DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam4 and him-4

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_001024582.1 Gene:him-4 / 181187 WormBaseID:WBGene00001863 Length:5198 Species:Caenorhabditis elegans


Alignment Length:2133 Identity:454/2133 - (21%)
Similarity:719/2133 - (33%) Gaps:644/2133 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 VEFSNNSGGLIECSGHGSPPPEVEWT----PIPPQQDMVFQLSNGSMMFYPFTAEKYRHEVHATV 102
            :|.:.....::.|...|:|.|..:|.    .:|  ::.||..:|.:::....|  ||    |..|
 Worm  1925 LEINEGEEIILTCDAEGNPTPTAKWDFNQGDLP--KEAVFVNNNHTVVVNNVT--KY----HTGV 1981

  Fly   103 YRCKLRNLVG-TVLSREVHVR-------GVVNQKYAVQVHDEYVMTGNTAVLKCQVPSYMSEFVL 159
            |:|...|.|| .|.:..||||       |:...:..|.:       ..:..|:|.|...:...: 
 Worm  1982 YKCYATNKVGQAVKTINVHVRTKPRFESGLTESELTVNL-------TRSITLECDVDDAIGVGI- 2038

  Fly   160 VTAWVQDTGMHLYPNTDIGGKYTVLSNGELYINNAGPNDAYKSYTCRTVNRLTGEVQISTYPGRI 224
              :|..: |......||  |..|:.....|:|.:|..:| :.||.|    .:|.|..::|....:
 Worm  2039 --SWTVN-GKPFLAETD--GVQTLAGGRFLHIVSAKTDD-HGSYAC----TVTNEAGVATKTFNL 2093

  Fly   225 IVTEPKGMVQPRINVEKHSMRHVVLNGQTTLPCIAQGHPVPTYRWFKEENEQLLPLQLSERITIV 289
            .|..|     |.| |.:.....|:.|....|||...|.|.|...|.|:..    |:...:.:.::
 Worm  2094 FVQVP-----PTI-VNEGGEYTVIENNSLVLPCEVTGKPNPVVTWTKDGR----PVGDLKSVQVL 2148

  Fly   290 SAG-LLKITKARLEDSGKYLCWVNNTAGEETIQVSLTV---TAPLTAHLQPQVQTVDVDKDAQFQ 350
            |.| ..||..|.:...|.|:|...|..|  |.::|..|   |.|:.......:.|........|:
 Worm  2149 SEGQQFKIVHAEIAHKGSYICMAKNDVG--TAEISFDVDIITRPMIQKGIKNIVTAIKGGALPFK 2211

  Fly   351 CIVSGHPVHD-------VNWLHDGKPI---LRDNRVEILTDPPRLIIKKVQKEDPGMYQCFVSNE 405
            |     |:.|       :.||.:.:||   ..|.|:..|::..||.|..|.:.|.|.|.|.|.| 
 Worm  2212 C-----PIDDDKNFKGQIIWLRNYQPIDLEAEDARITRLSNDRRLTILNVTENDEGQYSCRVKN- 2270

  Fly   406 WEQIQSTAELQLGDASPELLYWFSE---QTLQPGPTVSLKCVATGNPLPQFTWSLDGFPIPDSSR 467
             :..:::.:.:.....|..:....:   :|.....||:|.|.|||.|.|..||..||..|     
 Worm  2271 -DAGENSFDFKATVLVPPTIIMLDKDKNKTAVEHSTVTLSCPATGKPEPDITWFKDGEAI----- 2329

  Fly   468 FLVGQYVTIHDDVI-------SHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLP----- 520
                 ::....|:|       :.:.|:.:||.|.|:|||.|.|:.|.|.....||:..:|     
 Worm  2330 -----HIENIADIIPNGELNGNQLKITRIKEGDAGKYTCEADNSAGSVEQDVNVNVITIPKIEKD 2389

  Fly   521 --------------------YIREMPKITGISG-----SDLIVK--------------------- 539
                                |.|...|||.:..     ||..||                     
 Worm  2390 GIPSDYESQQNERVVISCPVYARPPAKITWLKAGKPLQSDKFVKTSANGQKLYLFKLRETDSSKY 2454

  Fly   540 ---------------------------------------------CPVAGYPIDKIHWERDGQTL 559
                                                         ||..|.|...|.|.:||..:
 Worm  2455 TCIATNEAGTDKRDFKVSMLVAPSFDEPNIVRRITVNSGNPSTLHCPAKGSPSPTITWLKDGNAI 2519

  Fly   560 PINRRQRAYNNGTLIIEQLQRLE--DAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNM 622
            ..|.|...::.|..:  |:.:.|  |.|.|||:|.|........|. ::|::||.|...:.....
 Worm  2520 EPNDRYVFFDAGRQL--QISKTEGSDQGRYTCIATNSVGSDDLENT-LEVIIPPVIDGERREAVA 2581

  Fly   623 LREGMRAAISCQILEGDLPVSFRWERNGKPLIGTGNEVFRRLDEY----SASLVIEHISS--DHS 681
            :.||..:.:.|.  .....|...|:::|.    |.|:...|.|.:    |:...:..:|:  ..|
 Worm  2582 VIEGFSSELFCD--SNSTGVDVEWQKDGL----TINQDTLRGDSFIQIPSSGKKMSFLSARKSDS 2640

  Fly   682 GNYTCIASNVAGTERFTVPLTVNVPPKWILEPKDSSAQAGA-----DVLLHCQSSGYPTPTITW- 740
            |.||||..|.||..|......||.||.  :..:.|||....     .|.::|..||.|.|.:.| 
 Worm  2641 GRYTCIVRNPAGEARKLFDFAVNDPPS--ISDELSSANIQTIVPYYPVEINCVVSGSPHPKVYWL 2703

  Fly   741 --KKAIGPTPGEYKDFLYEPTVQLFPNG-TIFFKKISKESQGHFLCEAKNNIGSGVSKVIFLKVN 802
              .|.:.|....|         :|..|| |:...:...|..|.:.|||:||:|. ..|...::|.
 Worm  2704 FDDKPLEPDSAAY---------ELTNNGETLKIVRSQVEHAGTYTCEAQNNVGK-ARKDFLVRVT 2758

  Fly   803 VPAHFQTKTKQISVAKGKQVHVQCNVQGDNPI-DFKWKIQATQQYLDES-----LDSRYTIRDQV 861
            .|.||:.:.:::....|..:.:.||.:...|: ...|...      |||     :.|:|...::.
 Worm  2759 APPHFEKEREEVVARVGDTMLLTCNAESSVPLSSVYWHAH------DESVQNGVITSKYAANEKT 2817

  Fly   862 LDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQEVP---EQPKNLRINSQQSRSLQ 923
            |:        :::....|.|.|.|.|.|..|..:...:|||.|.|   :|.|...|    ....:
 Worm  2818 LN--------VTNIQLDDEGFYYCTAVNEAGITKKFFKLIVIETPYFLDQQKLYPI----ILGKR 2870

  Fly   924 LTWSQPFAGNSPIEEYHIYYKQISDIWQNAEHLTIAGAQTVINIQQLRPAKAYHIRMS--AENKL 986
            ||......|..|..   |.:.:.......::.:.|.|:..||:    .|.|....|.:  ||||.
 Worm  2871 LTLDCSATGTPPPT---ILFMKDGKRLNESDEVDIIGSTLVID----NPQKEVEGRYTCIAENKA 2928

  Fly   987 GASEFSEVVQVTTLE---------EVPSGPPLAVRAEPKSSTEIFVTW----------DAPERDH 1032
            |.||...:|:|....         ||.:|.||.:....:.::.:.:||          |...:..
 Worm  2929 GRSEKDMMVEVLLPPKLSKEWINVEVQAGDPLTLECPIEDTSGVHITWSRQFGKDGQLDMRAQSS 2993

  Fly  1033 WNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGETVLANLNKFTQYHVIVQAYTSQ 1097
            .:...|     |.|..||||.:       |:..:.|....|.|.|.                   
 Worm  2994 SDKSKL-----YIMQATPEDAD-------SYSCIAVNDAGGAEAVF------------------- 3027

  Fly  1098 GSGPPSKEIAVQTMEDVPSSPPESPQCDVLGSTSIYITWSPPDIDGQNGKIKGYKVFYISVDELY 1162
                   ::.|.|                           ||.|.|.:                :
 Worm  3028 -------QVTVNT---------------------------PPKIFGDS----------------F 3042

  Fly  1163 ETDPEVVKSTNQYVTIENLRKYTNYTVWVLAYTKVGDGMKTKPFYCRTHEDVPSAPQAIKAIPAS 1227
            .| .|:|..|    |:|                          ..||| |.:| .|:        
 Worm  3043 ST-TEIVADT----TLE--------------------------IPCRT-EGIP-PPE-------- 3066

  Fly  1228 SSKIIISWLPPDLPNGDITGYTFYMSMLEGGREEGTHKRLLGPFVEMHETVRTQESATYQFWLTA 1292
                 |||.....|..::.|.|:        ::.....|:        :.::..:...|.  ..|
 Worm  3067 -----ISWFLDGKPILEMPGVTY--------KQGDLSLRI--------DNIKPNQEGRYT--CVA 3108

  Fly  1293 STKMGEGEKTQVVTVPPNNKVPARIVSFSQRIVTPWKEHLELPCRKVGAPAPVTIWRQDGHNMET 1357
            ..|.|..|:...|.:    ..|.|:|..|:.:.........:.|...|.|.||..|.:||....:
 Worm  3109 ENKAGRAEQDTYVEI----SEPPRVVMASEVMRVVEGRQTTIRCEVFGNPEPVVNWLKDGEPYTS 3169

  Fly  1358 SARKTIAKNGTLYMKECQASDAGNYTCSVENTWGKDEIVYNIVVKVPPEAPNLTVINAYTDSLLL 1422
            ...:...|...|:::|...:|.|.|||...|..|:.:...::.|.|||...:        :..:|
 Worm  3170 DLLQFSTKLSYLHLRETTLADGGTYTCIATNKAGESQTTTDVEVLVPPRIED--------EERVL 3226

  Fly  1423 EWMDNS----H---GGSPILGYVINYKRDNGDWEE----LQVDSKTTSHLLTNLWCGTRYQLYIT 1476
            :..:.:    |   .|.|: .|| .:||:..:.|:    |.:.:.|.:.       ..:|.  ..
 Worm  3227 QGKEGNTYMVHCQVTGRPV-PYV-TWKRNGKEIEQFNPVLHIRNATRAD-------EGKYS--CI 3280

  Fly  1477 AYNKIGTGLPCDIVNSYTKGNPPVQPKHS---QMITNNSTSVTCWLD-------SWGDGG----- 1526
            |.|:.||.:...:::.:||   |....|.   .::...|..:.|.:|       ||..||     
 Worm  3281 ASNEAGTAVADFLIDVFTK---PTFETHETTFNIVEGESAKIECKIDGHPKPTISWLKGGRPFNM 3342

  Fly  1527 --------------------CGILYFMIESRVYGRSSW---------------------AVVSNH 1550
                                .|.||..:.:..||.|..                     ||....
 Worm  3343 DNIILSPRGDTLMILKAQRFDGGLYTCVATNSYGDSEQDFKVNVYTKPYIDETIDQTPKAVAGGE 3407

  Fly  1551 I----------PPTERIYTVSDLVPG-------TKYQLKVT-------------AHNNAGSTTAI 1585
            |          .||.......|.||.       ..|.||:.             |.|.||:.|..
 Worm  3408 IILKCPVLGNPTPTVTWKRGDDAVPNDSRHTIVNNYDLKINSVTTEDAGQYSCIAVNEAGNLTTH 3472

  Fly  1586 Y------NFTTLSTQGVIY---NNDHSTPVSHLSD--LPFYANFKLLLPICFSLLMLLALIGAAL 1639
            |      ..|.:...|.:|   .||..|....::.  ||..:.|:...|:.......::..|:.:
 Worm  3473 YAAEVIGKPTFVRKGGNLYEVIENDTITMDCGVTSRPLPSISWFRGDKPVYLYDRYSISPDGSHI 3537

  Fly  1640 FLRKRKLASQARLASSSMSES--------------PSLANLQNKQNRDQQYLAV-------RCNP 1683
            .:.|.||:...:....:.:|:              |.:    :|.|.....||:       .| |
 Worm  3538 TINKAKLSDGGKYICRASNEAGTSDIDLILKILVPPKI----DKSNIIGNPLAIVARTIYLEC-P 3597

  Fly  1684 GTSAPRGS----------NSNDSGSFGKAEGNEYIEDICPYATFQL-NKQTYSESSYSGNVYSGP 1737
            .:..|:..          |..||... .|:.||         ||.: |.|...:..|:....:  
 Worm  3598 ISGIPQPDVIWTKNGMDINMTDSRVI-LAQNNE---------TFGIENVQVTDQGRYTCTATN-- 3650

  Fly  1738 YHSVRGSFVYHDVKPESYHSKEPEYTKVRRKVGRLRDPHSESQESDNPGSTDSEVRKILTLHIPI 1802
                ||....||...:..  ..||:           |.|.........|.|       :||..||
 Worm  3651 ----RGGKASHDFSLDVL--SPPEF-----------DIHGTQPTIKREGDT-------ITLTCPI 3691

  Fly  1803 TEYDTLGSESDNDVS----ARALNSAKYRAQRDTQDETSSSSETTPTSMTRKS 1851
            ...:.: ::...|||    :|||:.       |..|....|.:....::::.|
 Worm  3692 KLAEDI-ADQVMDVSWTKDSRALDG-------DLTDNVDISDDGRKLTISQAS 3736

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386 25/93 (27%)
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353 1/2 (50%)
Ig strand B 48..57 CDD:409353 1/8 (13%)
Ig strand D 75..78 CDD:409353 1/2 (50%)
Ig strand E 83..88 CDD:409353 0/4 (0%)
Ig strand F 101..109 CDD:409353 3/7 (43%)
Ig strand G 112..124 CDD:409353 6/19 (32%)
Ig 235..326 CDD:416386 26/91 (29%)
Ig strand A 235..238 CDD:409353 1/2 (50%)
Ig strand A' 244..248 CDD:409353 0/3 (0%)
Ig strand B 251..258 CDD:409353 2/6 (33%)
Ig strand C 266..271 CDD:409353 1/4 (25%)
Ig strand C' 276..279 CDD:409353 0/2 (0%)
Ig strand D 285..289 CDD:409353 0/3 (0%)
Ig strand E 292..298 CDD:409353 3/6 (50%)
Ig strand F 305..313 CDD:409353 3/7 (43%)
Ig strand G 316..326 CDD:409353 3/9 (33%)
IgC2_3_Dscam 329..417 CDD:409549 23/97 (24%)
Ig strand B 347..351 CDD:409549 1/3 (33%)
Ig strand C 360..364 CDD:409549 1/10 (10%)
Ig strand E 383..387 CDD:409549 2/3 (67%)
Ig strand F 397..402 CDD:409549 2/4 (50%)
Ig strand G 410..413 CDD:409549 0/2 (0%)
IgI_4_Dscam 422..516 CDD:409548 31/103 (30%)
Ig strand B 439..443 CDD:409548 2/3 (67%)
Ig strand C 452..456 CDD:409548 1/3 (33%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 3/4 (75%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 31/184 (17%)
Ig strand B 536..540 CDD:409550 2/69 (3%)
Ig strand C 549..553 CDD:409550 1/3 (33%)
Ig strand E 571..575 CDD:409550 1/3 (33%)
Ig strand F 586..591 CDD:409550 3/4 (75%)
Ig strand G 600..603 CDD:409550 0/2 (0%)
Ig 610..703 CDD:416386 25/98 (26%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 1/8 (13%)
Ig strand C 641..648 CDD:409353 2/6 (33%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 1/6 (17%)
Ig strand F 682..690 CDD:409353 5/7 (71%)
Ig strand G 693..702 CDD:409353 2/8 (25%)
IgI_7_Dscam 706..801 CDD:409546 28/103 (27%)
Ig strand B 724..728 CDD:409546 1/3 (33%)
Ig strand C 737..741 CDD:409546 1/6 (17%)
Ig strand E 766..770 CDD:409546 2/4 (50%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 1/2 (50%)
Ig 818..904 CDD:416386 21/91 (23%)
putative Ig strand B 820..827 CDD:409353 0/6 (0%)
putative Ig strand C 835..841 CDD:409353 1/5 (20%)
putative Ig strand C' 853..856 CDD:409353 1/2 (50%)
putative Ig strand D 862..866 CDD:409353 1/3 (33%)
putative Ig strand E 868..874 CDD:409353 0/5 (0%)
putative Ig strand F 881..889 CDD:409353 4/7 (57%)
putative Ig strand G 892..902 CDD:409353 2/9 (22%)
FN3 906..999 CDD:238020 25/97 (26%)
FN3 1006..1110 CDD:238020 19/113 (17%)
fn3 1117..1203 CDD:394996 10/85 (12%)
FN3 1215..1307 CDD:238020 15/91 (16%)
Ig <1334..1401 CDD:416386 18/66 (27%)
Ig strand C 1345..1349 CDD:409353 1/3 (33%)
Ig strand D 1363..1366 CDD:409353 0/2 (0%)
Ig strand E 1367..1372 CDD:409353 1/4 (25%)
Ig strand F 1380..1388 CDD:409353 4/7 (57%)
Ig strand G 1394..1401 CDD:409353 0/6 (0%)
FN3 1405..1494 CDD:238020 17/99 (17%)
FN3 1499..1580 CDD:238020 28/166 (17%)
him-4NP_001024582.1 IG_like 442..515 CDD:214653
IG 527..605 CDD:214652
Ig 628..694 CDD:319273
I-set 702..789 CDD:369462
I-set 793..881 CDD:369462
Ig 899..974 CDD:386229
I-set 1012..1081 CDD:369462
Ig 1109..1172 CDD:319273
Ig 1196..1263 CDD:319273
IG_like 1277..1358 CDD:214653
I-set 1373..1450 CDD:369462
Ig 1474..1544 CDD:386229
IGc2 1563..1628 CDD:197706
Ig 1651..1732 CDD:386229
Ig 1755..1818 CDD:319273
Ig 1839..1912 CDD:386229
Ig 1930..2002 CDD:386229 22/79 (28%)
IG_like 2014..2095 CDD:214653 20/98 (20%)
Ig 2094..2182 CDD:386229 27/99 (27%)
Ig 2190..2283 CDD:386229 23/99 (23%)
I-set 2296..2380 CDD:369462 30/93 (32%)
Ig 2384..2471 CDD:386229 10/86 (12%)
IGc2 2492..2556 CDD:197706 20/65 (31%)
Ig 2580..2654 CDD:386229 21/79 (27%)
Ig 2686..2753 CDD:319273 23/76 (30%)
IG_like 2768..2850 CDD:214653 19/95 (20%)
I-set 2854..2939 CDD:369462 24/95 (25%)
IG_like 2951..3031 CDD:214653 20/117 (17%)
I-set 3046..3116 CDD:369462 22/132 (17%)
I-set 3127..3213 CDD:369462 21/85 (25%)
Ig 3217..3292 CDD:386229 17/93 (18%)
I-set 3300..3386 CDD:369462 15/85 (18%)
I-set 3396..3472 CDD:369462 16/75 (21%)
I-set 3481..3569 CDD:369462 15/87 (17%)
I-set 3591..3663 CDD:369462 18/88 (20%)
Ig 3667..3762 CDD:386229 20/96 (21%)
Ig 3775..3848 CDD:386229
Ig 3859..3947 CDD:386229
IGc2 3968..4031 CDD:197706
Ig_3 4045..4119 CDD:372822
Ig_3 4136..4210 CDD:372822
Ig <4262..4314 CDD:386229
Ig 4318..4406 CDD:386229
IG_like 4418..4496 CDD:214653
I-set 4570..4654 CDD:369462
I-set 4752..4836 CDD:369462
EGF_CA 4996..5027 CDD:238011
EGF_CA 5034..5076 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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