DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and Dcc

DIOPT Version :10

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_031857.2 Gene:Dcc / 13176 MGIID:94869 Length:1447 Species:Mus musculus


Alignment Length:1627 Identity:359/1627 - (22%)
Similarity:576/1627 - (35%) Gaps:478/1627 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   429 SEQTLQPGPTVSLKCVA-TGNPLPQFTWSLDGF-----------PIPDSSRFLVGQYVTIHDDVI 481
            |:.....|..|.|.|.| :...:|...|..||.           .:|:.|.            :|
Mouse    47 SDAVTMRGGNVLLNCSAESDRGVPVIKWKKDGLILALGMDDRKQQLPNGSL------------LI 99

  Fly   482 SHVNISNVKEEDGGEYTCTAQNAIGK--VSHSAKVNIYG-LPYIREMPKITGISGSDLIVKCPVA 543
            .::..|...:.|.|.|.|.|..|...  :|.:|||.:.| |.::.:...||...|..:::||.|.
Mouse   100 QNILHSRHHKPDEGLYQCEASLADSGSIISRTAKVTV
AGPLRFLSQTESITAFMGDTVLLKCEVI 164

  Fly   544 GYPIDKIHWERDGQ---TLPINRRQRAYNNGTLIIEQLQRLEDAGTYTCMAQNKQKQTSRRNVEI 605
            |.|:..|||:::.|   .||.:.|.....:|.|.|.:||. .|:|.|.|.|:|.....:....|:
Mouse   165 GEPMPTIHWQKNQQDLNPLPGDSRVVVLPSGALQISRLQP-GDSGVYRCSARNPASIRTGNEAEV 228

  Fly   606 QVLVPP----KIMPIQAMTNMLR-EGMRAAISCQILEGDLPVSFRWERNGKPLIGTGNEVFR-RL 664
            ::|..|    ::..:|..:|::. ||..|.:.| .:.|..|.||.|.|        |.||.: |.
Mouse   229 RILSDPGLHRQLYFLQRPSNVIAIEGKDAVLEC-CVSGYPPPSFTWLR--------GEEVIQLRS 284

  Fly   665 DEYS----ASLVIEHISSDHSGNYTCIAS----NVAGTERFTVPLTVNVPPKWILEPKDSSAQAG 721
            .:||    ::|:|.:::.|.||.|||:.:    |::.    :..|||.|||.::..|.:..|...
Mouse   285 KKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISA----SAELTVLVPPWFLNHPSNLYAYES 345

  Fly   722 ADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQLFPNGTIFFKKISKESQGHFLCEAK 786
            .|:...|..||.|.||:.|.|                      ||.:.                 
Mouse   346 MDIEFECAVSGKPVPTVNWMK----------------------NGDVV----------------- 371

  Fly   787 NNIGSGVSKVIFLKVNVPA-HFQTKTKQISVAKGKQVHVQCNVQGDNPIDFKWKIQATQQYLDES 850
                            :|: :||.                  |.|.|                  
Mouse   372 ----------------IPSDYFQI------------------VGGSN------------------ 384

  Fly   851 LDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQE--------VPE 907
                               |.|....:.|.|.|.|.|.|..|..:.|.||||.:        :|.
Mouse   385 -------------------LRILGVVKSDEGFYQCVAENEAGNAQSSAQLIVPKPAIPSSSILPS 430

  Fly   908 QPKNLRINSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQISDIWQNAEHLTIAGAQTVINIQQLRP 972
            .|:::......||.::|:|..|......|:.:.:::.:..|..:.|.:.|..|: ..:.:..|:|
Mouse   431 APRDVLPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGS-LQLTVGNLKP 494

  Fly   973 AKAYHIRMSAENKLGASEFSEVVQVTTLEE--VPSGPPLAVRAEPKSSTEIFVTWDAPERDHWNG 1035
            ...|..|:.|.|:.|..|.|:.::|.|..|  || ||...:.|...|.|.|.:||:.|.  :.||
Mouse   495 EAMYTFRVVAYNEWGPGESSQPIKVATQPELQVP-GPVENLHAVSTSPTSILITWEPPA--YANG 556

  Fly  1036 ILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGETVLANLNKFTQYHVIVQAYTSQGSG 1100
            .:.||.:......|.:::.:. ..|.|:|             |..|.|||:|.:...||...|.|
Mouse   557 PVQGYRLFCTEVSTGKEQNIE-VDGLSYK-------------LEGLKKFTEYTLRFLAYNRYGPG 607

  Fly  1101 PPSKEIAVQTMEDVPSSPPESPQCDVLGSTSIYITWSPPDIDGQNGKIKGYKVFYISVDELYETD 1165
            ..:.:|.|.|:.||||:||::...:|:.|.||.::|.||....|||.|.|||:.:.......|. 
Mouse   608 VSTDDITVVTLSDVPSAPPQNISLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEM- 671

  Fly  1166 PEVVKSTNQYVTIENLRKYTNYTVWVLAYTKVGDGMKTKPFYCRTHED------VPSAPQAIKAI 1224
             |.::..|.:.....|.|.:.|:..|.|.|..|.|..:..:...|.|:      ||..|.::...
Mouse   672 -ETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVR 735

  Fly  1225 PASSSKIIISWLPPDLPN----GDITGYTFYMSMLEGGREEGTHKRLLGPFVEMHETVRTQESAT 1285
            |.::. ||:||.||..||    |.|.||.......|..|.:...:        .:...|.:.|:.
Mouse   736 PQTNC-IIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQR--------YYSIERLESSSH 791

  Fly  1286 YQFWLTASTKMGEG------EKTQVVTVP-----------------PNNKVP------ARIVSFS 1321
            |...|.|....|||      ..|:.:|.|                 |:...|      .:.|:.:
Mouse   792 YVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGVQAVALT 856

  Fly  1322 QRIV-TPWKEHLELPCRKVGAPAPVTI-WR-----------QDGHNMETSARKTIAKNGTLYMKE 1373
            ...| ..|.::.....:|.......|: ||           :|..::..:|  |..|..|:|  |
Mouse   857 HEAVRVSWADNSVPKNQKTSDVRLYTVRWRTSFSASAKYKSEDTTSLSYTA--TGLKPNTMY--E 917

  Fly  1374 CQASDAGNYTCSVENTWG--KDEIVYNIVVKVPPEAP-NLTVI--NAYTDSLLLEWMDNSHGGSP 1433
            .......|...|   ||.  .....|.   ..|..|| :||||  .....::::.|.........
Mouse   918 FSVMVTKNRRSS---TWSMTAHATTYE---AAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGK 976

  Fly  1434 ILGYVINYKRDNG----DWEELQVDSKTTSHLLTNLWCGTRYQLYITAYNKIGTGLPCDIVNSYT 1494
            |..|::.|..|..    ||....:.....:|.:.:|...|.|...|.|.|..|.|...|.:...|
Mouse   977 ITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNVKGVGPLSDPILFRT 1041

  Fly  1495 KGNPPVQPKHSQMITNNSTSVTCWLDSWGDGGCGILYFMIESRVYGRSSWAVVSNHIPPTERIYT 1559
                 ::.:|...:.|:.       ...||||    |:.:::.:..||:.     :.||..::  
Mouse  1042 -----LKVEHPDKMANDQ-------GRHGDGG----YWPVDTNLIDRSTL-----NEPPIGQM-- 1083

  Fly  1560 VSDLVPGTKYQLKVTAHNNAGSTTAIYNFTTLSTQGVIYNNDHSTPVSHLSDLPFYANFKLLLPI 1624
                            |...||.|...|                            :|..::..:
Mouse  1084 ----------------HPPHGSVTPQKN----------------------------SNLLVITVV 1104

  Fly  1625 CFSLLMLLALIGAALFLRKRKLASQ-ARLASSSMS------------------ESPSLANLQNKQ 1670
            ...:|.:|.::..|:...:|..|.| .:.|:.|:|                  |...:.|::...
Mouse  1105 TVGVLTVLVVVIVAVICTRRSSAQQRKKRATHSVSKRKGSQKDLRPPDLWIHHEEMEMKNIEKPT 1169

  Fly  1671 NRDQQYLAVRCNPGTSAPRGSNSNDSGSFGKAEGNEYIEDICPYATFQLNKQTYSESSYSGNVYS 1735
            ..|              |.|.:|                                          
Mouse  1170 GTD--------------PAGRDS------------------------------------------ 1178

  Fly  1736 GPYHSVRGSFVYHDVKPESYHSKEPEYTKVRRKVGRLRDPHSESQESDNPGSTDSEVRKILT--- 1797
             |..|.:      |:.|.|:...|.:       :|.....|| .|::::.||:.|.:.:.|.   
Mouse  1179 -PIQSCQ------DLTPVSHSQSETQ-------MGSKSASHS-GQDTEDAGSSMSTLERSLAARR 1228

  Fly  1798 -----LHIPITEYDTLGSESDNDVSARA-----LNSAKYRAQRDTQDETSSSSETTPTSMTRKSK 1852
                 |.||      :.::|.|.....|     |.||:|..             ..|:.......
Mouse  1229 ATRAKLMIP------MEAQSSNPAVVSAIPVPTLESAQYPG-------------ILPSPTCGYPH 1274

  Fly  1853 PPFAARKGGKPGTSGKRHVRSSSGYSSHNEETTFSISNYPPNYQDHINPPAR-FSDANDKTKTQT 1916
            |.|..|....|..|..|      |:.:..   |.|:|..|...|..:.|||: ...::::..::|
Mouse  1275 PQFTLRPVPFPTLSVDR------GFGAGR---TQSVSEGPTTQQQPMLPPAQPEHPSSEEAPSRT 1330

  Fly  1917 SP 1918
            .|
Mouse  1331 IP 1332

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:472250
Ig strand B 50..54 CDD:409353
Ig strand C 63..66 CDD:409353
Ig strand E 82..86 CDD:409353
Ig strand F 102..107 CDD:409353
Ig strand G 115..119 CDD:409353
Ig 235..326 CDD:472250
Ig strand B 253..257 CDD:409353
Ig strand C 266..270 CDD:409353
Ig strand E 292..296 CDD:409353
Ig strand F 306..311 CDD:409353
Ig strand G 319..322 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549
Ig strand A 330..335 CDD:409549
Ig strand A' 338..342 CDD:409549
Ig strand B 345..355 CDD:409549
Ig strand C 360..366 CDD:409549
Ig strand C' 367..370 CDD:409549
Ig strand E 383..389 CDD:409549
Ig strand F 396..404 CDD:409549
Ig strand G 407..417 CDD:409549
IgI_4_Dscam 422..516 CDD:409548 24/100 (24%)
Ig strand A' 430..434 CDD:409548 0/3 (0%)
Ig strand B 437..446 CDD:409548 4/9 (44%)
Ig strand C 451..457 CDD:409548 2/5 (40%)
Ig strand C' 459..462 CDD:409548 1/13 (8%)
Ig strand D 467..475 CDD:409548 0/7 (0%)
Ig strand E 479..488 CDD:409548 1/8 (13%)
Ig strand F 495..503 CDD:409548 4/7 (57%)
Ig strand G 506..516 CDD:409548 4/11 (36%)
IgI_5_Dscam 520..607 CDD:409550 27/89 (30%)
Ig strand A 520..522 CDD:409550 0/1 (0%)
Ig strand A' 527..531 CDD:409550 2/3 (67%)
Ig strand B 534..541 CDD:409550 1/6 (17%)
Ig strand C 548..554 CDD:409550 3/5 (60%)
Ig strand C' 555..557 CDD:409550 0/1 (0%)
Ig strand D 564..568 CDD:409550 1/3 (33%)
Ig strand E 571..577 CDD:409550 3/5 (60%)
Ig strand F 585..593 CDD:409550 4/7 (57%)
Ig strand G 597..607 CDD:409550 1/9 (11%)
Ig 610..703 CDD:472250 29/106 (27%)
Ig strand B 629..633 CDD:409353 1/3 (33%)
Ig strand C 643..647 CDD:409353 2/3 (67%)
Ig strand E 669..673 CDD:409353 1/3 (33%)
Ig strand F 683..688 CDD:409353 3/4 (75%)
Ig strand G 696..699 CDD:409353 0/2 (0%)
IgI_7_Dscam 706..801 CDD:409546 15/94 (16%)
Ig strand A 706..710 CDD:409546 2/3 (67%)
Ig strand A' 715..719 CDD:409546 0/3 (0%)
Ig strand B 722..731 CDD:409546 2/8 (25%)
Ig strand C 737..743 CDD:409546 2/5 (40%)
Ig strand C' 749..752 CDD:409546 0/2 (0%)
Ig strand D 760..763 CDD:409546 0/2 (0%)
Ig strand E 766..772 CDD:409546 1/5 (20%)
Ig strand F 779..787 CDD:409546 0/7 (0%)
Ig strand G 792..801 CDD:409546 0/8 (0%)
Ig 804..889 CDD:472250 13/85 (15%)
Ig strand B 822..826 CDD:409353 0/3 (0%)
Ig strand C 835..839 CDD:409353 0/3 (0%)
FN3 <850..1254 CDD:442628 119/423 (28%)
Ig strand F 882..887 CDD:409353 2/4 (50%)
FN3 906..999 CDD:238020 22/92 (24%)
fn3 1117..1203 CDD:394996 27/85 (32%)
FN3 1185..>1580 CDD:442628 95/455 (21%)
FN3 1405..1494 CDD:238020 23/95 (24%)
DccNP_031857.2 IgI_1_Neogenin_like 39..136 CDD:409387 24/100 (24%)
Ig strand A 39..42 CDD:409387
Ig strand A' 45..51 CDD:409387 1/3 (33%)
Ig strand B 55..65 CDD:409387 4/9 (44%)
Ig strand C 70..76 CDD:409387 2/5 (40%)
Ig strand C' 78..81 CDD:409387 1/2 (50%)
Ig strand D 88..93 CDD:409387 0/4 (0%)
Ig strand E 95..101 CDD:409387 2/17 (12%)
Ig strand F 113..120 CDD:409387 3/6 (50%)
Ig strand G 125..136 CDD:409387 4/10 (40%)
Ig_3 139..216 CDD:464046 26/77 (34%)
I-set 241..327 CDD:400151 28/98 (29%)
Ig strand B 257..261 CDD:409353 1/3 (33%)
Ig strand C 270..274 CDD:409353 2/3 (67%)
Ig strand E 293..297 CDD:409353 1/3 (33%)
Ig strand F 307..312 CDD:409353 3/4 (75%)
Ig strand G 322..325 CDD:409353 0/2 (0%)
IgI_4_Neogenin_like 334..417 CDD:409388 31/192 (16%)
Ig strand A 334..337 CDD:409388 0/2 (0%)
Ig strand A' 339..343 CDD:409388 0/3 (0%)
Ig strand B 346..355 CDD:409388 2/8 (25%)
Ig strand C 360..366 CDD:409388 3/5 (60%)
Ig strand C' 368..371 CDD:409388 1/2 (50%)
Ig strand D 376..380 CDD:409388 2/21 (10%)
Ig strand E 384..388 CDD:409388 2/40 (5%)
Ig strand F 396..404 CDD:409388 4/7 (57%)
Ig strand G 407..417 CDD:409388 4/9 (44%)
FN3 429..521 CDD:238020 22/92 (24%)
FN3 <478..901 CDD:442628 118/451 (26%)
FN3 946..1041 CDD:238020 23/94 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1153 5/26 (19%)
Neogenin_C 1148..1445 CDD:461954 48/284 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1166..1220 17/124 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1291..1329 10/46 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1419
Blue background indicates that the domain is not in the aligned region.

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