DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33233 and SLC22A8

DIOPT Version :9

Sequence 1:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001171661.1	Gene:	SLC22A8 / 9376	HGNCID:	10972	Length:	542	Species:	Homo sapiens

Alignment Length:	457	Identity:	99/457 - (21%)
Similarity:	180/457 - (39%)	Gaps:	90/457 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EFD---TSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIR---LALVGALSFSVISALMPD 108
            |:|   .|.|.|.:..:..:.|::..||.:|.|:||:||:.::.   |.|..:.|.:..|...|
Human   111 EWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFP- 174

  Fly   109 LYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITV-AICSQSQGLALIYCPLVAMAILPNN 172
            :|  .|.|.:.|..:|.: :|....|.    ::|.|..: ||.|.:.|    ||......|||
Human   175 IY--MVFRFLCGFGISGI-TLSTVILN----VEWVPTRMRAIMSTALG----YCYTFGQFILP-- 226

  Fly   173 FNVDLSSSYNLRVWRFLMMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWICRMNRKK 237
                 ..:|.:..||:|.:...||.::..:.....||:..:|:...:..|||..|:.:...|.||
Human   227 -----GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK 286

  Fly   238 WEDVDITLSEEKSSTNDQEGFWKTVWYEYKLLFSKPHVFKFFICLFLIF---GIFFTSIGLGIWF 299
            .|...::|.|.|.:...:....|.. |....||..|.:.:...||.|.:   |..:.|:.:|:
Human   287 EEGERLSLEELKLNLQKEISLAKAK-YTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGV-- 348

  Fly   300 PVIRNMDNSGSNRLCDLVNNNPTFINHEADDTNGTDSESPKCNDEMTNLIDPVYYGFTYIGCFIL 364
                  :..|.|.                                   .|..:.:|...:....:
Human   349 ------EEFGVNL-----------------------------------YILQIIFGGVDVPAKFI 372

  Fly   365 ASVLVHWMTRKYVIALHILIS--MILGIS---LNIMKQPTVVLIFFVLMMVLPGVLIPLATSVLV 424
            ..:.:.::.|....|..:|::  .||.::   |::....||:.:|....:......:.|.||.|
Human   373 TILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSEL- 436

  Fly   425 DCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRVTCDVTFNIFNLCLAICVVL----AVFQPK 485
              .|..:|...:.:.....|.|     :|:...:::|.:|...|.|:...|..:|    |:|.|:
Human   437 --YPTVIRQTGMGVSNLWTRVG-----SMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPE 494

  Fly   486 DI 487
            .:
Human   495 TL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	89/415 (21%)
		MFS	23..>208	CDD:119392	43/164 (26%)
		MFS	354..>482	CDD:304372	26/136 (19%)
SLC22A8	NP_001171661.1	2A0119	11..503	CDD:273328	99/457 (22%)
		MFS	96..493	CDD:119392	98/452 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153399
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840