Protein Alignment CG33233 and SV2A

DIOPT Version :9

• Sequence 1: NP_995978.2
• Gene: CG33233 / 2769005
• FlyBaseID: FBgn0053233
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_001315603.1
• Gene: SV2A / 9900
• HGNCID: 20566
• Length: 742
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 118/604 - (19%)
• Similarity: 216/604 - (35%)
• Gaps: 138/604 - (22%)

  Fly     3 AMDVDTALLTIGYGLGQVIIFMVSFFIYMYSVTESMTAGYLVVLTSCEFD--TSPKEKTLLANSL 65
            |...:..|...|:|..|..::.|.....|....|....|:  ||.|.|.|  .|...|.:|...:
Human   149 AQQYEAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGF--VLPSAEKDMCLSDSNKGMLGLIV 211

  Fly    66 LGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQ 130
            ..||:......|.||||.||:..:.::|.....|:..|:.:....:....|::.|..:.....:.
Human   212 YLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIV 276

  Fly   131 VGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILPN-NFNVDLSSSYNLRVWRFLMMFFM 194
            ..:..||.|.:.|...::.......:..:|...:|.||:|: .::..:.|:|....||..::...
Human   277 FSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCA 341

  Fly   195 IPGWLALVGICLVPETPHFLMSVNRPDKALLALKWICRMNRKKWEDVDITLSEEKSSTNDQE--- 256
            .|...|:..:...||:|.|.:...:.|:|.:.||.:...|.:.....:...|.....|..||
Human   342 FPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDEL 406

  Fly   257 -------GFWKTVWYEYKLLFSKPHVFKFFICLF---------LIFGIFFTS----IGLGIWFP- 300
                   |.|...| ..:.|.....|:..|:..|         ::.|::||.    .||.:|||
Human   407 IEIQSDTGTWYQRW-GVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPD 470

  Fly   301 VIRNM------------------------------------------------------------ 305
            :||::
Human   471 MIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECY 535

  Fly   306 --DNSGSN---RLCDLVNN------------------NPTFINHEADDTNGTDSESPKCNDEMTN 347
              |.:.||   |.|..:|.                  |.||::::..           |..::|.
Human   536 FEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEG-----------CPLDVTG 589

  Fly   348 LIDPVY--YGFTYIGCF------ILASVLVHWMTRKYVIALHILISMILGISLNIMKQPTVVLIF 404
            ..:..|  |..:::|..      |::::|:..:.|..::|...::|.:....|:.....:.::
Human   590 TGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMI-- 652

  Fly   405 FVLMMVLPGVLIPL--ATSVL-VDCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRVTCDVTF 466
             .|:.:..||.|..  |..|| |:..|.:.|..|...:.:|.:...|||.::...|:.:|.....
Human   653 -ALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPI 716

  Fly   467 NIFNLCLAICVVLAVFQPK 485
            ...:..||:...||:..|:
Human   717 LFASAALALGSSLALKLPE 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	105/549 (19%)
		MFS	23..>208	CDD:119392	41/187 (22%)
		MFS	354..>482	CDD:304372	29/136 (21%)
SV2A	NP_001315603.1	synapt_SV2	1..742	CDD:130366	118/604 (20%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..144

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5294
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870