DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and Iglon5

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_001157990.1 Gene:Iglon5 / 210094 MGIID:2686277 Length:336 Species:Mus musculus


Alignment Length:483 Identity:89/483 - (18%)
Similarity:142/483 - (29%) Gaps:189/483 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   263 PVPTYRWFKEENEQLLPLQLSERITIVSAGLLKITKARLEDSGKYLCWVNNTAGEETIQVSLTVT 327
            |.|..|.      :||.......:.::|.|||                          ..||..:
Mouse     4 PAPGARL------RLLAAAALAGLAVISRGLL--------------------------SQSLEFS 36

  Fly   328 APLTAHLQPQVQTVDVDKDAQFQCIVSGHPVHDVNWLHDGKPILRDN-------RVEILTDPPR- 384
            :|...:      ||....:|...|.:..| |..|.||:....:...|       ||.:|.:.|. 
Mouse    37 SPADNY------TVCEGDNATLSCFIDEH-VTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEE 94

  Fly   385 --LIIKKVQKEDPGMYQCFVSNEWEQIQSTAELQLGDASPELLYWFSEQTLQPGPTVSLKCVATG 447
              ::|.:|...|.|:|.|..... .|..:|....:......::...|...:..|..|:|.|:|.|
Mouse    95 FSILITQVGLGDEGLYTCSFQTR-HQPYTTQVYLIVHVPARIVNISSPVAVNEGGNVNLLCLAVG 158

  Fly   448 NPLPQFTWS--LDGFPIPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSH 510
            .|.|..||.  .|||              |...:::   .||:::....|||.|...|.:.....
Mouse   159 RPEPTVTWRQLRDGF--------------TSEGEIL---EISDIQRGQAGEYECVTHNGVNSAPD 206

  Fly   511 SAKVNIYGLPYIREMPKITGIS------GSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQRAYN 569
            |.:|    |..:...|.||.::      |...:::|.....|.....|.:|              
Mouse   207 SRRV----LVTVNYPPTITDVTSARTALGRAALLRCEAMAVPPADFQWYKD-------------- 253

  Fly   570 NGTLIIEQLQRLEDAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQ 634
                     .||..:|:    |:..:.||.|..                                
Mouse   254 ---------DRLLSSGS----AEGLKVQTERTR-------------------------------- 273

  Fly   635 ILEGDLPVSFRWERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIASNVAGTERFTV 699
                                              :.|:..::|:.|.|||||.|:|..|....::
Mouse   274 ----------------------------------SMLLFANVSARHYGNYTCRAANRLGASSASM 304

  Fly   700 -----------------PLTVNVPPKWI 710
                             |||:.....|:
Mouse   305 RLLRPGSLENSAPRPPGPLTLLSALSWL 332

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386 11/62 (18%)
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353 1/4 (25%)
Ig strand C' 276..279 CDD:409353 1/2 (50%)
Ig strand D 285..289 CDD:409353 0/3 (0%)
Ig strand E 292..298 CDD:409353 3/5 (60%)
Ig strand F 305..313 CDD:409353 0/7 (0%)
Ig strand G 316..326 CDD:409353 2/9 (22%)
IgC2_3_Dscam 329..417 CDD:409549 23/97 (24%)
Ig strand B 347..351 CDD:409549 1/3 (33%)
Ig strand C 360..364 CDD:409549 1/3 (33%)
Ig strand E 383..387 CDD:409549 1/6 (17%)
Ig strand F 397..402 CDD:409549 2/4 (50%)
Ig strand G 410..413 CDD:409549 0/2 (0%)
IgI_4_Dscam 422..516 CDD:409548 24/95 (25%)
Ig strand B 439..443 CDD:409548 2/3 (67%)
Ig strand C 452..456 CDD:409548 1/3 (33%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 3/4 (75%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 15/92 (16%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 0/3 (0%)
Ig strand E 571..575 CDD:409550 0/3 (0%)
Ig strand F 586..591 CDD:409550 0/4 (0%)
Ig strand G 600..603 CDD:409550 1/2 (50%)
Ig 610..703 CDD:416386 13/109 (12%)
Ig strand A 611..613 CDD:409353 0/1 (0%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 0/8 (0%)
Ig strand C 641..648 CDD:409353 0/6 (0%)
Ig strand C' 650..652 CDD:409353 0/1 (0%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 1/6 (17%)
Ig strand F 682..690 CDD:409353 6/7 (86%)
Ig strand G 693..702 CDD:409353 2/25 (8%)
IgI_7_Dscam 706..801 CDD:409546 1/5 (20%)
Ig strand B 724..728 CDD:409546
Ig strand C 737..741 CDD:409546
Ig strand E 766..770 CDD:409546
Ig strand F 780..785 CDD:409546
Ig strand G 794..797 CDD:409546
Ig 818..904 CDD:416386
putative Ig strand B 820..827 CDD:409353
putative Ig strand C 835..841 CDD:409353
putative Ig strand C' 853..856 CDD:409353
putative Ig strand D 862..866 CDD:409353
putative Ig strand E 868..874 CDD:409353
putative Ig strand F 881..889 CDD:409353
putative Ig strand G 892..902 CDD:409353
FN3 906..999 CDD:238020
FN3 1006..1110 CDD:238020
fn3 1117..1203 CDD:394996
FN3 1215..1307 CDD:238020
Ig <1334..1401 CDD:416386
Ig strand C 1345..1349 CDD:409353
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
Iglon5NP_001157990.1 Ig 41..129 CDD:416386 22/95 (23%)
Ig strand A' 41..46 CDD:409353 2/10 (20%)
Ig strand B 48..56 CDD:409353 2/7 (29%)
CDR1 56..60 CDD:409353 1/4 (25%)
FR2 61..68 CDD:409353 3/6 (50%)
Ig strand C 61..67 CDD:409353 2/5 (40%)
CDR2 69..79 CDD:409353 1/9 (11%)
Ig strand C' 71..74 CDD:409353 0/2 (0%)
Ig strand C' 76..79 CDD:409353 1/2 (50%)
FR3 80..115 CDD:409353 10/34 (29%)
Ig strand D 84..91 CDD:409353 3/6 (50%)
Ig strand E 94..100 CDD:409353 0/5 (0%)
Ig strand F 107..115 CDD:409353 3/7 (43%)
CDR3 116..120 CDD:409353 0/4 (0%)
Ig strand G 120..129 CDD:409353 1/8 (13%)
FR4 122..129 CDD:409353 1/6 (17%)
Ig strand A 132..137 CDD:409353 0/4 (0%)
Ig_3 134..199 CDD:404760 21/81 (26%)
Ig strand A' 140..145 CDD:409353 1/4 (25%)
Ig strand B 148..157 CDD:409353 3/8 (38%)
Ig strand C 163..167 CDD:409353 1/3 (33%)
Ig strand D 174..177 CDD:409353 1/2 (50%)
Ig strand E 178..183 CDD:409353 0/7 (0%)
Ig strand F 191..199 CDD:409353 4/7 (57%)
Ig_3 217..295 CDD:404760 24/170 (14%)
putative Ig strand A 218..224 CDD:409353 3/5 (60%)
Ig strand B 234..238 CDD:409353 0/3 (0%)
Ig strand C 247..251 CDD:409353 0/3 (0%)
Ig strand E 274..278 CDD:409353 1/3 (33%)
Ig strand F 288..293 CDD:409353 4/4 (100%)
Ig strand G 301..304 CDD:409353 0/2 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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