DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33233 and slc22a15

DIOPT Version :9

Sequence 1:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001103169.1	Gene:	slc22a15 / 555262	ZFINID:	ZDB-GENE-070928-5	Length:	497	Species:	Danio rerio

Alignment Length:	534	Identity:	106/534 - (19%)
Similarity:	190/534 - (35%)	Gaps:	128/534 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MDVDTALLTIG-YGLGQVIIFMVSFFIYMYSVTESMTAGYLVVLTSC--EFDTSP---------- 55
            ||::.|...:| :|..|..:..|..|:.:|...:||    |::|...  |:...|
Zfish     1 MDLEEAFQVVGEFGSHQKRMITVLVFLQIYMACQSM----LIILVGAVPEYHIEPVTEGVDGDVT 61

  Fly    56 ----------------------KEKTLLANSL-LGGMVASGLFIGFLADRYGRKFVIRLALVGAL 97
                                  ..|..||.|| ..|::...:..|.|:|:.|||.|....|...:
Zfish    62 QSVKFTEDVNSIVTEWYLVKHQAYKVNLAGSLFFAGVLIGNVVFGPLSDKIGRKPVFLTGLFFEV 126

  Fly    98 SFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAICSQ--SQGLALIY 160
            .|...:||.|...:.:|.|::||.....:|.:......|:....:..:|..:.:.  :.|::|.
Zfish   127 LFGYGTALAPSYEAFAVSRLLVGVMNGGMALVCFVLTQEYVGKSYWAMTGTLTNMTFAVGISLF- 190

  Fly   161 CPLVAMAILPNNFNVDLSSSYNLRVWRFLMMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALL 225
                            .:..|.:|.||.|......||.|..:....:||:|.:|.|....:||..
Zfish   191 ----------------AALGYYVRPWRNLATAANCPGLLLFLLCVTLPESPRWLYSRGYTEKAED 239

  Fly   226 ALKWICRMNRKKWEDVDITLSEEKSSTNDQEGFWKTVWYEYKLLFSKPHVFKFFICLFLIFGIFF 290
            .|:.....|.|  ..:.:.|....||.|.                |.|.||:......|.:.
Zfish   240 ILQDFALRNGK--GRIVVKLRRASSSPNS----------------SSPGVFQLVTHPVLRWR--- 283

  Fly   291 TSIGLGIWFPVIRNMDNSGSNRLCDLVNNNPTFINHEADDTNGTDSESPKCNDEMTNLIDPVYYG 355
            |.:.:.:|:             .|.||....| :|...|..|              ..:....||
Zfish   284 TVVLMYVWY-------------ACSLVYYGLT-LNAGEDKGN--------------RYLSVAMYG 320

  Fly   356 FTYIGCFILASVLVH--WMTRKYVIA-------LHILISMILGISLNIMKQPTVVLIFFVLMMVL 411
            ...:..:.|....::  |..|:..:|       :..|::|::.:|.:::...::.|: ..||:..
Zfish   321 LVELPAYPLCMYFINKPWAGRRKSMANFLAFAGISCLLTMVVPVSGSLLSATSLALV-GKLMVSA 384

  Fly   412 PGVLIPLATSVLVDCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRVTCDVTFNIFNL----- 471
            ...::.:.||.|   .|..:|...|.:.....|.||:| :..:.....:...:.|.:|.|
Zfish   385 AFNIVYVYTSEL---YPTVIRNAGLGVCSMSCRVGGIL-APFVPSMKSLHTSMPFMVFCLSGISA 445

  Fly   472 -CLAICVVLAVFQP 484
             ||.:.:...:.:|
Zfish   446 GCLGLLLPETLNKP 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	94/474 (20%)
		MFS	23..>208	CDD:119392	44/221 (20%)
		MFS	354..>482	CDD:304372	27/142 (19%)
slc22a15	NP_001103169.1	2A0119	11..463	CDD:273328	103/524 (20%)
slc22a15	NP_001103169.1	MFS	87..453	CDD:119392	89/436 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588617
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930