DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33234 and SV2C

DIOPT Version :9

Sequence 1:	NP_001097483.2	Gene:	CG33234 / 2769006	FlyBaseID:	FBgn0053234	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_055794.3	Gene:	SV2C / 22987	HGNCID:	30670	Length:	727	Species:	Homo sapiens

Alignment Length:	607	Identity:	114/607 - (18%)
Similarity:	223/607 - (36%)	Gaps:	176/607 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFTKLGFGKMQ---FIIL---LSCFNLQIWMTNEQLGFGVIIAGASCEMRIHDRRLAWLMAASFA 65
            :..:.|.|:.|   |.:|   |....:::::.      |.::..|..::.|.:....||.:..:.
Human   141 IIQECGHGRFQWALFFVLGMALMADGVEVFVV------GFVLPSAETDLCIPNSGSGWLGSIVYL 199

  Fly    66 AQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMT 130
            ..||..|.||.|||..||::.::|..:|....:.||:.|..:..|||.|.:.||.|..::.::.:
Human   200 GMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFS 264

  Fly   131 YLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLP---------LRTEPSSWRILLLCNQVP 186
            |.:|......|...|:.:.....:..||...:|..::|         ...:..|||:.::...:|
Human   265 YFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALP 329

  Fly   187 GIIGIIILVFLPESPKYYLSINNQEKAMQVM--------------EKICRMNKGK--KVTLNSLG 235
            .:..::.|.|:||||::.|.:...::|..::              ||:..:||.|  |.....:.
Human   330 CVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIE 394

  Fly   236 VESLTQP-------RLRQPTEKHGSCYETKVLLLNHAKIMWFFF----------------IIFFS 277
            :||.|..       |:|  ||.:|               :|..|                |::|:
Human   395 IESDTGTWYRRCFVRIR--TELYG---------------IWLTFMRCFNYPVRDNTIKLTIVWFT 442

  Fly   278 LSGLGFALPIW------------------------------------------------MLRVRV 294
            ||...:.|.:|                                                .:.|:.
Human   443 LSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKF 507

  Fly   295 LTATFTD----------------WDTMCSHLDGIKADSP------------------GRTECHLT 325
            .:.||.|                :...|:.:|.:..::.                  .:|.|.:|
Human   508 KSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQIT 572

  Fly   326 YEQMTDP-------MIHGCVVLALFVVTSVILTWLSRRWVIIGYICISIIGCVALNFMEHPNLIL 383
            ::.....       .:....||...:|:::::..:.|..::.|.:.:|.|.|..|.|....:: :
Human   573 FDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESM-M 636

  Fly   384 ISFFAIIDPLICSV-RLAGSMLIDLVPTHLRGKVFALISMTGRAGILITSVYVGYTLSYICYVTF 447
            |....:.:.|..|. .....:.::|.||..|...|..::...:|..::.::..|..:|    :|.
Human   637 IGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVS----ITK 697

  Fly   448 NIFIL----VLIVTGCHVYWLP 465
            :|.||    ||:..|.....||
Human   698 SIPILLASTVLVCGGLVGLCLP 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33234	NP_001097483.2	MFS	56..>198	CDD:119392	38/150 (25%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	114/607 (19%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..84
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128
		MFS	155..719	CDD:119392	109/591 (18%)
		Pentapeptide_3	507..561	CDD:290309	5/53 (9%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:27294781	519..563		2/43 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920