DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam4 and rig-4

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_501339.2 Gene:rig-4 / 177597 WormBaseID:WBGene00004371 Length:2325 Species:Caenorhabditis elegans


Alignment Length:2114 Identity:449/2114 - (21%)
Similarity:742/2114 - (35%) Gaps:606/2114 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 YRCKLRNLVGTVLSREVHVRGVVNQKYA--VQVHDEYVM----TGNTAVLKCQVPSYMS--EFVL 159
            |||..||.||..:|..    .:|..||.  ....||.|.    ||.......:.|:.::  ...:
 Worm    92 YRCVARNTVGAAISPP----SMVRSKYLDDFDASDESVQYEVTTGVGRYFVLRRPTLLASRNLDI 152

  Fly   160 VTAWVQDTGMHLYPNTDIGGKYTVLSNGELYINNAGPND--AYKSYTCRTVNRLTGEVQISTYPG 222
            ..:|::|....:.|:    ..:.|.|:|.|.:.....:|  |||             :..|:   
 Worm   153 SYSWIKDDSHQVTPD----ATHFVTSDGNLVVTGVKRDDFGAYK-------------LMASS--- 197

  Fly   223 RIIVTEPKGMVQPRINVEKHSMRHVVLNG-------------QTTLP------CIAQ--GHPVPT 266
                .:.|.:|....||..:.:...:.|.             ::|||      |:..  ......
 Worm   198 ----DDLKEIVSKEYNVRDNGLSPSLQNTLSIVYFPTDRTIIESTLPHDEIFDCVTSFGSKDDVR 258

  Fly   267 YRWFKEENEQLLPLQLSERITIVSAGLL-----KITKA--RLEDSGKYLCWVNNTAGEETIQVSL 324
            .|||. ..:|:...::....|:.:..|:     ..|:.  :||      |..:...|..:.|.|.
 Worm   259 IRWFL-NGQQISGSEVGMTTTLNNRRLIISNPSSFTRGEHKLE------CRADAAMGRTSDQKSA 316

  Fly   325 TVT---APLTAHLQPQVQTVDVDKDAQFQCIVSGHPVHDVNWLHDGKPILRDNRVEILTDPPRLI 386
            .:|   .|:...|..::|.. |......:|.|......|:.|..:|        :.:.|...:|.
 Worm   317 YMTFISRPILKDLPNEIQKT-VGSSLSLKCSVKKKSSMDIKWYKNG--------LMMTTQRGKLT 372

  Fly   387 IKKVQKEDPGMYQCFVSN------------EWEQIQSTA------------ELQLGDASPELLYW 427
            |.:::::|.|:|||..:|            |.|..::.|            |:.:....|..|.:
 Worm   373 IDRIKQDDFGLYQCEATNAAGADLASVWVKEGEANETVATEMSEDGMSLEEEISMETPPPRKLKF 437

  Fly   428 F----SEQTLQPGPT-----------------------VSLKCVATGNPLPQFTWSLDGFPI-PD 464
            |    |::.|.|..:                       :.::|.|||:|.|...|.|:|..| .|
 Worm   438 FDNSKSQEQLFPFTSELEPSQKLIKTPKDLTVASGTDRIMMECAATGSPPPNIIWLLNGHEIQTD 502

  Fly   465 SSRF-LVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLPYIREMP-K 527
            :.:: |....:.|||          :::.|.|||||....:  .|..:|.|.:.|...|...| .
 Worm   503 NVKYDLTNDGLAIHD----------IRKSDEGEYTCEISGS--NVKATANVQVNGDSLIEYGPAD 555

  Fly   528 ITGISGSDLIVKCPVAGYPIDK--IHWERDGQTLPIN-------RRQRAYNNGTLIIEQLQRLED 583
            ...:.|:::...|.||...:.|  :.|..:...||:|       .|.|   .|:|||.|:.. ::
 Worm   556 QKSLIGTNVEFSCEVAKEYVRKASVEWYLNDVLLPVNGNSGLRISRNR---KGSLIIRQVGP-DN 616

  Fly   584 AGTYTC--MAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISC---QILEGDLPV- 642
            .|.|.|  ....:::..|   ..:|::..| .||.:....:..|.|.|.:..   :..:|:.|: 
 Worm   617 TGEYRCRVTVDGREENAS---AMLQIIEKP-AMPERVRAELHNETMPAKVRVRWNEGFDGNEPII 677

  Fly   643 -----------SFRW-----------ERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYT 685
                       :..|           :..|||...|.               ||.:....:..:.
 Worm   678 KHAIEMRTMGPTGLWSDWTTAIDNIPKEEGKPCCWTD---------------IEDLRPSSTAEFR 727

  Fly   686 CIASNVAGTERFTVP---LTV-NVPPKWILEPKDSSAQA------------------GADVL--- 725
            .:|||..|..:.::|   :|: ..||.  ..|::.:|.|                  ..|||   
 Worm   728 VVASNKHGPGKPSLPSYSVTMPQQPPS--AAPRNVAASARSPHSVMVQWQQPKEELDSGDVLGYV 790

  Fly   726 LHCQSSGYPTPT-------------------ITWKKAIGPTPGEYKDFLYEPTVQLF-PNGT-IF 769
            :..:.:||.:.|                   |||::             ||..|..: ..|. :|
 Worm   791 VRYRLAGYSSLTWNEKNLTTKDARNTLVDELITWRE-------------YEIQVAAYNKRGLGVF 842

  Fly   770 FKKISKESQGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVA-----------KG---K 820
            .:.|...:......:|..|:...|.....:.:...|..|.:...:::.           ||   |
 Worm   843 SESIEVTTSEGRPTQAPKNVRVKVLNSTAVAIEFTAPEQQRIPGVNLGYKVQFWKGEPEKGELYK 907

  Fly   821 QVHVQ------------------------C-NVQGDNPIDFKWKIQATQQYLDESLD-------- 852
            ||.:.                        | ...||.|.....|: .|::...||:|        
 Worm   908 QVILDPDRRQLTTVVNELEKFGHYNLTTLCFTTPGDGPRSNVVKV-VTEEDTPESVDELSIAEVM 971

  Fly   853 ------------------SRYTIRDQVLD----------DGMVSELGISHTYRQDTGIYICQASN 889
                              ::||||.....          ||..:...|.       |:   |.|.
 Worm   972 YNGAVITWNSPLKQNGIVTKYTIRHWAASSPDVKTKHEVDGSTTNFTID-------GL---QPST 1026

  Fly   890 AFGQDEMSIQL--------------IVQEVPEQPKNLRINSQQSRSLQLTWSQPFAGNSPIEEYH 940
            .:|.|.|:...              :..|:|.:|..|.|....:.::||.::..|.|::.|.::.
 Worm  1027 RYGVDVMASTRKGDGPVEETKFESGVPPELPGRPSMLSIGDISATTVQLHFTPGFDGHTAIRQWV 1091

  Fly   941 IYYKQI-SDIWQNAEHLTIAGAQTVINIQQLRPAKAYHIRMSAENKLGASEFSEVVQ-VTTLEEV 1003
            :..|.. |.::.:..:::...|:: |.:..|||...|.:|:.|||..|....||..: ..||:..
 Worm  1092 VEGKMADSSVFAHVFNVSAPKARS-ITVTGLRPFTQYQLRLIAENVKGRGAPSEPSRSFETLQTN 1155

  Fly  1004 PSGPPLAVRAEPKSSTEIFVTWDAPERDHWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEV 1068
            |..|...:.|||.|:|.|.|:|......||||...||.:.|        :|::.......:|..:
 Worm  1156 PDTPSQRLFAEPVSATSISVSWTPLLATHWNGQPKGYLIVY--------REIDDENWKEVRTPAL 1212

  Fly  1069 RSHFGGETVLANLNKFTQYHVIVQAYTSQGSGPPSKEIAVQTMEDVPSSPPESPQCDVLGSTSIY 1133
            ||   .|..:.:|..||.|.|.|.:....|...|:..:..:|.|.|||..|.:......||.:..
 Worm  1213 RS---SEHTVTDLRPFTSYEVNVFSENGFGRSLPTDSVKARTYESVPSGSPRNIVVTAEGSKAAI 1274

  Fly  1134 ITWSPPDIDGQNGKIKGYKVFYISVDE-LYETDPEVVKSTNQ---YVTIENLRKYTNYTVWVLAY 1194
            |.|:|......||.:.|||:..:...| |...:.:|:....|   ...:.:||.:|:|.|::.||
 Worm  1275 IKWNPVAELSTNGDVIGYKLRVVPERESLMADETKVIDIPGQSTLMAKVSDLRPFTSYHVYMSAY 1339

  Fly  1195 TKVGDGMK-TKPFYCRTHEDVPSAPQAIKAIPASSSKIIISWLPPDLPNGDITGYTFYMSMLEGG 1258
            |.||:|.: :.|....|.||||:.|::.:....|..::.:.||||..|||.||.|..........
 Worm  1340 TIVGNGPENSTPISFETMEDVPAPPESFQCSYISEQEVRMKWLPPGSPNGKITNYIISYWKSHEP 1404

  Fly  1259 REEGTHKRLLGPFVEMHETVRTQESATYQFWLTASTKMGEGEK------TQVVTVPPNNKVPARI 1317
            |.......|||..: |...:....:..|.|.:.|....||.|:      |..|.:|..| .||.:
 Worm  1405 RSMAIDAPLLGNLL-MFAAMSLNPNTQYTFAIKARNSKGESEEAVAEVMTSSVRLPVRN-APAPV 1467

  Fly  1318 -VSFSQ----RIVTPWKEHL--------ELPCR-------KVGAPAPVTIWRQDGHNMETSARKT 1362
             .:.||    .|:..|.|.|        |.|.|       |......:|:.::..::...|..|.
 Worm  1468 RDTLSQHQATEIIIRWDESLPRKLTEDAESPVRAVQVSYQKTNEDEWITLEKKFEYSKRRSVIKH 1532

  Fly  1363 IAKNGTLYMKECQASDAGNYTCSVENTWGKDEIVYNIVVKVPPEAP-----NLTVINAYTDSLLL 1422
            ::.|.....:.....|....:.|.|:.|          ::..|.||     :|.......:|:.|
 Worm  1533 LSPNSMFRFRIRFIGDFLESSWSPESEW----------MRTLPSAPFAQPISLKATPYERNSVQL 1587

  Fly  1423 EWM--DNSHGGSPILGYVINYKR--DNGDW--EELQVDSK---TTSHLLTNLWCGTRYQLYITAY 1478
            ||:  ..|...|..:||.|:|:.  .|..|  ||:.:..:   ....:|..|.....|.|.:..:
 Worm  1588 EWVVPHKSTWNSDAIGYRIHYREYPSNETWQMEEIAIRDEHEDKEEKILAKLDSFKHYILRMRIF 1652

  Fly  1479 NKIGTGLPCDIVNSYTKGNPPVQPKHSQMITN--NSTSVTCWLDSWGD------GGCGILYFMIE 1535
            |..|.|.....|.:|...:.| :...:.:||.  :|:|:....|:|..      ....:.|..:.
 Worm  1653 NSEGEGPFSAPVFAYVGYSIP-KRNLNNIITEPLSSSSIRVKWDAWPKEDSETITSFKVRYVPVA 1716

  Fly  1536 SRVYGRSSWAVVSNHIPPTERIY-------TVSDLVPGTKYQLKVTAHNNAGSTTAIYNFTTLST 1593
            |          |.:.:...|.|.       |::||...|:||:.|:.:|.||             
 Worm  1717 S----------VLSSVSSEEEIMIVDTNECTLNDLRKFTEYQISVSPYNRAG------------- 1758

  Fly  1594 QGVIYNNDHSTPVSHLSDLPFYANFKLLLPICFSLLMLLALIGAALFLRKRKLASQARLASSSMS 1658
            :|.:......|    |.|.|                      |....||    .|...:.|..:|
 Worm  1759 EGKMSQVRDKT----LEDKP----------------------GPVGILR----FSDVLMDSVKVS 1793

  Fly  1659 -ESPSLAN--------------LQNK-QNRDQQYLAVRCNPGTSAPRGSNSNDSGSFGKAEGNEY 1707
             :.||..|              :|.: :|.|||              .::.|...:.|.|||..|
 Worm  1794 WDEPSQPNGNVIGYIVNYKGYRMQEEFKNEDQQ--------------RTSRNYFDTHGLAEGVTY 1844

  Fly  1708 IEDICPYATFQLNKQTYSESS------YSGNVYSGPYHSVRG-------------SFV---YHDV 1750
            ...:            ::|:|      .|.||..||  |..|             |:|   ::||
 Worm  1845 FFSV------------WAETSAGKGEQRSANVTIGP--SKDGPPPPSKPQITSGQSYVTLNWNDV 1895

  Fly  1751 -------------KPESYHSKEPE--YTKVRRKVGRLRDPHSESQESDNPGSTDSEVRKILTLHI 1800
                         |..|...:.|.  |...|.:...::...|.:|.:....:..:.         
 Worm  1896 ADSDEIVGHLLQAKRVSVAEEAPANGYVSQRPRRNEIKGAKSAAQTAAATSTRPTH--------- 1951

  Fly  1801 PITEYDTL----GSESDNDVSARALNSAKYRAQR 1830
            ||.|:.||    |......||.|.|..:.|.|.|
 Worm  1952 PIGEWITLRPTEGRSEKEQVSYRELQPSSYYAFR 1985

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386 8/20 (40%)
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353 3/5 (60%)
Ig strand G 112..124 CDD:409353 2/11 (18%)
Ig 235..326 CDD:416386 20/118 (17%)
Ig strand A 235..238 CDD:409353 0/2 (0%)
Ig strand A' 244..248 CDD:409353 0/3 (0%)
Ig strand B 251..258 CDD:409353 3/25 (12%)
Ig strand C 266..271 CDD:409353 2/4 (50%)
Ig strand C' 276..279 CDD:409353 1/2 (50%)
Ig strand D 285..289 CDD:409353 1/3 (33%)
Ig strand E 292..298 CDD:409353 1/10 (10%)
Ig strand F 305..313 CDD:409353 1/7 (14%)
Ig strand G 316..326 CDD:409353 3/9 (33%)
IgC2_3_Dscam 329..417 CDD:409549 22/111 (20%)
Ig strand B 347..351 CDD:409549 0/3 (0%)
Ig strand C 360..364 CDD:409549 1/3 (33%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 3/4 (75%)
Ig strand G 410..413 CDD:409549 0/2 (0%)
IgI_4_Dscam 422..516 CDD:409548 30/122 (25%)
Ig strand B 439..443 CDD:409548 0/3 (0%)
Ig strand C 452..456 CDD:409548 0/3 (0%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 4/4 (100%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 22/98 (22%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 1/5 (20%)
Ig strand E 571..575 CDD:409550 2/3 (67%)
Ig strand F 586..591 CDD:409550 2/6 (33%)
Ig strand G 600..603 CDD:409550 0/2 (0%)
Ig 610..703 CDD:416386 20/121 (17%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 2/11 (18%)
Ig strand C 641..648 CDD:409353 2/29 (7%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 1/6 (17%)
Ig strand F 682..690 CDD:409353 1/7 (14%)
Ig strand G 693..702 CDD:409353 2/11 (18%)
IgI_7_Dscam 706..801 CDD:409546 23/136 (17%)
Ig strand B 724..728 CDD:409546 2/6 (33%)
Ig strand C 737..741 CDD:409546 3/22 (14%)
Ig strand E 766..770 CDD:409546 1/4 (25%)
Ig strand F 780..785 CDD:409546 0/4 (0%)
Ig strand G 794..797 CDD:409546 0/2 (0%)
Ig 818..904 CDD:416386 27/163 (17%)
putative Ig strand B 820..827 CDD:409353 4/31 (13%)
putative Ig strand C 835..841 CDD:409353 1/5 (20%)
putative Ig strand C' 853..856 CDD:409353 0/2 (0%)
putative Ig strand D 862..866 CDD:409353 1/13 (8%)
putative Ig strand E 868..874 CDD:409353 1/5 (20%)
putative Ig strand F 881..889 CDD:409353 2/7 (29%)
putative Ig strand G 892..902 CDD:409353 3/23 (13%)
FN3 906..999 CDD:238020 24/94 (26%)
FN3 1006..1110 CDD:238020 29/103 (28%)
fn3 1117..1203 CDD:394996 26/90 (29%)
FN3 1215..1307 CDD:238020 26/97 (27%)
Ig <1334..1401 CDD:416386 11/73 (15%)
Ig strand C 1345..1349 CDD:409353 1/3 (33%)
Ig strand D 1363..1366 CDD:409353 0/2 (0%)
Ig strand E 1367..1372 CDD:409353 0/4 (0%)
Ig strand F 1380..1388 CDD:409353 1/7 (14%)
Ig strand G 1394..1401 CDD:409353 0/6 (0%)
FN3 1405..1494 CDD:238020 26/102 (25%)
FN3 1499..1580 CDD:238020 20/95 (21%)
rig-4NP_501339.2 IG_like 330..402 CDD:214653 16/80 (20%)
IGc2 338..393 CDD:197706 14/62 (23%)
I-set 459..543 CDD:254352 24/95 (25%)
IGc2 478..534 CDD:197706 21/67 (31%)
IG_like 553..639 CDD:214653 21/92 (23%)
Ig 564..635 CDD:143165 19/77 (25%)
FN3 643..747 CDD:238020 20/119 (17%)
FN3 756..850 CDD:238020 18/106 (17%)
FN3 858..954 CDD:238020 15/96 (16%)
FN3 959..1042 CDD:238020 16/92 (17%)
FN3 1057..1151 CDD:238020 24/94 (26%)
FN3 1156..1251 CDD:238020 30/105 (29%)
FN3 1258..1356 CDD:238020 27/97 (28%)
FN3 1361..1453 CDD:238020 24/92 (26%)
FN3 1464..1560 CDD:238020 19/95 (20%)
FN3 1572..1664 CDD:238020 22/91 (24%)
FN3 1679..1764 CDD:238020 22/107 (21%)
FN3 1774..1858 CDD:238020 23/135 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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