  1670 CVLYQLING---GDVKRIEVNN---PAQNSVLVQDLLPNQSYIFKVKAQSREGWGP--------E 1720

  Fly  1593 TQGVIYNNDHSTPVSHLSDLPFYANFKLLLPICFSLLMLLALIGAALFLRKRKLASQARLASSSM 1657
            .:|||....:..|.|.||.:| .:.|.|..|.....|:..||....|.|...|            
Zfish  1721 REGVITIESNVDPKSPLSPVP-GSPFTLSTPSAPGPLIFTALRPDTLQLSWEK------------ 1772

  Fly  1658 SESPSLANLQNKQNRDQQYLAVRCNPGTSAPRGSNSNDSGSF---GKAEGNEYIEDI---CPYAT 1716
                     ..|.|.|.....|.|.      :.....|..||   |.|..:..:.|:   .|| .
Zfish  1773 ---------PRKPNGDILGYVVTCE------QLHGGGDLRSFQVNGNAATSLTVSDLKENMPY-K 1821

  Fly  1717 FQLNKQT 1723
            |::..||
Zfish  1822 FKVQAQT 1828

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353
Ig strand C' 276..279 CDD:409353
Ig strand D 285..289 CDD:409353
Ig strand E 292..298 CDD:409353
Ig strand F 305..313 CDD:409353
Ig strand G 316..326 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549
Ig strand B 347..351 CDD:409549
Ig strand C 360..364 CDD:409549
Ig strand E 383..387 CDD:409549
Ig strand F 397..402 CDD:409549
Ig strand G 410..413 CDD:409549
IgI_4_Dscam 422..516 CDD:409548
Ig strand B 439..443 CDD:409548
Ig strand C 452..456 CDD:409548
Ig strand E 482..486 CDD:409548
Ig strand F 496..501 CDD:409548
Ig strand G 509..512 CDD:409548
IgI_5_Dscam 520..607 CDD:409550
Ig strand B 536..540 CDD:409550
Ig strand C 549..553 CDD:409550
Ig strand E 571..575 CDD:409550
Ig strand F 586..591 CDD:409550
Ig strand G 600..603 CDD:409550
Ig 610..703 CDD:416386 21/102 (21%)
Ig strand A 611..613 CDD:409353
Ig strand A' 620..624 CDD:409353
Ig strand B 627..636 CDD:409353 1/2 (50%)
Ig strand C 641..648 CDD:409353 2/6 (33%)
Ig strand C' 650..652 CDD:409353 0/1 (0%)
Ig strand D 659..664 CDD:409353 1/4 (25%)
Ig strand E 668..675 CDD:409353 1/7 (14%)
Ig strand F 682..690 CDD:409353 2/23 (9%)
Ig strand G 693..702 CDD:409353 3/9 (33%)
IgI_7_Dscam 706..801 CDD:409546 22/118 (19%)
Ig strand B 724..728 CDD:409546 2/11 (18%)
Ig strand C 737..741 CDD:409546 0/3 (0%)
Ig strand E 766..770 CDD:409546 0/3 (0%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 0/2 (0%)
Ig 818..904 CDD:416386 19/138 (14%)
putative Ig strand B 820..827 CDD:409353 1/6 (17%)
putative Ig strand C 835..841 CDD:409353 1/8 (13%)
putative Ig strand C' 853..856 CDD:409353 2/6 (33%)
putative Ig strand D 862..866 CDD:409353 0/3 (0%)
putative Ig strand E 868..874 CDD:409353 1/8 (13%)
putative Ig strand F 881..889 CDD:409353 1/7 (14%)
putative Ig strand G 892..902 CDD:409353 2/9 (22%)
FN3 906..999 CDD:238020 19/102 (19%)
FN3 1006..1110 CDD:238020 24/130 (18%)
fn3 1117..1203 CDD:394996 30/97 (31%)
FN3 1215..1307 CDD:238020 29/105 (28%)
Ig <1334..1401 CDD:416386 9/79 (11%)
Ig strand C 1345..1349 CDD:409353 0/3 (0%)
Ig strand D 1363..1366 CDD:409353 1/2 (50%)
Ig strand E 1367..1372 CDD:409353 2/4 (50%)
Ig strand F 1380..1388 CDD:409353 1/7 (14%)
Ig strand G 1394..1401 CDD:409353 0/19 (0%)
FN3 1405..1494 CDD:238020 18/99 (18%)
FN3 1499..1580 CDD:238020 21/87 (24%)
itgb4XP_005166847.1 Integrin_beta 37..457 CDD:278776
EGF_2 <468..490 CDD:285248
EGF_2 545..573 CDD:285248
Integrin_B_tail 625..709 CDD:285239 15/83 (18%)
Calx-beta 991..1064 CDD:295344 16/82 (20%)
FN3 1242..1326 CDD:238020 29/96 (30%)
FN3 1331..1420 CDD:238020 28/88 (32%)
fn3 1640..1720 CDD:278470 21/94 (22%)
fn3 1751..1835 CDD:278470 22/106 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.900

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