Protein Alignment CG33234 and Sv2a

DIOPT Version :10

• Sequence 1: NP_001097483.2
• Gene: CG33234 / 2769006
• FlyBaseID: FBgn0053234
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_071313.1
• Gene: Sv2a / 64051
• MGIID: 1927139
• Length: 742
• Species: Mus musculus
• Alignment Length: 580
• Identity: 111/580 - (19%)
• Similarity: 207/580 - (35%)
• Gaps: 167/580 - (28%)

  Fly     5 DEVFTKLGFGKMQ----FIILLSCF--NLQIWMTNEQLGFGVIIAGASCEMRIHDRRLAWLMAAS 63
            :.:..:.|.|:.|    |::.|:..  .:::::.      |.::..|..:|.:.|.....|....
Mouse   153 ETILRECGHGRFQWTLYFVLGLALMADGVEVFVV------GFVLPSAEKDMCLSDSNKGMLGLIV 211

  Fly    64 FAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSL 128
            :...||..||||.|||..|||:.::|:.:|.::.:..|:.|..:..|||.|.:.|..|..|:..:
Mouse   212 YLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIV 276

  Fly   129 MTYLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLP---------LRTEPSSWRILLLCNQ 184
            .:|.|||.....|...|:.:.....:..:|...:|..::|         ...:..|||:.:|...
Mouse   277 FSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCA 341

  Fly   185 VPGIIGIIILVFLPESPKYYLSINNQEKAMQVMEKICRMN---KGKKVTLNSL-GVESLTQ-PRL 244
            .|.:..|..|...||||:::|.....::|..|::::...|   ||....:.|: .::::.| ..|
Mouse   342 FPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDEL 406

  Fly   245 RQPTEKHGSCYET-KVLLLNHAKIMWFFFI----------------IFFSLSGLGFALPIWMLRV 292
            .:.....|:.|:. .|..|:....:|..|:                ::|::|...:.|.:|
Mouse   407 IEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFSPEYRRITLMMMGVWFTMSFSYYGLTVW---- 467

  Fly   293 RVLTATFTDWDTMCSHLDGIKADS-----PGRTECHLTYEQMTDPMIH----------------- 335
                  |.|   |..||..:...:     ||....|:|:....:..||
Mouse   468 ------FPD---MIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKS 523

  Fly   336 ----------------------------------------------------------GC----- 337
                                                                      ||
Mouse   524 VSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHNKEGCPLDVT 588

  Fly   338 ------------------VVLALFVVTSVILTWLSRRWVIIGYICISIIGCVALNF--MEHPNLI 382
                              .||...:|:::::..:.|..::.|...:|.:.|..|:|  .|...:.
Mouse   589 GTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVLSCVSCFFLSFGNSESAMIA 653

  Fly   383 LISFFAIIDPLICSVRLAGSMLIDLVPTHLRGKVF----ALISMTGRAGILITSVYVGYT 438
            |:..|..:.  |.|......:.::|.|:..|...|    ||..:....||.|.:.:||.|
Mouse   654 LLCLFGGVS--IASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGIT 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33234	NP_001097483.2	2A0119	<64..>234	CDD:273328	49/181 (27%)
Sv2a	NP_071313.1	synapt_SV2	1..742	CDD:130366	111/580 (19%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..145