DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam4 and Palld

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:XP_038950842.1 Gene:Palld / 100360205 RGDID:2322545 Length:1409 Species:Rattus norvegicus


Alignment Length:1238 Identity:237/1238 - (19%)
Similarity:354/1238 - (28%) Gaps:535/1238 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 EFSNNSGGLIECSGHGSPPPEVEW---------TPIPPQQDMVFQLSNGSMMFYPFTAEKYRHEV 98
            |.:..|...:||...|:|.|.|.|         .|     |:......|              |:
  Rat   289 EVAEGSRVYLECRVTGNPAPRVRWFCEGKELYNCP-----DIQIHCEGG--------------EL 334

  Fly    99 HATV-----------YRCKLRNLVGT-VLSREVHVRGV-------VNQKYAVQVHDEYVMTGNTA 144
            |..|           |.|...|..|: ..|.||.:.|.       .|..:..:|.........|.
  Rat   335 HTLVIAEAFEDDTGRYTCLATNPSGSDSTSAEVFIEGASSTDSESENSSFGSKVGAMPQAQKKTT 399

  Fly   145 VLKCQVPSYMSEFVLVTAWVQDTGMHLYPNTDIGGKYTVLSNGELYINNAGPNDAYKSYTCR--- 206
            .:...:.|...:..:.||.:|.                 ||.....:::|      .||.||   
  Rat   400 SVSLTIGSSSPKTGVTTAVIQP-----------------LSVPVQQVHSA------TSYLCRPDG 441

  Fly   207 -TVNRL----TGEVQ-ISTYPGRIIVTEPKGMVQPRINVEKHSMRHVVLNGQTTLPCIAQGHPVP 265
             |:..|    |.|:| .:...|:::|.|                            |..:|.|..
  Rat   442 TTMGCLLPVFTKELQNTAASEGQVVVLE----------------------------CRVRGAPPL 478

  Fly   266 TYRWFKEENE----------QLLPLQLSERITIVSAGLLKITKARLEDSGKYLCWVNNTAGEETI 320
            ..:||::.:|          |..|...:|...|.:   |.|.::..||:|.:.|...|..|..|.
  Rat   479 QVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEICT---LVIAESFPEDAGIFTCSARNDYGSVTS 540

  Fly   321 QVSLTVTA-------------PLTAHLQ------PQVQTVDVD----KDAQFQCI---------- 352
            ...|.||:             |.:.|.|      |.::|...:    |.::.|.:          
  Rat   541 TAQLVVTSANTENCSYDSMGEPNSDHFQHFPPPPPILETGSYELASQKPSEIQQVNTPNLGFNMA 605

  Fly   353 ------------VSG-HPVHDVNWLHDGK------PILRDNRVEILTDPPRLIIKKVQKEDPGMY 398
                        .:| ||.|.||.|.:||      |......:....:||.|:.|  .|.||...
  Rat   606 ALQMQFNSAERETNGVHPSHGVNGLINGKAYGNKSPPTPAALLSPTKEPPPLLAK--PKLDPLKL 668

  Fly   399 QCFVSNEWEQIQSTAELQL--------------------------------GDASPELL------ 425
            |        |:|:...|:.                                ..|.|||.      
  Rat   669 Q--------QLQNQVRLEQEACAWPPAPPGVPCNSSSSGSSAPPSPPFPPPPPAFPELAACASPV 725

  Fly   426 ---------------------------YWFSEQTLQPG-----PTVSLKCVATGNPL-------- 450
                                       .:.:.|.|.|.     ||.|....:..:||        
  Rat   726 PSEPMSALASRSTAMQSSGSFNYARPKQFIAAQNLGPASGLPTPTSSPSSSSLPSPLSPTPRPFG 790

  Fly   451 ---------PQFTWS----------------LDGFPIPD--------------------SSRFLV 470
                     |:..|.                ...||:||                    .:||..
  Rat   791 RAPGPPFVEPEAMWGPSSPSPPPPPPPVFSPSTAFPVPDVFPLPPPPPPLPSSTSHCASPARFSP 855

  Fly   471 GQ--------------------------------------------------------------Y 473
            ||                                                              .
  Rat   856 GQTPAAFLSALLPSQPPPVAVNALGLPKGVTPAGFPKKASRTARIASDEEIQGTKDAVIQDLERK 920

  Fly   474 VTIHDDVISH--------------------VNISNVKEEDGGEYTCTAQNA------IG------ 506
            :...:|::::                    .|:.|::|.   |.|...|:|      :|      
  Rat   921 LRFKEDLLNNGQPRLTYEERMARRLLGADSANVFNIQEP---EETAANQDAGAPRASVGGPLDGQ 982

  Fly   507 ---KVSHSAKVNIYGLPYIREMPKI--TG---------------------------ISGSDLIVK 539
               |||...:..|..:.|..|...:  ||                           ..|..:...
  Rat   983 KEYKVSSCEQRLISEIEYRLERSPVEETGDEVQEAEVPVENAAAPFFEMKLKHYKIFEGMPVTFT 1047

  Fly   540 CPVAGYPIDKIHWERDGQTLPINRRQRAYN-----NGTLIIE-QLQRLEDAGTYTCMAQNKQKQT 598
            |.|||.|..||:|.:||:  .|:.:...|.     :||..:. ....|:|.|.||.||.|.|.:.
  Rat  1048 CRVAGSPKPKIYWFKDGK--QISPKSDHYTIQRDVDGTCSLHTTASTLDDDGNYTIMAANTQGRV 1110

  Fly   599 S--------------------------RR-----------NVEIQ-------VLVPPKIMPIQAM 619
            |                          ||           |..||       .|..|..:.:|  
  Rat  1111 SCTGRLMVQAVNQRGRSPRSPPGHPHARRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQ-- 1173

  Fly   620 TNMLREGMRAAISCQILEGDLPV-SFRWERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGN 683
                 ||....:.|::  ..||. ...|:.:|||:...........:....||:||.::|..:|.
  Rat  1174 -----EGKLCRMDCKV--SGLPTPDLSWQLDGKPIRPDSAHKMLVRENGVHSLIIEPVTSRDAGI 1231

  Fly   684 YTCIASNVAGTERFTVPLTV-----NVPPKWILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKA 743
            |||||:|.||...|.:.|.|     :..|.:|.:.:::....|..|.|.|:.||.|.|.|.|||.
  Rat  1232 YTCIATNRAGQNSFNLELVVAAKEAHKAPVFIEKLQNTGVADGYPVRLECRVSGVPPPQIFWKKE 1296

  Fly   744 IGPTPGEYKDFLYEPT--VQLFPNG----TIFFKKISKESQGHFLCEAKNNIGSGVSKVIFLKVN 802
                    .:.|...|  |.:..:.    .:..:..:||..|.:...|||..|. ||....|.|.
  Rat  1297 --------NESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGI-VSCTARLDVY 1352

  Fly   803 VPAHFQTKTKQISVAKGKQVHVQCN---VQGDNPIDFKWKIQATQQYLDESLDSRYTIRDQVLDD 864
            ...|.|.:|     .|.|:|....:   ...|..:|.|...|      .|:..|..|     |:.
  Rat  1353 TQWHQQPQT-----TKPKKVRPSASRYAALSDQGLDIKAAFQ------PEASPSHLT-----LNS 1401

  Fly   865 GMV 867
            |:|
  Rat  1402 GLV 1404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386 22/101 (22%)
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353 1/1 (100%)
Ig strand B 48..57 CDD:409353 3/8 (38%)
Ig strand D 75..78 CDD:409353 0/2 (0%)
Ig strand E 83..88 CDD:409353 0/4 (0%)
Ig strand F 101..109 CDD:409353 3/18 (17%)
Ig strand G 112..124 CDD:409353 4/12 (33%)
Ig 235..326 CDD:416386 20/100 (20%)
Ig strand A 235..238 CDD:409353 0/2 (0%)
Ig strand A' 244..248 CDD:409353 0/3 (0%)
Ig strand B 251..258 CDD:409353 0/6 (0%)
Ig strand C 266..271 CDD:409353 1/4 (25%)
Ig strand C' 276..279 CDD:409353 1/2 (50%)
Ig strand D 285..289 CDD:409353 0/3 (0%)
Ig strand E 292..298 CDD:409353 2/5 (40%)
Ig strand F 305..313 CDD:409353 2/7 (29%)
Ig strand G 316..326 CDD:409353 3/9 (33%)
IgC2_3_Dscam 329..417 CDD:409549 28/126 (22%)
Ig strand B 347..351 CDD:409549 0/3 (0%)
Ig strand C 360..364 CDD:409549 2/3 (67%)
Ig strand E 383..387 CDD:409549 2/3 (67%)
Ig strand F 397..402 CDD:409549 1/4 (25%)
Ig strand G 410..413 CDD:409549 1/2 (50%)
IgI_4_Dscam 422..516 CDD:409548 33/281 (12%)
Ig strand B 439..443 CDD:409548 1/3 (33%)
Ig strand C 452..456 CDD:409548 0/3 (0%)
Ig strand E 482..486 CDD:409548 0/23 (0%)
Ig strand F 496..501 CDD:409548 2/4 (50%)
Ig strand G 509..512 CDD:409548 1/2 (50%)
IgI_5_Dscam 520..607 CDD:409550 34/165 (21%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 2/3 (67%)
Ig strand E 571..575 CDD:409550 2/3 (67%)
Ig strand F 586..591 CDD:409550 2/4 (50%)
Ig strand G 600..603 CDD:409550 2/13 (15%)
Ig 610..703 CDD:416386 27/93 (29%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 1/8 (13%)
Ig strand C 641..648 CDD:409353 2/7 (29%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 3/6 (50%)
Ig strand F 682..690 CDD:409353 6/7 (86%)
Ig strand G 693..702 CDD:409353 2/8 (25%)
IgI_7_Dscam 706..801 CDD:409546 27/100 (27%)
Ig strand B 724..728 CDD:409546 2/3 (67%)
Ig strand C 737..741 CDD:409546 1/3 (33%)
Ig strand E 766..770 CDD:409546 0/7 (0%)
Ig strand F 780..785 CDD:409546 0/4 (0%)
Ig strand G 794..797 CDD:409546 1/2 (50%)
Ig 818..904 CDD:416386 13/53 (25%)
putative Ig strand B 820..827 CDD:409353 2/6 (33%)
putative Ig strand C 835..841 CDD:409353 2/5 (40%)
putative Ig strand C' 853..856 CDD:409353 1/2 (50%)
putative Ig strand D 862..866 CDD:409353 1/3 (33%)
putative Ig strand E 868..874 CDD:409353 237/1238 (19%)
putative Ig strand F 881..889 CDD:409353
putative Ig strand G 892..902 CDD:409353
FN3 906..999 CDD:238020
FN3 1006..1110 CDD:238020
fn3 1117..1203 CDD:394996
FN3 1215..1307 CDD:238020
Ig <1334..1401 CDD:416386
Ig strand C 1345..1349 CDD:409353
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
PalldXP_038950842.1 IgI_2_Titin_Z1z2-like 278..369 CDD:409564 22/98 (22%)
Ig strand B 296..300 CDD:409564 0/3 (0%)
Ig strand C 309..313 CDD:409564 1/3 (33%)
Ig strand E 335..339 CDD:409564 1/3 (33%)
Ig strand F 349..354 CDD:409564 2/4 (50%)
Ig strand G 362..365 CDD:409564 0/2 (0%)
I-set 449..546 CDD:400151 26/127 (20%)
Ig strand A' 454..458 CDD:409353 2/3 (67%)
Ig strand B 466..474 CDD:409353 3/35 (9%)
Ig strand C 479..484 CDD:409353 1/4 (25%)
Ig strand C' 487..489 CDD:409353 0/1 (0%)
Ig strand D 495..500 CDD:409353 0/4 (0%)
Ig strand E 511..516 CDD:409353 2/7 (29%)
Ig strand F 525..533 CDD:409353 2/7 (29%)
Ig strand G 536..546 CDD:409353 3/9 (33%)
IgI_1_Palladin_C 1027..1118 CDD:409474 25/92 (27%)
Ig strand B 1044..1048 CDD:409474 0/3 (0%)
Ig strand C 1057..1061 CDD:409474 2/3 (67%)
Ig strand E 1084..1088 CDD:409474 0/3 (0%)
Ig strand F 1098..1103 CDD:409474 2/4 (50%)
Ig strand G 1111..1114 CDD:409474 1/2 (50%)
Ig 1161..1251 CDD:416386 28/98 (29%)
Ig strand A 1161..1164 CDD:409353 0/2 (0%)
Ig strand A' 1167..1172 CDD:409353 1/4 (25%)
Ig strand B 1177..1184 CDD:409353 1/6 (17%)
Ig strand C 1191..1197 CDD:409353 1/5 (20%)
Ig strand C' 1198..1201 CDD:409353 2/2 (100%)
Ig strand D 1207..1213 CDD:409353 0/5 (0%)
Ig strand E 1216..1226 CDD:409353 4/9 (44%)
Ig strand F 1230..1238 CDD:409353 6/7 (86%)
Ig strand G 1240..1251 CDD:409353 4/10 (40%)
IgI_Myotilin_C 1260..1351 CDD:409473 27/99 (27%)
Ig strand B 1277..1281 CDD:409473 2/3 (67%)
Ig strand C 1290..1294 CDD:409473 1/3 (33%)
Ig strand E 1317..1321 CDD:409473 0/3 (0%)
Ig strand F 1331..1336 CDD:409473 0/4 (0%)
Ig strand G 1344..1347 CDD:409473 1/2 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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