DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and Igsf9

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_001100667.1 Gene:Igsf9 / 304982 RGDID:1304566 Length:1179 Species:Rattus norvegicus


Alignment Length:781 Identity:179/781 - (22%)
Similarity:289/781 - (37%) Gaps:216/781 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   322 VSLTVTAPLTAHLQPQVQTV--DVDKDAQFQCIV---SGH-PVHDVNWLHDG--KPILRD----- 373
            :||.::.......:|:|.:|  ...:.|...|.:   :|. |:|.:.||..|  .||...     
  Rat    10 LSLILSQGADGRRKPEVVSVVGRAGESAVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYS 74

  Fly   374 --------NRVEILTDPPRLIIKKVQKEDPGMYQC-------------FVSNEWEQIQSTAELQL 417
                    .||.:.|. ..|.|:.::.||.|.|:|             |.:..|..:...:..|.
  Rat    75 PRIDPDYVGRVRLQTG-ASLQIEGLRVEDQGWYECRVLFLDQHSPEQDFANGSWVHLTVNSPPQF 138

  Fly   418 GDASPELLYWFSEQTLQPGPTVSLKCVATGNPLPQFTWSLDGFPIPDSSRFLVGQYVTIHDDVIS 482
            .:..|.:|      .::....|:|:|||.|:|.|..||...|..:....    || |.:.:..:.
  Rat   139 QETPPLVL------EVKELEAVTLRCVALGSPQPYVTWKFRGQDLGKGQ----GQ-VQVRNGTLW 192

  Fly   483 HVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLPYIREMPKITGISGS-DLIVKCPVAGYP 546
               |..|:....|:|||.|.:..|.|:|:.::.:.|.|.|...|....::.| |:.:.|....||
  Rat   193 ---IRRVERGSAGDYTCQASSTEGSVTHTTQLLVLGPPVIVVPPNNNTVNASQDVSLACRAEAYP 254

  Fly   547 IDKIH-WERDG-QTLPINR---RQRAYNNGTLIIEQLQRLEDAGTYTCMAQNKQKQTSRRNVEIQ 606
            .:..: |.:|. ....|:|   |.|...:|:|.::..|. :|||.|||:..|........:..:.
  Rat   255 ANLTYSWFQDRINVFHISRLQSRVRILVDGSLWLQATQP-DDAGHYTCVPSNGFPHPPSASAYLT 318

  Fly   607 VLVPPK--IMPIQAMTNMLREGMRAAISCQILEGDLPVSF-RWERNGKPLIGTGNEVFRRLDEY- 667
            ||.|.:  :||.:   ..|..|||..|.|.: ..:.|:.| .|.::|:.|         :||:: 
  Rat   319 VLYPAQVTVMPPE---TPLPIGMRGVIRCPV-RANPPLLFVTWTKDGQAL---------QLDKFP 370

  Fly   668 ------SASLVIEHISSDHSGNYTCIASNVAGTERFTVPLT---VNVPPKWILEPKDSSAQ-AGA 722
                  ..||||...:.|..|.|:|...|..||.. :.|:|   :..||.:|.:||:...| .|.
  Rat   371 GWSLGPEGSLVIALGNEDALGEYSCTPYNSLGTAG-SSPVTRVLLKAPPAFIDQPKEEYFQEVGR 434

  Fly   723 DVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQLFPNGTIFFKKISKESQGHFLCEAKN 787
            |:|:.|.:.|.|.|.::|.|......|:         .|:..|.::..:.::||:.|.:.|.|:|
  Rat   435 DLLIPCSARGDPPPIVSWAKVGRGLQGQ---------AQVDSNNSLILRPLTKEAHGRWECSARN 490

  Fly   788 NIGS-GVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDNPIDFKWKIQATQQYLDESL 851
            .:.. .:|..:::....| |..|....:.:.||..|              .|         :...
  Rat   491 AVAHVTISTNVYVLGTSP-HVVTNVSVVPLPKGANV--------------SW---------EPGF 531

  Fly   852 DSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQEVPEQPKNLRINS 916
            |..|..|..|                                                       
  Rat   532 DGGYLQRFSV------------------------------------------------------- 541

  Fly   917 QQSRSLQLTWSQPFAGNSPIEEYHIYYKQISDIWQNAEHLTIAGAQTVINIQQLRPAKAYHIRMS 981
                     |..|.| ..|...:|.:....  :...|.||.:.|.|....         |...:.
  Rat   542 ---------WYTPLA-KRPDRAHHDWVSLA--VPMGATHLLVPGLQAYTQ---------YQFSVL 585

  Fly   982 AENKLGASEFSEVV-----QVTTLEEVPSGPP-------------LAVRAEPKSSTEIFVTWDAP 1028
            |:||||:..|||:|     .:.|...||..||             :|||. |:.   :.:.||.|
  Rat   586 AQNKLGSGPFSEIVLSIPEGLPTTPAVPRLPPTEMPPPLSPPRGLVAVRT-PRG---VLLHWDPP 646

  Fly  1029 E 1029
            |
  Rat   647 E 647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386 2/3 (67%)
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353
Ig strand C' 276..279 CDD:409353
Ig strand D 285..289 CDD:409353
Ig strand E 292..298 CDD:409353
Ig strand F 305..313 CDD:409353
Ig strand G 316..326 CDD:409353 2/3 (67%)
IgC2_3_Dscam 329..417 CDD:409549 25/121 (21%)
Ig strand B 347..351 CDD:409549 1/3 (33%)
Ig strand C 360..364 CDD:409549 0/3 (0%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 2/17 (12%)
Ig strand G 410..413 CDD:409549 0/2 (0%)
IgI_4_Dscam 422..516 CDD:409548 26/93 (28%)
Ig strand B 439..443 CDD:409548 2/3 (67%)
Ig strand C 452..456 CDD:409548 1/3 (33%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 3/4 (75%)
Ig strand G 509..512 CDD:409548 1/2 (50%)
IgI_5_Dscam 520..607 CDD:409550 24/92 (26%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 0/4 (0%)
Ig strand E 571..575 CDD:409550 2/3 (67%)
Ig strand F 586..591 CDD:409550 3/4 (75%)
Ig strand G 600..603 CDD:409550 0/2 (0%)
Ig 610..703 CDD:416386 29/105 (28%)
Ig strand A 611..613 CDD:409353 0/3 (0%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 4/8 (50%)
Ig strand C 641..648 CDD:409353 3/7 (43%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 4/6 (67%)
Ig strand F 682..690 CDD:409353 3/7 (43%)
Ig strand G 693..702 CDD:409353 3/8 (38%)
IgI_7_Dscam 706..801 CDD:409546 25/96 (26%)
Ig strand B 724..728 CDD:409546 1/3 (33%)
Ig strand C 737..741 CDD:409546 0/3 (0%)
Ig strand E 766..770 CDD:409546 0/3 (0%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 1/2 (50%)
Ig 818..904 CDD:416386 8/85 (9%)
putative Ig strand B 820..827 CDD:409353 1/6 (17%)
putative Ig strand C 835..841 CDD:409353 1/5 (20%)
putative Ig strand C' 853..856 CDD:409353 0/2 (0%)
putative Ig strand D 862..866 CDD:409353 0/3 (0%)
putative Ig strand E 868..874 CDD:409353 0/5 (0%)
putative Ig strand F 881..889 CDD:409353 0/7 (0%)
putative Ig strand G 892..902 CDD:409353 0/9 (0%)
FN3 906..999 CDD:238020 20/97 (21%)
FN3 1006..1110 CDD:238020 10/37 (27%)
fn3 1117..1203 CDD:394996
FN3 1215..1307 CDD:238020
Ig <1334..1401 CDD:416386
Ig strand C 1345..1349 CDD:409353
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
Igsf9NP_001100667.1 IG 28..110 CDD:214652 21/82 (26%)
Ig strand A 136..139 CDD:409353 1/2 (50%)
IG_like 143..223 CDD:214653 26/93 (28%)
Ig strand A' 145..148 CDD:409353 1/8 (13%)
Ig strand B 154..161 CDD:409353 4/6 (67%)
Ig strand C 167..172 CDD:409353 2/4 (50%)
Ig strand C' 175..177 CDD:409353 0/1 (0%)
Ig strand D 183..187 CDD:409353 2/4 (50%)
Ig strand E 189..193 CDD:409353 0/6 (0%)
Ig strand F 202..210 CDD:409353 5/7 (71%)
Ig strand G 213..223 CDD:409353 3/9 (33%)
Ig_3 226..305 CDD:404760 23/79 (29%)
putative Ig strand A 226..230 CDD:409353 1/3 (33%)
putative Ig strand A' 235..239 CDD:409353 0/3 (0%)
putative Ig strand B 241..251 CDD:409353 3/9 (33%)
putative Ig strand C' 267..270 CDD:409353 0/2 (0%)
putative Ig strand D 279..282 CDD:409353 1/2 (50%)
putative Ig strand E 284..290 CDD:409353 2/5 (40%)
putative Ig strand F 297..305 CDD:409353 4/7 (57%)
putative Ig strand G 310..319 CDD:409353 0/8 (0%)
Ig 322..407 CDD:416386 27/98 (28%)
Ig strand A' 324..328 CDD:409353 0/3 (0%)
Ig strand B 333..347 CDD:409353 6/14 (43%)
Ig strand C 353..359 CDD:409353 2/5 (40%)
Ig strand C' 362..364 CDD:409353 0/1 (0%)
Ig strand D 371..374 CDD:409353 0/2 (0%)
Ig strand E 378..382 CDD:409353 2/3 (67%)
Ig strand F 391..399 CDD:409353 3/7 (43%)
Ig 418..503 CDD:416386 24/93 (26%)
Ig strand A 418..421 CDD:409353 1/2 (50%)
Ig strand A' 427..430 CDD:409353 0/2 (0%)
Ig strand B 436..443 CDD:409353 2/6 (33%)
Ig strand C 449..454 CDD:409353 1/4 (25%)
Ig strand C' 457..459 CDD:409353 0/1 (0%)
Ig strand D 462..466 CDD:409353 1/12 (8%)
Ig strand E 469..473 CDD:409353 0/3 (0%)
Ig strand F 482..490 CDD:409353 3/7 (43%)
Ig strand G 493..503 CDD:409353 1/9 (11%)
FN3 508..599 CDD:238020 30/190 (16%)
FN3 625..715 CDD:238020 8/27 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 766..807
PHA03247 <777..1062 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 869..895
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 942..979
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1016..1079
PDZ-binding. /evidence=ECO:0000250 1177..1179
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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