DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam4 and IGSF9B

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_001264214.1 Gene:IGSF9B / 22997 HGNCID:32326 Length:1437 Species:Homo sapiens


Alignment Length:1313 Identity:262/1313 - (19%)
Similarity:445/1313 - (33%) Gaps:441/1313 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   335 QPQVQTVDVDKDAQFQCIVSGHPV------HDVNWLHDGKPI-------LRDNRVE-------IL 379
            :|:..|....:....:|.|. |||      :.|.|...|.||       .....|:       .|
Human    29 EPEFVTARAGESVVLRCDVI-HPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92

  Fly   380 TDPPRLIIKKVQKEDPGMYQC-----------FVSNEWEQIQSTAELQLGDASPELLYWFSEQTL 433
            .|...|.:::|:.||.|.|:|           |.:..|..:...|.....:..|:.:      ..
Human    93 HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYI------EA 151

  Fly   434 QPGPTVSLKCVATGNPLPQFTWSLDGFPIPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYT 498
            :.|.::::.|.|.|||.|..||..:|..:..|.::.|..         ..:.:::|..||.|.||
Human   152 KEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSD---------GSLTVTSVSREDRGAYT 207

  Fly   499 CTAQNAIGKVSHSAKVNIYGLPYIREMPK-ITGISGSDLIVKCPVAGYP----------IDKIHW 552
            |.|.:..|:..|:..:.:.|.|:|...|: ||.....|.::.|....||          .:.:::
Human   208 CRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYF 272

  Fly   553 ERDGQTLPINRRQRAYNNGTLIIEQLQRLEDAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQ 617
            :.|     :..|.|...:|||||.:: :.||:|.|||:..|...::...:..:.|..|.:::   
Human   273 QND-----LKLRVRILIDGTLIIFRV-KPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVL--- 328

  Fly   618 AMTNM-----LREGMRAAISCQILEGDLPVS-FRWERNGKPLIGTGNEVFRRLDEYSASLVIEHI 676
               ||     :..|:...|.|.: :.:.|.: .:|.::|:||....|..:..:::  .|:.||..
Human   329 ---NMPPVIYVPVGIHGYIRCPV-DAEPPATVVKWNKDGRPLQVEKNLGWTLMED--GSIRIEEA 387

  Fly   677 SSDHSGNYTCIASNVAGTERFTVP--LTVNVPPKWILEPK-DSSAQAGADVLLHCQSSGYPTPTI 738
            :.:..|.|||:..|..||...:.|  |.:..||.:.:.|. :...:||.::|:.|.::|.|.|.|
Human   388 TEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVI 452

  Fly   739 TWKKAIGPTPGEYKDFLYEPTVQLFPNGTIFFKKISKESQGHFLCEAKNNIGSGVSKVIFLKVNV 803
            ||:|...|:..::         ...|:|::.|:.:|||..|.:.|.|.|.:.|         :..
Human   453 TWRKVGKPSRSKH---------SALPSGSLQFRALSKEDHGEWECVATNVVTS---------ITA 499

  Fly   804 PAHFQTKTKQISVAKGKQVHVQCNVQGDNPIDFKWKIQATQQYLDESLDSRYTIRDQVLDDGMVS 868
            ..|                                                            ::
Human   500 STH------------------------------------------------------------LT 504

  Fly   869 ELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQEVPEQPKNLRINSQQSRSLQLTWSQPFAGN 933
            .:|.|                                |..|.::|:....: :..::|...:.|.
Human   505 VIGTS--------------------------------PHAPGSVRVQVSMT-TANVSWEPGYDGG 536

  Fly   934 SPIEEYHIYYKQISDIW----QNAEH----LTIAGAQTVINIQQLRPAKAYHIRMSAENKLGASE 990
                     |:|...:|    |...|    |.:....:.:.:..|.|..||...:.|:||||.|.
Human   537 ---------YEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSA 592

  Fly   991 FSEVVQVTTLE-EVPSGPPLAVRAEP------KSSTEIFVTWDAPERDHWNGI---LLGYYVGYQ 1045
            |||||.|.||. .:.:..||.:...|      ::...:.::| .|..:|...|   ::.:.|..:
Human   593 FSEVVTVNTLAFPITTPEPLVLVTPPRCLIANRTQQGVLLSW-LPPANHSFPIDRYIMEFRVAER 656

  Fly  1046 MSLTPEDKEVNPTQGFSFKTVEVRSHFGGETVLANLNKFTQYHVIVQAYTSQGSGPPSKEIAVQT 1110
            ..|.  |..:..|:              ||....:|::.|.|...|.|........||....|.:
Human   657 WELL--DDGIPGTE--------------GEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSS 705

  Fly  1111 MEDVP-------------------------------------------------SSPP------- 1119
            .:..|                                                 ..||       
Human   706 TDIFPQPDLTEDGLARPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCR 770

  Fly  1120 ---ESP-QCDVLGSTSIYITWSPPDIDGQNGKIKGYKVFYISVDELYETDPEVVKSTNQYVTIEN 1180
               ||| ....:...||....:|.:.....|:....::    :....|.:..:.|.|.:.:   :
Human   771 KSLESPLSSGKVSPESIRTLRAPSESSDDQGQPAAKRM----LSPTREKELSLYKKTKRAI---S 828

  Fly  1181 LRKYT--------NYTVWVLAYTKVGDG------------MKTK-----PFYCRT---------- 1210
            .:||:        ..|..:...::..||            :|::     ||...|          
Human   829 SKKYSVAKAEAEAEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGFPFAEETDMYPEFRQSD 893

  Fly  1211 --HED--VPSAPQAIKA--IPASSSKIIISWLPPDL------PNGDITGYTFYMSMLEG-GREEG 1262
              :||  ||::..|:|:  .|.|||:  .|:|||..      |.|           ||| |..||
Human   894 EENEDPLVPTSVAALKSQLTPLSSSQ--ESYLPPPAYSPRFQPRG-----------LEGPGGLEG 945

  Fly  1263 THKRLLGPFVEMHETVRTQESATYQFWLTASTKMGEGEKTQVVTVPPNNKVPARIVSFSQRIVTP 1327
               ||...........|......|..:|::|:. ||.|       ||...||        .:.:|
Human   946 ---RLQATGQARPPAPRPFHHGQYYGYLSSSSP-GEVE-------PPPFYVP--------EVGSP 991

  Fly  1328 WKEHLELPCRKVGAPAPV-------TIWRQDGHNMETSARKTIAKNGTLYMKECQASDAGNYTCS 1385
            ....:..|      |.|.       ||..::|.|         |.|.||.:.:.......     
Human   992 LSSVMSSP------PLPTEGPFGHPTIPEENGEN---------ASNSTLPLTQTPTGGRS----- 1036

  Fly  1386 VENTWGKDEIVY-----------------NIVVKVPPEA--------PNLTVINAYTDSLLLE-- 1423
             ...||:.|..:                 ::...:.|:|        .:|.|..||...|.||  
Human  1037 -PEPWGRPEFPFGGLETPAMMFPHQLPPCDVPESLQPKAGLPRGLPPTSLQVPAAYPGILSLEAP 1100

  Fly  1424 --WMDNSHGGSPI 1434
              |...|.|..|:
Human  1101 KGWAGKSPGRGPV 1113

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353
Ig strand C' 276..279 CDD:409353
Ig strand D 285..289 CDD:409353
Ig strand E 292..298 CDD:409353
Ig strand F 305..313 CDD:409353
Ig strand G 316..326 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549 25/112 (22%)
Ig strand B 347..351 CDD:409549 0/3 (0%)
Ig strand C 360..364 CDD:409549 1/3 (33%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 2/15 (13%)
Ig strand G 410..413 CDD:409549 0/2 (0%)
IgI_4_Dscam 422..516 CDD:409548 23/93 (25%)
Ig strand B 439..443 CDD:409548 0/3 (0%)
Ig strand C 452..456 CDD:409548 1/3 (33%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 3/4 (75%)
Ig strand G 509..512 CDD:409548 1/2 (50%)
IgI_5_Dscam 520..607 CDD:409550 24/97 (25%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 0/3 (0%)
Ig strand E 571..575 CDD:409550 3/3 (100%)
Ig strand F 586..591 CDD:409550 3/4 (75%)
Ig strand G 600..603 CDD:409550 0/2 (0%)
Ig 610..703 CDD:416386 24/100 (24%)
Ig strand A 611..613 CDD:409353 0/1 (0%)
Ig strand A' 620..624 CDD:409353 2/8 (25%)
Ig strand B 627..636 CDD:409353 2/8 (25%)
Ig strand C 641..648 CDD:409353 2/7 (29%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 2/6 (33%)
Ig strand F 682..690 CDD:409353 4/7 (57%)
Ig strand G 693..702 CDD:409353 3/10 (30%)
IgI_7_Dscam 706..801 CDD:409546 26/95 (27%)
Ig strand B 724..728 CDD:409546 1/3 (33%)
Ig strand C 737..741 CDD:409546 2/3 (67%)
Ig strand E 766..770 CDD:409546 1/3 (33%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 0/2 (0%)
Ig 818..904 CDD:416386 2/85 (2%)
putative Ig strand B 820..827 CDD:409353 0/6 (0%)
putative Ig strand C 835..841 CDD:409353 0/5 (0%)
putative Ig strand C' 853..856 CDD:409353 0/2 (0%)
putative Ig strand D 862..866 CDD:409353 0/3 (0%)
putative Ig strand E 868..874 CDD:409353 1/5 (20%)
putative Ig strand F 881..889 CDD:409353 0/7 (0%)
putative Ig strand G 892..902 CDD:409353 0/9 (0%)
FN3 906..999 CDD:238020 27/100 (27%)
FN3 1006..1110 CDD:238020 21/112 (19%)
fn3 1117..1203 CDD:394996 17/116 (15%)
FN3 1215..1307 CDD:238020 28/100 (28%)
Ig <1334..1401 CDD:416386 14/90 (16%)
Ig strand C 1345..1349 CDD:409353 2/10 (20%)
Ig strand D 1363..1366 CDD:409353 1/2 (50%)
Ig strand E 1367..1372 CDD:409353 2/4 (50%)
Ig strand F 1380..1388 CDD:409353 0/7 (0%)
Ig strand G 1394..1401 CDD:409353 1/23 (4%)
FN3 1405..1494 CDD:238020 13/42 (31%)
FN3 1499..1580 CDD:238020
IGSF9BNP_001264214.1 IG_like 30..115 CDD:214653 22/85 (26%)
Ig 41..115 CDD:143165 20/74 (27%)
I-set 139..225 CDD:254352 23/100 (23%)
IGc2 153..210 CDD:197706 19/65 (29%)
I-set 229..321 CDD:254352 24/97 (25%)
Ig 235..321 CDD:299845 22/91 (24%)
IG_like 331..414 CDD:214653 20/85 (24%)
Ig <353..414 CDD:299845 17/62 (27%)
IG_like 426..505 CDD:214653 25/156 (16%)
Ig 442..505 CDD:299845 21/140 (15%)
FN3 510..601 CDD:238020 27/100 (27%)
FN3 617..699 CDD:238020 17/98 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 758..817 10/62 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 911..1081 46/222 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.