DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and CNTN4

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_001193884.1 Gene:CNTN4 / 152330 HGNCID:2174 Length:1026 Species:Homo sapiens


Alignment Length:1221 Identity:274/1221 - (22%)
Similarity:446/1221 - (36%) Gaps:303/1221 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 LQGPIFLHEPPHRVEF---SNNSGGLIECSGHGSPPPEVEW----TPIPPQQDMVFQLSNGSMMF 86
            |.||||:.| |..|.|   |......:.|...|:|.|.:.|    |.:....|..:.:..||::.
Human    23 LHGPIFIQE-PSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLI 86

  Fly    87 YPFTAEKYRHEVHATVYRCKLRNLVGTVLSREVHVRGVVNQKYAVQVHDEY-VMTGNTAVLKCQV 150
                 ........|..|:|...|..||::|||..::......:..:..... |..|...||.|..
Human    87 -----NNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGP 146

  Fly   151 PSYMSEFVLVTAWVQDTGMHLYPNTDIGGKYTVLSNGELYINNAGPNDAYKSYTCRTVNRLTGEV 215
            |.:..|  |..||:    .:.||:.....::.....|.|||.....:|. .:|||...|.:|.. 
Human   147 PPHSGE--LSYAWI----FNEYPSYQDNRRFVSQETGNLYIAKVEKSDV-GNYTCVVTNTVTNH- 203

  Fly   216 QISTYPGRIIVTEP--KGMVQPRINVEKHSMRHVVLNGQTTLPCIAQGHPVPTYRWFKEENEQLL 278
            ::...|..:|:...  .|..:|:|.|:..............|.|.|.|:||||..|.:.:.:   
Human   204 KVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGK--- 265

  Fly   279 PLQLSERITIVSAGLLKITKARLEDSGKYLCWVNNTAGEETIQVSLTVTAPLTAHLQPQ-VQTVD 342
            |:....| ...|.|:|:|...:.||:|.|.|...|:.|:...:      ..||.:.||. :|.::
Human   266 PIARKAR-RHKSNGILEIPNFQQEDAGLYECVAENSRGKNVAR------GQLTFYAQPNWIQKIN 323

  Fly   343 -----VDKDAQFQCIVSGHPVHDVNWLHDGKPILRDNRVEILTDPPRLIIKKVQKEDPGMYQCFV 402
                 ::::..::|..:|.|.....||.:|:|:|..:|::|  :...|.|..|...|.|||||..
Human   324 DIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQI--EQGTLNITIVNLSDAGMYQCLA 386

  Fly   403 SNEWEQIQSTAELQLGDASPELLYWFSEQTL------QPGPTVSLKCVATGNPLPQFTWSLDGFP 461
            .|:...|.|.|||.:....|:    ||...|      :.|..|.::|....:|.|.:||......
Human   387 ENKHGVIFSNAELSVIAVGPD----FSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDI 447

  Fly   462 IPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLPYIREMP 526
            :.::.|      :||.:|  .::.|.||.:.|.|.|||.|.|..|                    
Human   448 LKENER------ITISED--GNLRIINVTKSDAGSYTCIATNHFG-------------------- 484

  Fly   527 KITGISGSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQRAYNNGTLIIEQLQRLEDAGTYTCMA 591
              |..|..:|:||.|.                                                 
Human   485 --TASSTGNLVVKDPT------------------------------------------------- 498

  Fly   592 QNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQIL-EGDLPVSFRWERNGKPL-I 654
                          :|:|||..|.:..       |....:.||:. :..|.:.|.|..||..: .
Human   499 --------------RVMVPPSSMDVTV-------GESIVLPCQVTHDHSLDIVFTWSFNGHLIDF 542

  Fly   655 GTGNEVFRRL--DEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTVNVPP-----KWILE 712
            ....:.|.|:  .:.:..|:|.:|...|:|.|.|:.............|.|..||     ..|.|
Human   543 DRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDE 607

  Fly   713 PKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQLFPNGTIFFKKISKES 777
            ..|::||                  ::|:    |.|..:.....                     
Human   608 ITDTTAQ------------------LSWR----PGPDNHSPITM--------------------- 629

  Fly   778 QGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDNP-IDFKWKIQ 841
               ::.:|:.....|...|    ..||.....||            ....|.|.|| ::::::  
Human   630 ---YVIQARTPFSVGWQAV----STVPELIDGKT------------FTATVVGLNPWVEYEFR-- 673

  Fly   842 ATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIV--QE 904
                          |:...|:..|..|.  .|...|.:..:.....:|..|......:|::  :.
Human   674 --------------TVAANVIGIGEPSR--PSEKRRTEEALPEVTPANVSGGGGSKSELVITWET 722

  Fly   905 VPEQPKNLRINSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQISDIWQNAEHLTIAGAQTVINIQQ 969
            |||:.:|.|                  |...:..:..|.|.   ||......:...::.|...:.
Human   723 VPEELQNGR------------------GFGYVVAFRPYGKM---IWMLTVLASADASRYVFRNES 766

  Fly   970 LRPAKAYHIRMSAENKLGASEFSEVVQVTTLEEVPSGPPLAVRAEPKSSTEIFVTWDAP-ERDHW 1033
            :.|...:.:::...|..|...||....|.:.||.|:.||.::.|...|:|:|.|.|.:| |::  
Human   767 VHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKN-- 829

  Fly  1034 NGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGETVLANLNKFTQYHVIVQAYTSQG 1098
            .|.:.||.|.|...   ||||.|..:   .:||..::    .|.:.||.....||:.|:||.|.|
Human   830 RGRIQGYEVKYWRH---EDKEENARK---IRTVGNQT----STKITNLKGSVLYHLAVKAYNSAG 884

  Fly  1099 SGPPSKEIAVQTMEDVPSSPPESPQCDVLGSTS---IYITWSPPDIDGQNGKIKGYKVFY----- 1155
            :||.|..:.|.|.:..||.||.    :::.::|   |.:.|..........::|||||.|     
Human   885 TGPSSATVNVTTRKPPPSQPPG----NIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQ 945

  Fly  1156 --ISVDELYETDPEVVKSTNQYVTIENLRKYTNYTVWVLAYTKVGDGMKTK 1204
              .||.|..:|..|:           :|....:|.:.:..::..|||..::
Human   946 SSTSVIETNKTSVEL-----------SLPFDEDYIIEIKPFSDGGDGSSSE 985

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386 27/99 (27%)
Ig strand A 32..35 CDD:409353 2/2 (100%)
Ig strand A' 41..45 CDD:409353 2/6 (33%)
Ig strand B 48..57 CDD:409353 1/8 (13%)
Ig strand D 75..78 CDD:409353 0/2 (0%)
Ig strand E 83..88 CDD:409353 1/4 (25%)
Ig strand F 101..109 CDD:409353 2/7 (29%)
Ig strand G 112..124 CDD:409353 5/11 (45%)
Ig 235..326 CDD:416386 25/90 (28%)
Ig strand A 235..238 CDD:409353 1/2 (50%)
Ig strand A' 244..248 CDD:409353 0/3 (0%)
Ig strand B 251..258 CDD:409353 1/6 (17%)
Ig strand C 266..271 CDD:409353 2/4 (50%)
Ig strand C' 276..279 CDD:409353 0/2 (0%)
Ig strand D 285..289 CDD:409353 1/3 (33%)
Ig strand E 292..298 CDD:409353 3/5 (60%)
Ig strand F 305..313 CDD:409353 3/7 (43%)
Ig strand G 316..326 CDD:409353 1/9 (11%)
IgC2_3_Dscam 329..417 CDD:409549 30/93 (32%)
Ig strand B 347..351 CDD:409549 0/3 (0%)
Ig strand C 360..364 CDD:409549 0/3 (0%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 4/4 (100%)
Ig strand G 410..413 CDD:409549 1/2 (50%)
IgI_4_Dscam 422..516 CDD:409548 26/99 (26%)
Ig strand B 439..443 CDD:409548 1/3 (33%)
Ig strand C 452..456 CDD:409548 1/3 (33%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 3/4 (75%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 6/86 (7%)
Ig strand B 536..540 CDD:409550 2/3 (67%)
Ig strand C 549..553 CDD:409550 0/3 (0%)
Ig strand E 571..575 CDD:409550 0/3 (0%)
Ig strand F 586..591 CDD:409550 0/4 (0%)
Ig strand G 600..603 CDD:409550 0/2 (0%)
Ig 610..703 CDD:416386 21/96 (22%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 2/8 (25%)
Ig strand C 641..648 CDD:409353 2/6 (33%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 1/4 (25%)
Ig strand E 668..675 CDD:409353 2/6 (33%)
Ig strand F 682..690 CDD:409353 3/7 (43%)
Ig strand G 693..702 CDD:409353 0/8 (0%)
IgI_7_Dscam 706..801 CDD:409546 13/99 (13%)
Ig strand B 724..728 CDD:409546 0/3 (0%)
Ig strand C 737..741 CDD:409546 0/3 (0%)
Ig strand E 766..770 CDD:409546 0/3 (0%)
Ig strand F 780..785 CDD:409546 0/4 (0%)
Ig strand G 794..797 CDD:409546 0/2 (0%)
Ig 818..904 CDD:416386 13/88 (15%)
putative Ig strand B 820..827 CDD:409353 0/6 (0%)
putative Ig strand C 835..841 CDD:409353 0/5 (0%)
putative Ig strand C' 853..856 CDD:409353 0/2 (0%)
putative Ig strand D 862..866 CDD:409353 0/3 (0%)
putative Ig strand E 868..874 CDD:409353 1/5 (20%)
putative Ig strand F 881..889 CDD:409353 0/7 (0%)
putative Ig strand G 892..902 CDD:409353 2/9 (22%)
FN3 906..999 CDD:238020 16/92 (17%)
FN3 1006..1110 CDD:238020 36/104 (35%)
fn3 1117..1203 CDD:394996 21/95 (22%)
FN3 1215..1307 CDD:238020
Ig <1334..1401 CDD:416386
Ig strand C 1345..1349 CDD:409353
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
CNTN4NP_001193884.1 Ig 25..118 CDD:325142 27/98 (28%)
Ig 120..213 CDD:325142 23/100 (23%)
Ig 225..313 CDD:325142 27/97 (28%)
Ig 318..401 CDD:325142 26/84 (31%)
Ig5_Contactin 422..494 CDD:319278 25/101 (25%)
Ig6_Contactin-4 513..597 CDD:143261 18/83 (22%)
FN3 597..690 CDD:238020 24/172 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 685..710 5/26 (19%)
FN3 703..795 CDD:238020 19/112 (17%)
FN3 804..896 CDD:238020 36/103 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 886..907 9/24 (38%)
FN3 904..989 CDD:238020 21/97 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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