DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam4 and dpr18

DIOPT Version :9

Sequence 1:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster
Sequence 2:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	103/521 - (19%)
Similarity:	153/521 - (29%)	Gaps:	215/521 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 SNGELYINNAGPNDAYKSYTCRT-------VNRLTGEVQIS--------TYPGRIIVTEPKGMVQ 234
            |:..|.|.|.|..|...:.|..|       |:|.|.:..|.        |..|...|||     :
  Fly   145 SSNSLPIKNVGTTDQLTTVTMPTTAFASLKVDRSTMKQPIDSTRTRNHWTASGFARVTE-----R 204

  Fly   235 PRINVEKHSMRHVVLNGQTTLPCIAQGHPVPTYRW--FKEE--NEQLLPLQLSERITIVSAGLLK 295
            ||   .||...|                     .|  |.||  |.......|...:.:.:..:|.
  Fly   205 PR---SKHHHEH---------------------HWGPFFEEPINSATSGDNLVSAVHLFTEAVLN 245

  Fly   296 ITKARLEDSGKYLCWVNNTAGEETIQVSLTVTAPLTAHLQPQVQTVDVDKDAQFQCIVSGHPVHD 360
            .....|:|  |.:.||..||.    :|||.....:|....|:::       .:||        :.
  Fly   246 CRVGMLKD--KTVMWVRRTAE----KVSLLTVGNVTYSGDPRIR-------VKFQ--------YP 289

  Fly   361 VNWLHDGKPILRDNRVEILTDPPRLIIKKVQKEDPGMYQCFVSNEWEQIQST------------- 412
            .||                    ||:|...|.||.|:|.|.||....::.:|
  Fly   290 NNW--------------------RLLINPTQTEDAGVYMCQVSTHPPRVFTTNLTVLEPPLRIID 334

  Fly   413 -AELQLGDASPELLYWFSEQTLQPGPTVSLKCVATGNPLPQFTWSLDGFPIPDSSRFLVGQYVTI 476
             .|..:||.     |:.|      |.||.|:|..                   |..|...:..||
  Fly   335 EHERDVGDR-----YYKS------GSTVDLQCQI-------------------SRSFFQKERQTI 369

  Fly   477 -------HDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLPYIREMPKITGISGS 534
                   :|.|...:|           .|.:..|.||.|:.:..                ..||.
  Fly   370 LKSTDSANDAVQKLIN-----------ETTSELNLIGNVNQTQH----------------KFSGQ 407

  Fly   535 DLIVKCPVAGYPIDKIHWERDGQTLPINRRQRAYNNGTLIIEQLQ----RLEDAGTYTCMAQNKQ 595
            ||      ..|....|.|.:|.:.|.....:|...:...:..::.    :|.|:|.|:|
  Fly   408 DL------EKYFTKFITWAKDEEPLQGMTNRRLSVSDVWLTSRISIGDAKLSDSGNYSC------ 460

  Fly   596 KQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQILEGDLPVSFRWERNGKPLIGTGNEV 660
                                      .|.......:..|:|.|:||.:.:..      ||:..|:
  Fly   461 --------------------------SLGRLFTVIVQVQVLTGELPAAVQHN------IGSRTEI 493

  Fly   661 F 661
            :
  Fly   494 Y 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386	22/94 (23%)
		Ig strand A	235..238	CDD:409353	2/2 (100%)
		Ig strand A'	244..248	CDD:409353	1/3 (33%)
		Ig strand B	251..258	CDD:409353	0/6 (0%)
		Ig strand C	266..271	CDD:409353	1/6 (17%)
		Ig strand C'	276..279	CDD:409353	0/2 (0%)
		Ig strand D	285..289	CDD:409353	0/3 (0%)
		Ig strand E	292..298	CDD:409353	1/5 (20%)
		Ig strand F	305..313	CDD:409353	3/7 (43%)
		Ig strand G	316..326	CDD:409353	3/9 (33%)
		IgC2_3_Dscam	329..417	CDD:409549	19/101 (19%)
		Ig strand B	347..351	CDD:409549	1/3 (33%)
		Ig strand C	360..364	CDD:409549	1/3 (33%)
		Ig strand E	383..387	CDD:409549	2/3 (67%)
		Ig strand F	397..402	CDD:409549	2/4 (50%)
		Ig strand G	410..413	CDD:409549	1/16 (6%)
		IgI_4_Dscam	422..516	CDD:409548	19/100 (19%)
		Ig strand B	439..443	CDD:409548	2/3 (67%)
		Ig strand C	452..456	CDD:409548	0/3 (0%)
		Ig strand E	482..486	CDD:409548	0/3 (0%)
		Ig strand F	496..501	CDD:409548	1/4 (25%)
		Ig strand G	509..512	CDD:409548	0/2 (0%)
		IgI_5_Dscam	520..607	CDD:409550	15/90 (17%)
		Ig strand B	536..540	CDD:409550	1/3 (33%)
		Ig strand C	549..553	CDD:409550	1/3 (33%)
		Ig strand E	571..575	CDD:409550	0/3 (0%)
		Ig strand F	586..591	CDD:409550	2/4 (50%)
		Ig strand G	600..603	CDD:409550	0/2 (0%)
		Ig	610..703	CDD:416386	9/52 (17%)
		Ig strand A	611..613	CDD:409353	0/1 (0%)
		Ig strand A'	620..624	CDD:409353	0/3 (0%)
		Ig strand B	627..636	CDD:409353	1/8 (13%)
		Ig strand C	641..648	CDD:409353	1/6 (17%)
		Ig strand C'	650..652	CDD:409353	0/1 (0%)
		Ig strand D	659..664	CDD:409353	1/3 (33%)
		Ig strand E	668..675	CDD:409353
		Ig strand F	682..690	CDD:409353
		Ig strand G	693..702	CDD:409353
		IgI_7_Dscam	706..801	CDD:409546
		Ig strand B	724..728	CDD:409546
		Ig strand C	737..741	CDD:409546
		Ig strand E	766..770	CDD:409546
		Ig strand F	780..785	CDD:409546
		Ig strand G	794..797	CDD:409546
		Ig	818..904	CDD:416386
		putative Ig strand B	820..827	CDD:409353
		putative Ig strand C	835..841	CDD:409353
		putative Ig strand C'	853..856	CDD:409353
		putative Ig strand D	862..866	CDD:409353
		putative Ig strand E	868..874	CDD:409353
		putative Ig strand F	881..889	CDD:409353
		putative Ig strand G	892..902	CDD:409353
		FN3	906..999	CDD:238020
		FN3	1006..1110	CDD:238020
		fn3	1117..1203	CDD:394996
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	29/123 (24%)
		Ig	<258..326	CDD:299845	25/106 (24%)
		IGc2	<417..461	CDD:197706	10/75 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900