DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33234 and Sv2c

DIOPT Version :9

Sequence 1:	NP_001097483.2	Gene:	CG33234 / 2769006	FlyBaseID:	FBgn0053234	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_113781.1	Gene:	Sv2c / 29643	RGDID:	619718	Length:	727	Species:	Rattus norvegicus

Alignment Length:	586	Identity:	111/586 - (18%)
Similarity:	221/586 - (37%)	Gaps:	148/586 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFTKLGFGKMQ---FIIL---LSCFNLQIWMTNEQLGFGVIIAGASCEMRIHDRRLAWLMAASFA 65
            :..:.|.|:.|   |.:|   |....:::::.      |.::..|..::.|.:....||.:..:.
  Rat   141 IIQECGHGRFQWALFFVLGMALMADGVEVFVV------GFVLPSAETDLCIPNSGSGWLGSIVYL 199

  Fly    66 AQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMT 130
            ..||..|.||.|||..||::.::|..:|....:.||:.|..:..||..|.:.||.|..::.::.:
  Rat   200 GMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLLCRLLSGFGIGGAIPTVFS 264

  Fly   131 YLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLP---------LRTEPSSWRILLLCNQVP 186
            |.:|......|...|:.:.....:..||...:|..::|         ...:..|||:.::...:|
  Rat   265 YFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALP 329

  Fly   187 GIIGIIILVFLPESPKYYLSINNQEKAMQVM--------------EKICRMNKGK--KVTLNSLG 235
            .:..::.|.|:||||::.|.:...::|..::              ||:..:||.|  |.....:.
  Rat   330 CVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIE 394

  Fly   236 VESLTQP-------RLRQPTEKHG------SCYETKVLLLNHAKIMWFFFIIFFSLSGLGFALPI 287
            :||.|..       |:|  ||.:|      .|:...| ..|..|:.    |::|:||...:.|.:
  Rat   395 IESDTGTWYRRCFVRIR--TELYGIWLTFMRCFNYPV-RENTIKLT----IVWFTLSFGYYGLSV 452

  Fly   288 W------------------------------------------------MLRVRVLTATFTD--- 301
            |                                                .|.|:..:.||.|
  Rat   453 WFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTMENQVHTGMEYDNGRFLGVKFKSVTFKDSVF 517

  Fly   302 ----WDTM---------CSHLDGIKADSP------------------GRTECHLTYEQMTDP--- 332
                :|.:         |:.:|.:..::.                  .:|.|.:|::.....
  Rat   518 KSCTFDDVTSVNTYFKNCTFIDTLFENTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWI 582

  Fly   333 ----MIHGCVVLALFVVTSVILTWLSRRWVIIGYICISIIGCVALNFMEHPNLILISFFAIIDPL 393
                .:....||...:|:::::..:.|..::.|.:.:|.|.|..|.|....:: :|....:.:.|
  Rat   583 YFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESM-MIGMLCLYNGL 646

  Fly   394 ICSV-RLAGSMLIDLVPTHLRGKVFALISMTGRAGILITSVYVGYTLSYICYVTFNIFILVLIVT 457
            ..|. .....:.::|.||..|...|..::...:|..::.::..|..:|....:...:...||:..
  Rat   647 TISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVLVCG 711

  Fly   458 G 458
            |
  Rat   712 G 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33234	NP_001097483.2	MFS	56..>198	CDD:119392	37/150 (25%)
Sv2c	NP_113781.1	synapt_SV2	1..727	CDD:130366	111/586 (19%)
		Interaction with SYT1. /evidence=ECO:0000269\|PubMed:15866046	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..120
		MFS	155..719	CDD:119392	108/572 (19%)
		Pentapeptide_3	507..561	CDD:290309	6/53 (11%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:16543415, ECO:0000269\|PubMed:27294781	529..566		2/36 (6%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920