DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33234 and sv2a

DIOPT Version :9

Sequence 1:	NP_001097483.2	Gene:	CG33234 / 2769006	FlyBaseID:	FBgn0053234	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	XP_012825002.1	Gene:	sv2a / 100379721	XenbaseID:	XB-GENE-968429	Length:	729	Species:	Xenopus tropicalis

Alignment Length:	583	Identity:	117/583 - (20%)
Similarity:	208/583 - (35%)	Gaps:	181/583 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFTKLGFGKMQ----FIILLSCF--NLQIWMTNEQLGFGVIIAGASCEMRIHDRRLAWLMAASFA 65
            :..:.|.|:.|    |::.|:..  .::|::.      |.::..|..:|.:.|.....|....:.
Frog   142 ILQECGHGRFQWTLYFVLGLALMADGVEIFVV------GFVLPSAEKDMCLSDSNKGMLGLIVYL 200

  Fly    66 AQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMT 130
            ..||..||||.:||..|||:.::|:.:|.::.:..|:.|..:..|||.|.:.|..|..|:..:.:
Frog   201 GMMVGAFLWGGMADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFS 265

  Fly   131 YLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLP---------LRTEPSSWRILLLCNQVP 186
            |.|||.....|...|:.:.....:..||...:|..::|         ...:..|||:.:|....|
Frog   266 YFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFP 330

  Fly   187 GIIGIIILVFLPESPKYYLSINNQEKAMQVMEKICRMN---KGKKVTLNSLGVESLTQPR-LRQP 247
            .:..|..|..:||||:::|.....::|..|::::...|   ||     :...|.|:||.: ::|.
Frog   331 SVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMRAKG-----HPERVFSVTQIKTIKQD 390

  Fly   248 TEKHGSCYETKVL-------LLNHAKIMWFFF----------------IIFFSLSGLGFALPIWM 289
            .|......:|..|       |||.::.:|..|                .::|::|...:.|.:|
Frog   391 DELVEIQSDTGALHRRWMIKLLNLSQEVWANFHQCFAPEYRRITLMMMAVWFTMSFSYYGLTVW- 454

  Fly   290 LRVRVLTATFTDWDTMCSHLDGIKADSPGR----------------------------------- 319
                     |.|   |..||..|...|..:
Frog   455 ---------FPD---MIKHLQNIDYASRTKYFHNESVNNFNFNFTLENQVHRKGEYHNDKFIGLK 507

  Fly   320 -----------TECHLTYEQMT---------------------------------DPMIH---GC 337
                       |:|:  :|.:|                                 ...:|   ||
Frog   508 LKSVIFEDSLFTDCY--FEDITSSNTFFKNCSFIRTMFYNTDLFDYKFINSKFTNSTFLHSKEGC 570

  Fly   338 -----------------------VVLALFVVTSVILTWLSRRWVIIGYICISIIGCVALNF--ME 377
                                   .||...:|:::::..:.|..::.|...:|.|.|..|.|  .|
Frog   571 QLDFSDDINNAYMIYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCISCFFLFFGNSE 635

  Fly   378 HPNLILISFFAIIDPLICSVRLAGSMLIDLVPTHLRGKVF----ALISMTGRAGILITSVYVG 436
            ...:.|:..|..:.  |.|......:.::|.|:..|...|    ||..:....||.|.:.:||
Frog   636 SAMIALLCLFGGVS--IASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVG 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33234	NP_001097483.2	MFS	56..>198	CDD:119392	40/150 (27%)
sv2a	XP_012825002.1	synapt_SV2	1..729	CDD:130366	117/583 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920