DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and Ncam1

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:XP_038936733.1 Gene:Ncam1 / 24586 RGDID:67378 Length:1136 Species:Rattus norvegicus


Alignment Length:1067 Identity:231/1067 - (21%)
Similarity:387/1067 - (36%) Gaps:224/1067 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   402 VSNEWEQIQSTAELQL-----------GDASPELLYWFSEQTLQPGPTVSLKCVATGNPLPQFTW 455
            ||.:.:.:.|..|:.:           |||..:.:.|||..    |..:|               
  Rat    18 VSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPN----GEKLS--------------- 63

  Fly   456 SLDGFPIPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTC-------TAQNAIGKVSHSAK 513
                   |:..|.    .|..:||..|.:.|.|...:|.|.|.|       |...|...|....|
  Rat    64 -------PNQQRI----SVVWNDDDSSTLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQK 117

  Fly   514 VNIYGLPYIREMPKITGISGSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQR--AYNNGTLIIE 576
            :.....|..:|..:     |.|.::.|.|.......|.|:..|:.:.:.:..|  ..:|..|.|.
  Rat   118 LMFKNAPTPQEFKE-----GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIR 177

  Fly   577 QLQRLEDAGTYTCMAQNKQK-QTSRRNVEIQVLVPPKIMPIQAMTNMLRE-GMRAAISCQILEGD 639
            .::: .|.|||.|..:...: :.:.:::::.|.|||.:...|::.|.... |....:.|. .:|.
  Rat   178 GIKK-TDEGTYRCEGRILARGEINFKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCD-ADGF 240

  Fly   640 LPVSFRWERNGKPLIGTGNEVFRRL-DEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTV 703
            ...:..|.::|:|:.....:..:.: .:.|:.|.|.::..:....|.|||.|.||.:..::.|.|
  Rat   241 PEPTMSWTKDGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASIHLKV 305

  Fly   704 NVPPKWILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQLFPNG-- 766
            ...||.......::.:....|.|.|::||.|.|:|||:.:......|.|.....|..|...:|  
  Rat   306 FAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHM 370

  Fly   767 ---------TIFFKKISKESQGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQV 822
                     ::..|.|.....|.::|.|.|.||.. |:.::|:|......|... .:...:|.||
  Rat   371 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD-SQSMYLEVQYAPKLQGPV-AVYTWEGNQV 433

  Fly   823 HVQCNVQGDNPIDFKWKIQATQQYLDESL--DSRYTIRDQVLDDGMVSELGISHTYRQDTGIYIC 885
            ::.|.|       |.:.......:.|..|  .|.|: ..::.:....|.|.::.....|.|.|.|
  Rat   434 NITCEV-------FAYPSATISWFRDGQLLPSSNYS-NIKIYNTPSASYLEVTPDSENDFGNYNC 490

  Fly   886 QASNAFGQDEMSIQLIVQEVPEQPKNLRINSQQSRSLQLTWSQPFA-GNSPIEEYHIYYKQISD- 948
            .|.|..||:.:...|:..:.|..|...|:....| :.|:.:.:|.| |..||.:|...:|.:.: 
  Rat   491 TAVNRIGQESLEFILVQADTPSSPSIDRVEPYSS-TAQVQFDEPEATGGVPILKYKAEWKSLGEE 554

  Fly   949 ----IWQNAEHLTIAGAQTVINIQQLRPAKAYHIRMSAENKLGASEFSEVVQVTTLEEVPSGPPL 1009
                .|.:|:...:.|   ::.|..|:|...|.:|::|.|..|..|.|...:..| :.|.|.||.
  Rat   555 AWHSKWYDAKEANMEG---IVTIMGLKPETRYAVRLAALNGKGLGEISAATEFKT-QPVHSPPPQ 615

  Fly  1010 AVRAEPKSSTEI-----FVTWDAPERDHWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEVR 1069
            ...:.||...::     .:..:..::|.....:..|.|.|:..|..|.|.            |:|
  Rat   616 GEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVKYRAKLASEWKP------------EIR 668

  Fly  1070 SHFGGETV-LANLNKFTQYHVIVQAYTSQGSGPPSKEIAVQTMEDVPSSPPE--SP--------- 1122
            ...|.:.| |.:|:...:|.|.|.|...||....:..:...:.:  |::.|.  ||         
  Rat   669 LPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQ--PTAIPANGSPTAGLSTGAI 731

  Fly  1123 -----------------------QCDVLGSTSIYITW-SPPDIDGQNGKIKGYKVFYISVDELYE 1163
                                   :|.:|...::.:.. :.|...|::.: :|...|  |.||..|
  Rat   732 VGILIVIFVLLLVVMDITCYFLNKCGLLMCIAVNLCGKAGPGAKGKDME-EGKAAF--SKDESKE 793

  Fly  1164 -----------------------------TDPEVVKSTNQYVTIEN-LRKYTNYTVWVLAYTKVG 1198
                                         |:||:...|.  .|:|: |...|..|......|:..
  Rat   794 PIVEVRTEEERTPNHDGGKHTEPNETTPLTEPELPADTT--ATVEDMLPSVTTVTTNSDTITETF 856

  Fly  1199 DGMKTKPFYCRTHEDVPSAPQAIKAIPASSSKIIISWLPPDLPNGDIT---GYTFYMSMLEGGRE 1260
            ...:..|....|......||.| ..:|.|:|          :|.|..|   |.|...|.......
  Rat   857 ATAQNSPTSETTTLTSSIAPPA-TTVPESNS----------VPAGQATPSKGVTASSSSPPASVP 910

  Fly  1261 EGTHKRLLGPFVEMHETVRTQES---------ATYQFWLTASTKMGEGEKTQVVTVPPNNKVPAR 1316
            :      :.|.|::.:|..:..|         |.....|:.||....||         .:|||| 
  Rat   911 K------VAPLVDLSDTPTSAPSANNLSSTVLANQGAVLSPSTPASAGE---------TSKVPA- 959

  Fly  1317 IVSFSQRIVTPWKEHLELPCRKVGAPA 1343
             .|......||.......|...|.|||
  Rat   960 -TSKPSPTPTPTPAGAASPLAAVAAPA 985

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353
Ig strand C' 276..279 CDD:409353
Ig strand D 285..289 CDD:409353
Ig strand E 292..298 CDD:409353
Ig strand F 305..313 CDD:409353
Ig strand G 316..326 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549 4/14 (29%)
Ig strand B 347..351 CDD:409549
Ig strand C 360..364 CDD:409549
Ig strand E 383..387 CDD:409549
Ig strand F 397..402 CDD:409549 231/1067 (22%)
Ig strand G 410..413 CDD:409549 1/2 (50%)
IgI_4_Dscam 422..516 CDD:409548 21/100 (21%)
Ig strand B 439..443 CDD:409548 1/3 (33%)
Ig strand C 452..456 CDD:409548 0/3 (0%)
Ig strand E 482..486 CDD:409548 1/3 (33%)
Ig strand F 496..501 CDD:409548 2/11 (18%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 18/89 (20%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 1/3 (33%)
Ig strand E 571..575 CDD:409550 1/3 (33%)
Ig strand F 586..591 CDD:409550 3/4 (75%)
Ig strand G 600..603 CDD:409550 0/2 (0%)
Ig 610..703 CDD:416386 21/94 (22%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 1/3 (33%)
Ig strand B 627..636 CDD:409353 1/8 (13%)
Ig strand C 641..648 CDD:409353 1/6 (17%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 3/6 (50%)
Ig strand F 682..690 CDD:409353 4/7 (57%)
Ig strand G 693..702 CDD:409353 1/8 (13%)
IgI_7_Dscam 706..801 CDD:409546 27/105 (26%)
Ig strand B 724..728 CDD:409546 2/3 (67%)
Ig strand C 737..741 CDD:409546 2/3 (67%)
Ig strand E 766..770 CDD:409546 1/14 (7%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 1/2 (50%)
Ig 818..904 CDD:416386 21/87 (24%)
putative Ig strand B 820..827 CDD:409353 2/6 (33%)
putative Ig strand C 835..841 CDD:409353 1/5 (20%)
putative Ig strand C' 853..856 CDD:409353 1/2 (50%)
putative Ig strand D 862..866 CDD:409353 0/3 (0%)
putative Ig strand E 868..874 CDD:409353 2/5 (40%)
putative Ig strand F 881..889 CDD:409353 4/7 (57%)
putative Ig strand G 892..902 CDD:409353 3/9 (33%)
FN3 906..999 CDD:238020 25/98 (26%)
FN3 1006..1110 CDD:238020 23/109 (21%)
fn3 1117..1203 CDD:394996 23/150 (15%)
FN3 1215..1307 CDD:238020 22/103 (21%)
Ig <1334..1401 CDD:416386 5/10 (50%)
Ig strand C 1345..1349 CDD:409353
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
Ncam1XP_038936733.1 IgI_1_NCAM-1 20..116 CDD:409451 25/125 (20%)
Ig strand B 37..41 CDD:409451 0/3 (0%)
Ig strand C 51..55 CDD:409451 0/3 (0%)
Ig strand E 79..83 CDD:409451 1/3 (33%)
Ig strand F 93..98 CDD:409451 2/4 (50%)
Ig strand G 107..110 CDD:409451 1/2 (50%)
IG_like 124..190 CDD:214653 17/71 (24%)
Ig strand B 135..139 CDD:409353 0/3 (0%)
Ig strand C 148..152 CDD:409353 1/3 (33%)
Ig strand E 172..176 CDD:409353 1/3 (33%)
Ig strand F 186..191 CDD:409353 3/4 (75%)
IgI_3_NCAM-1 211..308 CDD:143207 22/97 (23%)
Ig strand B 231..235 CDD:143207 0/3 (0%)
Ig strand C 244..248 CDD:143207 0/3 (0%)
Ig strand E 271..275 CDD:143207 1/3 (33%)
Ig strand F 285..290 CDD:143207 2/4 (50%)
Ig strand G 298..301 CDD:143207 0/2 (0%)
IgI_NCAM-1 307..413 CDD:143277 27/106 (25%)
Ig strand B 326..330 CDD:143277 2/3 (67%)
Ig strand C 339..343 CDD:143277 2/3 (67%)
Ig strand E 379..383 CDD:143277 0/3 (0%)
Ig strand F 393..398 CDD:143277 1/4 (25%)
Ig strand G 406..409 CDD:143277 1/2 (50%)
Ig_3 422..494 CDD:404760 17/80 (21%)
Ig strand B 433..437 CDD:409353 1/3 (33%)
Ig strand C 446..450 CDD:409353 0/3 (0%)
Ig strand E 473..477 CDD:409353 2/3 (67%)
Ig strand F 487..492 CDD:409353 2/4 (50%)
FN3 509..606 CDD:238020 25/100 (25%)
fn3 619..701 CDD:394996 21/93 (23%)
Herpes_BLLF1 <842..1133 CDD:282904 39/172 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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