DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam4 and LRIT1

DIOPT Version :9

Sequence 1:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster
Sequence 2:	NP_056428.1	Gene:	LRIT1 / 26103	HGNCID:	23404	Length:	623	Species:	Homo sapiens

Alignment Length:	407	Identity:	81/407 - (19%)
Similarity:	143/407 - (35%)	Gaps:	91/407 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1334 LPCRKVGAPAPVTIWRQ-DGHNMETSARKTIAKNGT----LYMKECQASDAGNYTCSVENTWGKD 1393
            |.|...|.|.|...||: :|..:..:..:.::.:||    |.:......|:|:|.|..:|..|..
Human   273 LRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGAS 337

  Fly  1394 EIVYNIVVKVPPEAPNLTVINAYTDSLLLEWMDNSHGGSPILGYVINYKRDNGDWEELQVDSKTT 1458
            |.|.:::|..||.:                   ..|.|||  |.:  :.|..|..|....::|..
Human   338 ETVISLIVTEPPTS-------------------TEHSGSP--GAL--WARTGGGGEAAAYNNKLV 379

  Fly  1459 SHLLTNLWCGTRYQLYITAYNKIGTGLP------------CDIVNSYTKGNPPVQPKHSQMI--- 1508
            :..:.        |:...|....|..:|            .|.:...:.|.  ..|..::|:
Human   380 ARHVP--------QIPKPAVLATGPSVPSTKEELTLEHFQMDALGELSDGR--AGPSEARMVRSV 434

  Fly  1509 -----TNNSTSVTCWL--DSWGDGGCGILYFMIESRVYGRSSWAVVSNHIPPTERIYTVSDLVPG 1566
                 |.:|.|:. |.  .:.......:||     .|:|:.|...|.  :.|.:...|::.|:|.
Human   435 KVVGDTYHSVSLV-WKAPQAKNTTAFSVLY-----AVFGQHSMRRVI--VQPGKTRVTITGLLPK 491

  Fly  1567 TKYQLKVTAHNNAGSTTAIYNFTTLSTQGVIYNNDHSTPVSHLSDLPFYANFKLLLPICFSLLML 1631
            |||.          :...:........|.||::.:......:...|.......:.:.|...|.:|
Human   492 TKYV----------ACVCVQGLVPRKEQCVIFSTNEVVDAENTQQLINVVVISVAIVIALPLTLL 546

  Fly  1632 LALIGAALFLRKRKLASQARLASSSMSESPSLANLQNKQNRDQQYLAVRCNPGTSAPR---GSNS 1693
            :..  :||..|.||..::     .|...:.:..||:.....:.....:..:..:.|.|   ..:|
Human   547 VCC--SALQKRCRKCFNK-----DSTEATVTYVNLERLGYSEDGLEELSRHSVSEADRLLSARSS 604

  Fly  1694 NDSGSFGKAEG---NEY 1707
            .|..:||...|   |||
Human   605 VDFQAFGVKGGRRINEY 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386
		Ig strand A	235..238	CDD:409353
		Ig strand A'	244..248	CDD:409353
		Ig strand B	251..258	CDD:409353
		Ig strand C	266..271	CDD:409353
		Ig strand C'	276..279	CDD:409353
		Ig strand D	285..289	CDD:409353
		Ig strand E	292..298	CDD:409353
		Ig strand F	305..313	CDD:409353
		Ig strand G	316..326	CDD:409353
		IgC2_3_Dscam	329..417	CDD:409549
		Ig strand B	347..351	CDD:409549
		Ig strand C	360..364	CDD:409549
		Ig strand E	383..387	CDD:409549
		Ig strand F	397..402	CDD:409549
		Ig strand G	410..413	CDD:409549
		IgI_4_Dscam	422..516	CDD:409548
		Ig strand B	439..443	CDD:409548
		Ig strand C	452..456	CDD:409548
		Ig strand E	482..486	CDD:409548
		Ig strand F	496..501	CDD:409548
		Ig strand G	509..512	CDD:409548
		IgI_5_Dscam	520..607	CDD:409550
		Ig strand B	536..540	CDD:409550
		Ig strand C	549..553	CDD:409550
		Ig strand E	571..575	CDD:409550
		Ig strand F	586..591	CDD:409550
		Ig strand G	600..603	CDD:409550
		Ig	610..703	CDD:416386
		Ig strand A	611..613	CDD:409353
		Ig strand A'	620..624	CDD:409353
		Ig strand B	627..636	CDD:409353
		Ig strand C	641..648	CDD:409353
		Ig strand C'	650..652	CDD:409353
		Ig strand D	659..664	CDD:409353
		Ig strand E	668..675	CDD:409353
		Ig strand F	682..690	CDD:409353
		Ig strand G	693..702	CDD:409353
		IgI_7_Dscam	706..801	CDD:409546
		Ig strand B	724..728	CDD:409546
		Ig strand C	737..741	CDD:409546
		Ig strand E	766..770	CDD:409546
		Ig strand F	780..785	CDD:409546
		Ig strand G	794..797	CDD:409546
		Ig	818..904	CDD:416386
		putative Ig strand B	820..827	CDD:409353
		putative Ig strand C	835..841	CDD:409353
		putative Ig strand C'	853..856	CDD:409353
		putative Ig strand D	862..866	CDD:409353
		putative Ig strand E	868..874	CDD:409353
		putative Ig strand F	881..889	CDD:409353
		putative Ig strand G	892..902	CDD:409353
		FN3	906..999	CDD:238020
		FN3	1006..1110	CDD:238020
		fn3	1117..1203	CDD:394996
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386	19/71 (27%)
Ig strand C	1345..1349	CDD:409353	0/3 (0%)
Ig strand D	1363..1366	CDD:409353	0/2 (0%)
Ig strand E	1367..1372	CDD:409353	3/8 (38%)
Ig strand F	1380..1388	CDD:409353	3/7 (43%)
Ig strand G	1394..1401	CDD:409353	2/6 (33%)
FN3	1405..1494	CDD:238020	15/100 (15%)
FN3	1499..1580	CDD:238020	19/90 (21%)
LRIT1	NP_056428.1	LRR 1	60..81
		leucine-rich repeat	61..84	CDD:275378
		LRR_8	63..143	CDD:290566
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..129
		LRR_8	131..202	CDD:290566
		LRR_4	131..171	CDD:289563
		LRR 4	132..153
		leucine-rich repeat	133..156	CDD:275378
		LRR 5	156..177
		leucine-rich repeat	157..180	CDD:275378
		leucine-rich repeat	181..205	CDD:275378
		TPKR_C2	201..>240	CDD:301599
		Ig	267..345	CDD:299845	19/71 (27%)
		IG_like	267..345	CDD:214653	19/71 (27%)
		FN3	431..498	CDD:214495	17/84 (20%)
		LRR 6. /evidence=ECO:0000305	571..594		2/22 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900