DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam4 and syg-1

DIOPT Version :9

Sequence 1:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster
Sequence 2:	NP_001123159.1	Gene:	syg-1 / 180555	WormBaseID:	WBGene00006365	Length:	730	Species:	Caenorhabditis elegans

Alignment Length:	652	Identity:	130/652 - (19%)
Similarity:	221/652 - (33%)	Gaps:	176/652 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   436 GPTVSLKCVATGNPLPQFTWSLDGF--------PIPDSSRFLV------GQYVTIHDDVISHVNI 486
            |.|..|.|.......| ..|..|.|        |:|.:.|:.:      |:|         ::.|
Worm    37 GETAILTCRVEHQQGP-VQWMKDDFGLGTDRDKPLPGNKRYRMVGSAANGEY---------NLEI 91

  Fly   487 SNVKEEDGGEYTC---TAQNAIGKVSHSAKVNIYGLP----YIREMPKITGISGSDLIVKC---- 540
            |||...|..::.|   .:.:|...||..||:.:...|    .::....:..|:|..:...|
Worm    92 SNVTLFDDDDFACQISESDHAKAVVSSKAKLTVLVRPTPPKIVKSHHSLKAIAGDPITQSCLSRK 156

  Fly   541 ----PVAGYPIDK-------IHW--ERDGQTLPINRRQR-------AYNNGTLIIEQ-------- 577
                |..|:.|..       :.|  |...:...|:.:..       |:.|.|..:|:
Worm   157 GKPPPTIGWAIASDEHGKHIVSWLGESRSKFGGIHAKPEISQETVIAHVNETTQVEEGGNNSRED 221

  Fly   578 ------------LQRLEDAGTY-TCMAQ-----NKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLR 624
                        :.|.||...| .|::|     ||.:..|   |::.:...|:|....|....||
Worm   222 SSIYSIMSNLSFIPRPEDDHKYLICISQHMTFPNKIEVDS---VKLSLRYAPQINLTVASKLPLR 283

  Fly   625 EGMRAAISCQILEGDLPVSFRWERNGKPLIGT------GNEVFRRLDEYSASLVIEHIS-SDHSG 682
            |...|.::|.:             |.|||...      ||:   :|.|...:|..|.:. .||:.
Worm   284 ENGSALLACNV-------------NAKPLDNVKISWYKGNQ---KLRETGDTLTFETLKMEDHNR 332

  Fly   683 NYTCIASNVAGTERFTVPLTVNVPPKWILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGPT 747
            :..|.|:|..||.|.::.|.|....:.:...:|.....|.:...||.:...|.|.|.|      |
Worm   333 DIFCEATNEIGTTRGSIKLNVAFGARIMSTSQDKEVNEGDNAFFHCATLANPAPAIFW------T 391

  Fly   748 PGEYKDFLYEPTVQLFPNG-TIFFKKISKESQGHFLCEAKNNIGSGVSKVI---FLKVNVPAHFQ 808
            .|:        :.::..:| .:..:.:....||::.|.|   ...|..|.|   :|.:..|....
Worm   392 RGD--------SDEIIGHGENLTLENVRTWQQGNYNCTA---TVEGFRKQILSHYLHIRGPPTVS 445

  Fly   809 TKTKQISVAKGKQVHVQCNVQG-DNPIDFKWKIQATQQYLDESLDSRYTIRDQVLDDGMVSELGI 872
            .| .::|.:..:...:.|.:.| ....:.:|.:...:...:   :.|.|:.......|..|.|.|
Worm   446 MK-DEVSASLDEATEIICEISGRPKTNNVRWTVNGKEINFN---NGRITVHQYPKPYGKESILKI 506

  Fly   873 SHTYRQDTGIYICQASNAFGQDEMSIQLIVQEVPE------------------------------ 907
            .....:|.|:|.|.|:|..|.|.....|..:.:.:
Worm   507 KDLKEEDFGVYNCSANNGLGFDNRGTLLKKRNILDWIVITAKFDRMVALAIISAGVLLVSLLCCL 571

  Fly   908 --------QPKNLRINSQ-----QSRSLQLTWSQPFAGNSPIEEYHIYYKQISDIWQNAEHLTIA 959
                    ..|:..|:.|     :..:|...:......:||::..|:..|....|.||...|...
Worm   572 CMCRSNCRSRKSKFIDDQSDVTVKCEALDGQYFPEMYSSSPVDNVHLSTKDYISIPQNNPDLDFL 636

  Fly   960 GA 961
            ||
Worm   637 GA 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386
		Ig strand A	235..238	CDD:409353
		Ig strand A'	244..248	CDD:409353
		Ig strand B	251..258	CDD:409353
		Ig strand C	266..271	CDD:409353
		Ig strand C'	276..279	CDD:409353
		Ig strand D	285..289	CDD:409353
		Ig strand E	292..298	CDD:409353
		Ig strand F	305..313	CDD:409353
		Ig strand G	316..326	CDD:409353
		IgC2_3_Dscam	329..417	CDD:409549
		Ig strand B	347..351	CDD:409549
		Ig strand C	360..364	CDD:409549
		Ig strand E	383..387	CDD:409549
		Ig strand F	397..402	CDD:409549
		Ig strand G	410..413	CDD:409549
		IgI_4_Dscam	422..516	CDD:409548	24/96 (25%)
		Ig strand B	439..443	CDD:409548	1/3 (33%)
		Ig strand C	452..456	CDD:409548	0/3 (0%)
		Ig strand E	482..486	CDD:409548	0/3 (0%)
		Ig strand F	496..501	CDD:409548	1/7 (14%)
		Ig strand G	509..512	CDD:409548	1/2 (50%)
		IgI_5_Dscam	520..607	CDD:409550	24/140 (17%)
		Ig strand B	536..540	CDD:409550	0/3 (0%)
		Ig strand C	549..553	CDD:409550	1/12 (8%)
		Ig strand E	571..575	CDD:409550	1/3 (33%)
		Ig strand F	586..591	CDD:409550	2/5 (40%)
		Ig strand G	600..603	CDD:409550	0/2 (0%)
		Ig	610..703	CDD:416386	27/99 (27%)
		Ig strand A	611..613	CDD:409353	1/1 (100%)
		Ig strand A'	620..624	CDD:409353	0/3 (0%)
		Ig strand B	627..636	CDD:409353	2/8 (25%)
		Ig strand C	641..648	CDD:409353	0/6 (0%)
		Ig strand C'	650..652	CDD:409353	0/1 (0%)
		Ig strand D	659..664	CDD:409353	0/4 (0%)
		Ig strand E	668..675	CDD:409353	1/6 (17%)
		Ig strand F	682..690	CDD:409353	2/7 (29%)
		Ig strand G	693..702	CDD:409353	3/8 (38%)
		IgI_7_Dscam	706..801	CDD:409546	19/98 (19%)
		Ig strand B	724..728	CDD:409546	0/3 (0%)
		Ig strand C	737..741	CDD:409546	1/3 (33%)
		Ig strand E	766..770	CDD:409546	1/4 (25%)
		Ig strand F	780..785	CDD:409546	1/4 (25%)
		Ig strand G	794..797	CDD:409546	1/2 (50%)
		Ig	818..904	CDD:416386	18/86 (21%)
		putative Ig strand B	820..827	CDD:409353	0/6 (0%)
		putative Ig strand C	835..841	CDD:409353	1/5 (20%)
		putative Ig strand C'	853..856	CDD:409353	1/2 (50%)
		putative Ig strand D	862..866	CDD:409353	0/3 (0%)
		putative Ig strand E	868..874	CDD:409353	3/5 (60%)
		putative Ig strand F	881..889	CDD:409353	4/7 (57%)
		putative Ig strand G	892..902	CDD:409353	3/9 (33%)
		FN3	906..999	CDD:238020	14/99 (14%)
		FN3	1006..1110	CDD:238020
		fn3	1117..1203	CDD:394996
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
syg-1	NP_001123159.1	I-set	24..124	CDD:254352	24/96 (25%)
		Ig	30..124	CDD:299845	24/96 (25%)
		Ig	<151..265	CDD:299845	21/116 (18%)
		Ig_2	276..353	CDD:290606	25/92 (27%)
		IG_like	283..353	CDD:214653	23/85 (27%)
		IG_like	363..427	CDD:214653	15/80 (19%)
		Ig_2	368..438	CDD:290606	18/86 (21%)
		Ig	440..528	CDD:299845	19/91 (21%)
		IG_like	450..535	CDD:214653	18/87 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910