DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam4 and dscaml1

DIOPT Version :9

Sequence 1:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster
Sequence 2:	XP_005157551.1	Gene:	dscaml1 / 100002762	-ID:	-	Length:	2158	Species:	Danio rerio

Alignment Length:	2063	Identity:	642/2063 - (31%)
Similarity:	953/2063 - (46%)	Gaps:	264/2063 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILILYVIRAETSQFVNGLDLQGPIFLHEPPHRVEFSNNSGGLIECSGHGSPPPEVEWTPIPPQQD 74
            :|:||..:...|:.|....|   .|::....||.||::.|..:.|...|:|...:.|  .....|
Zfish    75 LLLLYSFQEVHSEDVVSTRL---YFVNASLQRVTFSSSVGVSLPCPAGGAPHAVLRW--YLATGD 134

  Fly    75 MVFQL-------SNGSMMFYPFTAEKYRHEVHATVYRCKLRNLVGTVLSREVHVRGVVNQKYAVQ 132
            .::.:       :||::..|||:...:...:|...|.|...|..|.:.|..:.|:.|..:.|.|:
Zfish   135 DIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENQAGKIRSPSIRVKAVFREPYTVR 199

  Fly   133 VHDEYVMTGNTAVLKCQVPSYMSEFVLVTAWVQDTGMHLYPNTDIGGKYTVLSNGELYINNAGPN 197
            |.|:..|.||.||.||.:||.:.|:|.|.:|.:|| :.:.|    |.::.:.|.|.|||::....
Zfish   200 VADQRSMRGNVAVFKCLIPSAVQEYVSVVSWEKDT-VSIVP----GNRFFLTSYGALYISDVQKE 259

  Fly   198 DAYKSYTCRTVNRLTGEVQISTYPGRIIVTEPKGMVQPRINVEKHSMRHVVLNGQTTLPCIAQGH 262
            ||..:|.|.|.::.:||.:.|. ..|:.|.:|.... |.: ::......|.:.....|||||.|:
Zfish   260 DALSTYRCITKHKYSGETRQSN-GARLSVLDPTEST-PSV-MDSFQSGEVQVGRSIELPCIASGY 321

  Fly   263 PVPTYRWFKEENEQLLPLQLSERITIVSAGLLKITKARLEDSGKYLCWVNNTAGEETIQVSLTVT 327
            |.||.||.|:..    ||....|.|....| |.|:..||||||.|:|.|.|:.|.:.:...|.|.
Zfish   322 PNPTIRWLKDGR----PLPADSRWTRRLTG-LTISDLRLEDSGNYICEVTNSFGSKEVTGHLNVI 381

  Fly   328 APLTAHLQPQVQTVDVDKDAQFQCIVSGHPVHDVNWLHDGKPILRDNRVEIL-TDPPRLIIKKVQ 391
            .||...|.|:.....:.......|.|.|.|...|:|..:.:||:.|....|. .....|.|...|
Zfish   382 EPLRVTLSPKNLKTGISSTVILSCAVQGSPHFTVSWFRNTEPIVPDQHFSIQGAHNETLFITAAQ 446

  Fly   392 KEDPGMYQCFVSNEWEQIQSTAELQLGDASPELLYWFSEQTLQPGPTVSLKCVATGNPLPQFTWS 456
            |...|.||||.:.:.:..|..:.:.|.|.:|.::..|||:.:.||...||.|.|.|.|.|..||:
Zfish   447 KRHSGAYQCFATRKGQTAQDFSIILLEDGTPRIVSSFSERVVAPGEPFSLMCAAKGAPPPTITWT 511

  Fly   457 LDGFPIPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLPY 521
            ||..|:...|.....||.......:||||::|.:..|||.|.|.|:|:.|...:.|::|:.|.|.
Zfish   512 LDDEPVARDSAHRASQYTLSDGSTVSHVNVTNPQIRDGGVYRCAARNSAGSAEYQARINVRGPPS 576

  Fly   522 IREMPKITGISGSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQRAYNNGTLIIEQLQRLEDAGT 586
            ||.|..||.::|.:..:.|.|.|||...|.|.:||..||.|.||..|.||||.:..:|:..|.|.
Zfish   577 IRAMRNITAVAGRNTFINCRVIGYPYYSIKWYKDGMLLPDNHRQVVYENGTLKLSDVQKGMDEGA 641

  Fly   587 YTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQILEGDLPVSFRWERNGK 651
            |.|....:.:.:..:.|.:.|.|||.|.|.......:  |....|:|.:..||:|:...|.::|:
Zfish   642 YLCSVLIQPQLSISQTVYVTVKVPPLIQPFDFPPTSI--GKLMYIACVVSSGDMPIRITWRKDGQ 704

  Fly   652 PLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTVNVPPKWILEPKDS 716
            .::.....|.....|:.:||.|..:|..|:|||||||||.|.|......|.|.|||::.::|.:.
Zfish   705 EIVSGTAGVTIETKEFMSSLQISKVSLKHNGNYTCIASNDAATVSSERQLIVTVPPRFRVQPNNQ 769

  Fly   717 SAQAGADVLLHCQSSGYPTPTITWK--KAIGPTPGEYKDFLYEPTVQLFPNGTIFFKKISKESQG 779
            ....|...:|:|...|||.|.:.||  |.|| .|.:|........:|:..||::..:.:.:|.:|
Zfish   770 DGIYGKSEVLNCSVEGYPPPKVVWKHAKGIG-NPQQYHPVPLTGRIQILSNGSLLIRHVLEEDRG 833

  Fly   780 HFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDNPIDFKWKIQATQ 844
            ::||:|.|.:||.:||.:.|.|.:||...:........||:...:.|..:|:.||..:|:...|
Zfish   834 YYLCQASNGVGSDISKSMMLTVKIPAMITSHPNTTMAIKGQNKELNCTARGEYPIIIRWERGDT- 897

  Fly   845 QYLDESLDSRYTIRDQVLD--DGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQEVPE 907
             .:|...:.||:|.....:  |.::|.|.:....|.|:..:.|.|.|::|:....|||.|||.|:
Zfish   898 -VIDPDRNPRYSITTSPNEKSDEVISTLKLKPAERGDSVFFSCHAINSYGEGRGLIQLTVQEPPD 961

  Fly   908 QPKNLRINSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQISDIWQNAEHLT--IAGAQTVINIQQL 970
            .|: |.:...:.||:.|.|:|.|.|||.|..|.|.||..||.|: .:|.|  |:......||.:|
Zfish   962 PPE-LEVREVKDRSMNLRWTQRFDGNSIITSYDIEYKNKSDPWE-LKHATRKISPTNNQANIVEL 1024

  Fly   971 RPAKAYHIRMSAENKLGASEFSEVVQVTTLEEVPSGPPLAVRAEPKSSTEIFVTWDAPERDHWNG 1035
            .||..|.|||.:.||:|.|:.|:.:.::|.|..|.|||:.|..:|.:|..|.|||.||:::..||
Zfish  1025 HPASVYSIRMYSYNKIGRSQASKELTISTEEAPPDGPPMEVILQPMTSQSIRVTWKAPKKELQNG 1089

  Fly  1036 ILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGET-VLANLNKFTQYHVIVQAYTSQGS 1099
            ::.||.:||        :|..|.....:..||:::....|. .|.||.||.||.|:|||:...|:
Zfish  1090 VIRGYQIGY--------RENGPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGT 1146

  Fly  1100 GPPSKEIAVQTMEDVPSSPPESPQCDVLGSTSIYITWSPPDIDGQNGKIKGYKVFYISVDELYET 1164
            ||.|.||...|:|||||.||::.:...:.|....||||.|.....||.:|||:|.:.|   ||..
Zfish  1147 GPSSSEINATTLEDVPSQPPQNVRAITVTSDEAVITWSEPPRMTLNGVLKGYRVVFWS---LYPD 1208

  Fly  1165 -----------------DPEVVKSTNQYVTIENLRKYTNYTVWVLAYTKVGDGMKTKPFYCRTHE 1212
                             :.:.:.:|.:.|.::.|.|:|||:|.|||||:.|||:::...|.:|.|
Zfish  1209 GGGCCGGQTLGLNQKWGEMQNITTTREQVELKGLEKFTNYSVQVLAYTQAGDGVRSNVLYIQTRE 1273

  Fly  1213 DVPSAPQAIKAIPASSSKIIISWLPPDLPNGDITGYTFYMSMLEGGREEGTHKRLLGPFVEMHET 1277
            |.|..|..|||:|:|:|.:::|||||..|||.|..||.|.|. .|..:....:....|.:.::..
Zfish  1274 DHPGPPAGIKAVPSSASSVVVSWLPPVKPNGIIRKYTIYCSS-PGSGQPAPSEYEANPELLIYRI 1337

  Fly  1278 VRTQESATYQFWLTASTKMGEGEKTQVVTVPPNNKVPARIVSFSQRIVTPWKEHLELPCRKVGAP 1342
            ........|..|..|.|..|.|..::.|||.|..|.||:|:||...:.|||.:.:.|||..||.|
Zfish  1338 THLTRGQQYLIWAAAVTTAGRGNISEKVTVEPAGKAPAKILSFGGTVTTPWMKEVRLPCSSVGEP 1402

  Fly  1343 APVTIW-----------RQDGHNMETSARKTIAKNGTLYMKECQASDAGNYTCSVENTWGKDEIV 1396
            .|...|           .||||       :.|..||||.::..:|.|:|.|||:..||.|.|.|:
Zfish  1403 TPTIKWTKDSEDTAIPVTQDGH-------RNILSNGTLVLRSVKAEDSGYYTCTATNTLGFDTII 1460

  Fly  1397 YNIVVKVPPEAPNLTVINAYTDSLLLEWMDNSHGGSPILGYVINYKRDN-GDWEELQVDSKTTSH 1460
            .|::|:|||:.|.|||....|.|:.|.|:...:|||.|.|:|:.|..|| .:|:::.:.|...|.
Zfish  1461 VNLLVQVPPDQPRLTVSTTSTSSITLAWIPGDNGGSSIRGFVLQYSVDNTEEWKDVFISSSERSF 1525

  Fly  1461 LLTNLWCGTRYQLYITAYNKIGTGLPCDIVNSYTKGNPPVQPKHSQMITN-NSTSVTCWLDSWGD 1524
            .|.||.|||.|::.:.|.|.:|.|...:|:.:.|.|..|...|...:.|: |||.....|..|..
Zfish  1526 KLDNLRCGTWYKVKLAAKNSVGAGRISEIIEAKTHGREPQFNKDQPLFTHINSTHARMNLQGWTS 1590

  Fly  1525 GGCGILYFMIESRVYGRSSWAVVSNHIPPTERIYTVSDLVPGTKYQLKVTAHNNAGSTTAIYNFT 1589
            |||.|...::|.|..|  :||..|.....:..|: :::|...|.|:||:.|.|:||.......|.
Zfish  1591 GGCPITAVLLEFRPKG--TWAWQSVRTNASADIF-LAELREATWYELKMKACNSAGCGNQSSQFA 1652

  Fly  1590 TLSTQGVIYNNDHSTPVSHLSDLPFYAN-----------FKLLLPICFSLLMLLALIGAALFLRK 1643
            ||...|              |.:|...:           |.:..|:      :|..:|.||....
Zfish  1653 TLDYDG--------------STIPPIKSARGEGDDVKKLFSIGCPV------ILVTLGMALLFII 1697

  Fly  1644 RKLASQARLASSSMSESPSLAN--LQNKQNRDQQYLAVRCNPGTSAPRGSNSN-----------D 1695
            ||...:.||  ..:.::.|||.  :.:|.||...      .|....|:|...:           |
Zfish  1698 RKKRKEKRL--KRLRDAKSLAEMLISSKNNRSFD------TPVKGPPQGPRLHIDIPRVQLLIED 1754

  Fly  1696 SGSFGKAEGNEYI-EDICPYATFQLNKQTYSESSYSGNVYSGPYHSVRGSFVYH----------- 1748
            .      ||.:.| ||   .||..:....:|:|       ..|.....|..|:|
Zfish  1755 K------EGIKQIGED---KATIPVTDTEFSQS-------VNPQSFCTGVSVHHPALIQNTGPLI 1803

  Fly  1749 ---DVKP----------ESYHSKEPEY------TKVR------------RKVGRLR-------DP 1775
               |::|          :|.||....|      ||.:            |.||...       |.
Zfish  1804 DMSDIRPGTNPVSRKSVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGITVTESDS 1868

  Fly  1776 HSESQESDNPGSTDSEVRKILTLHIPITEYDTLGSESDNDVSARALNSAKYRAQRDTQDETSSSS 1840
            :|.|...|    ||.....:::.....:.|:.|....::......|..||:........::||..
Zfish  1869 YSASLSQD----TDKGRNSMVSTESASSTYEELARAYEHAKLEEHLQHAKFEITECFISDSSSDQ 1929

  Fly  1841 ETTPT-----SMTRKSKPPFAARKGGKPGTSGKRHVRSSSGYSSHNEETTFSISNYPPNYQDH-- 1898
            .||.|     |||..|.|       .:||.                  ..|:.|  ||..||:
Zfish  1930 MTTGTNDNADSMTSMSTP-------SEPGI------------------CRFTAS--PPKPQDYDR 1967

  Fly  1899 -----INPPARFSDA---NDKTKTQTSPRMRANQKLH--------REA 1930
                 :..|.|.:.:   |.....:|.|..|...:||        |||
Zfish  1968 GKNVAVPIPHRANKSEYCNLPLYMKTDPFFRKQAELHDPCPVVPPREA 2015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386	23/99 (23%)
		Ig strand A	32..35	CDD:409353	0/2 (0%)
		Ig strand A'	41..45	CDD:409353	2/3 (67%)
		Ig strand B	48..57	CDD:409353	2/8 (25%)
		Ig strand D	75..78	CDD:409353	0/2 (0%)
		Ig strand E	83..88	CDD:409353	0/4 (0%)
		Ig strand F	101..109	CDD:409353	2/7 (29%)
		Ig strand G	112..124	CDD:409353	3/11 (27%)
		Ig	235..326	CDD:416386	33/90 (37%)
		Ig strand A	235..238	CDD:409353	1/2 (50%)
		Ig strand A'	244..248	CDD:409353	0/3 (0%)
		Ig strand B	251..258	CDD:409353	2/6 (33%)
		Ig strand C	266..271	CDD:409353	3/4 (75%)
		Ig strand C'	276..279	CDD:409353	0/2 (0%)
		Ig strand D	285..289	CDD:409353	2/3 (67%)
		Ig strand E	292..298	CDD:409353	3/5 (60%)
		Ig strand F	305..313	CDD:409353	4/7 (57%)
		Ig strand G	316..326	CDD:409353	2/9 (22%)
		IgC2_3_Dscam	329..417	CDD:409549	24/88 (27%)
		Ig strand B	347..351	CDD:409549	0/3 (0%)
		Ig strand C	360..364	CDD:409549	1/3 (33%)
		Ig strand E	383..387	CDD:409549	1/3 (33%)
		Ig strand F	397..402	CDD:409549	3/4 (75%)
		Ig strand G	410..413	CDD:409549	1/2 (50%)
		IgI_4_Dscam	422..516	CDD:409548	35/93 (38%)
		Ig strand B	439..443	CDD:409548	2/3 (67%)
		Ig strand C	452..456	CDD:409548	1/3 (33%)
		Ig strand E	482..486	CDD:409548	3/3 (100%)
		Ig strand F	496..501	CDD:409548	2/4 (50%)
		Ig strand G	509..512	CDD:409548	0/2 (0%)
		IgI_5_Dscam	520..607	CDD:409550	32/86 (37%)
		Ig strand B	536..540	CDD:409550	0/3 (0%)
		Ig strand C	549..553	CDD:409550	1/3 (33%)
		Ig strand E	571..575	CDD:409550	3/3 (100%)
		Ig strand F	586..591	CDD:409550	2/4 (50%)
		Ig strand G	600..603	CDD:409550	0/2 (0%)
		Ig	610..703	CDD:416386	31/92 (34%)
		Ig strand A	611..613	CDD:409353	1/1 (100%)
		Ig strand A'	620..624	CDD:409353	0/3 (0%)
		Ig strand B	627..636	CDD:409353	2/8 (25%)
		Ig strand C	641..648	CDD:409353	2/6 (33%)
		Ig strand C'	650..652	CDD:409353	1/1 (100%)
		Ig strand D	659..664	CDD:409353	1/4 (25%)
		Ig strand E	668..675	CDD:409353	3/6 (50%)
		Ig strand F	682..690	CDD:409353	7/7 (100%)
		Ig strand G	693..702	CDD:409353	1/8 (13%)
		IgI_7_Dscam	706..801	CDD:409546	31/96 (32%)
		Ig strand B	724..728	CDD:409546	1/3 (33%)
		Ig strand C	737..741	CDD:409546	0/3 (0%)
		Ig strand E	766..770	CDD:409546	1/3 (33%)
		Ig strand F	780..785	CDD:409546	2/4 (50%)
		Ig strand G	794..797	CDD:409546	2/2 (100%)
		Ig	818..904	CDD:416386	25/87 (29%)
		putative Ig strand B	820..827	CDD:409353	0/6 (0%)
		putative Ig strand C	835..841	CDD:409353	1/5 (20%)
		putative Ig strand C'	853..856	CDD:409353	1/2 (50%)
		putative Ig strand D	862..866	CDD:409353	1/5 (20%)
		putative Ig strand E	868..874	CDD:409353	2/5 (40%)
		putative Ig strand F	881..889	CDD:409353	2/7 (29%)
		putative Ig strand G	892..902	CDD:409353	4/9 (44%)
		FN3	906..999	CDD:238020	37/94 (39%)
		FN3	1006..1110	CDD:238020	40/104 (38%)
		fn3	1117..1203	CDD:394996	33/102 (32%)
		FN3	1215..1307	CDD:238020	30/91 (33%)
Ig	<1334..1401	CDD:416386	29/77 (38%)
Ig strand C	1345..1349	CDD:409353	1/14 (7%)
Ig strand D	1363..1366	CDD:409353	1/2 (50%)
Ig strand E	1367..1372	CDD:409353	3/4 (75%)
Ig strand F	1380..1388	CDD:409353	4/7 (57%)
Ig strand G	1394..1401	CDD:409353	2/6 (33%)
FN3	1405..1494	CDD:238020	33/89 (37%)
FN3	1499..1580	CDD:238020	26/81 (32%)
dscaml1	XP_005157551.1	IG_like	112..184	CDD:214653	15/73 (21%)
		Ig	112..183	CDD:143165	15/72 (21%)
		Ig	194..287	CDD:299845	35/98 (36%)
		I-set	302..380	CDD:254352	32/82 (39%)
		IGc2	309..370	CDD:197706	29/65 (45%)
		IGc2	399..458	CDD:197706	19/58 (33%)
		I-set	477..571	CDD:254352	35/93 (38%)
		Ig	477..567	CDD:299845	34/89 (38%)
		IG_like	581..662	CDD:214653	28/80 (35%)
		IGc2	588..646	CDD:197706	25/57 (44%)
		Ig	684..751	CDD:143165	25/66 (38%)
		IG_like	686..756	CDD:214653	25/69 (36%)
		I-set	760..855	CDD:254352	30/95 (32%)
		Ig7_DSCAM	778..855	CDD:143211	27/77 (35%)
		IG_like	865..956	CDD:214653	24/92 (26%)
		Ig	873..963	CDD:299845	27/91 (30%)
		FN3	959..1053	CDD:238020	37/95 (39%)
		FN3	1060..1157	CDD:238020	40/104 (38%)
		FN3	1165..1271	CDD:238020	34/108 (31%)
		FN3	1276..1367	CDD:238020	30/91 (33%)
		IGc2	1392..1455	CDD:197706	25/69 (36%)
		FN3	1486..1559	CDD:238020	26/72 (36%)
		FN3	1573..1649	CDD:238020	26/78 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I10108
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	917	1.000	Inparanoid score	I353
OMA	1	1.010	-	-		QHG47134
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	1	1.000	-	-		FOG0003568
OrthoInspector	1	1.000	-	-		mtm6394
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1391
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.880