DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33234 and sv2a

DIOPT Version :9

Sequence 1:	NP_001097483.2	Gene:	CG33234 / 2769006	FlyBaseID:	FBgn0053234	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	XP_696434.2	Gene:	sv2a / 568033	ZFINID:	ZDB-GENE-131001-1	Length:	733	Species:	Danio rerio

Alignment Length:	581	Identity:	110/581 - (18%)
Similarity:	207/581 - (35%)	Gaps:	170/581 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DEVFTKLGFGKMQ----FIILLSCF--NLQIWMTNEQLGFGVIIAGASCEMRIHDRRLAWLMAAS 63
            :.:..:.|.|:.|    |::.|:..  .::|::.      |.::..|..:|.:.:.....|....
Zfish   145 ETILQECGHGRFQWTLYFVLGLALMADGVEIFVV------GFVLPSAEKDMCLSEPNKGMLGLIV 203

  Fly    64 FAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSL 128
            :...||..|:||.|||..|||:.::|:.::.::.:..|:.|..:..|||.|.:.|..|..|:..:
Zfish   204 YLGMMVGAFVWGGLADRIGRRQTLLISLSINSVFAFFSSFVQGYSSFLFCRLLSGVGIGGSIPIV 268

  Fly   129 MTYLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLP---------LRTEPSSWRILLLCNQ 184
            .:|.|||.....|...|:.:.....:..||...:|..::|         ...:..|||:.:|...
Zfish   269 FSYYSEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCA 333

  Fly   185 VPGIIGIIILVFLPESPKYYLSINNQEKAMQVMEKICRMN-KGKKVTLNSLGVESL-TQPRLRQP 247
            .|.:..|..|..:||||::||.....::|..:::::...| :.|........|.:: |..::.:.
Zfish   334 FPSVAAIAALTTMPESPRFYLENGKHDEAWMILKQVHDTNMRAKGYPERVFSVTTIKTVKQMDEL 398

  Fly   248 TEKHGSC------YETKVLLLNH--------------AKIMWFFFIIFFSLSGLGFALPIWMLRV 292
            .:..|..      :..|:..|.|              .:|.:....::||:|...:.|.:|
Zfish   399 VDMGGEATAWHQRWRIKLTNLFHQVWGNFLTVFNPEYRRITYMMMAVWFSMSFSYYGLTVW---- 459

  Fly   293 RVLTATFTDWDTMCSHLDGIKADSPGRTEC-------HLTYEQMTDPMIH--------------- 335
                  |.|   |..:|.  |.:...||:.       |:|:....:..||
Zfish   460 ------FPD---MIKYLQ--KQEYSSRTKVFIKEKVEHVTFNFTLENQIHRNGEYFNNKFLNLKM 513

  Fly   336 ------------------------------------------------------------GCVV- 339
                                                                        ||::
Zfish   514 KSMVFEDSLFEECYFEDITSSNTFFRNCTFISTLFYNTDLFKYRLINSKLINSTFLHNKEGCMLD 578

  Fly   340 ------------------LALF---VVTSVILTWLSRRWVIIGYICISIIGCVALNF--MEHPNL 381
                              ||:.   :|:::::..:.|..::.|...||.:.|..|:|  .|...:
Zfish   579 FSDENNAYMIYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVISCVSCFFLSFGNSESAMI 643

  Fly   382 ILISFFAIIDPLICSVRLAGSMLIDLVPTHLRGKVF----ALISMTGRAGILITSVYVGYT 438
            .|:..|..|.  |.|......:.::|.|:..|...|    ||..:....||.|...:||.|
Zfish   644 ALLCLFGGIS--IASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFQSFVGIT 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33234	NP_001097483.2	MFS	56..>198	CDD:119392	39/150 (26%)
sv2a	XP_696434.2	synapt_SV2	1..733	CDD:130366	110/581 (19%)
sv2a	XP_696434.2	MFS	162..725	CDD:119392	107/564 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920