Protein Alignment CG33233 and SLC22A4

DIOPT Version :10

• Sequence 1: NP_995978.2
• Gene: CG33233 / 2769005
• FlyBaseID: FBgn0053233
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 108/521 - (20%)
• Similarity: 186/521 - (35%)
• Gaps: 143/521 - (27%)

  Fly     2 PAMDVDTALLTIGYGLGQVIIFMVSFFIYMYSVTESMTAG-------YL-VVLTSCEFDTSPKEK 58
            |..|||         |||:             ..||...|       || .|:|..........|
Human    99 PGRDVD---------LGQL-------------EQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWK 141

  Fly    59 TLLANSLLGGMVASGLFI-GFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTF 122
            ..|..||....|..|.|: |.|:||:|||.|:...:.....||.:..........:|:.:|||
Human   142 VPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVG-- 204

  Fly   123 LSAVASLQVGF------LGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILPNNFNVDLSSSY 181
            :..:::..|.|      ||:         :|.|...:.|:...:.  |...:||       ..:|
Human   205 MGQISNYVVAFILGTEILGK---------SVRIIFSTLGVCTFFA--VGYMLLP-------LFAY 251

  Fly   182 NLRVWRFLMMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWICRMNRKKWEDVDITLS 246
            .:|.||.|::...:||.|.:.....:||:|.:|:|..|..:|...::...:||......|.....
Human   252 FIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSV 316

  Fly   247 EEKSSTNDQEGFWKTVWYEYKLLFSKPHVFKFFICLFLIFGIFFTSIGLGIWFPVIRNMDNSGSN 311
            ||.:....|:.|...       ||...::....|...|::  ..||:|   :|.:
Human   317 EELNPLKQQKAFILD-------LFRTRNIAIMTIMSLLLW--MLTSVG---YFAL---------- 359

  Fly   312 RLCDLVNNNPTFINHEADDTNGTDSESPKCNDEMTNLIDPVYYGFTYIGCF----------ILAS 366
                                               :|..|..:|..|:.||          |.|.
Human   360 -----------------------------------SLDAPNLHGDAYLNCFLSALIEIPAYITAW 389

  Fly   367 VLVHWMTRKYVIALHILISMIL----GISLNIMKQPTVVLIFFVLMMVLPGVLIPLATSVL---- 423
            :|:..:.|:|:||      .:|    |:.|.|...|.......:.:::|....|..|.|:|
Human   390 LLLRTLPRRYIIA------AVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFT 448

  Fly   424 VDCLPVNLRGKALCMVRSLARFGGVLGS--TMIGLFIRVTCDVTFNIFNLCLAICVVLAVFQPKD 486
            .:..|..:|..|:.:..:.:|.|.::..  ..:|.:.|:   :.:.:......:..:|.:|.|:.
Human   449 AELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRM---LPYIVMGSLTVLIGILTLFFPES 510

  Fly   487 I 487
            :
Human   511 L 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33233	NP_995978.2	2A0119	<49..>295	CDD:273328	59/252 (23%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	108/521 (21%)