DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33233 and Slc22a23

DIOPT Version :9

Sequence 1:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_072146.1	Gene:	Slc22a23 / 64559	RGDID:	620302	Length:	689	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	92/460 - (20%)
Similarity:	180/460 - (39%)	Gaps:	104/460 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVAS 128
            |||.|::...|..|.:||..||:.|:..:::..|.|.:..||..::...|.:|...|..|:
  Rat   230 SLLVGLIFGYLITGCIADWVGRRPVLLFSVIFILIFGLTVALSVNVTMFSTLRFFEGFCLA---- 290

  Fly   129 LQVGFLGEFHAIKWRPITVAICSQSQGLAL-IYCPLVAMA---ILPNNFNVDLSSSYNLRVWRFL 189
               |.:...:|::     :.:|...:...: :....||||   ::|.     |::.  .|.|:.|
  Rat   291 ---GIILTLYALR-----IELCPPGKRFIITMVASFVAMAGQFLMPG-----LAAL--CRDWQVL 340

  Fly   190 MMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWICRMNRKKWEDVDITLSEEKSSTND 254
            ....:.|..|.|:...:.||:..:||:..:.:.|...:.::.:.|         .:|.|    :|
  Rat   341 QALIICPFLLMLLYWSIFPESLRWLMATQQFESAKKLILYLTQKN---------CVSPE----SD 392

  Fly   255 QEGFWKTVWYEYKLLFSKPHVFKFFICLFLIFGIFFTSIGLGIWFPVIRNMDNSGSNRLCDLVNN 319
            .:|....:   .|.|..:|..    :|:..:.|.      ..:|..::         .||  ||:
  Rat   393 IKGVMPEL---EKELSRRPKK----VCIVKVVGT------RNLWKNIV---------VLC--VNS 433

  Fly   320 NPTFINHE--ADDTNGTDSESPKCNDEMTNLIDPVYYGFTYIGCFILASVL-----VHWMTRKYV 377
            ...:..|.  |....|.:.:.|        |::..|..:..:....|||.|     |.::.|:..
  Rat   434 LTGYGIHHCFARSMMGHEVKVP--------LLENFYADYYTMASIALASCLAMCLVVRFLGRRGG 490

  Fly   378 IALHILISMI-----LGISLNIM----KQPTVVL------------------IFFVLMMVLPGVL 415
            :.|.::::.:     ||: ||::    :.|...|                  .|.::.|.....:
  Rat   491 LLLFMILTALASLLQLGL-LNLIGKYSQHPDSELQLKLAVGMSDSVKDKFSIAFSIVGMFASHAV 554

  Fly   416 IPLATSVLVDCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRVTCDVTFNIFNLCLAICVVLA 480
            ..|:.....:..|..:|...|.:|.:.|.| |:|.:.:|.|..:....:...||..|..||::..
  Rat   555 GSLSVFFCAEITPTVIRCGGLGLVLASAGF-GMLTAPIIELHNQKGYFLHHIIFACCTLICIICI 618

  Fly   481 VFQPK 485
            :..|:
  Rat   619 LLLPE 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	84/424 (20%)
		MFS	23..>208	CDD:119392	34/147 (23%)
		MFS	354..>482	CDD:304372	31/159 (19%)
Slc22a23	NP_072146.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..188
		MFS_SLC22A23	187..608	CDD:341002	87/443 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346848
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930