back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam4 and igsf9b

DIOPT Version :10

Sequence 1:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster
Sequence 2:	XP_031761656.1	Gene:	igsf9b / 100379858	XenbaseID:	XB-GENE-5887265	Length:	1392	Species:	Xenopus tropicalis

Alignment Length:	1165	Identity:	241/1165 - (20%)
Similarity:	408/1165 - (35%)	Gaps:	396/1165 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 WVNNTAGEETIQVSLTVTAPLTAHLQPQVQTVDVDKDAQFQCIVSGHPVHDVNWLHDGKPI---- 370
            :|...|||..| :...|..|||  :||                    |.:.|.|...|.||
Frog    32 FVTARAGESVI-LGCDVVHPLT--VQP--------------------PPYVVEWFKFGVPIPIFI 73

  Fly   371 ---LRDNRVE-------ILTDPPRLIIKKVQKEDPGMYQC-----------FVSNEWEQIQSTAE 414
               .....|:       .|.|...|.|::|:.:|.|.|:|           |.:..|..:...|.
Frog    74 KFGFYPPHVDPEYVGRAALYDKASLRIEQVRSQDQGWYECKVLMLEHQYDTFHNGSWVHLTVNAP 138

  Fly   415 LQLGDASPELLYWFSEQTLQPGPTVSLKCVATGNPLPQFTWSLDGFPIPDSSRFLVGQYVTIHDD 479
            ....:..|:.|      .::.|.:::|.|.|.|||.|..:|..:|..:..:|::.:..
Frog   139 PTFTETPPQYL------EVKEGSSITLTCTAFGNPKPTVSWLREGEFLGRTSKYQLSD------- 190

  Fly   480 VISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLPYIREMPK-ITGISGSDLIVKCPVA 543
              ..:.||::..||.|.|.|.|.:..|:..||.::.:.|.|:|...|: ||.....|.:..|...
Frog   191 --GSLTISSIGREDRGSYMCRATSIQGEAVHSTRLLVQGSPFIVSPPENITVNISQDALFTCQAE 253

  Fly   544 GYPIDKI---HWERDGQTL--PINRRQRAYNNGTLIIEQLQRLEDAGTYTCMAQNKQKQTSRRNV 603
            .||.:..   :|:.:....  .:..|.|...:|||||.:: :.||||.|||:..|...::...:.
Frog   254 AYPGNLTYTWYWQEENVFFKNDLKLRVRILIDGTLIIFRV-KPEDAGKYTCVPSNSLGRSPSASA 317

  Fly   604 EIQVLVPPKIMPIQAMTNM-----LREGMRAAISCQILEGDLPVSF-RWERNGKPLIGTGNEVFR 662
            .:.|..|.:::      ||     :..|:...|.|.: |...||:| :|.::|:||
Frog   318 YLTVQYPARVV------NMPPVIYVPVGIHGHIRCPV-EAVPPVTFVKWNKDGRPL--------- 366

  Fly   663 RLDEYS-------ASLVIEHISSDHSGNYTCIASNVAGTERFTVP--LTVNVPPKWILEPK-DSS 717
            |:|::|       .::.:|..:.:..|.|||:..|..||...:.|  |.:..||.:.:.|. :..
Frog   367 RIDKFSGWKLLDDGTIHVEEATEELLGTYTCVPYNALGTMGQSPPARLLLKDPPYFTVLPGWEYR 431

  Fly   718 AQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQLFPNGTIFFKKISKESQGHFL 782
            .:||.::|:.|.::|.|.|:|:|:|...|:..::         .:.|:|::.|:.:|||..|.:.
Frog   432 QEAGRELLIPCAAAGDPFPSISWRKVGRPSFSKH---------SVLPSGSLQFRSLSKEDHGEWE 487

  Fly   783 CEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDNPIDFKWKIQATQQYL 847
            |.|.|.:.|         :...||
Frog   488 CVASNVVTS---------ITASAH----------------------------------------- 502

  Fly   848 DESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQEVPEQPKNL 912
                               ::.:|.|                                |..|.|:
Frog   503 -------------------LTVIGTS--------------------------------PHAPSNV 516

  Fly   913 RINSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQISDIWQNA--------EH----LTIAGAQTVI 965
            |:....: :..::|...:.|.         ::|...:|..|        .|    :.:....:.:
Frog   517 RVVVSMN-TANVSWEAGYDGG---------FEQTFSVWYGALIKRAQFGPHDWVSMPVPSGSSFL 571

  Fly   966 NIQQLRPAKAYHIRMSAENKLGASEFSEVVQVTTLEEVPSGP-PLAVRAEPKSSTE------IFV 1023
            .:..|.|...|...:.|:||||.|.|||||.:.||....:.| ||.|...|:..|.      :.:
Frog   572 LVDSLDPETEYQFSVLAQNKLGTSSFSEVVTLRTLAFPLTTPEPLLVLTSPRCLTANRTQQGVLL 636

  Fly  1024 TWDAPERDHWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVE-----VRSHFGGET-VLA-NL 1081
            :|..|....:                |.|:.:     ..|:..|     ..|..|.:| :|| .|
Frog   637 SWLPPSNHSF----------------PLDRYI-----MEFRLAERWEILDDSILGSDTEILAKEL 680

  Fly  1082 NKFTQYHVIVQAYTSQGSGPPSKEIAVQTMEDVPSSPPESPQCDVLGSTSIYITWSPPDIDGQNG 1146
            ::.|.|...|.|                .|:|:.|.|     .::.|.:|..: :..||:..:
Frog   681 SQDTWYEFRVLA----------------VMQDLISEP-----SNIAGVSSSDV-FPSPDLSEE-- 721

  Fly  1147 KIKGY----------KVFYISVDELYETDPEVVKSTNQYVTIENLRKYTNYTVWVLAYTKVGDGM 1201
               |:          .:.:::...|:.|....|      |..:..||        :...||....
Frog   722 ---GFARPVLAGIVATICFLAAAILFSTLAACV------VNRQRKRK--------MKRKKVSHSC 769

  Fly  1202 KTKP----FYCRTHEDVP-----SAPQAIKAIPASSSKIIISWLPPDLPNGDITGYTFYMSMLEG 1257
            .|.|    .:||...:.|     .:|::::.:.|.|                           |.
Frog   770 PTDPPLSITHCRKSMESPLSSGKVSPESVRTLRAPS---------------------------ES 807

  Fly  1258 GREEG-THKRLLGPFVEMH-----ETVRTQESATYQFWLTASTKMGEGEKT------------QV 1304
            ..::| ..||.|.|..|..     :|.|...|..|      |....|.|.|            :.
Frog   808 SEDQGPPSKRPLSPGREKELSLYKKTKRAMTSKKY------SVSQAEAEVTTPIELISRGPDGRF 866

  Fly  1305 VTVPPNNKVPARIVSFSQRIV-TPWKEHLELPCRKVGAPAPVTIWRQ-DGHNMETSARKT 1362
            ||..|..:...|    |:||. .|:.|..::          ...:|| |..|.|.|..|:
Frog   867 VTAGPEQEPTLR----SRRIQGFPFAEETDM----------YPEFRQSDEENDEPSGLKS 912

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.