DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and Ncam2

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_981954.2 Gene:Ncam2 / 288280 RGDID:1303131 Length:837 Species:Rattus norvegicus


Alignment Length:727 Identity:184/727 - (25%)
Similarity:304/727 - (41%) Gaps:81/727 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   418 GDASPELLYWFSEQTLQPGPTVSLKCVATGNPLPQFTWSLDGFPIPDSSRFLVGQYVTIH-DDVI 481
            |.|..::....|:..|..|.:....|.|.|.|     .|:|.:. |...:.:..|.|.:. :.|.
  Rat    17 GQALLQVTISLSKVELSVGESKFFTCTAIGEP-----ESIDWYN-PQGEKIISTQRVMLQKEGVR 75

  Fly   482 SHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKV-NIYGLPYIREMPKITGIS------GSDLIVK 539
            |.:.|.|...||.|.|.|.|.:|.|:...:..| .||.....||:     :|      |.|..|.
  Rat    76 SRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREV-----LSPQEFKQGEDAEVV 135

  Fly   540 CPVAGYPIDKIHW---ERDGQTLPINRRQRAYNNGTLIIEQLQRLEDAGTYTCMAQNKQK-QTSR 600
            |.|:..|...:.|   ..:..|:|.||.....||...|:.  ....|.|.|.|..:.:.: :...
  Rat   136 CRVSSSPAPAVSWLYHNEEVTTIPDNRFAVLANNNLQILN--INKSDEGIYRCEGRVEARGEIDF 198

  Fly   601 RNVEIQVLVPPKI-MPIQAMTNMLREGMRAAISCQILEGDLPVSFRWERNGKPLIGTGNEVFRRL 664
            |::.:.|.|||.| ||.::.......|....::|: ..|....:..|.||||.:  ..||.: .|
  Rat   199 RDIIVIVNVPPAIVMPQKSFNATAERGEEMTLTCK-ASGSPDPAISWFRNGKLI--EENEKY-IL 259

  Fly   665 DEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTVNVPPKWILEPKDSSAQAGADVLLHCQ 729
            ...:..|.:.:|.:...|:|.|.|:|.||.::....|.|.|.|. ||:.|:.:......|.|.|:
  Rat   260 KGSNTELTVRNIINKDGGSYVCKATNKAGEDQKQAFLQVFVQPH-ILQLKNETTSENGHVTLICE 323

  Fly   730 SSGYPTPTITWKKAI-GPTPGEYKDFLYEPTVQLFPNG-----TIFFKKISKESQGHFLCEAKNN 788
            :.|.|.|.||||:|| |.|   :.:....|..::...|     ::..:.:.....|.:.|||.:.
  Rat   324 AEGEPVPEITWKRAIDGVT---FSEGDKSPDGRIEVKGQHGRSSLHIRDVKLSDSGRYDCEAASR 385

  Fly   789 IGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDNPIDFKWKIQATQQYLDESLDS 853
            || |..:.:.|.:.....|.:........:|..:::.|:|:.:.|....|:.:..      .|.:
  Rat   386 IG-GHQRSMHLDIEYAPKFVSNQTMYYSWEGNPINISCDVKANPPASIHWRREKL------VLPA 443

  Fly   854 RYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQEVPEQPKNLRINSQQ 918
            :.|...:....|....|.|:.|...|.|.|.|.|:|..|.......|.:.:||..|:.::|....
  Rat   444 KNTTHLKTHSVGRKMILEIAPTSDNDFGRYNCTATNRIGTRFQEYILELADVPSSPRGVKIIELS 508

  Fly   919 SRSLQLTWSQPFA-GNSPIEEYHIYYKQI-SDIWQNA-EHLTIAGAQTVINIQQLRPAKAYHIRM 980
            ..:.::::::|.: |..||..|.:..|:: |:.|:.. .|    |.||.:.:..|.|...|.:|:
  Rat   509 QTTAKISFNKPESHGGVPIHHYQVDVKEVTSETWKIVRSH----GVQTTVVLSSLEPNTTYEVRV 569

  Fly   981 SAENKLGASEFSEVVQVTTLEEVPSGPPLAVRAEPKS--STEIFVTWDAPERDHWNGILLGYYVG 1043
            :|.|..|..::|::....||......|| ::..:|.|  |.:|.:|    ::|.....:|.|.|.
  Rat   570 AAVNGKGQGDYSKIEIFQTLPVREPSPP-SIHGQPSSGKSFKISIT----KQDDGGAPILEYIVK 629

  Fly  1044 YQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGETVLANLNKFTQYHVIVQAYTSQG---------S 1099
            |:    .:|||   .|....|....:.|.    :|.:|.....|.|.:.|....|         |
  Rat   630 YR----SKDKE---DQWLEKKVQGNKDHI----ILEHLQWTMGYEVQITAANRLGYSEPTVYEFS 683

  Fly  1100 GPPSKEIAVQTM 1111
            .||...|...|:
  Rat   684 MPPKPNIIKDTL 695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353
Ig strand C' 276..279 CDD:409353
Ig strand D 285..289 CDD:409353
Ig strand E 292..298 CDD:409353
Ig strand F 305..313 CDD:409353
Ig strand G 316..326 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549
Ig strand B 347..351 CDD:409549
Ig strand C 360..364 CDD:409549
Ig strand E 383..387 CDD:409549
Ig strand F 397..402 CDD:409549
Ig strand G 410..413 CDD:409549
IgI_4_Dscam 422..516 CDD:409548 25/95 (26%)
Ig strand B 439..443 CDD:409548 0/3 (0%)
Ig strand C 452..456 CDD:409548 0/3 (0%)
Ig strand E 482..486 CDD:409548 1/3 (33%)
Ig strand F 496..501 CDD:409548 2/4 (50%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 22/96 (23%)
Ig strand B 536..540 CDD:409550 1/3 (33%)
Ig strand C 549..553 CDD:409550 1/6 (17%)
Ig strand E 571..575 CDD:409550 0/3 (0%)
Ig strand F 586..591 CDD:409550 2/4 (50%)
Ig strand G 600..603 CDD:409550 1/2 (50%)
Ig 610..703 CDD:416386 26/93 (28%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 1/8 (13%)
Ig strand C 641..648 CDD:409353 1/6 (17%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 1/4 (25%)
Ig strand E 668..675 CDD:409353 1/6 (17%)
Ig strand F 682..690 CDD:409353 4/7 (57%)
Ig strand G 693..702 CDD:409353 1/8 (13%)
IgI_7_Dscam 706..801 CDD:409546 28/100 (28%)
Ig strand B 724..728 CDD:409546 2/3 (67%)
Ig strand C 737..741 CDD:409546 2/3 (67%)
Ig strand E 766..770 CDD:409546 1/8 (13%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 0/2 (0%)
Ig 818..904 CDD:416386 19/85 (22%)
putative Ig strand B 820..827 CDD:409353 0/6 (0%)
putative Ig strand C 835..841 CDD:409353 1/5 (20%)
putative Ig strand C' 853..856 CDD:409353 0/2 (0%)
putative Ig strand D 862..866 CDD:409353 0/3 (0%)
putative Ig strand E 868..874 CDD:409353 2/5 (40%)
putative Ig strand F 881..889 CDD:409353 4/7 (57%)
putative Ig strand G 892..902 CDD:409353 2/9 (22%)
FN3 906..999 CDD:238020 23/95 (24%)
FN3 1006..1110 CDD:238020 28/114 (25%)
fn3 1117..1203 CDD:394996
FN3 1215..1307 CDD:238020
Ig <1334..1401 CDD:416386
Ig strand C 1345..1349 CDD:409353
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
Ncam2NP_981954.2 IgI_1_NCAM-2 21..113 CDD:409452 26/97 (27%)
Ig strand B 38..42 CDD:409452 0/3 (0%)
Ig strand C 50..54 CDD:409452 2/3 (67%)
Ig strand E 76..80 CDD:409452 1/3 (33%)
Ig strand F 90..95 CDD:409452 2/4 (50%)
Ig strand G 104..107 CDD:409452 0/2 (0%)
IGc2 128..189 CDD:197706 18/62 (29%)
Ig strand B 130..139 CDD:409353 3/8 (38%)
Ig strand C 145..153 CDD:409353 1/7 (14%)
Ig strand C' 156..159 CDD:409353 1/2 (50%)
Ig strand D 162..167 CDD:409353 1/4 (25%)
Ig strand E 168..175 CDD:409353 3/6 (50%)
IgI_1_MuSK 209..298 CDD:409562 25/92 (27%)
Ig strand B 228..232 CDD:409562 0/3 (0%)
Ig strand C 241..245 CDD:409562 0/3 (0%)
Ig strand E 264..268 CDD:409562 1/3 (33%)
Ig strand F 278..283 CDD:409562 2/4 (50%)
Ig strand G 291..294 CDD:409562 0/2 (0%)
Ig 300..397 CDD:416386 29/101 (29%)
Ig strand A 300..305 CDD:409353 2/5 (40%)
Ig strand A' 309..313 CDD:409353 0/3 (0%)
Ig strand B 317..325 CDD:409353 3/7 (43%)
Ig strand C 331..337 CDD:409353 4/5 (80%)
Ig strand C' 340..343 CDD:409353 2/5 (40%)
Ig strand D 353..359 CDD:409353 0/5 (0%)
Ig strand E 362..368 CDD:409353 0/5 (0%)
Ig strand F 376..384 CDD:409353 4/7 (57%)
Ig strand G 387..397 CDD:409353 3/10 (30%)
Ig_3 401..479 CDD:404760 17/83 (20%)
Ig strand B 418..422 CDD:409353 0/3 (0%)
Ig strand C 431..435 CDD:409353 0/3 (0%)
Ig strand E 458..462 CDD:409353 1/3 (33%)
Ig strand F 472..477 CDD:409353 2/4 (50%)
Ig strand G 486..489 CDD:409353 0/2 (0%)
FN3 496..588 CDD:238020 23/95 (24%)
fn3 594..678 CDD:394996 24/99 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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