DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and HSPG2

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:XP_011539620.1 Gene:HSPG2 / 3339 HGNCID:5273 Length:4574 Species:Homo sapiens


Alignment Length:1973 Identity:413/1973 - (20%)
Similarity:654/1973 - (33%) Gaps:559/1973 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 QGPIFLHEPPHRVEFSNNSGGLIECSGHGSPPPEVEWT-----PIPPQQDMVFQLSNGSMMFYPF 89
            |.|:.:...|.|..........:.|...||||....|:     |:|....   |...||.:.:|.
Human  1857 QAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQ---QRHQGSELHFPS 1918

  Fly    90 TAEKYRHEVHATVYRCKLRNLVGTVLSR-EVHVRGVVNQKYAVQVHD---EYVMTGNTAVLKCQV 150
            ....     .|.||.|..|||..:..|| |:.|....::...|.|.:   :.|..|......|..
Human  1919 VQPS-----DAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTA 1978

  Fly   151 PSYMSEFVLVTAWVQDTGMHLYPNTDIGGKYTVLS---NGELYINNAGPNDAYKSYTCRTVNRL- 211
            .|....:.||  |   |.:|       .||....:   ||.|.|.|...:|| .:|.|...|.. 
Human  1979 KSKSPAYTLV--W---TRLH-------NGKLPTRAMDFNGILTIRNVQLSDA-GTYVCTGSNMFA 2030

  Fly   212 ------TGEVQIS-TYPGRIIVTEPKGMVQPRINVEKHSMRHVVLNGQ-TTLPCIAQGHPVPTYR 268
                  |..||.| |....::...|     |::.|:.         || ....|.|.|.|.||..
Human  2031 MDQGTATLHVQASGTLSAPVVSIHP-----PQLTVQP---------GQLAEFRCSATGSPTPTLE 2081

  Fly   269 WFKEENEQLLPLQLSERITIVSAGLLKITKARLEDSGKYLCWVNNTAGEETIQVSLTVTAPLTAH 333
            |......| ||.:..     :..|:|::......|..:|||..:::||::..:..|.|.......
Human  2082 WTGGPGGQ-LPAKAQ-----IHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPR 2140

  Fly   334 LQ--PQVQTVDVDKDAQFQCIVSGHPVHDVNWLHDG---KPILRDNRVEILTDPPRLIIKKVQKE 393
            :|  |:...|...:..:..|..:|.|...:.|..:|   .|..|..|.:|.|    |:|..:...
Human  2141 VQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIAT----LLIPAITTA 2201

  Fly   394 DPGMYQCFVSNEWEQIQSTAE---LQLGDAS-PELLYWFSEQTLQPGPTVSLKCVATGNPLPQFT 454
            |.|.|.|..::.....|:..:   |...||| |.:....|..::..|.|:.|.||..|:...|.|
Human  2202 DAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVT 2266

  Fly   455 WSLDGFPIPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIY-- 517
            |...|..:|        .:..:|.   |.:.:..|...|.|||.|..:|..|....|..|::.  
Human  2267 WYRRGGSLP--------PHTQVHG---SRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHG 2320

  Fly   518 ---GLPY---------IREMPKITGIS-GSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQRAYN 569
               |..|         ||..|..:.:: |..|.:.|.|.|....::.|.:.|.:||    .|...
Human  2321 THSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLP----ARHQT 2381

  Fly   570 NGTLIIEQLQRLEDAGTYTCMAQNKQKQTSRRNVEIQVLV-------PPKIMP--IQAMTNMLRE 625
            :|:|:........|:|.|.|....     :...:|..|||       |..|.|  |::.::.:.|
Human  2382 HGSLLRLHQVTPADSGEYVCHVVG-----TSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAE 2441

  Fly   626 GMRAAISCQILEGDLPVSFRWERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIASN 690
            |....:|| ::.|.......|.:.|..|..       |.....:.|.|...|...:|.|.|.|||
Human  2442 GQTLDLSC-VVAGQAHAQVTWYKRGGSLPA-------RHQVRGSRLYIFQASPADAGQYVCRASN 2498

  Fly   691 ---------VAGTE--RFTVPLTVNVPPKWILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAI 744
                     |.||:  ....|.....|.:  :||..|....|..:.|:|...|.....:||.|..
Human  2499 GMEASITVTVTGTQGANLAYPAGSTQPIR--IEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG 2561

  Fly   745 GPTPGEYKDFLYEPTVQLFPNGTIF-FKKISKESQGHFLCEAKNNIGSGV----SKVIFLKV--N 802
            |..|..::           .:|::. ..:.|....|.::|..   :||.|    |.::.::.  :
Human  2562 GSLPVRHQ-----------THGSLLRLYQASPADSGEYVCRV---LGSSVPLEASVLVTIEPAGS 2612

  Fly   803 VPAHFQTKTKQI-----SVAKGKQVHVQCNVQGDNPIDFKWKIQATQQYLDESLDSRYTIRDQVL 862
            |||...|.|.:|     .||:|:.:.:.|.|.|.......|..:.      .||.:|:.:..   
Human  2613 VPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG------GSLPARHQVHG--- 2668

  Fly   863 DDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQEVPEQPKNLRINSQQSRS----LQ 923
                 |.|.:......|:|.|:|:...:.|..|.|:.:.:|:        |::...|:.    ::
Human  2669 -----SRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQ--------RLSGSHSQGVAYPVR 2720

  Fly   924 LTWSQPFAGN-----------SPIEEYHIYYKQISDIWQNAEHLTIAGAQTVINIQQLRPAKAYH 977
            :..|.....|           |.......:||:...:  .:.| .|.|::  :.|.|:.||.:..
Human  2721 IESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL--PSRH-QIVGSR--LRIPQVTPADSGE 2780

  Fly   978 IRMSAENKLGASEFSEVV--QVTTLEEVPS-GPPLAVRAEPKSST-----------------EIF 1022
            ......|..|:.|.|.:|  |.:....||| .||  :|.|..|.|                 :..
Human  2781 YVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPP--IRIESSSPTVVEGQTLDLNCVVARQPQAI 2843

  Fly  1023 VTW-----DAPERDHWNGILLGYYVGYQMSLTPEDK------------------EVNPTQG---- 1060
            :||     ..|.|...:|..|..   :|||:....:                  .|:|:.|    
Human  2844 ITWYKRGGSLPSRHQTHGSHLRL---HQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSA 2905

  Fly  1061 ----FSFKTVEVRSHFG-GETVLANLNKFTQYHVIVQAYTSQGSGP------------------- 1101
                ...:.....||.. |||:..|.....|.|..|..:...||.|                   
Human  2906 PGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPAD 2970

  Fly  1102 -------------PSKEIAVQTMEDVPSSPPESP-------------------------QCDVLG 1128
                         |.:...:.|:|...||....|                         :|.|.|
Human  2971 SGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPG 3035

  Fly  1129 STSIYITW-----------------------SPPD-------IDGQNGKIKGYKVFYISVDELYE 1163
            .....:||                       ||.|       :.|.:|.::              
Human  3036 QAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLE-------------- 3086

  Fly  1164 TDPEVVKSTNQYVTIENLRKYTNYTVWVLAYTKVGDGMKTKPFYCRTHEDVPSAPQAIKA----- 1223
                    .:..||||                                   ||:|..|.|     
Human  3087 --------ASVLVTIE-----------------------------------PSSPGPIPAPGLAQ 3108

  Fly  1224 ---IPASSSKII------ISWLPPDLPNGDITGYTFYMSMLEGGREEGTHKRLLGPFVEMHETVR 1279
               |.||||.:.      ::.:.|...:..:|.|.      .||.....| :..|..:.:| .|.
Human  3109 PIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYK------RGGSLPARH-QTHGSQLRLH-LVS 3165

  Fly  1280 TQESATYQFWLTASTKMGEGEKTQVVTVPPNN----KVPARIVSFSQRIVTPWK-EHLELPCRKV 1339
            ..:|..| ....||....|.|.:..|||||:.    ::.:.::|......|..: :.....|...
Human  3166 PADSGEY-VCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIH 3229

  Fly  1340 GAPAPVTI-WRQDGHNMETSARKTIAKNGTLY-MKECQASDAGNYTCSVENTWGKDEIVYNIVVK 1402
            ...||::: |:.....:|.:..  |:.||::. :...:.|:.|.|.|...|.:|..:.|.|:.|.
Human  3230 DGAAPISLEWKTRNQELEDNVH--ISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVH 3292

  Fly  1403 VPPEAPNLTVINAYTDSLLLE---W--------MDNSHGGSPILGYVINYKRDNGDWEEL----- 1451
            .||           |.|:|.|   |        ::....|.|         |.:..|..:     
Human  3293 GPP-----------TVSVLPEGPVWVKVGKAVTLECVSAGEP---------RSSARWTRISSTPA 3337

  Fly  1452 QVDSKT----TSHLLTNLW------CGTRYQLYI-TAYNKIGTG-LPCDIV---NSYTKGNPPVQ 1501
            :::.:|    .||.:..:.      .||    |: .|.|.:||. ...:::   .:...|.|.||
Human  3338 KLEQRTYGLMDSHAVLQISSAKPSDAGT----YVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQ 3398

  Fly  1502 PKHSQMITNNSTSVTCWLDSWGDGGCGILYFMIES----------------RVYGRSSWAVVSNH 1550
            .:.:::......:.|....:.|.....|.:..:.|                ||..:.|...:.|.
Human  3399 AEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNA 3463

  Fly  1551 IPPTERI-YTVSDLVPGTKYQLKVTAHNN--AGSTTAIYNFTTLSTQGVIYNNDHSTPVSHLSDL 1612
            ..|.... .|:...|....|...|..|.:  ||.|..:....            |.||       
Human  3464 TSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLA------------HGTP------- 3509

  Fly  1613 PFYANFKLLLPICFSLLMLLALIGAALFLR---KRKLASQARLASSSMSESPSLANLQNKQNRDQ 1674
                      |:.|.    .:.:|::|..|   :.:|....|.|......  ....:.||....:
Human  3510 ----------PLTFQ----WSRVGSSLPGRATARNELLHFERAAPEDSGR--YRCRVTNKVGSAE 3558

  Fly  1675 QY--LAVRCNPG----TSAPRGS 1691
            .:  |.|:..||    ||.|.||
Human  3559 AFAQLLVQGPPGSLPATSIPAGS 3581

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386 26/98 (27%)
Ig strand A 32..35 CDD:409353 1/2 (50%)
Ig strand A' 41..45 CDD:409353 1/3 (33%)
Ig strand B 48..57 CDD:409353 1/8 (13%)
Ig strand D 75..78 CDD:409353 0/2 (0%)
Ig strand E 83..88 CDD:409353 1/4 (25%)
Ig strand F 101..109 CDD:409353 3/7 (43%)
Ig strand G 112..124 CDD:409353 4/12 (33%)
Ig 235..326 CDD:416386 23/91 (25%)
Ig strand A 235..238 CDD:409353 1/2 (50%)
Ig strand A' 244..248 CDD:409353 0/3 (0%)
Ig strand B 251..258 CDD:409353 2/7 (29%)
Ig strand C 266..271 CDD:409353 2/4 (50%)
Ig strand C' 276..279 CDD:409353 1/2 (50%)
Ig strand D 285..289 CDD:409353 0/3 (0%)
Ig strand E 292..298 CDD:409353 2/5 (40%)
Ig strand F 305..313 CDD:409353 3/7 (43%)
Ig strand G 316..326 CDD:409353 2/9 (22%)
IgC2_3_Dscam 329..417 CDD:409549 21/95 (22%)
Ig strand B 347..351 CDD:409549 0/3 (0%)
Ig strand C 360..364 CDD:409549 0/3 (0%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 2/4 (50%)
Ig strand G 410..413 CDD:409549 1/2 (50%)
IgI_4_Dscam 422..516 CDD:409548 25/93 (27%)
Ig strand B 439..443 CDD:409548 1/3 (33%)
Ig strand C 452..456 CDD:409548 2/3 (67%)
Ig strand E 482..486 CDD:409548 1/3 (33%)
Ig strand F 496..501 CDD:409548 3/4 (75%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 21/96 (22%)
Ig strand B 536..540 CDD:409550 1/3 (33%)
Ig strand C 549..553 CDD:409550 0/3 (0%)
Ig strand E 571..575 CDD:409550 2/3 (67%)
Ig strand F 586..591 CDD:409550 2/4 (50%)
Ig strand G 600..603 CDD:409550 0/2 (0%)
Ig 610..703 CDD:416386 26/105 (25%)
Ig strand A 611..613 CDD:409353 0/1 (0%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 2/8 (25%)
Ig strand C 641..648 CDD:409353 1/6 (17%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 2/6 (33%)
Ig strand F 682..690 CDD:409353 4/7 (57%)
Ig strand G 693..702 CDD:409353 3/10 (30%)
IgI_7_Dscam 706..801 CDD:409546 21/99 (21%)
Ig strand B 724..728 CDD:409546 1/3 (33%)
Ig strand C 737..741 CDD:409546 1/3 (33%)
Ig strand E 766..770 CDD:409546 1/4 (25%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 1/2 (50%)
Ig 818..904 CDD:416386 17/85 (20%)
putative Ig strand B 820..827 CDD:409353 0/6 (0%)
putative Ig strand C 835..841 CDD:409353 1/5 (20%)
putative Ig strand C' 853..856 CDD:409353 1/2 (50%)
putative Ig strand D 862..866 CDD:409353 0/3 (0%)
putative Ig strand E 868..874 CDD:409353 2/5 (40%)
putative Ig strand F 881..889 CDD:409353 3/7 (43%)
putative Ig strand G 892..902 CDD:409353 3/9 (33%)
FN3 906..999 CDD:238020 20/109 (18%)
FN3 1006..1110 CDD:238020 31/184 (17%)
fn3 1117..1203 CDD:394996 16/140 (11%)
FN3 1215..1307 CDD:238020 26/105 (25%)
Ig <1334..1401 CDD:416386 16/68 (24%)
Ig strand C 1345..1349 CDD:409353 0/4 (0%)
Ig strand D 1363..1366 CDD:409353 1/2 (50%)
Ig strand E 1367..1372 CDD:409353 1/5 (20%)
Ig strand F 1380..1388 CDD:409353 3/7 (43%)
Ig strand G 1394..1401 CDD:409353 2/6 (33%)
FN3 1405..1494 CDD:238020 20/119 (17%)
FN3 1499..1580 CDD:238020 16/99 (16%)
HSPG2XP_011539620.1 SEA 80..193 CDD:214554
LDLa 216..251 CDD:238060
LDLa 302..336 CDD:238060
LDLa 342..376 CDD:238060
LDLa 385..420 CDD:238060
IG 431..507 CDD:214652
Ig_Perlecan_D2_like 438..515 CDD:143220
LamB 608..734 CDD:214597
EGF_Lam 782..824 CDD:238012
EGF_Lam 831..888 CDD:238012
Laminin_EGF 897..939 CDD:278482
LamB 1003..1130 CDD:214597
EGF_Lam 1176..1225 CDD:238012
EGF_Lam 1227..1282 CDD:238012
Laminin_EGF 1293..1340 CDD:278482
LamB 1574..1699 CDD:214597
EGF_Lam 1746..1794 CDD:238012
Laminin_EGF 1796..1851 CDD:278482
Ig_2 1866..1958 CDD:290606 26/99 (26%)
IG_like 1866..1946 CDD:214653 24/87 (28%)
Ig3_Perlecan_like 1954..2039 CDD:143231 24/97 (25%)
IG 1961..2040 CDD:214652 22/91 (24%)
I-set 2049..2133 CDD:254352 24/103 (23%)
Ig 2063..2133 CDD:299845 21/75 (28%)
I-set 2139..2225 CDD:254352 20/89 (22%)
IGc2 2153..2215 CDD:197706 16/65 (25%)
IG_like 2240..2317 CDD:214653 24/87 (28%)
IGc2 2247..2307 CDD:197706 20/70 (29%)
IG 2341..2418 CDD:214652 21/85 (25%)
IGc2 2348..2408 CDD:197706 16/68 (24%)
IG_like 2434..2508 CDD:214653 18/81 (22%)
IGc2 2441..2500 CDD:197706 18/66 (27%)
IG_like 2530..2607 CDD:214653 19/90 (21%)
IGc2 2537..2595 CDD:197706 13/71 (18%)
I-set 2620..2703 CDD:254352 21/96 (22%)
IGc2 2633..2693 CDD:197706 14/73 (19%)
IG 2731..2800 CDD:214652 15/73 (21%)
IGc2 2731..2790 CDD:197706 11/63 (17%)
IG_like 2819..2896 CDD:214653 11/79 (14%)
IGc2 2826..2885 CDD:197706 9/61 (15%)
IG 2916..2993 CDD:214652 13/76 (17%)
IGc2 2923..2983 CDD:197706 10/59 (17%)
IG 3016..3093 CDD:214652 11/98 (11%)
IGc2 3023..3083 CDD:197706 9/59 (15%)
Ig_2 3112..3192 CDD:290606 21/88 (24%)
IG_like 3115..3192 CDD:214653 19/85 (22%)
I-set 3205..3291 CDD:254352 18/87 (21%)
ig 3209..3289 CDD:278476 16/81 (20%)
IG 3303..3385 CDD:214652 15/94 (16%)
Ig 3313..3382 CDD:143165 14/81 (17%)
IG 3404..3478 CDD:214652 10/73 (14%)
IGc2 3409..3468 CDD:197706 9/58 (16%)
I-set 3482..3565 CDD:254352 20/117 (17%)
IGc2 3496..3555 CDD:197706 15/93 (16%)
IG_like 3589..3666 CDD:214653
Ig 3600..3666 CDD:299845
I-set 3676..3755 CDD:254352
IGc2 3686..3745 CDD:197706
I-set 3764..3841 CDD:254352
Ig 3779..3834 CDD:299845
LamG 3848..4008 CDD:238058
EGF_CA <4035..4064 CDD:238011
LamG 4117..4266 CDD:238058
EGF 4291..4321 CDD:278437
EGF_CA 4328..4359 CDD:238011
LamG 4386..4545 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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