DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and ncam1a

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:XP_009293555.1 Gene:ncam1a / 30447 ZFINID:ZDB-GENE-990415-31 Length:1010 Species:Danio rerio


Alignment Length:1193 Identity:232/1193 - (19%)
Similarity:401/1193 - (33%) Gaps:346/1193 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   324 LTVTAPLTAHLQPQVQTVDVDKDAQFQCIVSGHPVHDVNW-------LHDGKPILRDNRVEILTD 381
            |...|.|...:.|....:.|.:...|.|.|.| ...:::|       |..|:|.:..::.:  ..
Zfish    14 LGYAAALQVEITPTQGEISVGESKFFLCEVVG-DAKEIDWFAPNGEKLLPGRPDISISKTD--ES 75

  Fly   382 PPRLIIKKVQKEDPGMYQCFVSNEWEQIQSTAELQLGDASPELLYWF--SEQTLQPGPTVSLKCV 444
            ...|.|.....:..|||:|...:..::.|.|..:::   ..:|.:.:  |.|....|....:.|.
Zfish    76 SSTLTIYNANVDHAGMYKCVAKSGEKESQGTIIVKI---FQKLTFQYAPSPQEFNEGDDADIICD 137

  Fly   445 ATGNPLPQFTWSLDGFPI-PDSSRFLVGQYVTIHDDVIS--HVNISNVKEEDGGEYTCTAQ-NAI 505
            ...:|.|...|......| |::.         :...|:|  |:.|..:|:.|.|:|||..: .|.
Zfish   138 VISSPPPTIIWRYKKMRIQPETD---------VRLKVLSNNHLQIRGIKKTDEGDYTCEGRIMAR 193

  Fly   506 GKVS-HSAKVNIYGLPYIR----EMPKITGISGSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQ 565
            |::. ...||.:..||.||    |:.....|:.: :.:.|...|||...:.|             
Zfish   194 GEIDLRVIKVIVNVLPSIRTRYTELNATADINQA-VTLACHADGYPEPTVKW------------- 244

  Fly   566 RAYNNGTLIIEQLQRLEDAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAA 630
                                             :|.|.|                          
Zfish   245 ---------------------------------ARGNTE-------------------------- 250

  Fly   631 ISCQILEGDLPVSFRWERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIASNVAGTE 695
                 ||.|...|                    |:|..:.|.|:.::....|:|.|||.|.||..
Zfish   251 -----LESDEKYS--------------------LNEDGSELTIKDVNKLDEGDYKCIARNKAGER 290

  Fly   696 RFTVPLTVNVPPKWILEPKDSSAQAGADVLLHCQSSGYPTPTITW----------KKAIGPTPGE 750
            ...|.|.|.|.||.......::::....:.|.|:::|.|||.|.|          ::|....|.:
Zfish   291 SEEVTLNVFVQPKITFLENQTASELEEQITLTCEATGDPTPNIIWSFGRRVFTENEQASWTRPEK 355

  Fly   751 YKDFLYEPTVQLFPNGTIFFKKISKESQ-----------GHFLCEAKNNIGSGVSKVIFLKVNVP 804
            :|..          :|.:..:..::.|.           |.:||.|:|:||..:.. ::|:|...
Zfish   356 HKSL----------DGNVVVRSDARVSSLTLKYVQFTDAGQYLCTARNSIGQDIQS-MYLEVRYA 409

  Fly   805 AHFQTKTKQISVAKGKQVHVQCNVQGDNPIDFKWKIQATQQYLD-ESLDSRYTIRDQVLDDGMVS 868
            ...| ..:.:...:|...::.|...........|       :.| :.|.|..|...::.:...||
Zfish   410 PKIQ-GPQAVFTWEGNPANITCEALAHPGASVLW-------FRDGQQLPSANTTNVKIYNTPTVS 466

  Fly   869 ELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQEVPEQPKNLRINSQQSRSLQLTWSQP-FAG 932
            .|.::...:.|.|.|.|.|:|..|.:.....|:..:||..|...|:....|.:: :.:.:| .:|
Zfish   467 FLEVTPDSQNDFGSYNCTATNVIGTESKEFILVQADVPSAPSIERVEPYSSTAM-IEFEEPASSG 530

  Fly   933 NSPIEEYHIYYKQISDIWQNAEHLTIAGAQTVINIQQLRPAKAYHIRMSAENKLGASEFSEVVQV 997
            ..|:.:|...::.....|.:.|: .:.....:|.|..|:|...|.:::||.|..|..|.|.....
Zfish   531 GVPVLKYKAEWRIAGQDWTDREY-ELEDGLNLITIVGLKPETTYEVKISAINGKGEGESSAPESF 594

  Fly   998 TT---------LEEVPSG-PPLA-----------VRAEPKSS-TEIFVTWDAPERDHWNGILLGY 1040
            .|         ..|.|:. ||..           :.|:|:|: .|:.|.:  .::|.....:..|
Zfish   595 KTQPVRLPFRMSPETPTSIPPTTADIKGEPNPPKLEAKPQSTGNEMKVHF--IKQDDGGSPIKHY 657

  Fly  1041 YVGYQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGE-TVLANLNKFTQYHVIVQAYTSQGSGPPSK 1104
            .|.|:.....:.|.            |:|.....: .||..|:..|:|.|.|.|...:|...|. 
Zfish   658 LVRYRAKNRQDWKP------------EIRMPDASDYIVLRGLDWNTEYEVYVIAENQRGRSEPG- 709

  Fly  1105 EIAVQTMEDVPSSPPESPQCDVLGSTSIYITWSPPDIDGQNGKIKGYKV---------------- 1153
            .::.:|:.: |::.||:  ...||:                |.|.|..:                
Zfish   710 TLSFRTLPE-PTAIPET--SSGLGT----------------GAIVGILIVVFILLLFGVDVTCYF 755

  Fly  1154 -------FYISVDELYETDPEVVKSTNQYVTIENLRKYTNYTVWVLAYTKVGDGMKTKPFYCRTH 1211
                   ..|:|:...::.|. .||.:    ||..:         .|:||  |..|......||.
Zfish   756 LNKCGLLMCIAVNFCGKSGPS-AKSKD----IEEGK---------AAFTK--DESKEPIVEVRTE 804

  Fly  1212 ED--------VPSAPQAIKAI-----PASSSKIIISWLPPDLPNGDITGYTFYMSMLEGGREEGT 1263
            |:        .|:.|.....:     .|.::..::..||....|.|                   
Zfish   805 EERTPNHEGGGPTEPNETTPLTDPEHAADTTATVVDLLPSVTTNSD------------------- 850

  Fly  1264 HKRLLGPFVEMHETVRTQESATYQFWLTAS-----TKMGEGEKTQVV--TVPPNNKVPARIVSFS 1321
                          ..|:..|:....||.|     |......|..|.  |.||....|  :|..|
Zfish   851 --------------PGTESPASDSTTLTTSTDPKPTPQSSTPKPSVTSPTSPPQAVAP--LVDLS 899

  Fly  1322 QRIVTPWKEHLELPCRKVGAPAPVTIWRQDGHNMETSARKTIAKNGTLYMKECQASDAGNYTCSV 1386
            :   ||.|:    ..:.:...:|..:.|.||.:....|:...:|:..:.....|.:|:.....|.
Zfish   900 E---TPSKQ----TSKSLDDSSPAEVARADGQSPAEPAKAPQSKDSQVQAGSHQTTDSDPAKNSS 957

  Fly  1387 ENTWGKDEIVYNIVVKVPPEAPN 1409
            :::             ..|.|||
Zfish   958 DSS-------------SAPSAPN 967

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386 1/1 (100%)
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353
Ig strand C' 276..279 CDD:409353
Ig strand D 285..289 CDD:409353
Ig strand E 292..298 CDD:409353
Ig strand F 305..313 CDD:409353
Ig strand G 316..326 CDD:409353 1/1 (100%)
IgC2_3_Dscam 329..417 CDD:409549 19/94 (20%)
Ig strand B 347..351 CDD:409549 1/3 (33%)
Ig strand C 360..364 CDD:409549 1/10 (10%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 3/4 (75%)
Ig strand G 410..413 CDD:409549 1/2 (50%)
IgI_4_Dscam 422..516 CDD:409548 24/100 (24%)
Ig strand B 439..443 CDD:409548 0/3 (0%)
Ig strand C 452..456 CDD:409548 0/3 (0%)
Ig strand E 482..486 CDD:409548 2/5 (40%)
Ig strand F 496..501 CDD:409548 3/4 (75%)
Ig strand G 509..512 CDD:409548 0/3 (0%)
IgI_5_Dscam 520..607 CDD:409550 13/90 (14%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 0/3 (0%)
Ig strand E 571..575 CDD:409550 0/3 (0%)
Ig strand F 586..591 CDD:409550 0/4 (0%)
Ig strand G 600..603 CDD:409550 1/2 (50%)
Ig 610..703 CDD:416386 18/92 (20%)
Ig strand A 611..613 CDD:409353 0/1 (0%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 0/8 (0%)
Ig strand C 641..648 CDD:409353 1/6 (17%)
Ig strand C' 650..652 CDD:409353 0/1 (0%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 2/6 (33%)
Ig strand F 682..690 CDD:409353 5/7 (71%)
Ig strand G 693..702 CDD:409353 2/8 (25%)
IgI_7_Dscam 706..801 CDD:409546 23/115 (20%)
Ig strand B 724..728 CDD:409546 1/3 (33%)
Ig strand C 737..741 CDD:409546 2/13 (15%)
Ig strand E 766..770 CDD:409546 1/3 (33%)
Ig strand F 780..785 CDD:409546 2/4 (50%)
Ig strand G 794..797 CDD:409546 0/2 (0%)
Ig 818..904 CDD:416386 18/86 (21%)
putative Ig strand B 820..827 CDD:409353 0/6 (0%)
putative Ig strand C 835..841 CDD:409353 1/5 (20%)
putative Ig strand C' 853..856 CDD:409353 1/2 (50%)
putative Ig strand D 862..866 CDD:409353 0/3 (0%)
putative Ig strand E 868..874 CDD:409353 2/5 (40%)
putative Ig strand F 881..889 CDD:409353 4/7 (57%)
putative Ig strand G 892..902 CDD:409353 2/9 (22%)
FN3 906..999 CDD:238020 21/93 (23%)
FN3 1006..1110 CDD:238020 24/117 (21%)
fn3 1117..1203 CDD:394996 18/108 (17%)
FN3 1215..1307 CDD:238020 15/103 (15%)
Ig <1334..1401 CDD:416386 9/66 (14%)
Ig strand C 1345..1349 CDD:409353 0/3 (0%)
Ig strand D 1363..1366 CDD:409353 0/2 (0%)
Ig strand E 1367..1372 CDD:409353 0/4 (0%)
Ig strand F 1380..1388 CDD:409353 1/7 (14%)
Ig strand G 1394..1401 CDD:409353 0/6 (0%)
FN3 1405..1494 CDD:238020 4/5 (80%)
FN3 1499..1580 CDD:238020
ncam1aXP_009293555.1 Ig 20..112 CDD:299845 19/97 (20%)
I-set 21..111 CDD:254352 18/92 (20%)
IG_like 121..200 CDD:214653 21/87 (24%)
IGc2 128..189 CDD:197706 17/69 (25%)
Ig 208..301 CDD:299845 33/190 (17%)
IG_like 219..298 CDD:214653 27/176 (15%)
Ig 300..406 CDD:299845 24/116 (21%)
IG_like 308..406 CDD:214653 21/108 (19%)
ig 413..498 CDD:278476 18/92 (20%)
IG_like 415..498 CDD:214653 17/89 (19%)
fn3 505..589 CDD:278470 19/85 (22%)
FN3 624..715 CDD:238020 22/105 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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