DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33234 and Sv2b

DIOPT Version :9

Sequence 1:	NP_001097483.2	Gene:	CG33234 / 2769006	FlyBaseID:	FBgn0053234	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_001103223.1	Gene:	Sv2b / 64176	MGIID:	1927338	Length:	683	Species:	Mus musculus

Alignment Length:	583	Identity:	107/583 - (18%)
Similarity:	208/583 - (35%)	Gaps:	160/583 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDIDE-------VFTKLGFGKMQ---FIIL---LSCFNLQIWMTNEQLGFGVIIAGASCEMRIH 52
            |.|.:|       :..:.|.|:.|   |.:|   |....::|::.:      ..:..|..:|.:.
Mouse    85 MEDEEELAHQYETIIDECGHGRFQWTLFFVLGLALMADGVEIFVVS------FALPSAEKDMCLS 143

  Fly    53 DRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVG 117
            ..:...|....:...|...|:.|.|||..||:|::.::..:....:.||:.|..:..|||.|.:.
Mouse   144 SSKKGMLGLIVYLGMMAGAFILGGLADKLGRKKVLSMSLAINASFASLSSFVQGYGAFLFCRLIS 208

  Fly   118 GFFIAASVVSLMTYLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLP---------LRTEP 173
            |..|..|:..:..|.|||.....|...|:.:........||...:|..::|         .....
Mouse   209 GIGIGGSLPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGIYASAMAWSIIPHYGWGFSMGTNYHF 273

  Fly   174 SSWRILLLCNQVPGIIGIIILVFLPESPKYYLSINNQEKAMQVMEKICRMNKGKKVTLNSLGVES 238
            .|||:.::...:|..:.::.|.|:||||::.|.:...::|..:::::...|...|.|...:
Mouse   274 HSWRVFVIVCALPATVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKV---- 334

  Fly   239 LTQPRLRQPTE---------KHGSCYET-KVLLLNHAKIMW----------------FFFIIFFS 277
            .|...::.|.:         ..|:.|:. .|..:...|.:|                ...:::|:
Mouse   335 FTVSHIKTPKQMDEFIEIQSSTGTWYQRWLVRFMTIFKQVWDNALYCVMGPYRMNTLILAVVWFT 399

  Fly   278 LSGLGFALPIW---MLR------------------VRVLTATFT--------------------- 300
            ::...:.|.:|   |:|                  |...|..||
Mouse   400 MALSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTMENQIHQHGKLVNDKFIKMYF 464

  Fly   301 ----DWDTM---CSHLDGIKADS---------------------------------PGRTECHLT 325
                ..||.   |...|....|:                                 ..:..||:.
Mouse   465 KHVLFEDTFFDKCYFEDVTSTDTYFKNCTIESTTFYNTDLYKHKFINCRFINSTFLEQKEGCHMD 529

  Fly   326 YEQMTDPMIH------GCVVLALFVVTSVILTWLSRRWVIIGYICISIIGCVALNFMEHPNLILI 384
            :|:..|.:|:      ...||...:::::::..:.|..:|.|.:.||.:.|..| |..:....:|
Mouse   530 FEEDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFL-FFGNSESAMI 593

  Fly   385 SFFAIIDPLICSVRLAG-----SMLIDLVPTHLRGKVFALISMTGRAGIL----ITSVYVGYT 438
            .:    ..|.|...:|.     .:.::|.||:.|...|.:::...:.|.:    |.:.:||.|
Mouse   594 GW----QCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGIT 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33234	NP_001097483.2	MFS	56..>198	CDD:119392	36/150 (24%)
Sv2b	NP_001103223.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
Sv2b	NP_001103223.1	synapt_SV2	8..683	CDD:130366	107/583 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920