DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam4 and Bsg

DIOPT Version :9

Sequence 1:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster
Sequence 2:	NP_723346.2	Gene:	Bsg / 318841	FlyBaseID:	FBgn0261822	Length:	648	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	103/563 - (18%)
Similarity:	190/563 - (33%)	Gaps:	151/563 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 TPIPPQQDMVFQLSNGSMMFYPFTAEKYRH--EVHATVYRCKLRNLVGTVLSREVH-VRGVVNQK 128
            |.|.|..|.:..|.||.    |.|....||  :.||.|       |..:.:..|.| :...::.:
  Fly    57 TCIIPITDQIHWLKNGE----PITRHNLRHGRDDHAYV-------LSESAIEGEKHKIEAHLSVR 110

  Fly   129 YAVQVHD----------EYVM-----------------TGNTAVLKCQVPSYMSEFVLVTAWVQD 166
            :|::||:          .|::                 :|...:.:. .|:...:| ...||::.
  Fly   111 HALKVHEGRYQCNRRRGSYILHVRDPKGVGAGAGEPTESGYQTIDEL-TPNSADDF-FTRAWLEQ 173

  Fly   167 TGM--------HLYPNTDIGGKYTVLSNGELYINNAGPNDAYKSYTCR-------TVNRLTGEV- 215
            ...        |....:.:|.....||..:.:..:||....::.|:..       .:|.|...|
  Fly   174 QQQQQQLPHQSHKLHKSHLGYGNASLSGSQPWHPSAGGGGIHRVYSATPPDFPPPRLNLLEQTVA 238

  Fly   216 ----------QISTYPGRIIVTEPKGMVQPRINVEKHSMRHVVLNGQTT-----LPCIAQGHPVP 265
                      ...|:|..........::....:...|..:.:....|.|     ||...:.:|..
  Fly   239 PPEPPTILYNPNPTHPTASATATETSVLLTTAHHHAHHQQQLQQQSQHTLNAFQLPLPPRPNPGQ 303

  Fly   266 TYRWFKEENEQLLPLQLS----------------ERITIVSAGLLKITKARLEDSGKYLCWVNNT 314
            ..|:.......:.|:.:|                |:.||.:|   ..|:|.:...|. :.....:
  Fly   304 NERYQTYAPHYVPPVVVSGAGAGAGADPGAGASGEQTTISAA---TSTRAMMGGGGG-VAGAGFS 364

  Fly   315 AG-------------------------EETIQVSLTVTAPLTAHLQPQVQTVDVDKDAQFQC-IV 353
            ||                         :..:.|.:....|...:.:.|::..|:.......| :.
  Fly   365 AGASGPMLGAGGHMLMGGQGHQVHLQHQTLLPVKMDKLVPNYDNAEHQMKFYDIRSPLVLSCNVK 429

  Fly   354 SGHPVHDVNWLHDGK-----PILRDNRVEILTDPPRLIIKKVQKEDPGMYQCFVSNEWEQIQSTA 413
            .|.|...:.|..:|.     |.|| .|.:::.|..:.||.|....|.|.|.|......::|:..|
  Fly   430 DGTPGGVLIWKKNGTAVTDVPSLR-GRFKLIADENKFIIDKTDTNDDGKYSCEFDGVSKEIEVIA 493

  Fly   414 ELQLGDASPELLYWFSEQTLQPGPTVSLKCVATGNPLPQFTWSLDGFPIPDSS-RFLVGQYVTIH 477
            .:.:  ..|      |...:..|..:|:.|...|.. |:.||:.....:.::: ||::..    .
  Fly   494 RVVV--RVP------SNTAVVEGEKMSVTCSVVGTK-PELTWTFANVTLTNATDRFILKP----D 545

  Fly   478 DDVISH--VNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYG 518
            |:.:.:  :.:.||..:|.|||.|..:||         .|:||
  Fly   546 DNGVPNAILTLDNVTLDDRGEYKCIGRNA---------ANVYG 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386	17/59 (29%)
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353	0/2 (0%)
		Ig strand E	83..88	CDD:409353	0/4 (0%)
		Ig strand F	101..109	CDD:409353	1/7 (14%)
		Ig strand G	112..124	CDD:409353	2/12 (17%)
		Ig	235..326	CDD:416386	19/136 (14%)
		Ig strand A	235..238	CDD:409353	0/2 (0%)
		Ig strand A'	244..248	CDD:409353	0/3 (0%)
		Ig strand B	251..258	CDD:409353	4/11 (36%)
		Ig strand C	266..271	CDD:409353	1/4 (25%)
		Ig strand C'	276..279	CDD:409353	0/2 (0%)
		Ig strand D	285..289	CDD:409353	1/3 (33%)
		Ig strand E	292..298	CDD:409353	0/5 (0%)
		Ig strand F	305..313	CDD:409353	1/7 (14%)
		Ig strand G	316..326	CDD:409353	2/34 (6%)
		IgC2_3_Dscam	329..417	CDD:409549	22/93 (24%)
		Ig strand B	347..351	CDD:409549	0/3 (0%)
		Ig strand C	360..364	CDD:409549	0/3 (0%)
		Ig strand E	383..387	CDD:409549	0/3 (0%)
		Ig strand F	397..402	CDD:409549	2/4 (50%)
		Ig strand G	410..413	CDD:409549	0/2 (0%)
		IgI_4_Dscam	422..516	CDD:409548	21/96 (22%)
		Ig strand B	439..443	CDD:409548	1/3 (33%)
		Ig strand C	452..456	CDD:409548	1/3 (33%)
		Ig strand E	482..486	CDD:409548	0/5 (0%)
		Ig strand F	496..501	CDD:409548	3/4 (75%)
		Ig strand G	509..512	CDD:409548	0/2 (0%)
		IgI_5_Dscam	520..607	CDD:409550
		Ig strand B	536..540	CDD:409550
		Ig strand C	549..553	CDD:409550
		Ig strand E	571..575	CDD:409550
		Ig strand F	586..591	CDD:409550
		Ig strand G	600..603	CDD:409550
		Ig	610..703	CDD:416386
		Ig strand A	611..613	CDD:409353
		Ig strand A'	620..624	CDD:409353
		Ig strand B	627..636	CDD:409353
		Ig strand C	641..648	CDD:409353
		Ig strand C'	650..652	CDD:409353
		Ig strand D	659..664	CDD:409353
		Ig strand E	668..675	CDD:409353
		Ig strand F	682..690	CDD:409353
		Ig strand G	693..702	CDD:409353
		IgI_7_Dscam	706..801	CDD:409546
		Ig strand B	724..728	CDD:409546
		Ig strand C	737..741	CDD:409546
		Ig strand E	766..770	CDD:409546
		Ig strand F	780..785	CDD:409546
		Ig strand G	794..797	CDD:409546
		Ig	818..904	CDD:416386
		putative Ig strand B	820..827	CDD:409353
		putative Ig strand C	835..841	CDD:409353
		putative Ig strand C'	853..856	CDD:409353
		putative Ig strand D	862..866	CDD:409353
		putative Ig strand E	868..874	CDD:409353
		putative Ig strand F	881..889	CDD:409353
		putative Ig strand G	892..902	CDD:409353
		FN3	906..999	CDD:238020
		FN3	1006..1110	CDD:238020
		fn3	1117..1203	CDD:394996
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
Bsg	NP_723346.2	IG_like	420..497	CDD:214653	19/77 (25%)
		Ig	423..497	CDD:299845	19/74 (26%)
		IG_like	500..583	CDD:214653	24/100 (24%)
		Ig	512..575	CDD:143165	18/76 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010