DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and Kirrel2

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_766486.1 Gene:Kirrel2 / 243911 MGIID:2442334 Length:700 Species:Mus musculus


Alignment Length:527 Identity:124/527 - (23%)
Similarity:199/527 - (37%) Gaps:94/527 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   420 ASPELLYWFSEQTLQPGPTVSLKCVATGNPLPQFTWSLDGF------PIPDSSRFLV------GQ 472
            :||..|....:..:..|....|.| |.|.......|:.||.      .:|..||:.:      ||
Mouse    19 SSPHFLQQPEDMVVLLGEEARLPC-ALGAYRGLVQWTKDGLALGGERDLPGWSRYWISGNSASGQ 82

  Fly   473 YVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLPYIREMPKITG------I 531
                ||     ::|..|:.||...|.|.|..| |..|..|::::...|   |.|::.|      :
Mouse    83 ----HD-----LHIKPVELEDEASYECQASQA-GLRSRPAQLHVMVPP---EAPQVLGGPSVSLV 134

  Fly   532 SGSDLIVKCPVAG--YPIDKIHWERDG---------QTLPINRRQRAYNNGTLIIEQLQRLEDAG 585
            :|....:.|...|  .|..::.|.|||         ||...::......| ||.:..... :|..
Mouse   135 AGVPGNLTCRSRGDSRPAPELLWFRDGIRLDGSSFHQTTLKDKATGTVEN-TLFLTPSSH-DDGA 197

  Fly   586 TYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQILEGDLPVSFRWERNG 650
            |..|.|:::...|.|.......|..|.::.:.|....::||.:....||.........:||.:.|
Mouse   198 TLICRARSQALPTGRDTAVTLSLQYPPMVTLSAEPQTVQEGEKVTFLCQATAQPPVTGYRWAKGG 262

  Fly   651 KPLIGTGNEVFRRLDEYS-ASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTVNVPPKWILEPK 714
            .|::|....   ||:..: |:.:.|.:|        |..||..|:...:..|.|...|....:||
Mouse   263 SPVLGARGP---RLEVVADATFLTEPVS--------CEVSNAVGSANRSTALEVLYGPILQAKPK 316

  Fly   715 DSSAQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQLFPNG-TIFFKKISKESQ 778
            ..|...|.|....|...|.|.|.|||.:..|.              |:..:| |:....::.|..
Mouse   317 SVSVDVGKDASFSCVWRGNPLPRITWTRMGGS--------------QVLSSGPTLRLPSVALEDA 367

  Fly   779 GHFLCEA---KNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNV---QGDNPIDFK 837
            |.::|.|   :..:|.|.::. .|.||.|..........:..:| ...:||.|   ...:.:.:.
Mouse   368 GDYVCRAEPRRTGLGGGKAQA-RLTVNAPPVVTALQPAPAFLRG-PARLQCVVFASPAPDSVVWS 430

  Fly   838 WKIQATQQYLDESLDSRYTIR-------DQVLDDGMVSELGISHTYRQD--TGIYICQASNAFGQ 893
            |    .:.:|:.....|:.:.       :.....|::|.|.||.|...|  || :.|.|.|..|:
Mouse   431 W----DEGFLEAGSLGRFLVEAFPAPEVEGGQGPGLISVLHISGTQESDFTTG-FNCSARNRLGE 490

  Fly   894 DEMSIQL 900
            ..:.|.|
Mouse   491 GRVQIHL 497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353
Ig strand C' 276..279 CDD:409353
Ig strand D 285..289 CDD:409353
Ig strand E 292..298 CDD:409353
Ig strand F 305..313 CDD:409353
Ig strand G 316..326 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549
Ig strand B 347..351 CDD:409549
Ig strand C 360..364 CDD:409549
Ig strand E 383..387 CDD:409549
Ig strand F 397..402 CDD:409549
Ig strand G 410..413 CDD:409549
IgI_4_Dscam 422..516 CDD:409548 28/105 (27%)
Ig strand B 439..443 CDD:409548 1/3 (33%)
Ig strand C 452..456 CDD:409548 0/3 (0%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 2/4 (50%)
Ig strand G 509..512 CDD:409548 1/2 (50%)
IgI_5_Dscam 520..607 CDD:409550 23/103 (22%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 0/3 (0%)
Ig strand E 571..575 CDD:409550 2/3 (67%)
Ig strand F 586..591 CDD:409550 2/4 (50%)
Ig strand G 600..603 CDD:409550 1/2 (50%)
Ig 610..703 CDD:416386 21/93 (23%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 2/8 (25%)
Ig strand C 641..648 CDD:409353 2/6 (33%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 1/7 (14%)
Ig strand F 682..690 CDD:409353 1/7 (14%)
Ig strand G 693..702 CDD:409353 1/8 (13%)
IgI_7_Dscam 706..801 CDD:409546 24/98 (24%)
Ig strand B 724..728 CDD:409546 0/3 (0%)
Ig strand C 737..741 CDD:409546 2/3 (67%)
Ig strand E 766..770 CDD:409546 2/4 (50%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 0/2 (0%)
Ig 818..904 CDD:416386 22/95 (23%)
putative Ig strand B 820..827 CDD:409353 1/6 (17%)
putative Ig strand C 835..841 CDD:409353 1/5 (20%)
putative Ig strand C' 853..856 CDD:409353 1/2 (50%)
putative Ig strand D 862..866 CDD:409353 0/3 (0%)
putative Ig strand E 868..874 CDD:409353 3/5 (60%)
putative Ig strand F 881..889 CDD:409353 3/7 (43%)
putative Ig strand G 892..902 CDD:409353 3/9 (33%)
FN3 906..999 CDD:238020
FN3 1006..1110 CDD:238020
fn3 1117..1203 CDD:394996
FN3 1215..1307 CDD:238020
Ig <1334..1401 CDD:416386
Ig strand C 1345..1349 CDD:409353
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
Kirrel2NP_766486.1 IG 27..116 CDD:214652 26/99 (26%)
Ig 122..220 CDD:416386 21/99 (21%)
Ig strand A 123..126 CDD:409353 1/2 (50%)
Ig strand A' 129..133 CDD:409353 0/3 (0%)
Ig strand B 140..147 CDD:409353 1/6 (17%)
Cell attachment site. /evidence=ECO:0000255 146..148 0/1 (0%)
Ig strand C 153..158 CDD:409353 0/4 (0%)
Ig strand C' 161..163 CDD:409353 1/1 (100%)
Ig strand D 166..173 CDD:409353 1/6 (17%)
Ig strand E 180..188 CDD:409353 3/8 (38%)
Ig strand F 197..205 CDD:409353 3/7 (43%)
Ig strand G 211..217 CDD:409353 1/5 (20%)
Ig_3 223..292 CDD:404760 17/79 (22%)
Ig strand B 241..245 CDD:409353 0/3 (0%)
Ig strand C 255..259 CDD:409353 1/3 (33%)
Ig strand E 272..275 CDD:409353 2/2 (100%)
Ig strand F 281..290 CDD:409353 3/16 (19%)
Ig strand G 298..301 CDD:409353 0/2 (0%)
Ig 315..392 CDD:416386 23/91 (25%)
Ig strand A' 316..321 CDD:409353 2/4 (50%)
Ig strand B 324..333 CDD:409353 2/8 (25%)
Ig strand C 339..343 CDD:409353 2/3 (67%)
Ig strand C' 346..348 CDD:409353 0/1 (0%)
Ig strand D 351..354 CDD:409353 0/2 (0%)
Ig strand E 355..360 CDD:409353 1/4 (25%)
Ig strand F 368..376 CDD:409353 3/7 (43%)
Ig strand G 382..392 CDD:409353 3/10 (30%)
Ig 394..498 CDD:416386 23/110 (21%)
Ig strand A 395..399 CDD:409353 1/3 (33%)
Ig strand A' 401..404 CDD:409353 0/2 (0%)
Ig strand B 412..419 CDD:409353 2/6 (33%)
Ig strand C 426..431 CDD:409353 0/4 (0%)
Ig strand C' 433..436 CDD:409353 0/2 (0%)
Ig strand D 444..451 CDD:409353 0/6 (0%)
Ig strand E 461..468 CDD:409353 3/6 (50%)
Ig strand F 479..486 CDD:409353 3/7 (43%)
Ig strand G 489..496 CDD:409353 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..576
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 671..700
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11159
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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