DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33233 and Slc22a21

DIOPT Version :9

Sequence 1:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_062697.1	Gene:	Slc22a21 / 56517	MGIID:	1929481	Length:	564	Species:	Mus musculus

Alignment Length:	477	Identity:	89/477 - (18%)
Similarity:	170/477 - (35%)	Gaps:	134/477 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EFDTSPKE--KTLLANSLLGGMVASGLFI-GFLADRYGRKFVIRLALVGALSFSVISALMPDLYS 111
            |:|...|:  |..|..|.....|..|.|| |.|:||:|||.::.|.:.....||.|.....:...
Mouse   131 EWDLVCKDDWKAPLTTSFFYVGVLLGSFISGQLSDRFGRKNILFLTMAMHTGFSFIQVFSVNFEM 195

  Fly   112 LSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILPNNFNVD 176
            .:::..:||          :|.:..:.|    ...:.....|:.:.:|:..|.........|.|.
Mouse   196 FTLLYTLVG----------MGHISNYVA----AFVLGTEMLSKSVRIIFATLGVCIFFAFGFMVL 246

  Fly   177 LSSSYNLRVWRFLMMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWICRMNRKKWEDV 241
            ...:|.:|.||.|::...:||.|.......:||:|.:|:|..|..:|.:.::...::|.......
Mouse   247 PLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPST 311

  Fly   242 DITLSEEKSSTNDQEGFWKTVWYEYKLLFSKP---HVFKFF----ICLFLIFG-IFFTSIGLGIW 298
            ....||.....:|..              .||   |::...    |.:..|.. |.:.:|.:|.:
Mouse   312 IFDPSETNKLQDDSS--------------KKPQSHHIYDLVRTPNIRILTIMSIILWLTISVGYF 362

  Fly   299 FPVIRNMDNSGSNRLCDLVNNNPTFINHEADDTNGTDSESPKCNDEMTNLIDPVYYGFTYIGCFI 363
                                              |...::|..|            |..|:.||:
Mouse   363 ----------------------------------GLSLDTPNLN------------GNIYVNCFL 381

  Fly   364 LASV----------LVHWMTRKYVIALHILISMILGISLNIMKQPTVVLIFFVLMMVLPGVLIPL 418
            ||:|          |:..::|:|.:|    .|:.||.|:            .:|:.::|..|..|
Mouse   382 LAAVEVPAYVLAWLLLQHVSRRYSMA----GSLFLGGSV------------LLLVQLVPSDLHYL 430

  Fly   419 ATSVLV------------------DCLPVNLRGKALCMVRSLARFGGVLGS--TMIGLFIRVTCD 463
            :|::::                  :..|..:|...:.:..:.:|.|.:|..  ..:|.:.|   .
Mouse   431 STTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDR---R 492

  Fly   464 VTFNIFNLCLAICVVLAVFQPK 485
            :.:.:......:..::.:|.|:
Mouse   493 LPYILMGSLTILTAIITLFFPE 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	85/439 (19%)
		MFS	23..>208	CDD:119392	38/160 (24%)
		MFS	354..>482	CDD:304372	27/157 (17%)
Slc22a21	NP_062697.1	2A0119	12..523	CDD:273328	89/477 (19%)
		MFS	123..513	CDD:119392	88/474 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843436
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840