DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam4 and Lrit1

DIOPT Version :9

Sequence 1:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster
Sequence 2:	NP_647547.2	Gene:	Lrit1 / 246214	RGDID:	628607	Length:	623	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	112/524 - (21%)
Similarity:	181/524 - (34%)	Gaps:	174/524 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 VTEPKGMVQP---RINVEKHSMRHVVLNGQTTLPCIAQGHPVPTYRWFKEENEQLLPLQ-LSERI 286
            :|.|...:.|   ::.:|:.::|.|               |..|:|......:..||.. |||..
  Rat    50 LTLPPASIPPDTCKLRLERTAIRRV---------------PGETFRPLSRLEQLWLPYNALSELS 99

  Fly   287 TIVSAGLLKITKARLEDSGKYLCWVNNTAGEETIQVSLTVTAPLTAHLQ-PQVQTVDVDKDAQFQ 350
            |::..||.::.:.||  .|.:|                 ||.|..|... ||:|.:|:..:.
  Rat   100 TLMLRGLRRLRELRL--PGNHL-----------------VTFPWAALKDTPQLQLLDLQANR--- 142

  Fly   351 CIVSGHPVHDVNWLHD-------GKPILR------DNRVEILTDP------PRLIIKKVQKEDPG 396
              :|..|...|::|.:       ...::|      |....:.|.|      .||::.  .:::|.
  Rat   143 --LSTLPPEAVHFLENLTFLDLSNNQLMRLPEELLDTWAHLKTGPYLSSRRTRLVLG--LQDNPW 203

  Fly   397 MYQC------FVSNEWEQIQSTAELQLGDASPELL--YWFSEQTLQP-----------------G 436
            :..|      .:.:.|.......|.:|...||..|  ..||:..|:.                 |
  Rat   204 VCDCRLYDLVHLLDGWASNLIFIEARLRCGSPRSLAGVAFSQLELRKCQSPELRPGVTSIISPLG 268

  Fly   437 PTVSLKCVATGNPLPQFTW-SLDGFPIPDSSRFLVGQYVTIHDDVISH------VNISNVKEEDG 494
            .||.|:|.|||.|.|:.:| ..:|.|:..          |:|.:|.|.      :::..|...|.
  Rat   269 STVLLRCGATGIPGPEMSWRRANGRPLNG----------TVHQEVSSDGSSWTLLDLPVVSLFDS 323

  Fly   495 GEYTCTAQNAIGKVSHSAKVNIYGLPYIREMPKITGISGSDLIVKCPVAGYPIDKIHWERDGQTL 559
            |:|.|.|:|.:| .|.:....|...|  :...:.|||.|:                .|.|.|:
  Rat   324 GDYICQAKNFLG-ASETLISLIVTEP--QTSTEYTGIPGA----------------LWARTGE-- 367

  Fly   560 PINRRQRAYNNGTLIIEQLQRLEDAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLR 624
              .....||||                         |..:|.       ||....|:...|....
  Rat   368 --GAEAAAYNN-------------------------KLVARH-------VPHVPEPVALATKPSV 398

  Fly   625 EGMRAAISCQILEGDLPVSFRWERNGKPLIGTGNEVFRRL----DEY-SASLVIEHISSDHSGNY 684
            ..::..:..|..:.|:|..|..|    |......::.|.|    |.| |.|||.:   :..:||.
  Rat   399 PSIKEELPLQNFQMDVPGEFSRE----PSEHQETQMVRSLKVVGDTYHSVSLVWK---APQAGNT 456

  Fly   685 TCIA 688
            |..:
  Rat   457 TAFS 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386	19/94 (20%)
		Ig strand A	235..238	CDD:409353	1/5 (20%)
		Ig strand A'	244..248	CDD:409353	1/3 (33%)
		Ig strand B	251..258	CDD:409353	0/6 (0%)
		Ig strand C	266..271	CDD:409353	2/4 (50%)
		Ig strand C'	276..279	CDD:409353	0/2 (0%)
		Ig strand D	285..289	CDD:409353	1/3 (33%)
		Ig strand E	292..298	CDD:409353	2/5 (40%)
		Ig strand F	305..313	CDD:409353	2/7 (29%)
		Ig strand G	316..326	CDD:409353	0/9 (0%)
		IgC2_3_Dscam	329..417	CDD:409549	20/113 (18%)
		Ig strand B	347..351	CDD:409549	0/3 (0%)
		Ig strand C	360..364	CDD:409549	1/3 (33%)
		Ig strand E	383..387	CDD:409549	2/3 (67%)
		Ig strand F	397..402	CDD:409549	1/10 (10%)
		Ig strand G	410..413	CDD:409549	0/2 (0%)
		IgI_4_Dscam	422..516	CDD:409548	31/119 (26%)
		Ig strand B	439..443	CDD:409548	2/3 (67%)
		Ig strand C	452..456	CDD:409548	1/4 (25%)
		Ig strand E	482..486	CDD:409548	1/9 (11%)
		Ig strand F	496..501	CDD:409548	2/4 (50%)
		Ig strand G	509..512	CDD:409548	1/2 (50%)
		IgI_5_Dscam	520..607	CDD:409550	14/86 (16%)
		Ig strand B	536..540	CDD:409550	0/3 (0%)
		Ig strand C	549..553	CDD:409550	0/3 (0%)
		Ig strand E	571..575	CDD:409550	0/3 (0%)
		Ig strand F	586..591	CDD:409550	0/4 (0%)
		Ig strand G	600..603	CDD:409550	1/2 (50%)
		Ig	610..703	CDD:416386	20/84 (24%)
		Ig strand A	611..613	CDD:409353	0/1 (0%)
		Ig strand A'	620..624	CDD:409353	1/3 (33%)
		Ig strand B	627..636	CDD:409353	1/8 (13%)
		Ig strand C	641..648	CDD:409353	2/6 (33%)
		Ig strand C'	650..652	CDD:409353	0/1 (0%)
		Ig strand D	659..664	CDD:409353	1/4 (25%)
		Ig strand E	668..675	CDD:409353	4/6 (67%)
		Ig strand F	682..690	CDD:409353	3/7 (43%)
		Ig strand G	693..702	CDD:409353
		IgI_7_Dscam	706..801	CDD:409546
		Ig strand B	724..728	CDD:409546
		Ig strand C	737..741	CDD:409546
		Ig strand E	766..770	CDD:409546
		Ig strand F	780..785	CDD:409546
		Ig strand G	794..797	CDD:409546
		Ig	818..904	CDD:416386
		putative Ig strand B	820..827	CDD:409353
		putative Ig strand C	835..841	CDD:409353
		putative Ig strand C'	853..856	CDD:409353
		putative Ig strand D	862..866	CDD:409353
		putative Ig strand E	868..874	CDD:409353
		putative Ig strand F	881..889	CDD:409353
		putative Ig strand G	892..902	CDD:409353
		FN3	906..999	CDD:238020
		FN3	1006..1110	CDD:238020
		fn3	1117..1203	CDD:394996
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
Lrit1	NP_647547.2	LRRNT	23..61	CDD:214470	3/10 (30%)
		LRR 1	60..81		5/35 (14%)
		LRR_8	63..143	CDD:290566	26/118 (22%)
		leucine-rich repeat	64..84	CDD:275378	6/34 (18%)
		LRR 2	84..105		6/20 (30%)
		leucine-rich repeat	85..132	CDD:275378	16/65 (25%)
		LRR 3	108..128		8/38 (21%)
		LRR_8	131..>176	CDD:290566	9/49 (18%)
		LRR_4	131..172	CDD:289563	9/45 (20%)
		LRR 4	132..153		6/25 (24%)
		leucine-rich repeat	133..156	CDD:275378	6/27 (22%)
		LRR 5	156..177		1/20 (5%)
		leucine-rich repeat	157..180	CDD:275378	2/22 (9%)
		leucine-rich repeat	181..205	CDD:275378	5/25 (20%)
		TPKR_C2	201..>240	CDD:301599	8/38 (21%)
		Ig	257..345	CDD:299845	26/98 (27%)
		IG_like	267..345	CDD:214653	26/88 (30%)
		FN3	431..501	CDD:214495	11/33 (33%)
		LRR 6	525..548
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900