DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and egl-15

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_001300356.1 Gene:egl-15 / 181291 WormBaseID:WBGene00001184 Length:1153 Species:Caenorhabditis elegans


Alignment Length:1129 Identity:202/1129 - (17%)
Similarity:354/1129 - (31%) Gaps:370/1129 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   329 PLTAHLQPQVQTVDVDKDAQFQCIVSGHPVHD-VNWLHDGKPILRDNRVE---ILTDPPRLI--I 387
            |...|:..:...|.:..:.:|.|..:...:.. |.|..:.| :|::::::   |..|..|::  :
 Worm    33 PRFKHVANERYEVFLGDEIKFDCQTAASKISAFVEWYRNDK-LLKNDQIDKDKIRKDNNRMMLHL 96

  Fly   388 KKVQKEDPGMYQCFVSNEWEQIQSTAELQLGDASPELLYWFSEQTLQPG---PTVSLKCV----- 444
            |.:...|.|::.|.|.|.:.||.....:::.|        |.:..|.|.   ..:.::||     
 Worm    97 KNIDVSDQGLWSCRVHNAYGQISRNFTVEVID--------FCDYFLFPDIHHLNIPMECVCLWKY 153

  Fly   445 -------------ATG---------------NPLPQF----------------TWSLDGFPIPDS 465
                         .||               .|||..                .:.|.|.|..|.
 Worm   154 NKEAKRSDVNYAAVTGEVCSKYASRMINRARKPLPMIPCFGDHCKEFDTTPVSDFGLPGKPEDDP 218

  Fly   466 SRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGL----------- 519
               ||.:.|...||||..|:.|   ||...|......||..|.:...:...|.:           
 Worm   219 ---LVKRVVLKKDDVIVPVHDS---EESPSESRTEFINADEKENKEDEEEDYSVSQPVAPDAGLT 277

  Fly   520 ---------PYIREMPKITGI-------SGSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQRA- 567
                     ||.:....|...       :|..|.:.|...|||..:|.|.::|:.|..:..:.. 
 Worm   278 ELNITAEEPPYFKSNDNIVLFNETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGG 342

  Fly   568 ----YNNGTLIIEQLQRLEDAGTYTCMAQNKQKQTSRRNVEIQVLV------PPKIMPIQAMTNM 622
                :|..:|.:|... :.|:|.:.|.|.||.....:   ...|::      ||.|:|.......
 Worm   343 YEFKFNRWSLEVEDAV-VADSGEFHCEALNKVGSAKK---YFHVIIVNRMRRPPIIVPNILANQS 403

  Fly   623 LREGMRAAISCQILEGDLPVSFRWERNGKPLIGTGNEVFRRLDEY-------------------- 667
            :.....|...|:::...|| ...|.|..| :.|:.:......:||                    
 Worm   404 VNINDTATFHCKVVSDLLP-HIIWVRINK-INGSYSYYNNSAEEYMFNYTEMDTFDKAHVHHVGD 466

  Fly   668 SASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTVNVPPKWILEPKDSSAQAGADVLLHCQSSG 732
            .::|.|.::|.|..|.|.|::.|..|.......||||.                           
 Worm   467 ESTLTIFNVSLDDQGIYACLSGNSLGMSMANATLTVNE--------------------------- 504

  Fly   733 YPTPTITWKKAIGPTPGEYKDFLYEPTVQLFPNGTIFFKKISKESQGHFLCEAKNNIGSGVSKVI 797
                    ..||....|:      ||.:..:......|..|..     ||..|....|     ::
 Worm   505 --------FMAIHLLTGD------EPKIDRWTTSDYIFTTILL-----FLLLAATLFG-----IL 545

  Fly   798 FLKVNVPAH---FQTKTKQISVAKGKQVHVQ---CNVQGDNPID--FKWKIQ-----ATQQYLDE 849
            |:......|   |...|..: ||:.|:|.|.   .|...:|..|  ..::||     .|::....
 Worm   546 FMVCKQTLHKKGFMDDTVGL-VARKKRVVVSKRPMNEDNENSDDEPSPYQIQIIETPITKKEAAR 609

  Fly   850 SLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQ-----------DEMSIQLIVQ 903
            ....|....:.||.:..|....:....|....:.......|||:           :|:::.:   
 Worm   610 KQRKRMNSENTVLSEYEVDSDPVWEVERSKLSLVHMLGEGAFGEVWKATYKETENNEIAVAV--- 671

  Fly   904 EVPEQPKNLRINSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQISDIWQNAEHLTIAGAQT----- 963
                  |.|::::.:...:.|.        |.:|.:.:       |.::...|.:.|..|     
 Worm   672 ------KKLKMSAHEKELIDLV--------SEMETFKV-------IGEHENVLRLIGCCTGAGPL 715

  Fly   964 --VINI---QQLRPAKAYHIRMSAENKLGASEFSEVVQVTTLEEVPSGPPLAVRAEPKSSTEIFV 1023
              |:.:   ..||.....|.....:.|..:.|.::.::..             :|..|...|:. 
 Worm   716 YVVVELCKHGNLRDFLRAHRPKEEKAKKSSQELTDYLEPR-------------KASDKDDIELI- 766

  Fly  1024 TWDAPERDHWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGETVLANLNKF---- 1084
                |.....:.:...:.|...|:.....|.::       :.:..|:...|:..:..::.|    
 Worm   767 ----PNLTQRHLVQFAWQVAQGMNFLASKKIIH-------RDLAARNVLVGDGHVLKISDFGLSR 820

  Fly  1085 ----TQYHVIVQAYTSQGSGP-PSKEIAVQTMEDVPSSPPESPQCDV------------LGSTSI 1132
                ..|      |..:|:|. |.|.:|::.::    |...:.:.||            ||.|. 
 Worm   821 DVHCNDY------YRKRGNGRLPIKWMALEALD----SNVYTVESDVWSYGVLLWEIMTLGGTP- 874

  Fly  1133 YITWSPPDIDGQNGKIKGYKVFYISVDELYETDP-----------------EVVKSTNQYVTIEN 1180
            |.|.:.|::             |.::.|.|..:|                 |.::....:.||  
 Worm   875 YPTIAMPEL-------------YANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTI-- 924

  Fly  1181 LRKYTNYTVWVLAYTK---VGDGMKTKPFYC------------------RTHE------DVPSAP 1218
                .:|..|:|..|.   .|.......|:.                  |.|.      ::||.|
 Worm   925 ----VDYLDWMLTMTNETIEGSQEFNDQFFSERSTASGPVSPMESFQKKRKHRPLSAPVNLPSEP 985

  Fly  1219 QAIKAIPASSSKIIISWLPPDLPN 1242
            |........|:   .|..||:.||
 Worm   986 QHTICDDYESN---FSVEPPNDPN 1006

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353
Ig strand C' 276..279 CDD:409353
Ig strand D 285..289 CDD:409353
Ig strand E 292..298 CDD:409353
Ig strand F 305..313 CDD:409353
Ig strand G 316..326 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549 20/93 (22%)
Ig strand B 347..351 CDD:409549 1/3 (33%)
Ig strand C 360..364 CDD:409549 1/4 (25%)
Ig strand E 383..387 CDD:409549 1/5 (20%)
Ig strand F 397..402 CDD:409549 1/4 (25%)
Ig strand G 410..413 CDD:409549 0/2 (0%)
IgI_4_Dscam 422..516 CDD:409548 29/145 (20%)
Ig strand B 439..443 CDD:409548 0/3 (0%)
Ig strand C 452..456 CDD:409548 0/19 (0%)
Ig strand E 482..486 CDD:409548 1/3 (33%)
Ig strand F 496..501 CDD:409548 1/4 (25%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 22/98 (22%)
Ig strand B 536..540 CDD:409550 1/3 (33%)
Ig strand C 549..553 CDD:409550 1/3 (33%)
Ig strand E 571..575 CDD:409550 1/3 (33%)
Ig strand F 586..591 CDD:409550 1/4 (25%)
Ig strand G 600..603 CDD:409550 0/2 (0%)
Ig 610..703 CDD:416386 24/112 (21%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 2/8 (25%)
Ig strand C 641..648 CDD:409353 2/6 (33%)
Ig strand C' 650..652 CDD:409353 0/1 (0%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 2/6 (33%)
Ig strand F 682..690 CDD:409353 3/7 (43%)
Ig strand G 693..702 CDD:409353 1/8 (13%)
IgI_7_Dscam 706..801 CDD:409546 12/94 (13%)
Ig strand B 724..728 CDD:409546 0/3 (0%)
Ig strand C 737..741 CDD:409546 0/3 (0%)
Ig strand E 766..770 CDD:409546 0/3 (0%)
Ig strand F 780..785 CDD:409546 2/4 (50%)
Ig strand G 794..797 CDD:409546 0/2 (0%)
Ig 818..904 CDD:416386 18/106 (17%)
putative Ig strand B 820..827 CDD:409353 3/9 (33%)
putative Ig strand C 835..841 CDD:409353 1/7 (14%)
putative Ig strand C' 853..856 CDD:409353 1/2 (50%)
putative Ig strand D 862..866 CDD:409353 1/3 (33%)
putative Ig strand E 868..874 CDD:409353 0/5 (0%)
putative Ig strand F 881..889 CDD:409353 0/7 (0%)
putative Ig strand G 892..902 CDD:409353 2/20 (10%)
FN3 906..999 CDD:238020 15/102 (15%)
FN3 1006..1110 CDD:238020 17/112 (15%)
fn3 1117..1203 CDD:394996 21/117 (18%)
FN3 1215..1307 CDD:238020 10/28 (36%)
Ig <1334..1401 CDD:416386
Ig strand C 1345..1349 CDD:409353
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
egl-15NP_001300356.1 IG_like 41..126 CDD:214653 18/85 (21%)
Ig 47..126 CDD:299845 17/79 (22%)
Ig 302..382 CDD:299845 19/83 (23%)
IG_like 306..384 CDD:214653 20/81 (25%)
IG_like 401..502 CDD:214653 20/102 (20%)
Ig3_FGFR 407..503 CDD:143175 21/97 (22%)
PKc_like 627..933 CDD:304357 56/384 (15%)
Pkinase_Tyr 640..928 CDD:285015 52/366 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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