DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and Lrit1

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_666357.2 Gene:Lrit1 / 239037 MGIID:2385320 Length:624 Species:Mus musculus


Alignment Length:398 Identity:91/398 - (22%)
Similarity:144/398 - (36%) Gaps:123/398 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   226 VTEPKGMVQP---RINVEKHSMRHVVLNGQTTLPCIAQGHPVPTYRWFKEENEQLLPLQ-LSERI 286
            :|.|...:.|   ::.:|:.::|.|               |..|:|......:..||.. |||..
Mouse    50 LTLPPASIPPDTCKLRLERTAIRRV---------------PGETFRPLSRLEQLWLPYNALSELS 99

  Fly   287 TIVSAGLLKITKARLEDSGKYLCWVNNTAGEETIQVS--------LTVTAPLTAHLQPQVQTVDV 343
            .::..||.::.:.||  .|..|......|..:|.|:.        |:...|..||....:..:|:
Mouse   100 ALMLRGLRRLRELRL--PGNRLVTFPWAALRDTPQLQLLDLQANRLSTLPPEAAHFLENLTFLDL 162

  Fly   344 DKDAQFQCIVSGHPVHDVNWLHDGKPILRDNRVEILTDP------PRLIIKKVQKEDPGMYQC-- 400
            ..:   |.:.....:.|| |.|            :.|.|      .|||:.  .:::|.:..|  
Mouse   163 SNN---QLMRLPEELLDV-WAH------------LKTGPFLSGHHARLILG--LQDNPWVCDCRL 209

  Fly   401 ----FVSNEWEQIQST---AELQLGDASPELL--YWFSEQTLQP-----------------GPTV 439
                .:.:.|  :.|.   .|.:|..|||..|  ..||:..|:.                 |.||
Mouse   210 YDLVHLLDGW--VSSNLIFIEARLRCASPRSLAGVAFSQLELRKCQSPELRPGVTSIISPLGSTV 272

  Fly   440 SLKCVATGNPLPQFTW-SLDGFPIPDSSRFLVGQYVTIHDDVISH------VNISNVKEEDGGEY 497
            .|:|.|||.|.|:.:| ..:|.|:..          |:|.:|.|.      :::..|...|.|:|
Mouse   273 LLRCGATGIPGPEMSWRRANGRPLNG----------TVHQEVSSDGSSWTLLDLPVVSLFDSGDY 327

  Fly   498 TCTAQNAIGKVSHSAKVNIYGLPYIREMPKITGISGSDLIVKCPVAGYPIDKIHWERDGQTLPIN 562
            .|.|:|.:|     |...:..| .:.|....||.||             |..:.|.|.|:    .
Mouse   328 ICQAKNFLG-----ASETLISL-IVTEPQTSTGYSG-------------IPGVLWARTGE----G 369

  Fly   563 RRQRAYNN 570
            ....||||
Mouse   370 AEAAAYNN 377

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386 22/102 (22%)
Ig strand A 235..238 CDD:409353 1/5 (20%)
Ig strand A' 244..248 CDD:409353 1/3 (33%)
Ig strand B 251..258 CDD:409353 0/6 (0%)
Ig strand C 266..271 CDD:409353 2/4 (50%)
Ig strand C' 276..279 CDD:409353 0/2 (0%)
Ig strand D 285..289 CDD:409353 0/3 (0%)
Ig strand E 292..298 CDD:409353 2/5 (40%)
Ig strand F 305..313 CDD:409353 2/7 (29%)
Ig strand G 316..326 CDD:409353 3/17 (18%)
IgC2_3_Dscam 329..417 CDD:409549 19/102 (19%)
Ig strand B 347..351 CDD:409549 0/3 (0%)
Ig strand C 360..364 CDD:409549 2/3 (67%)
Ig strand E 383..387 CDD:409549 2/3 (67%)
Ig strand F 397..402 CDD:409549 1/10 (10%)
Ig strand G 410..413 CDD:409549 1/5 (20%)
IgI_4_Dscam 422..516 CDD:409548 31/119 (26%)
Ig strand B 439..443 CDD:409548 2/3 (67%)
Ig strand C 452..456 CDD:409548 1/4 (25%)
Ig strand E 482..486 CDD:409548 1/9 (11%)
Ig strand F 496..501 CDD:409548 2/4 (50%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 13/51 (25%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 0/3 (0%)
Ig strand E 571..575 CDD:409550 91/398 (23%)
Ig strand F 586..591 CDD:409550
Ig strand G 600..603 CDD:409550
Ig 610..703 CDD:416386
Ig strand A 611..613 CDD:409353
Ig strand A' 620..624 CDD:409353
Ig strand B 627..636 CDD:409353
Ig strand C 641..648 CDD:409353
Ig strand C' 650..652 CDD:409353
Ig strand D 659..664 CDD:409353
Ig strand E 668..675 CDD:409353
Ig strand F 682..690 CDD:409353
Ig strand G 693..702 CDD:409353
IgI_7_Dscam 706..801 CDD:409546
Ig strand B 724..728 CDD:409546
Ig strand C 737..741 CDD:409546
Ig strand E 766..770 CDD:409546
Ig strand F 780..785 CDD:409546
Ig strand G 794..797 CDD:409546
Ig 818..904 CDD:416386
putative Ig strand B 820..827 CDD:409353
putative Ig strand C 835..841 CDD:409353
putative Ig strand C' 853..856 CDD:409353
putative Ig strand D 862..866 CDD:409353
putative Ig strand E 868..874 CDD:409353
putative Ig strand F 881..889 CDD:409353
putative Ig strand G 892..902 CDD:409353
FN3 906..999 CDD:238020
FN3 1006..1110 CDD:238020
fn3 1117..1203 CDD:394996
FN3 1215..1307 CDD:238020
Ig <1334..1401 CDD:416386
Ig strand C 1345..1349 CDD:409353
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
Lrit1NP_666357.2 LRRNT 23..61 CDD:214470 3/10 (30%)
LRR 1 60..81 5/35 (14%)
LRR_8 63..143 CDD:290566 20/96 (21%)
leucine-rich repeat 64..84 CDD:275378 6/34 (18%)
LRR 2 84..105 5/20 (25%)
leucine-rich repeat 85..132 CDD:275378 13/48 (27%)
LRR 3 108..129 5/22 (23%)
LRR_8 131..>176 CDD:290566 7/47 (15%)
LRR_4 131..172 CDD:289563 7/43 (16%)
LRR 4 132..153 4/20 (20%)
leucine-rich repeat 133..156 CDD:275378 4/22 (18%)
LRR 5 156..177 2/23 (9%)
leucine-rich repeat 157..180 CDD:275378 5/26 (19%)
leucine-rich repeat 181..205 CDD:275378 6/25 (24%)
TPKR_C2 201..>241 CDD:301599 10/41 (24%)
Ig 258..346 CDD:299845 27/103 (26%)
IG_like 268..346 CDD:214653 27/93 (29%)
FN3 432..502 CDD:214495
LRR 6 526..549
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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