DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and CNTN6

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_001276009.1 Gene:CNTN6 / 27255 HGNCID:2176 Length:1028 Species:Homo sapiens


Alignment Length:1176 Identity:281/1176 - (23%)
Similarity:468/1176 - (39%) Gaps:248/1176 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   208 VNRLTGEVQISTYPGRIIVTEPKGMVQPRINVEKHSMRHVVLNGQTTLPCIAQGHPVPTYRWFKE 272
            :|...|:..:|.   .|...||..::.| :::.|   ..|:||      |.|.|:|.|.|||  :
Human    14 INSSAGDGLLSR---PIFTQEPHDVIFP-LDLSK---SEVILN------CAANGYPSPHYRW--K 63

  Fly   273 ENEQLLPLQLSERITIVSAGLLKITKARL-EDSGKYLCWVNNTAGEETIQVSLTVTAPLT-AHLQ 335
            :|...:...:|....: ..|.|.|..... :|.|.|.|...|..|  ||   |:..|.|. |:::
Human    64 QNGTDIDFTMSYHYRL-DGGSLAINSPHTDQDIGMYQCLATNLLG--TI---LSRKAKLQFAYIE 122

  Fly   336 ----PQVQTVDVDKDAQFQCIVSGHPVH--DVN--WLHDGKP--ILRDNRVEILTDPPRLIIKKV 390
                ....||.| ::.|...::.|.|.|  |::  |..:..|  :..|||..:..:...|.|.||
Human   123 DFETKTRSTVSV-REGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKV 186

  Fly   391 QKEDPGMYQCFVSNEWEQ----------IQSTAELQLGDASPELLYWFSEQTLQPG--PTVSLKC 443
            :..|.|.|.||::|:..|          :|.|..: :|:..|::...|.| |:|..  .:|.|:|
Human   187 EPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGV-MGEYEPKIEVRFPE-TIQAAKDSSVKLEC 249

  Fly   444 VATGNPLPQFTW-SLDGFPIPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGK 507
            .|.|||:|..:| .|||.|:|...::...|.:         :.|.|.::||.|.|.|.|.|..|:
Human   250 FALGNPVPDISWRRLDGSPLPGKVKYSKSQAI---------LEIPNFQQEDEGFYECIASNLRGR 305

  Fly   508 VSHSAKVNIYGLPYIREMPKITGISGSD-LIVKCPVAGYPIDKIHWERDGQTL-PINRRQRAYNN 570
            .....::..|..|...:..:.|.:|..| |:.:|..:|.|.....|.::|:.| |..|.|  ..|
Human   306 NLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEERIQ--IEN 368

  Fly   571 GTLIIEQLQRLEDAGTYTCMAQNKQKQTSRRNVEIQVLV-PPKI--MPIQAMTNMLREGMRAAIS 632
            |||||..| .:.|:|.|.|.|:||. |....|.|::||. .|..  .|:: ..:.::.|....|.
Human   369 GTLIITML-NVSDSGVYQCAAENKY-QIIYANAELRVLASAPDFSKSPVK-KKSFVQVGGDIVIG 430

  Fly   633 CQILEGDLPVSF-----RWERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIASNVA 692
            |:      |.:|     .|:| |...:.....:|...|   .||.|.:|:...:|:|||||:|..
Human   431 CK------PNAFPRAAISWKR-GTETLRQSKRIFLLED---GSLKIYNITRSDAGSYTCIATNQF 485

  Fly   693 GTERFTVPLTVNVPPKWILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYE 757
            ||.:.|..|.|.......:.|.......|..::|.||.|                        ::
Human   486 GTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVS------------------------HD 526

  Fly   758 PTVQL----FPNGTIFFKKISKESQGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAK 818
            |::::    |.||                            .||.||..| |||:          
Human   527 PSIEVVFVWFFNG----------------------------DVIDLKKGV-AHFE---------- 552

  Fly   819 GKQVHVQCNVQGDNPIDFKWKIQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIY 883
                    .:.|::                             :.|.|:..:.:.|     :|.|
Human   553 --------RIGGES-----------------------------VGDLMIRNIQLHH-----SGKY 575

  Fly   884 ICQASNAFGQDEMSIQLIVQEVPEQPKNLRINSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQISD 948
            :|..............:||:..|..|:::::....|.:.||:|......||||:.:.|..:....
Human   576 LCTVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFS 640

  Fly   949 I-WQNAEHLTIAGAQTVIN-------IQQLRPAKAYHIRMSAENKLGASEFSEVVQ-VTTLEEVP 1004
            : ||     .:|....::|       :..|.|...|..|:.|.|.:|..|.||..: :.|...||
Human   641 VGWQ-----AVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVP 700

  Fly  1005 SGPPLAVRAEPKSSTEIFVTWDAPERDHWNGILLGYYVGYQM--SLTPEDKEVNPTQGFSFKTVE 1067
            ...|:.:.....|.:|:.:||::...:..||...||.:.::.  |.|...::|:..:...|.   
Human   701 VVAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFV--- 762

  Fly  1068 VRSHFGGETVLANLNKFTQYHVIVQAYTSQGSGPPSKEIAVQTMEDVPSSPPESPQCDVLGSTSI 1132
                :..|:::    ..:.:.|.|..|.::|.|..|....|.:.||.|...|.........::.:
Human   763 ----YRNESII----PLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEM 819

  Fly  1133 YITWSPPDIDGQNGKIKGYKVFYISVDELYETDPEVVKSTNQYVTIEN---LRKYTNYTVWVLAY 1194
            .::|:....:...|::.||:|.|.:.|.......::..|.|  ||.:|   |:..|.|...|.||
Human   820 EVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGN--VTTKNITGLKANTIYFASVRAY 882

  Fly  1195 TKVGDGMKTKPFYCRTHEDVPSAPQAIKAIPASSSKIIISW--LPPDLPNGDITGYTFYMSMLEG 1257
            ...|.|..:.|....|.:..||.|.|..|...::||:.::|  :.......::.||..   :...
Human   883 NTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMENESEVLGYKI---LYRQ 944

  Fly  1258 GREEGTH--------KRLLGPFVEMHETVRTQESATYQFWLTASTKMGEGEKTQVVTVPPNNKVP 1314
            .|:..||        ..||.||.|           .|...:...:..|:|..::.:.:|..:.:.
Human   945 NRQSKTHILETNNTSAELLVPFEE-----------DYLIEIRTVSDGGDGSSSEEIRIPKMSSLS 998

  Fly  1315 ARIVSF 1320
            :|.:.|
Human   999 SRGIQF 1004

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386 27/91 (30%)
Ig strand A 235..238 CDD:409353 1/2 (50%)
Ig strand A' 244..248 CDD:409353 0/3 (0%)
Ig strand B 251..258 CDD:409353 0/6 (0%)
Ig strand C 266..271 CDD:409353 3/4 (75%)
Ig strand C' 276..279 CDD:409353 0/2 (0%)
Ig strand D 285..289 CDD:409353 0/3 (0%)
Ig strand E 292..298 CDD:409353 3/5 (60%)
Ig strand F 305..313 CDD:409353 3/7 (43%)
Ig strand G 316..326 CDD:409353 4/9 (44%)
IgC2_3_Dscam 329..417 CDD:409549 28/108 (26%)
Ig strand B 347..351 CDD:409549 1/3 (33%)
Ig strand C 360..364 CDD:409549 1/5 (20%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 2/4 (50%)
Ig strand G 410..413 CDD:409549 1/2 (50%)
IgI_4_Dscam 422..516 CDD:409548 30/96 (31%)
Ig strand B 439..443 CDD:409548 2/3 (67%)
Ig strand C 452..456 CDD:409548 1/4 (25%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 2/4 (50%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 31/88 (35%)
Ig strand B 536..540 CDD:409550 1/3 (33%)
Ig strand C 549..553 CDD:409550 0/3 (0%)
Ig strand E 571..575 CDD:409550 3/3 (100%)
Ig strand F 586..591 CDD:409550 2/4 (50%)
Ig strand G 600..603 CDD:409550 0/2 (0%)
Ig 610..703 CDD:416386 27/99 (27%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 2/8 (25%)
Ig strand C 641..648 CDD:409353 3/11 (27%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 1/4 (25%)
Ig strand E 668..675 CDD:409353 3/6 (50%)
Ig strand F 682..690 CDD:409353 6/7 (86%)
Ig strand G 693..702 CDD:409353 3/8 (38%)
IgI_7_Dscam 706..801 CDD:409546 13/98 (13%)
Ig strand B 724..728 CDD:409546 1/3 (33%)
Ig strand C 737..741 CDD:409546 0/3 (0%)
Ig strand E 766..770 CDD:409546 1/3 (33%)
Ig strand F 780..785 CDD:409546 0/4 (0%)
Ig strand G 794..797 CDD:409546 0/2 (0%)
Ig 818..904 CDD:416386 9/85 (11%)
putative Ig strand B 820..827 CDD:409353 0/6 (0%)
putative Ig strand C 835..841 CDD:409353 0/5 (0%)
putative Ig strand C' 853..856 CDD:409353 0/2 (0%)
putative Ig strand D 862..866 CDD:409353 1/3 (33%)
putative Ig strand E 868..874 CDD:409353 0/5 (0%)
putative Ig strand F 881..889 CDD:409353 3/7 (43%)
putative Ig strand G 892..902 CDD:409353 0/9 (0%)
FN3 906..999 CDD:238020 25/101 (25%)
FN3 1006..1110 CDD:238020 21/105 (20%)
fn3 1117..1203 CDD:394996 21/88 (24%)
FN3 1215..1307 CDD:238020 21/101 (21%)
Ig <1334..1401 CDD:416386
Ig strand C 1345..1349 CDD:409353
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
CNTN6NP_001276009.1 Ig 26..118 CDD:325142 32/109 (29%)
Ig 120..214 CDD:325142 24/94 (26%)
Ig 227..315 CDD:325142 30/97 (31%)
Ig 319..403 CDD:325142 30/87 (34%)
Ig 424..496 CDD:325142 25/81 (31%)
Ig 515..598 CDD:325142 25/187 (13%)
FN3 598..691 CDD:238020 25/97 (26%)
FN3 703..796 CDD:238020 20/103 (19%)
FN3 805..898 CDD:238020 22/94 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 887..908 6/20 (30%)
FN3 906..991 CDD:238020 19/98 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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