DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and VSIG10L

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_001157394.1 Gene:VSIG10L / 147645 HGNCID:27111 Length:867 Species:Homo sapiens


Alignment Length:714 Identity:140/714 - (19%)
Similarity:251/714 - (35%) Gaps:185/714 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 PSYMSEFVLVTAW--VQDTGMHLYPNTDIGGKYTVLSNGELYINNAGP----NDAYKSYTCRT-V 208
            |..:|..:..:.|  |...|..|.|.:    .::.....|::.:.:.|    .|...|:|.:| .
Human    82 PEALSSNMSGSFWSNVSAEGQDLSPVS----PFSETPGSEVFPDISDPQVPAKDPKPSFTVKTPA 142

  Fly   209 NRLTGEVQISTYPGRIIVTEPKGMVQP--------------RINVEKHSMRH---------VVLN 250
            :.::.:|..:    ::.|..|.....|              :.:.|.||...         .||.
Human   143 SNISTQVSHT----KLSVEAPDSKFSPDDMDLKLSAQSPESKFSAETHSAASFPQQVGGPLAVLV 203

  Fly   251 GQT-TLPCIA---QGHPVPTYRWFKEE----------NEQLLPLQLSERITI---VSAGLLKITK 298
            |.| .||.:.   .|.|.....|.:..          ...|:.|..:.|..:   .:.|:|::..
Human   204 GTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELAS 268

  Fly   299 ARLEDSGKYLCWVNNT-AGEETIQVSLTVTAPL-TAHLQPQV-QTVDVDKDAQFQCIVSGHPVHD 360
            |:|:|:|.|...|... ..::|.:.::.|..|| ...:||:. :|.:...:.:.:|:..|....:
Human   269 AQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGE 333

  Fly   361 VNWLHDGK------------PILRDNRVEILTDPPRLIIKKVQKEDPGMYQCFVSNEWEQIQSTA 413
            ::|..||:            |.:|       ::..:|:|.:..:.|...|.|.|.:.:...::.|
Human   334 LSWSRDGRALEAAESEGAETPRMR-------SEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAA 391

  Fly   414 ELQL--GDASPELLYWFSEQTLQP------GPTVSLKCVATGNPLPQFTWSLDG---FPIPDSSR 467
            ::.:  |...|.:.. .|::...|      |..|:|:|.|...|....||||..   ..:|..||
Human   392 DVSVFYGPDPPTITV-SSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEAAVPAGSR 455

  Fly   468 FLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLPYI-REMPKITGI 531
            .|                :..|.....|.|.|.|.|                |.. |....:..:
Human   456 LL----------------LPAVGPGHAGTYACLAAN----------------PRTGRRRRSLLNL 488

  Fly   532 SGSDL---IVKCPVAGYPID-----KIHWERDG-------QTLPINRRQRAYNNGTLIIEQLQRL 581
            :.:||   ..:|.|.|.|.|     :..|....       |.||...|....::..|........
Human   489 TVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPR 553

  Fly   582 EDAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIM--PIQAMTNMLREGMRAAISCQILEGDLPVSF 644
            ......||:|::   ..:.|...:....|.:::  |:.|.|.:    ..|.::.:......|...
Human   554 LSGVPITCLARH---LVATRTCTVTPEAPREVLLHPLVAETRL----GEAEVALEASGCPPPSRA 611

  Fly   645 RWERNGKPLI-GTGNEVFRRLDEYSASLVIEHISSDHS-GNYTCIASNV--AGTERFTVPLTVNV 705
            .|.|.|:||. |.|:.:  ||.:....|.|.:.|.|.. |||:.:.|..  ||.::.|:     :
Human   612 SWAREGRPLAPGGGSRL--RLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGGDQITL-----I 669

  Fly   706 PP---KWILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQLFPNG 766
            .|   .|.|:....:|                  .:||....|.....::       :|.:|:|
Human   670 GPSISSWRLQRARDAA------------------VLTWDVERGALISSFE-------IQAWPDG 708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386 25/131 (19%)
Ig strand A 235..238 CDD:409353 1/16 (6%)
Ig strand A' 244..248 CDD:409353 0/12 (0%)
Ig strand B 251..258 CDD:409353 4/7 (57%)
Ig strand C 266..271 CDD:409353 1/4 (25%)
Ig strand C' 276..279 CDD:409353 1/2 (50%)
Ig strand D 285..289 CDD:409353 1/6 (17%)
Ig strand E 292..298 CDD:409353 2/5 (40%)
Ig strand F 305..313 CDD:409353 3/7 (43%)
Ig strand G 316..326 CDD:409353 1/9 (11%)
IgC2_3_Dscam 329..417 CDD:409549 19/101 (19%)
Ig strand B 347..351 CDD:409549 0/3 (0%)
Ig strand C 360..364 CDD:409549 0/3 (0%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 2/4 (50%)
Ig strand G 410..413 CDD:409549 0/2 (0%)
IgI_4_Dscam 422..516 CDD:409548 23/102 (23%)
Ig strand B 439..443 CDD:409548 2/3 (67%)
Ig strand C 452..456 CDD:409548 1/3 (33%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 2/4 (50%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 19/102 (19%)
Ig strand B 536..540 CDD:409550 1/6 (17%)
Ig strand C 549..553 CDD:409550 0/3 (0%)
Ig strand E 571..575 CDD:409550 1/3 (33%)
Ig strand F 586..591 CDD:409550 2/4 (50%)
Ig strand G 600..603 CDD:409550 1/2 (50%)
Ig 610..703 CDD:416386 26/98 (27%)
Ig strand A 611..613 CDD:409353 0/1 (0%)
Ig strand A' 620..624 CDD:409353 1/3 (33%)
Ig strand B 627..636 CDD:409353 1/8 (13%)
Ig strand C 641..648 CDD:409353 2/6 (33%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 2/6 (33%)
Ig strand F 682..690 CDD:409353 3/7 (43%)
Ig strand G 693..702 CDD:409353 2/8 (25%)
IgI_7_Dscam 706..801 CDD:409546 10/64 (16%)
Ig strand B 724..728 CDD:409546 0/3 (0%)
Ig strand C 737..741 CDD:409546 1/3 (33%)
Ig strand E 766..770 CDD:409546 1/1 (100%)
Ig strand F 780..785 CDD:409546
Ig strand G 794..797 CDD:409546
Ig 818..904 CDD:416386
putative Ig strand B 820..827 CDD:409353
putative Ig strand C 835..841 CDD:409353
putative Ig strand C' 853..856 CDD:409353
putative Ig strand D 862..866 CDD:409353
putative Ig strand E 868..874 CDD:409353
putative Ig strand F 881..889 CDD:409353
putative Ig strand G 892..902 CDD:409353
FN3 906..999 CDD:238020
FN3 1006..1110 CDD:238020
fn3 1117..1203 CDD:394996
FN3 1215..1307 CDD:238020
Ig <1334..1401 CDD:416386
Ig strand C 1345..1349 CDD:409353
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
VSIG10LNP_001157394.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..60
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 104..186 13/89 (15%)
Ig 198..298 CDD:299845 21/99 (21%)
I-set 302..395 CDD:254352 17/99 (17%)
Ig 320..389 CDD:143165 13/75 (17%)
IG_like 418..490 CDD:214653 22/103 (21%)
IGc2 421..476 CDD:197706 20/86 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 602..627 8/24 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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